Forschungszentrum Borstel
Forschungszentrum Borstel

Programmbereich Asthma und Allergie




Steffens, T, Duda, K, Lindner, B, Vorhölter, F-J, Bednarz, H, Niehaus, K & Holst, O 2017, 'The lipopolysaccharide of the crop pathogen Xanthomonas translucens pv. translucens: chemical characterization and determination of signaling events in plant cells' GLYCOBIOLOGY, Bd 27, Nr. 3, S. 264-274. DOI: 10.1093/glycob/cww093

Kolbe, K, Möckl, L, Sohst, V, Brandenburg, J, Engel, R, Malm, S, Bräuchle, C, Holst, O, Lindhorst, TK & Reiling, N 2017, 'Azido pentoses: A New Tool to Efficiently Label Mycobacterium tuberculosis Clinical Isolates' Chembiochem : a European journal of chemical biology. DOI: 10.1002/cbic.201600706

Westphal, A, Cheng, W, Yu, J, Grassl, G, Krautkrämer, M, Holst, O, Föger, N & Lee, K-H 2017, 'Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor-mediated inflammatory responses' JOURNAL OF EXPERIMENTAL MEDICINE, Bd 214, Nr. 1, S. 227-244. DOI: 10.1084/jem.20141461


Duda, K, Petersen, S & Holst, O 2016, 'Structural characterization of the lipoteichoic acid isolated from Staphylococcus sciuri W620' CARBOHYDRATE RESEARCH, Bd 430, S. 44-47.

Haji-Ghassemi, O, Müller-Loennies, S, Rodriguez, T, Brade, L, Grimmecke, H-D, Brade, H & Evans, SV 2016, 'The Combining Sites of Anti-Lipid A Antibodies Reveal a Widely-Utilized Motif Specific for Negatively Charged Groups' The Journal of biological chemistry, Bd 291, Nr. 19, S. 10104-18. DOI: 10.1074/jbc.M115.712448

Diederich, A-K, Duda, KA, Romero-Saavedra, F, Engel, R, Holst, O & Huebner, J 2016, 'Deletion of fabN in Enterococcus faecalis results in unsaturated fatty acid auxotrophy and decreased release of inflammatory cytokines' INNATE IMMUNITY, Bd 22, Nr. 4, S. 284-93. DOI: 10.1177/1753425916639669

Fontana, C, Conde-Álvarez, R, Ståhle, J, Holst, O, Iriarte, M, Zhao, Y, Arce-Gorvel, V, Hanniffy, S, Gorvel, J-P, Moriyón, I & Widmalm, G 2016, 'Structural Studies of Lipopolysaccharide-defective Mutants from Brucella melitensis Identify a Core Oligosaccharide Critical in Virulence' The Journal of biological chemistry, Bd 291, Nr. 14, S. 7727-41. DOI: 10.1074/jbc.M115.701540

Blackler, RJ, Evans, DW, Smith, DF, Cummings, RD, Brooks, CL, Braulke, T, Liu, X, Evans, SV & Müller-Loennies, S 2016, 'Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†' GLYCOBIOLOGY, Bd 26, Nr. 2, S. 181-92. DOI: 10.1093/glycob/cwv093

Torrealba, D, Seras-Franzoso, J, Mamat, U, Wilke, K, Villaverde, A, Roher, N & Garcia-Fruitós, E 2016, 'Complex Particulate Biomaterials as Immunostimulant-Delivery Platforms' PLOS ONE, Bd 11, Nr. 10, S. e0164073. DOI: 10.1371/journal.pone.0164073

Günther, J, Czabanska, A, Bauer, I, Leigh, JA, Holst, O & Seyfert, H-M 2016, 'Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages' Veterinary Research, Bd 47, Nr. 1, S. 13. DOI: 10.1186/s13567-015-0287-8

Rueda, F, Céspedes, MV, Sánchez-Chardi, A, Seras-Franzoso, J, Pesarrodona, M, Ferrer-Miralles, N, Vázquez, E, Rinas, U, Unzueta, U, Mamat, U, Mangues, R, García-Fruitós, E & Villaverde, A 2016, 'Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli' Microbial Cell Factories, Bd 15, Nr. 1, S. 59. DOI: 10.1186/s12934-016-0457-z


Kasperkiewicz, K, Swierzko, AS, Bartlomiejczyk, MA, Cedzynski, M, Noszczynska, M, Duda, KA, Michalski, M & Skurnik, M 2015, 'Interaction of human mannose-binding lectin (MBL) with Yersinia enterocolitica lipopolysaccharide' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY., 10.1016/j.ijmm.2015.07.001

Lind, M, Sipka, AS, Schuberth, H-J, Blutke, A, Wanke, R, Sauter-Louis, C, Duda, KA, Holst, O, Rainard, P, Germon, P, Zerbe, H & Petzl, W 2015, 'Location-specific expression of chemokines, TNF-α and S100 proteins in a teat explant model' INNATE IMMUNITY, Bd 21, Nr. 3, S. 322-31.

Weber, J, Illi, S, Nowak, D, Schierl, R, Holst, O, von Mutius, E & Ege, MJ 2015, 'Asthma and the hygiene hypothesis. Does cleanliness matter?' American journal of respiratory and critical care medicine, Bd 191, Nr. 5, S. 522-9.

Diercks, H, Semeniuk, A, Gisch, N, Hermann, M, Duda, KA & Hölzl, G 2015, 'Accumulation of novel Glycolipids and Ornithine Lipids in Mesorhizobium loti under Phosphate Deprivation' JOURNAL OF BACTERIOLOGY, Bd 197, Nr. 3, S. 497-509.

Turska-Szewczuk, A, Pietras, H, Duda, KA, Kozińska, A, Pękala, A & Holst, O 2015, 'Structure of the O-specific polysaccharide from the lipopolysaccharide of Aeromonas sobria strain Pt312' CARBOHYDRATE RESEARCH, Bd 403, S. 142-8.

Krylov, VB, Gerbst, AG, Argunov, DA, Dmitrenok, AS, Shashkov, AS, Kaczynski, Z, Huebner, J, Holst, O & Nifantiev, NE 2015, 'Definitive Structural Assessment of Enterococcal Diheteroglycan' CHEMISTRY - A EUROPEAN JOURNAL, Bd 21, Nr. 4, S. 1749-54.

Molinaro, A, Holst, O, Di Lorenzo, F, Callaghan, M, Nurisso, A, D'Errico, G, Zamyatina, A, Peri, F, Berisio, R, Jerala, R, Jiménez-Barbero, J, Silipo, A & Martín-Santamaría, S 2015, 'Chemistry of Lipid A At the Heart of Innate Immunity' CHEMISTRY - A EUROPEAN JOURNAL, Bd 21, Nr. 2, S. 500-519.

Raedler, D, Ballenberger, N, Klucker, E, Böck, A, Otto, R, Prazeres da Costa, O, Holst, O, Illig, T, Buch, T, von Mutius, E & Schaub, B 2015, 'Identification of novel immune phenotypes for allergic and nonallergic childhood asthma' The Journal of allergy and clinical immunology, Bd 135, Nr. 1, S. 81-91.

Beczała, A, Ovchinnikova, OG, Datta, N, Mattinen, L, Knapska, K, Radziejewska-Lebrecht, J, Holst, O & Skurnik, M 2015, 'Structure and genetic basis of Yersinia similis serotype O:9 O-specific polysaccharide' INNATE IMMUNITY, Bd 21, Nr. 1, S. 3-16.

Danis-Wlodarczyk, K, Olszak, T, Arabski, M, Wasik, S, Majkowska-Skrobek, G, Augustyniak, D, Gula, G, Briers, Y, Jang, HB, Vandenheuvel, D, Duda, KA, Lavigne, R & Drulis-Kawa, Z 2015, 'Characterization of the Newly Isolated Lytic Bacteriophages KTN6 and KT28 and Their Efficacy against Pseudomonas aeruginosa Biofilm' PLOS ONE, Bd 10, Nr. 5, S. e0127603.

Mamat, U, Wilke, K, Bramhill, D, Schromm, AB, Lindner, B, Kohl, TA, Corchero, JL, Villaverde, A, Schaffer, L, Head, SR, Souvignier, C, Meredith, TC & Woodard, RW 2015, 'Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins' Microbial Cell Factories, Bd 14, S. 57.

Noszczyńska, M, Kasperkiewicz, K, Duda, KA, Podhorodecka, J, Rabsztyn, K, Gwizdała, K, Swierzko, AS, Radziejewska-Lebrecht, J, Holst, O & Skurnik, M 2015, 'Serological characterization of the enterobacterial common antigen substitution of the lipopolysaccharide of Yersinia enterocolitica O:3' MICROBIOLOGY-SGM , Nr. 161, S. 219-227.


Pirson, C, Engel, R, Jones, GJ, Holder, T, Holst, O & Vordermeier, HM 2014, 'Highly purified mycobacterial phosphatidylinositol mannosides drive cell mediated responses and activate NKT cells in cattle' Clinical and Vaccine Immunology, Bd 22, Nr. 2, S. 178-84., 10.1128/CVI.00638-14

Krylov, VB, Argunov, DA, Vinnitskiy, DZ, Verkhnyatskaya, SA, Gerbst, AG, Ustyuzhanina, NE, Dmitrenok, AS, Huebner, J, Holst, O, Siebert, H-C & Nifantiev, NE 2014, 'Pyranoside-into-Furanoside Rearrangement: New Reaction in Carbohydrate Chemistry and Its Application in Oligosaccharide Synthesis' Chemistry (Weinheim an der Bergstrasse, Germany), Bd 20, Nr. 50, S. 16516-22.,

Schmidt, A, Belaaouaj, A, Bissinger, R, Koller, G, Malleret, L, D'Orazio, C, Facchinelli, M, Schulte-Hubbert, B, Molinaro, A, Holst, O, Hammermann, J, Schniederjans, M, Meyer, KC, Damkiaer, S, Piacentini, G, Assael, B, Bruce, K, Häußler, S, Lipuma, JJ, Seelig, J, Worlitzsch, D & Döring, G 2014, 'Neutrophil elastase-mediated increase in airway temperature during inflammation' Journal of cystic fibrosis, Bd 13 , Nr. 6, S. 623-631.

Komaniecka, I, Choma, A, Mazur, A, Duda, KA, Lindner, B, Schwudke, D & Holst, O 2014, 'Occurrence of an unusual hopanoid-containing lipid A among lipopolysaccharides from Bradyrhizobium species' The Journal of biological chemistry, Bd 289, Nr. 51, S. 35644-35655.

Rueda, F, Cano-Garrido, O, Mamat, U, Wilke, K, Seras-Franzoso, J, García-Fruitós, E & Villaverde, A 2014, 'Production of functional inclusion bodies in endotoxin-free Escherichia coli' APPLIED MICROBIOLOGY AND BIOTECHNOLOGY , Bd 98, Nr. 22, S. 9229-38.

Haji-Ghassemi, O, Müller-Loennies, S, Saldova, R, Muniyappa, M, Brade, L, Rudd, PM, Harvey, DJ, Kosma, P, Brade, H & Evans, SV 2014, 'Groove-type Recognition of Chlamydiaceae-specific Lipopolysaccharide Antigen by a Family of Antibodies Possessing an Unusual Variable Heavy Chain N-Linked Glycan' The Journal of biological chemistry, Bd 289, Nr. 24, S. 16644-16661.

Pokorny, B, Müller-Loennies, S & Kosma, P 2014, 'Synthesis of α-d-glucosyl substituted methyl glycosides of 3-deoxy-α-d-manno- and d-glycero-α-d-talo-oct-2-ulosonic acid (Kdo/Ko) corresponding to inner core fragments of Acinetobacter lipopolysaccharide' CARBOHYDRATE RESEARCH, Bd 391, S. 66-81.

Neiwert, O, Holst, O & Duda, KA 2014, 'Structural investigation of rhamnose-rich polysaccharides from Streptococcus dysgalactiae bovine mastitis isolate' CARBOHYDRATE RESEARCH, Bd 389, S. 192-195.

Semeniuk, A, Sohlenkamp, C, Duda, K & H Oumllzl, G 2014, 'A bifunctional glycosyltransferase from Agrobacterium tumefaciens synthesizes monoglucosyl and glucuronosyl diacylglycerol under phosphate deprivation' The Journal of biological chemistry, Bd 289, S. 10104-10114.

Gronbach, K, Flade, I, Holst, O, Lindner, B, Ruscheweyh, HJ, Wittmann, A, Menz, S, Schwiertz, A, Adam, P, Stecher, B, Josenhans, C, Suerbaum, S, Gruber, AD, Kulik, A, Huson, D, Autenrieth, IB & Frick, J-S 2014, 'Endotoxicity of lipopolysaccharide as a determinant of T-cell-mediated colitis induction in mice' GASTROENTEROLOGY, Bd 146, Nr. 3, S. 765-75.

Böcking, C, Harb, H, Ege, MJ, Zehethofer, N, Fischer, K, Krauß, J, Holst, O, Nüsing, RM, Lindner, B, von Mutius, E, Renz, H, Garn, H & Pfefferle, PI 2014, 'Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation' International archives of allergy and immunology, Bd 163, Nr. 3, S. 234-42.

Winstel, V, Sanchez-Carballo, P, Holst, O, Xia, G & Peschel, A 2014, 'Biosynthesis of the unique wall teichoic acid of Staphylococcus aureus lineage ST395' mBio, Bd 5, Nr. 2, S. e00869.

Silipo, A, Vitiello, G, Gully, D, Sturiale, L, Chaintreuil, C, Fardoux, J, Gargani, D, Lee, H-I, Kulkarni, G, Busset, N, Marchetti, R, Palmigiano, A, Hermann, M, Engel, R, Lanzetta, R, Paduano, L, Parrilli, M, Chang, W-S, Holst, O, Newman, DK, Garozzo, D, D'Errico, G, Giraud, E & Molinaro, A 2014, 'Covalently linked hopanoid-lipid A improves outer-membrane resistance of a Bradyrhizobium symbiont of legumes' Nature communications, Bd 5, S. 5106.

Turska-Szewczuk, A, Duda, KA, Schwudke, D, Pekala, A, Kozinska, A & Holst, O 2014, 'Structural Studies of the Lipopolysaccharide from the Fish Pathogen Aeromonas veronii Strain Bs19, Serotype O16' Marine Drugs, Bd 12, Nr. 3, S. 1298-316.

Meißner, T, Eckelt, E, Basler, T, Meens, J, Heinzmann, J, Suwandi, A, Oelemann, WMR, Trenkamp, S, Holst, O, Weiss, S, Bunk, B, Spröer, C, Gerlach, G-F & Goethe, R 2014, 'The Mycobacterium avium ssp. paratuberculosis specific mptD gene is required for maintenance of the metabolic homeostasis necessary for full virulence in mouse infections' Frontiers in Cellular and Infection Microbiology, Bd 4, S. 110.


Hong Y, Duda KA, Cunneen MM, Holst O, Reeves PR. The WbaK acetyltransferase of Salmonella enterica group E gives insights into O antigen evolution. Microbiology. 2013 Sep 6. [Epub ahead of print]

Winstel V, Liang C, Sanchez-Carballo P, Steglich M, Munar M, Bröker BM, Penadés JR, Nübel U, Holst O, Dandekar T, Peschel A, Xia G. Wall teichoic acid structure governs horizontal gene transfer between major bacterial pathogens. Nat Commun. 2013 Aug 22;4:2345.

Czabańska A, Holst O, Duda KA. Chemical structures of the secondary cell wall polymers (SCWPs) isolated from bovine mastitis Streptococcus uberis. Carbohydr Res. 2013 Aug 9;377:58-62.

Muszynski A, Rabsztyn K, Knapska K, Duda KA, Duda-Grychtol KT, Kasperkiewicz K, Radziejewska-Lebrecht J, Holst O, Skurnik M. Enterobacterial common antigen and O-specific polysaccharide coexist in the lipopolysaccharide of Yersinia enterocolitica serotype O:3. Microbiology. 2013 Jun 19. [Epub ahead of print]

Lindström C, Xu J, Oste R, Holst O, Molin G. Oral administration of live exopolysaccharide-producing Pediococcus parvulus, but not purified exopolysaccharide, suppressed Enterobacteriaceae without affecting bacterial diversity in ceca of mice. Appl Environ Microbiol. 2013 Aug;79(16):5030-7.

Patel A, Falck P, Shah N, Immerzeel P, Adlercreutz P, Stålbrand H, Prajapati JB, Holst O, Nordberg Karlsson E. Evidence for xylooligosaccharide utilization in Weissella strains isolated from Indian fermented foods and vegetables. FEMS Microbiol Lett. 2013 Sep;346(1):20-8.

Posch G, Andrukhov O, Vinogradov E, Lindner B, Messner P, Holst O, Schäffer C. Structure and immunogenicity of the rough-type lipopolysaccharide from the periodontal pathogen Tannerella forsythia. Clin Vaccine Immunol. 2013 Jun;20(6):945-53.

Turska-Szewczuk A, Lindner B, Komaniecka I, Kozinska A, Pekala A, Choma A, Holst O. Structural and immunochemical studies of the lipopolysaccharide from the fish pathogen, Aeromonas bestiarum strain K296, serotype O18. Mar Drugs. 2013 Apr 17;11(4):1235-55.

Duda KA, Fruth A, Holst O. Structural studies of the O-antigenic polysaccharide of the bovine mastitis isolate Escherichia coli serotype O174. Carbohydr Res. 2013 May 24;373:18-21.

Lotter H, Helk E, Bernin H, Jacobs T, Prehn C, Adamski J, González-Roldán N, Holst O, Tannich E. Testosterone increases susceptibility to amebic liver abscess in mice and mediates inhibition of IFNγ secretion in natural killer T cells. PLoS One. 2013;8(2):e55694.

Hagner S, Harb H, Zhao M, Stein K, Holst O, Ege MJ, Mayer M, Matthes J, Bauer J, von Mutius E, Renz H, Heine H, Pfefferle PI, Garn H. Farm-derived Gram-positive bacterium Staphylococcus sciuri W620 prevents asthma phenotype in HDM- and OVA-exposed mice. Allergy. 2013 Mar;68(3):322-9.

Sydor T, von Bargen K, Hsu FF, Huth G, Holst O, Wohlmann J, Becken U, Dykstra T, Söhl K, Lindner B, Prescott JF, Schaible UE, Utermöhlen O, Haas A. Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length. Cell Microbiol. 2013 Mar;15(3):458-73.

De Castro C, Kenyon JJ, Cunneen MM, Molinaro A, Holst O, Skurnik M, Reeves PR. The O-specific polysaccharide structure and gene cluster of serotype O:12 of  the Yersinia pseudotuberculosis complex, and the identification of a novel L-quinovose biosynthesis gene. Glycobiology. 2013 Mar;23(3):346-53.

Lindström C, Holst O, Nilsson L, Oste R, Andersson KE. Effects of Pediococcus parvulus 2.6 and its exopolysaccharide on plasma cholesterol levels and inflammatory markers in mice. AMB Express. 2012 Dec 13;2(1):66.


Czabańska A, Neiwert O, Lindner B, Leigh J, Holst O, Duda KA. Structural analysis of the lipoteichoic acids isolated from bovine mastitis Streptococcus uberis 233, Streptococcus dysgalactiae 2023 and Streptococcus agalactiae 0250. CARBOHYDRATE RESEARCH 2012 Nov;361:200–205.

