Forschungszentrum Borstel
Forschungszentrum Borstel

Programmbereich Infektionen





Martin, L, Horst, K, Chiazza, F, Oggero, S, Collino, M, Brandenburg, K, Hildebrand, F, Marx, G, Thiemermann, C & Schuerholz, T 2016, 'The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis' Scientific Reports, Bd 6, S. 37277. DOI: 10.1038/srep37277

Blodkamp, S, Kadlec, K, Gutsmann, T, Naim, HY, von Köckritz-Blickwede, M & Schwarz, S 2016, 'In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus' Veterinary Microbiology. DOI: 10.1016/j.vetmic.2015.09.018

Malgorzata-Miller, G, Heinbockel, L, Brandenburg, K, van der Meer, JWM, Netea, MG & Joosten, LAB 2016, 'Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications' Scientific Reports, Bd 6, S. 34221. DOI: 10.1038/srep34221

Martin, L, Peters, C, Heinbockel, L, Moellmann, J, Martincuks, A, Brandenburg, K, Lehrke, M, Müller-Newen, G, Marx, G & Schuerholz, T 2016, 'The synthetic antimicrobial peptide 19-2.5 attenuates mitochondrial dysfunction in cardiomyocytes stimulated with human sepsis serum' INNATE IMMUNITY. DOI: 10.1177/1753425916667474

Manrique-Moreno, M, Heinbockel, L, Suwalsky, M, Garidel, P & Brandenburg, K 2016, 'Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes' Biochimica et biophysica acta, Bd 1858, Nr. 9, S. 2123-31. DOI: 10.1016/j.bbamem.2016.06.009

de Buhr, N, Reuner, F, Neumann, A, Stump-Guthier, C, Tenenbaum, T, Schroten, H, Ishikawa, H, Müller, K, Beineke, A, Hennig-Pauka, I, Gutsmann, T, Valentin-Weigand, P, Baums, CG & von Köckritz-Blickwede, M 2016, 'Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment' CELLULAR MICROBIOLOGY. DOI: 10.1111/cmi.12649

Gutsmann, T 2016, 'Interaction between antimicrobial peptides and mycobacteria' BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Bd 1858, Nr. 5, S. 1034-43. DOI: 10.1016/j.bbamem.2016.01.031

Brandenburg, K, Heinbockel, L, Correa-Vargas, W & Lohner, K 2016, 'Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis' BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Bd 1858, Nr. 5, S. 971-979. DOI: 10.1016/j.bbamem.2016.01.011

Moyes, DL, Wilson, D, Richardson, JP, Mogavero, S, Tang, SX, Wernecke, J, Höfs, S, Gratacap, RL, Robbins, J, Runglall, M, Murciano, C, Blagojevic, M, Thavaraj, S, Förster, TM, Hebecker, B, