Forschungszentrum Borstel
Forschungszentrum Borstel

Programmbereich Asthma und Allergie

Biochem. Immunologie

Publikationen

2017

Michelfelder, M, Becker, W-M, Riedlinger, A, Siegert, E, Drömann, D, Yu, X, Petersen, F & Riemekasten, G 2017, 'Interstitial lung disease increases mortality in systemic sclerosis patients with pulmonary arterial hypertension without affecting hemodynamics and exercise capacity' Clinical Rheumatology, Bd 36, Nr. 2, S. 381-390. DOI: 10.1007/s10067-016-3504-6

2016

Akbarzadeh Najar, R, Yu, X, Vogl, T, Ludwig, RJ, Schmidt, E, Zillikens, D & Petersen, F 2016, 'Myeloid-related proteins-8 and -14 are expressed but dispensable in the pathogenesis of experimental epidermolysis bullosa acquisita and bullous pemphigoid' Journal of dermatological science, Bd 81, Nr. 3, S. 165-72., 10.1016/j.jdermsci.2015.12.001

Chen, Y, Zheng, J, Huang, Q, Deng, F, Huang, R, Zhao, W, Yin, J, Song, L, Chen, J, Gao, X, Liu, Z, Petersen, F & Yu, X 2016, 'Autoantibodies against the Second Extracellular Loop of M3R Do neither Induce nor Indicate Primary Sjögren's Syndrome' PLOS ONE, Bd 11, Nr. 2, S. e0149485., 10.1371/journal.pone.0149485

2015

Yu, X, Kasprick, A & Petersen, F 2015, 'Revisiting the role of mast cells in autoimmunity' AUTOIMMUNITY REVIEWS , Bd 14, Nr. 9, S. 751-9.

Kasprick, A, Yu, X, Scholten, J, Hartmann, K, Pas, HH, Zillikens, D, Ludwig, RJ & Petersen, F 2015, 'Conditional depletion of mast cells has no impact on the severity of experimental epidermolysis bullosa acquisita' European journal of immunology, Bd 45, Nr. 5, S. 1462-70.

Zheng, J, Huang, R, Huang, Q, Deng, F, Chen, Y, Yin, J, Chen, J, Wang, Y, Shi, G, Gao, X, Liu, Z, Petersen, F & Yu, X 2015, 'The GTF2I rs117026326 polymorphism is associated with anti-SSA-positive primary Sjögren's syndrome' RHEUMATOLOGY, Bd 54, Nr. 3, S. 562-564.

Yu, X, Huang, Q & Petersen, F 2015, 'History and milestones of mouse models of autoimmune diseases'  CURRENT PHARMACEUTICAL DESIGN , Bd 21, Nr. 18, S. 2308-19.

2014

Bermbach, S, Weinhold, K, Roeder, T, Petersen, F, Kugler, C, Goldmann, T, Rupp, J & König, P 2014, 'Mechanisms of Cilia-Driven Transport in the Airways in the Absence of Mucus' American journal of respiratory cell and molecular biology, Bd 51, Nr. 1, S. 56-67.

Yu, X, Zheng, J, Collin, M, Schmidt, E, Zillikens, D & Petersen, F 2014, 'EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils' PLOS ONE, Bd 9, Nr. 2, S. e85317.

Zheng, J, Petersen, F & Yu, X 2014, 'The role of PTPN22 in autoimmunity:Learning from mice.' Autoimmunity reviews, Bd 13, Nr. 3, S. 266-271.

Zheng, J, Chen, Y, Deng, F, Huang, R, Petersen, F, Ibrahim, S & Yu, X 2014, 'mtDNA sequence, phylogeny and evolution of laboratory mice' Mitochondrion, Bd 17, S. 126-131.

2013

Sandig H, Jobbings CE, Roldan NG, Whittingham-Dowd JK, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S. IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol. 2013 Apr;43(4):979-88.

Zheng J, Yin J, Huang R, Petersen F, Yu X. Meta-analysis reveals an association of STAT4 polymorphisms with systemic autoimmune disorders and anti-dsDNA antibody. Hum Immunol. 2013 Aug;74(8):986-92.

Wygrecka, M, Dahal, BK, Kosanovic, D, Petersen, F, Taborski, B, von Gerlach, S, Didiasova, M, Zakrzewicz, D, Preissner, KT, Schermuly, RT & Markart, P 2013, 'Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: role of transmembrane SCF and the PAR-2/PKC-α/Raf-1/p44/42 signaling pathway' The American journal of pathology, Bd 182, Nr. 6, S. 2094-108.

D'Orlando, O, Zhao, F, Kasper, B, Orinska, Z, Müller, J, Hermans-Borgmeyer, I, Griffiths, GM, Zur Stadt, U & Bulfone-Paus, S 2013, 'Syntaxin 11 is required for NK and CD8(+) T-cell cytotoxicity and neutrophil degranulation' EUROPEAN JOURNAL OF IMMUNOLOGY, Bd 43, Nr. 1, S.  194-208.

Bär, F, Bochmann, W, Widok, A, von Medem, K, Pagel, R, Hirose, M, Yu, X, Kalies, K, König, P, Böhm, R, Herdegen, T, Reinicke, AT, Büning, J, Lehnert, H, Fellermann, K, Ibrahim, S & Sina, C 2013, 'Mitochondrial Gene Polymorphisms That Protect Mice from Colitis' Gastroenterology Nov;145(5):1055-1063.e3.

2012

Zheng J, Ibrahim S, Petersen F, Yu X. Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue. GENES AND IMMUNITY 2012 Dec;13(8):641-652.

Keitel U, Schilling E, Knappe D, Al-Mekhlafi M, Petersen F, Hoffmann R, Hauschildt S. Effect of antimicrobial peptides from Apis mellifera hemolymph and its optimized version Api88 on biological activities of human monocytes and mast cells. INNATE IMMUNITY 2012 Oct (in press).

D’Orlando O, Zhao F, Kasper B, Orinska Z, Müller J, Hermans-Borgmeyer I, Griffiths GM, Zur Stadt U, Bulfone-Paus S. Syntaxin 11 is required for NK and CD8(+) T-cell cytotoxicity and neutrophil degranulation. EUROPEAN JOURNAL OF IMMUNOLOGY 2012 Oct (in press).

Kasperkiewicz M, Nimmerjahn F, Wende S, Hirose M, Iwata H, Jonkman MF, Samavedam U, Gupta Y, Möller S, Rentz E, Hellberg L, Kalies K, Yu X, Schmidt E, Häsler R, Laskay T, Westermann J, Köhl J, Zillikens D, Ludwig RJ. Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury. JOURNAL OF PATHOLOGY 2012 Sep;228(1):8–19.

Schwartzkopff F, Petersen F, Grimm TA, Brandt E. CXC chemokine ligand 4 (CXCL4) down-regulates CC chemokine receptor expression on human monocytes. INNATE IMMUNITY 2012 Feb;18(1):124-139.

2011

Yu X, Ibrahim SM. Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis. ARTHRITIS RESEARCH & THERAPY 2011 Oct;13(5):132. Open Access

Kasper B, Petersen F. Molecular pathways of platelet factor 4/CXCL4 signaling. EUROPEAN JOURNAL OF CELL BIOLOGY 2011 Jun;90(6-7):521-6.

2010

Yu X, Holdorf K, Kasper B, Zillikens D, Ludwig RJ, Petersen F. FcγRIIA and FcγRIIIB Are Required for Autoantibody-Induced Tissue Damage in Experimental Human Models of Bullous Pemphigoid. JOURNAL OF INVESTIGATIVE DERMATOLOGY 2010 Dec;130(12):2841-2844.

Petersen F, Yu X. A novel preclinical model for rheumatoid arthritis research. ARTHRITIS RESEARCH AND THERAPY 2010 Nov;12(6):148.

Kasper B, Winoto-Morbach S, Mittelstädt J, Brandt E, Schütze S, Petersen F. CXCL4-induced monocyte survival, cytokine expression, and oxygen radical formation is regulated by sphingosine kinase 1. EUROPEAN JOURNAL OF IMMUNOLOGY 2010 Apr;40(4):1162-1173.