Geiss-Liebisch S, Rooijakkers SHM, Beczala A, Sanchez-Carballo P, Kruszynska K, Repp C, Sakinc T, Vinogradov E, Holst O, Huebner J, Theilacker C. Secondary Cell Wall Polymers of Enterococcus faecalis Are Critical for Resistance to Complement Activation via Mannose-binding Lectin. JOURNAL OF BIOLOGICAL CHEMISTRY 2012 Nov;287(45):37769–37777.

Sydor T, Von Bargen K, Hsu F-F, Huth G, Holst O, Wohlmann J, Becken U, Dykstra T, Söhl K, Lindner B, Prescott JF, Schaible UE, Utermöhlen O, Haas A. Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length. CELLULAR MICROBIOLOGY 2012 Oct (in press).

Beczała A, Duda KA, Skurnik M, Holst O. The structure of the O-specific polysaccharide of the lipopolysaccharide from Yersinia enterocolitica serotype O:50 strain 3229. CARBOHYDRATE RESEARCH 2012 Oct;359:97–101.

Brade L, Hensen S, Brade H. Evaluation of a LPS-based glycoconjugate vaccine against bovine Escherichia coli mastitis: Formation of LPS Abs in cows after immunization with E. coli core oligosaccharides conjugated to hemocyanine. INNATE IMMUNITY 2012 Oct (in press).

Krauel K, Weber C, Brandt S, Zähringer U, Mamat U, Greinacher A, Hammerschmidt S. Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes. BLOOD 2012 Oct;120(16):3345–3352.

De Castro C, Holst O, Lanzetta R, Parrilli M, Molinaro A. Bacterial lipopolysaccharides in plant and Mammalian innate immunity. PROTEIN AND PEPTIDE LETTERS 2012 Oct;19(10):1040–1044.

Miki T, Holst O, Hardt W-D. The Bactericidal Activity of the C-type Lectin RegIII  against Gram-negative Bacteria involves Binding to Lipid A. JOURNAL OF BIOLOGICAL CHEMISTRY 2012 Oct;287(41):34844–34855.

Fischer K, Vinogradov E, Lindner B, Heine H, Holst O. The structure of the extracellular teichoic acids from the allergy-protective bacterium Lactococcus lactis G121. BIOLOGICAL CHEMISTRY 2012 Aug;393(8): 749-55.

Theilacker C, Holst O, Lindner B, Huebner J, Kaczyński Z. The structure of the wall teichoic acid isolated from Enterococcus faecalis strain 12030. CARBOHYDRATE RESEARCH 2012 Jun;354(0):106–109.

Turska-Szewczuk A, Lindner B, Pękała A, Palusińska-Szysz M, Choma A, Russa R, Holst O. Structural analysis of the O-specific polysaccharide from the lipopolysaccharide of Aeromonas veronii bv. sobria strain K49. CARBOHYDRATE RESEARCH 2012 May;353:62–68.

Schmidt H, Hansen G, Singh S, Hanuszkiewicz A, Lindner B, Fukase K, Woodard RW, Holst O, Hilgenfeld R, Mamat U, Mesters JR. Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2012 Apr;109(16):6253–6258.

Makrypidi G, Damme M, Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T Mannose 6 dephosphorylation of lysosomal proteins mediated by Acid phosphatases acp2 and acp5. MOLECULAR AND CELLULAR BIOLOGY 2012 Feb;32(4):774–782.

Brade L, Heine H, Raina S, Klein G, di Padova F, Brade H, Müller-Loennies S. Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits. INNATE IMMUNITY 2012 Feb;18(2):279-93.



Bychowska A, Theilacker C, Czerwicka M, Marszewska K, Huebner J, Holst O, Stepnowski P, Kaczyński Z. Chemical structure of wall teichoic acid isolated from Enterococcus faecium strain U0317. CARBOYDRATE RESEARCH 2011 Dec;346(17):2816-2819.

Fischer K, Stein K, Ulmer AJ, Lindner B, Heine H, Holst O. Cytokine-inducing lipoteichoic acids of the allergy-protective bacterium Lactococcus lactis G121 do not activate via Toll-like receptor 2. GLYCOBIOLOGY 2011 Dec;21(12):1588-1595.

Kenyon JJ, De Castro C, Cunneen MM, Reeves PR, Molinaro A, Holst O, Skurnik M. The genetics and structure of the O-specific polysaccharide of Yersinia pseudotuberculosis serotype O:10 and its relationship with Escherichia coli O111 and Salmonella enterica O35. GLYCOBIOLOGY 2011 Sep;21(9):1131-1139.

Kiljunen S, Datta N, Dentovskaya SV, Anisimov AP, Knirel YA, Bengoechea JA, Holst O, Skurnik M. Identification of the Lipopolysaccharide Core of Yersinia pestis and Yersinia pseudotuberculosis as the Receptor for Bacteriophage  A1122. JOURNAL OF BACTERIOLOGY 2011 Sep;193(18):4963-4972.

Kirschner R, Hubmacher D, Iyengar G, Kaur J, Fagotto-Kaufmann C, Bromme D, Bartels R, Reinhardt DP. Classical and Neonatal Marfan Syndrome Mutations in Fibrillin-1 Cause Differential Protease Susceptibilities and Protein Function. JOURNAL OF BIOLOGICALl CHEMISTRY 2011 Sep;286(37):32810-32823.

Schmidt H, Mesters JR, Wu J, Woodard RW, Hilgenfeld R, Mamat U. Evidence for a Two-Metal-Ion Mechanism in the Cytidyltransferase KdsB, an Enzyme Involved in Lipopolysaccharide Biosynthesis. PloS One 2011;6(8):e23231. Open Access

Rabsztyn K, Kasperkiewicz K, Duda KA, Li C-M, Łukasik M, Radziejewska-Lebrecht J, Skurnik M. Characterization of anti-ECA antibodies in rabbit antiserum against rough Yersinia enterocolitica O:3. BIOCHEMISTRY-MOSCOW 2011 Jul;76(7):832-839.

Duda KA, Lindner B, Brade H, Leimbach A, Brzuszkiewicz E, Dobrindt U, Holst O. The lipopolysaccharide of the mastitis isolate Escherichia coli strain 1303 comprises a novel O-antigen and the rare K-12 core type. MICROBIOLOGY 2011 Jun;157(Pt 6):1750-60.

Fregolino E, Gargiulo V, Lanzetta R, Parrilli M, Holst O, Castro CD. Identification and structural determination of the capsular polysaccharides from two Acinetobacter baumannii clinical isolates, MG1 and SMAL. CARBOHYDRATE RESEARCH 2011 May;346(7):973-977.

Turska-Szewczuk A, Guz L, Lindner B, Pietras H, Russa R, Holst O. Structural characterization of the O-specific polysaccharide from the lipopolysaccharide of the fish pathogen Aeromonas bestiarum strain P1S. CARBOYDRATE RESEARCH 2011 May;346(6):815-821.

Keck M, Gisch N, Moll H, Vorhölter F-J, Gerth K, Kahmann U, Lissel M, Lindner B, Niehaus K, Holst O. Unusual outer membrane lipid composition of the gram-negative, lipopolysaccharide-lacking myxobacterium Sorangium cellulosum So ce56. The Journal of Biological Chemistry 2011 Apr;286(15):12850-12859.

Theilacker C, Sava I, Sanchez-Carballo P, Bao Y, Kropec A, Grohmann E, Holst O, Huebner J. Deletion of the glycosyltransferase bgsB of Enterococcus faecalis leads to a complete loss of glycolipids from the cell membrane and to impaired biofilm formation. BMC MICROBIOLOGY 2011 Apr;11:67.

De Castro C, Kenyon JJ, Cunneen M, Reeves PR, Molinaro A, Holst O, Skurnik M. Genetic characterisation and structural analysis of the O-specific polysaccharide of Yersinia pseudotuberculosis serotype O:1c. INNATE IMMUNITY 2011 Apr;17(2):183-90.

Theilacker C, Kaczyński Z, Kropec A, Sava I, Ye L, Bychowska A, Holst O, Huebner J. Serodiversity of opsonic antibodies against Enterococcus faecalis--glycans of the cell wall revisited. PLoS ONE 2011 Mar;6(3):e17839.

Books & Chapters 2011

Holst, Otto (Editor): Microbial Toxins : Methods and Protocols. (Methods in Molecular Biology ; 739).  New York : Springer; 2011.

Holst O. Structure of the lipopolysaccharide core region. In: Knirel YA, Valvano MA, Bacterial Lipopolysaccharides: Structure, Chemical Synthesis, Biogenesis and Interaction with Host Cells. Vienna: Springer-Verlag/Wien; 2011 p. 21-39.



Mertens K, Muller-Loennies S, Stengel P, Podschun R, Hansen DS, Mamat U. Antiserum against Raoultella terrigena ATCC 33257 identifies a large number of Raoultella and Klebsiella clinical isolates as serotype O12. INNATE IMMUNITY 2010 Dec;16(6):366-380.

Trautmann M, Scheibe C, Wellinghausen N, Holst O, Lepper PM. Low Endotoxin Release from Escherichia coli and Bacteroides fragilis during Exposure to Moxifloxacin. CHEMOTHERAPY 2010 Oct;56(5):364-370.

Pinta E, Duda KA, Hanuszkiewicz A, Salminen TA, Bengoechea JA, Hyytiainen H, Lindner B, Radziejewska-Lebrecht J, Holst O, Skurnik M. Characterization of the Six Glycosyltransferases Involved in the Biosynthesis of Yersinia enterocolitica Serotype O:3 Lipopolysaccharide Outer Core. JOURNAL OF BIOLOGICAL CHEMISTRY 2010 Sep;285(36):28333-28342.

Peters M, Kauth M, Scherner O, Gehlhar K, Steffen I, Wentker P, von Mutius E, Holst O, Bufe A. Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2010 Sep;126(3):648-656.e4.

Paściak M, Kaczyński Z, Lindner B, Holst O, Gamian A. Immunochemical studies of trehalose-containing major glycolipid from Tsukamurella pulmonis. CARBOHYDRATE RESEARCH 2010 Jul;345(11):1570-1574.

Paściak M, Sanchez-Carballo P, Duda-Madej A, Lindner B, Gamian A, Holst O. Structural characterization of the major glycolipids from Arthrobacter globiformis and Arthrobacter scleromae. CARBOHYDRATE RESEARCH 2010 Jul;345(10):1497-1503.

Suomalainen M, Lobo LA, Brandenburg K, Lindner B, Virkola R, Knirel YA, Anisimov AP, Holst O, Korhonen TK. Temperature-Induced Changes in the Lipopolysaccharide of Yersinia pestis Affect Plasminogen Activation by the Pla Surface Protease. INFECTION AND IMMUNITY 2010 Jun;78(6):2644-2652.

Xia G, Maier L, Sanchez-Carballo P, Li M, Otto M, Holst O, Peschel A. Glycosylation of Wall Teichoic Acid in Staphylococcus aureus by TarM. JOURNAL OF BIOLOGICAL CHEMISTRY 2010 Apr;285(18):13405-13415.

Turska-Szewczuk A, Kozinska A, Russa R, Holst O. The structure of the O-specific polysaccharide from the lipopolysaccharide of Aeromonas bestiarum strain 207. CARBOHYDRATE RESEARCH 2010 Mar;345(5):680-684.

Fregolino E, Fugazza G, Galano E, Gargiulo V, Landini P, Lanzetta R, Lindner B, Pagani L, Parrilli M, Holst O, De Castro C. Complete Lipooligosaccharide Structure of the Clinical Isolate Acinetobacter baumannii, Strain SMAL. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2010 Mar;(7):1345-1352.

Carballo P, Vilen H, Palva A, Holst O. Structural characterization of teichoic acids from Lactobacillus brevis. CARBOHYDRATE RESEARCH 2010 Feb;345(4):538-542.

Komaniecka I, Choma A, Lindner B, Holst O. The Structure of a Novel Neutral Lipid A from the Lipopolysaccharide of Bradyrhizobium elkanii Containing Three Mannose Units in the Backbone. CHEMISTRY-A EUROPEAN JOURNAL 2010;16(9):2922-2929.

Debarry J, Hanuszkiewicz A, Stein K, Holst O, Heine H. The allergy-protective properties of Acinetobacter lwoffi F78 are imparted by its lipopolysaccharide. ALLERGY 2010;65(6):690-697.

Book Chapters 2010

De Castro C, Parrilli M, Holst O, Molinaro A. Microbe-Associated Molecular Patterns in Innate ImmunityExtraction and Chemical Analysis of Gram-Negative Bacterial Lipopolysaccharides.  In: METHODS IN ENZYMOLOGY, VOL 480: GLYCOBIOLOGY. Elsevier; 2010 p. 89-115.

Feodorova V, Pan’kina L, Savostina E, Kuznetsov O, Konnov N, Sayapina L, Dentovskaya S, Shaikhutdinova R, Ageev S, Lindner B, Kondakova A, Holst O, Pier G, Knirel Y, Anisimov A, Motin A. A Live Plaque Vaccine Candidate with Improved Safety and Immunogenecity [Internet].  In: Shafferman A, Ordentlich A, Velan B, (Eds): The Challenge of Highly Pathogenic Microorganisms : Mechanisms of Virulence and Novel Medical Countermeasures.  Dordrecht: Springer; 2010 p. 261-268.