Tu-Rapp H, Pu L, Marques A, Kulisch C, Yu X, Gierer P, Ibrahim SM, Vollmar B. Genetic control of leucocyte--endothelial cell interaction in collagen-induced arthritis. ANNALS OF RHEUMATIC DISEASES 2010 Mar;69(3):606-610.

Mikkat S, Lorenz P, Scharf C, Yu X, Glocker MO, Ibrahim SM. MS characterization of qualitative protein polymorphisms in the spinal cords of inbred mouse strains. PROTEOMICS 2010 Mar;10(5):1050-1062.

Hellberg L, Holdorf K, Hansel M, Yu X, Recke A, Petersen F, Zillikens D, Ludwig R, Laskay T. Modulation of neutrophil effector functions by methylprednisolone. EXPERIMENTAL DERMATOLOGY 2010 Feb;19(2):186-186.

Bieber K, Sun S, Ishii N, Kasperkiewicz M, Schmidt E, Hirose M, Westermann J, Yu X, Zillikens D, Ludwig R. Animal models for autoimmune bullous dermatoses. EXPERIMENTAL DERMATOLOGY 2010 Jan;19(1):2-11.

2009

Schwartzkopff F, Grimm T, Lankford C, Fields K, Wang J, Brandt E, Clouse K. Platelet factor 4 (CXCL4) facilitates human macrophage infection with HIV-1 and potentiates virus replication. INNATE IMMUNITY 2009 Dec;15(6):368-379.

zur Stadt U, Rohr J, Seifert W, Koch F, Grieve S, Pagel J, Strauss J, Kasper B, Nurnberg G, Becker C, Maul-Pavicic A, Beutel K, Janka G, Griffiths G, Ehl S, Hennies H. Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11. AMERICAN JOURNAL OF HUMAN GENETICS 2009 Oct;85(4):482-492.

Yu X, Wieczorek S, Franke A, Yin H, Pierer M, Sina C, Karlsen T, Boberg K, Bergquist A, Kunz M, Witte T, Gross W, Epplen J, Alarcon-Riquelme M, Schreiber S, Ibrahim S. Association of UCP2-866 G/A polymorphism with chronic inflammatory diseases. GENES AND IMMUNITY 2009 Sep;10(6):601-605.

Schiemann F, Brandt E, Gross R, Lindner B, Mittelstadt J, Sommerhoff C, Schulmistrat J, Petersen F. The Cathelicidin LL-37 Activates Human Mast Cells and Is Degraded by Mast Cell Tryptase: Counter-Regulation by CXCL4. JOURNAL OF IMMUNOLOGY 2009 Aug;183(4):2223-2231.

2008

Vogel K, Blumer N, Korthals M, Mittelstadt J, Garn H, Ege M, von Mutius E, Gatermann S, Bufe A, Goldmann T, Schwaiger K, Renz H, Brandau S, Bauer J, Heine H, Holst O. Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2008 Aug;122(2):307-312.

Woller G, Brandt E, Mittelstadt J, Rybakowski C, Petersen F. Platelet factor 4/CXCL4-stimulated human monocytes induce apoptosis in endothelial cells by the release of oxygen radicals. JOURNAL OF LEUKOCYTE BIOLOGY 2008 Apr;83(4):936-945.

2007

Kasper B, Brandt E, Brandau S, Petersen F. Platelet factor 4 (CXC chemokine ligand 4) differentially regulates respiratory burst, survival, and cytokine expression of human monocytes by using distinct signaling pathways. JOURNAL OF IMMUNOLOGY 2007 Aug;179(4):2584-2591.

Wittkowski M, Mittelstadt J, Brandau S, Reiling N, Lindner B, Torrelles J, Brennan P, Holst O. Capsular arabinomannans from Mycobacterium avium with morphotype-specific structural differences but identical biological activity. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 Jun;282(26):19103-19112.

von Hundelshausen P, Petersen F, Brandt E. Platelet-derived chemokines in vascular biology. THROMBOSIS AND HAEMOSTASIS 2007 May;97(5):704-713.