Bade S, Rockendorf N, Franek M, Gorris H, Lindner B, Olivier V, Schaper K, Frey A. Biolabeling with 2,4-Dichlorophenoxyacetic Acid Derivatives: The 2,4-D Tag. ANALYTICAL CHEMISTRY 2009 Dec;81(23):9695-9702.

Perlovich G, Tkachev V, Strakhova N, Kazachenko V, Volkova T, Surov O, Schaper K, Raevsky O. Thermodynamic and Structural Aspects of Sulfonamide Crystals and Solutions. JOURNAL OF PHARMACEUTICAL SCIENCES 2009 Dec;98(12):4738-4755.

De Castro C, Skurnik M, Molinaro A, Holst O. Characterization of the specific O-polysaccharide structure and biosynthetic gene cluster of Yersinia pseudotuberculosis serotype O:15. INNATE IMMUNITY 2009 Dec;15(6):351-359.

Patel G, Behrens-Kneip S, Holst O, Kleinschmidt J. The Periplasmic Chaperone Skp Facilitates Targeting, Insertion, and Folding of OmpA into Lipid Membranes with a Negative Membrane Surface Potential. BIOCHEMISTRY 2009 Nov;48(43):10235-10245.

Cunneen M, De Castro C, Kenyon J, Parrilli M, Reeves P, Molinaro A, Holst O, Skurnik M. The O-specific polysaccharide structure and biosynthetic gene cluster of Yersinia pseudotuberculosis serotype O:11. CARBOHYDRATE RESEARCH 2009 Aug;344(12):1533-1540.

Mamat U, Schmidt H, Munoz E, Lindner B, Fukase K, Hanuszkiewicz A, Wu J, Meredith T, Woodard R, Hilgenfeld R, Mesters J, Holst O. WaaA of the Hyperthermophilic Bacterium Aquifex aeolicus Is a Monofunctional 3-Deoxy-D-manno-oct-2-ulosonic Acid Transferase Involved in Lipopolysaccharide Biosynthesis. JOURNAL OF BIOLOGICAL CHEMISTRY 2009 Aug;284(33):22248-22262.

Sava I, Zhang F, Toma I, Theilacker C, Li B, Baumert T, Holst O, Linhardt R, Huebner J. Novel Interactions of Glycosaminoglycans and Bacterial Glycolipids Mediate Binding of Enterococci to Human Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 2009 Jul;284(27):18194-18201.

Qu J, Behrens-Kneip S, Holst O, Kleinschmidt J. Binding Regions of Outer Membrane Protein A in Complexes with the Periplasmic Chaperone Skp. A Site-Directed Fluorescence Study. BIOCHEMISTRY 2009 Jun;48(22):4926-4936.

Lotter H, Gonzalez-Roldan N, Lindner B, Winau F, Isibasi A, Moreno-Lafont M, Ulmer A, Holst O, Tannich E, Jacobs T. Natural Killer T Cells Activated by a Lipopeptidophosphoglycan from Entamoeba histolytica Are Critically Important To Control Amebic Liver Abscess. PLOS PATHOGENS 2009 May;5(5):e1000434. Open Access

Feodorova VA, Pan'kina LN, Savostina EP, Kuznetsov OS, Konnov NP, Sayapina LV, Dentovskaya SV, Shaikhutdinova RZ, Ageev SA, Lindner B, Kondakova AN, Bystrova OV, Kocharova NA, Senchenkova SN, Holst O, Pier GB, Knirel YA, Anisimov AP, Motin VL. Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens. VACCINE 2009 Apr;27(16):2240-2250.

Theilacker C, Sanchez-Carballo P, Toma I, Fabretti F, Sava I, Kropec A, Holst O, Huebner J. Glycolipids are involved in biofilm accumulation and prolonged bacteraemia in Enterococcus faecalis. MOLECULAR MICROBIOLOGY 2009 Feb;71(4):1055-1069.

Pinta E, Duda K, Hanuszkiewiez A, Kaczynski Z, Lindner B, Miller W, Hyytiainen H, Vogel C, Borowski S, Kasperkiewicz K, Lam J, Radziejewska-Lebrecht J, Skurnik M, Holst O. Identification and Role of a 6-Deoxy-4-Keto-Hexosamine in the Lipopolysaccharide Outer Core of Yersinia enterocolitica Serotype O:3. CHEMISTRY-A EUROPEAN JOURNAL 2009;15(38):9747-9754.

Feodorova V, Pan'kina L, Savostina E, Kuznetsov O, Konnov N, Sayapina L, Dentovskaya S, Shaikhutdinova R, Ageev S, Lindner B, Kondakova A, Kocharova N, Senchenkova S, Holst O, Pier G, Knirel Y, Anisimov A, Motin V. Yersinia pestis Live Vaccine with Improved Characteristics. PROCEDIA IN VACCINOLOGY 2009;1(1):97-100.

Conrad ML, Ferstl R, Teich R, Brand S, Blumer N, Yildirim AO, Patrascan CC, Hanuszkiewicz A, Akira S, Wagner H, Holst O, von Mutius E, Pfefferle PI, Kirschning CJ, Garn H, Renz H. Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78. JOURNAL OF EXPERIMENTAL MEDICINE 2009;206(13):2869-2877.

Book Chapters 2009

Holst O, Molinaro A. Core region and lipid A components of lipopolysaccharides. In: Moran, Anthony P. (Ed.): Microbial glycobiology : structures, relevance and applications. Amsterdam: Academic Press; 2009 p. 29-56.

Holst O, Moran A, Brennan P. Overview of the glycosylated components of the bacterial cell envelope. In: Moran, Anthony P. (Ed.): Microbial glycobiology : structures, relevance and applications. Amsterdam: Academic Press; 2009 p. 3-13.



Piotrowska-Seget Z, Engel R, Nowak E, Kozdroj J. Successive soil treatment with captan or oxytetracycline affects non-target microorganisms. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2008 Dec;24(12):2843-2848.

Hanuszkiewicz A, Kaczynski Z, Lindner B, Goldmann T, Vollmer E, Debarry J, Heine H, Holst O. Structural Analysis of the Capsular Polysaccharide from Acinetobacter lwoffii F78. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2008 Dec;(36):6183-6188.

Gorelik L, Kauth M, Gehlhar K, Bufe A, Holst O, Peters M. Modulation of dendritic cell function by cowshed dust extract. INNATE IMMUNITY 2008 Dec;14(6):345-355.

Malm S, Walter K, Engel R, Maass S, Pfau S, Hubner G, Lindner B, Holst O, Ehlers S, Bange F. In vitro and in vivo characterization of a Mycobacterium tuberculosis mutant deficient in glycosyltransferase Rv1500. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 2008 Oct;298(7-8):645-655.

Holst O, Defaye J. Special issue: Selected papers from the 14th European Carbohydrate Symposium - Lubeck, Germany, September 2007 - Foreword. CARBOHYDRATE RESEARCH 2008 Aug;343(12):1887-1887.

Vogel K, Blumer N, Korthals M, Mittelstadt J, Garn H, Ege M, von Mutius E, Gatermann S, Bufe A, Goldmann T, Schwaiger K, Renz H, Brandau S, Bauer J, Heine H, Holst O. Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2008 Aug;122(2):307-312.

Borowski S, Michalik D, Reinke H, Vogel C, Hanuszkiewicz A, Duda K, Holst O. Synthesis of methyl 2-acetamido-2,6-dideoxy-alpha- and beta-D-xylo-hexopyranosid-4-ulose, a keto sugar which misled the analytical chemists. CARBOHYDRATE RESEARCH 2008 May;343(6):1004-1011.

Ramu P, Lobo L, Kukkonen M, Bjur E, Suomalainen M, Raukola H, Miettinen M, Julkunen I, Holst O, Rhen M, Korhonen T, Lahteenmaki K. Activation of pro-matrix metalloproteinase-9 and degradation of gelatin by the surface protease PgtE of Salmonella enterica serovar Typhimurium. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 2008 Apr;298(3-4):263-278.

Leone S, Lanzetta R, Scognamiglio R, Alfieri F, Izzo V, Di Donato A, Parrilli M, Holst O, Molinaro A. The structure of the O-specific polysaccharide from the lipopolysaccharide of Pseudomonas sp OX1 cultivated in the presence of the azo dye Orange II. CARBOHYDRATE RESEARCH 2008 Mar;343(4):674-684.

Perlovich G, Strakhova N, Kazachenko V, Volkova T, Tkachev V, Schaper K, Raevsky O. Sulfonamides as a subject to study molecular interactions in crystals and solutions: Sublimation, solubility, solvation, distribution and crystal structure. INTERNATIONAL JOURNAL OF PHARMACEUTICS 2008 Feb;349(1-2):300-313.

Cimmino A, Marchi G, Surico G, Hanuszkiewicz A, Evidente A, Holst O. The structure of the O-specific polysaccharide of the lipopolysaccharide from Pantoea agglomerans strain FL1. CARBOHYDRATE RESEARCH 2008 Feb;343(2):392-396.

Pieretti G, Corsaro M, Lanzetta R, Parrilli M, Nicolaus B, Gambacorta A, Lindner B, Holst O. Structural characterization of the core region of the lipopolysaccharide from the haloalkaliphilic Halomonas pantelleriensis: Identification of the biological O-antigen repeating unit. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2008 Feb;(4):721-728.

Mamat U, Meredith T, Aggarwal P, Kuhl A, Kirchhoff P, Lindner B, Hanuszkiewicz A, Sun J, Holst O, Woodard R. Single amino acid substitutions in either YhjD or MsbA confer viability to 3-deoxy-D-manno-oct-2-ulosonic acid-depleted Escherichia coli. MOLECULAR MICROBIOLOGY 2008 Feb;67(3):633-648.

Holst O. From JER to INI. INNATE IMMUNITY 2008 Feb;14(1):3-3.

Hanuszkiewicz A, Hubner G, Vinogradov E, Lindner B, Brade L, Brade H, Debarry J, Heine H, Holst O. Structural and Immunochemical Analysis of the Lipopolysaccharide from Acinetobacter Iwoffii F78 Located Outside Chlamydiaceae with a Chlamydia-Specific Lipopolysaccharide Epitope. CHEMISTRY-A EUROPEAN JOURNAL 2008;14(33):10251-10258.

Esposito N, Ovchinnikova O, Barone A, Zoina A, Holst O, Evidente A. Host and Non-Host Plant Response to Bacterial Wilt in Potato: Role of the Lipopolysaccharide Isolated from Ralstonia solanacearum and Molecular Analysis of Plant-Pathogen Interaction. CHEMISTRY & BIODIVERSITY 2008;5(12):2662-2675.

Book Chapters 2008

Holst O. Glycolipids: Occurrence, Significance, and Properties. In: Fraser-Reid, Bertram O (Ed.): Glycoscience : Chemistry and Chemical Biology. Berlin, Heidelberg: Springer; 2008 p. 1603-1627 [].



Qu J, Mayer C, Behrens S, Holst O, Kleinschmidt J. The trimeric periplasmic chaperone skp of Escherichia coli forms 1 : 1 complexes with outer membrane proteins via hydrophobic and electrostatic interactions. JOURNAL OF MOLECULAR BIOLOGY 2007 Nov;374(1):91-105.

Feodorova V, Pan'kina L, Savostina E, Sayapina L, Motin V, Dentovskaya S, Shaikhutdinova R, Ivanov S, Lindner B, Kondakova A, Bystrova O, Kocharova N, Senchenkova S, Holst O, Pier G, Knirel Y, Anisimov A. A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. VACCINE 2007 Nov;25(44):7620-7628.

Richter E, Tortoli E, Fischer A, Hendricks O, Engel R, Hillemann D, Schubert S, Kristiansen J. Mycobacterium alsiense, novel, slowly growing species isolated from patients with pulmonary disease. JOURNAL OF CLINICAL MICROBIOLOGY 2007 Nov;45(11):3837-3839.

Raevsky O, Raevskaja O, Schaper K. Physicochemical properties/descriptors governing the solubility and partitioning of chemicals in water-solvent-gas systems. Vapor pressure and concentration of chemicals above saturated aqueous solutions. QSAR & COMBINATORIAL SCIENCE 2007 Oct;26(10):1060-1064.

Andra J, Howe J, Garidel P, Rossle M, Richter W, Leiva-Leon J, Moriyon I, Bartels R, Gutsmann T, Brandenburg K. Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis. BIOCHEMICAL JOURNAL 2007 Sep;406:297-307.

Wittkowski M, Mittelstadt J, Brandau S, Reiling N, Lindner B, Torrelles J, Brennan P, Holst O. Capsular arabinomannans from Mycobacterium avium with morphotype-specific structural differences but identical biological activity. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 Jun;282(26):19103-19112.

Holst O. The structures of core regions from enterobacterial lipopolysaccharides - an update. FEMS MICROBIOLOGY LETTERS 2007 Jun;271(1):3-11.

Hansen L, Perlovich G, Schaper K, Bauer-Brandl A. Pyridine-3-carbaldehyde 2-pyridylhydrazone. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE 2007 Jun;63:O3042-U3461.