1998 – 2006 (Selection)

Schiemann F, Grimm T, Hoch J, Gross R, Lindner B, Petersen F, Bulfone-Paus S, Brandt E. Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G. BLOOD 2006 Mar;107(6):2234-2242.

Kasper B, Brandt E, Ernst M, Petersen F. Neutrophil adhesion to endothelial cells induced by platelet factor 4 requires sequential activation of Ras, Syk, and JNK MAP kinases. BLOOD 2006 Mar;107(5):1768-1775.

Pervushina O, Scheuerer B, Reiling N, Behnke L, Schroder J, Kasper B, Brandt E, Bulfone-Paus S, Petersen F. Platelet factor 4/CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients. JOURNAL OF IMMUNOLOGY 2004 Aug;173(3):2060-2067.

Fricke I, Mitchell D, Petersen F, Bohle A, Bulfone-Paus S, Brandau S. Platelet factor 4 in conjunction with IL-4 directs differentiation of human monocytes into specialized antigen-presenting cells. FASEB JOURNAL 2004 Aug;18(13):1588-1590.

Kasper B, Brandt E, Bulfone-Paus S, Petersen F. Platelet factor 4 (PF-4)-induced neutrophil adhesion is controlled by src-kinases, whereas PF-4-mediated exocytosis requires the additional activation of p38 MAP kinase and phosphatidylinositol 3-kinase. BLOOD 2004 Mar;103(5):1602-1610.

Schenk B, Petersen F, Flad H, Brandt E. Platelet-derived chemokines CXC chemokine ligand (CXCL)7, connective tissue-activating peptide III, and CXCL4 differentially affect and cross-regulate neutrophil adhesion and transendothelial migration. JOURNAL OF IMMUNOLOGY 2002 Sep;169(5):2602-2610.

Fleischer J, Grage-Griebenow E, Kasper B, Heine H, Ernst M, Brandt E, Flad H, Petersen F. Platelet factor 4 inhibits proliferation and cytokine release of activated human T cells. JOURNAL OF IMMUNOLOGY 2002 Jul;169(2):770-777.

Schwartzkopff F, Brandt E, Petersen F, Flad H, Bock L, Ludwig A. The CXC chemokine NAP-2 mediates differential heterologous desensitization of neutrophil effector functions elicited by platelet-activating factor. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 2002 Feb;22(2):257-267.

Brandt E, Ludwig A, Petersen F, Flad H. Platelet-derived CXC chemokines: old players in new games. IMMUNOLOGICAL REVIEWS 2000 Oct;177:204-216.

Brandt E, Petersen F, Ludwig A, Ehlert J, Bock L, Flad H. The beta-thromboglobulins and platelet factor 4: blood platelet-derived CXC chemokines with divergent roles in early neutrophil regulation. JOURNAL OF LEUKOCYTE BIOLOGY 2000 Apr;67(4):471-478.

Scheuerer B, Ernst M, Durrbaum-Landmann I, Fleischer J, Grage-Griebenow E, Brandt E, Flad H, Petersen F. The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. BLOOD 2000 Feb;95(4):1158-1166.

Petersen F, Bock L, Flad H, Brandt E. Platelet factor 4-induced neutrophil-endothelial cell interaction: Involvement of mechanisms and functional consequences different from those elicited by interleukin-8. BLOOD 1999 Dec;94(12):4020-4028.

Petersen F, Brandt E, Lindahl U, Spillmann D. Characterization of a neutrophil cell surface glycosaminoglycan that mediates binding of platelet factor 4. JOURNAL OF BIOLOGICAL CHEMISTRY 1999 Apr;274(18):12376-12382.

Petersen F, Bock L, Flad H, Brandt E. A chondroitin sulfate proteoglycan on human neutrophils specifically binds platelet factor 4 and is involved in cell activation. JOURNAL OF IMMUNOLOGY 1998 Oct;161(8):4347-4355.