Debarry J, Garn H, Hanuszkiewicz A, Dickgreber N, Blumer N, von Mutius E, Bufe A, Gatermann S, Renz H, Holst O, Heine H. Acinetobacter lwoffli and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2007 Jun;119(6):1514-1521.

Andra J, Monreal D, de Tejada G, Olak C, Brezesinski G, Gomez S, Goldmann T, Bartels R, Brandenburg K, Moriyon I. Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against gram-negative pathogens. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 Mai;282(20):14719-14728.

Perlovich G, Strakhova N, Kazachenko V, Volkova T, Tkachev V, Schaper K, Raevsky O. Studying thermodynamic aspects of sublimation, solubility and solvation processes and crystal structure analysis of some sulfonamides. INTERNATIONAL JOURNAL OF PHARMACEUTICS 2007 Apr;334(1-2):115-124.

Anisimov A, Shaikhutdinova R, Pan'kina L, Feodorova V, Savostina E, Bystrova O, Lindner B, Mokrievich A, Bakhteeva I, Titareva G, Dentovskaya S, Kocharova N, Senchenkova S, Holst O, Devdarian Z, Popov Y, Pier G, Knirel Y. Effect of deletion of the IpxM gene on virulence and vaccine potential of Yersinia pestis in mice. JOURNAL OF MEDICAL MICROBIOLOGY 2007 Apr;56(4):443-453.

Meredith T, Mamat U, Kaczynski Z, Lindner B, Holst O, Woodard R. Modification of lipopolysaccharide with colanic acid (M-antigen) repeats in Escherichia coli. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 Mar;282(11):7790-7798.

Raevsky O, Perlovich G, Schaper K. Physicochemical properties/descriptors governing the solubility and partitioning of chemicals in water-solvent-gas systems. Part 2. Solubility in 1-octanol. SAR AND QSAR IN ENVIRONMENTAL RESEARCH 2007;18(5-6):543-578.

Kaczynski Z, Braun S, Lindner B, Niehaus K, Holst O. Investigation of the chemical structure and biological activity of oligosaccharides isolated from rough-type Xanthomonas campestris pv. campestris B100 lipopolysaccharide. JOURNAL OF ENDOTOXIN RESEARCH 2007;13(2):101-108.

Holst O. Goodbye MANEY, hello SAGE. JOURNAL OF ENDOTOXIN RESEARCH 2007;13(2):67-67.

Book Chapters 2007

Holst O, Müller-Loennies S. Microbial Polysaccharide Structures. In: Kamerling, Johannis P. (Ed.): Comprehensive glycoscience : from chemistry and systems biology. Vol. 1: Introduction to Glycoscience. Synthesis of Carbohydrates. Amsterdam: Elsevier; 2007 p. 123-179.


2006 (Selection)

Theilacker C, Kaczynski Z, Kropec A, Fabretti F, Sange T, Holst O, Huebner J. Opsonic antibodies to Enterococcus faecalis strain 12030 are directed against lipoteichoic acid. INFECTION AND IMMUNITY 2006 Oct;74(10):5703-5712.

Eder W, Klimecki W, Yu L, von Mutius E, Riedler J, Braun-Fahrlander C, Nowak D, Holst O, Martinez F. Association between exposure to farming, allergies and genetic variation in CARD4/NOD1. ALLERGY 2006 Sep;61(9):1117-1124.

Vinogradov E, Lindner B, Seltmann G, Radziejewska-Lebrecht J, Holst O. Lipopolysaccharides from Serratia marcescens possess one or two 4-amino-4-deoxy-L-arabinopyranose 1-phosphate residues in the lipid A and D-glycero-D-talo-Oct-2-ulopyranosonic acid in the inner core region. CHEMISTRY-A EUROPEAN JOURNAL 2006 Aug;12(25):6692-6700.

Leone S, Molinaro A, Lindner B, Romano I, Nicolaus B, Parrilli M, Lanzetta R, Holst O. The structures of glycolipids isolated from the highly thermophilic bacterium Thermus thermophilus Samu-SA1. GLYCOBIOLOGY 2006 Aug;16(8):766-775.

Fabretti F, Theilacker C, Baldassarri L, Kaczynski Z, Kropec A, Holst O, Huebner J. Alanine esters of enterococcal lipoteichoic acid play a role in biofilm formation and resistance to antimicrobial peptides. INFECTION AND IMMUNITY 2006 Jul;74(7):4164-4171.

De Castro C, Carannante A, Lanzetta R, Lindner B, Nunziata R, Parrilli M, Holst O. Structural characterisation of the core oligosaccharides isolated from the lipooligosaccharide fraction of Agrobacterium tumefaciens A1. CHEMISTRY-A EUROPEAN JOURNAL 2006 Jun;12(17):4668-4674.

Taylor A, Holst O, Thomas-Oates J. Mass spectrometric profiling of O-linked glycans released directly from glycoproteins in gels using in-gel reductive beta-elimination. PROTEOMICS 2006 May;6(10):2936-2946.

Peters M, Kauth M, Schwarze J, Korner-Rettberg C, Riedler J, Nowak D, Braun-Fahrlander C, von Mutius E, Bufe A, Holst O. Inhalation of stable dust extract prevents allergen induced airway inflammation and hyperresponsiveness. THORAX 2006 Feb;61(2):134-139.


2005 (Selection)

Anisimov A, Dentovskaya S, Titareva G, Bakhteeva I, Shaikhutdinova R, Balakhonov S, Lindner B, Kocharova N, Senchenkova S, Holst O, Pier G, Knirel Y. Intraspecies and temperature-dependent variations in susceptibility of Yersinia pestis to the bactericidal action of serum and to polymyxin B. INFECTION AND IMMUNITY 2005 Nov;73(11):7324-7331.

Knirel Y, Lindner B, Vinogradov E, Kocharova N, Senchenkova S, Shaikhutdinova R, Dentovskaya S, Fursova N, Bakhteeva I, Titareva G, Balakhonov S, Holst O, Gremyakova T, Pier G, Anisimov A. Temperature-dependent variations and intraspecies diversity of the structure of the lipopolysaccharide of Yersinia pestis. BIOCHEMISTRY 2005 Feb;44(5):1731-1743.

Fraysse N, Lindner B, Kaczynski Z, Sharypova L, Holst O, Niehaus K, Poinsot V. Sinorhizobium meliloti strain 1021 produces a low-molecular-mass capsular polysaccharide that is a homopolymer of 3-deoxy-D-manno-oct-2-ulosonic acid harboring a phospholipid anchor. GLYCOBIOLOGY 2005 Jan;15(1):101-108.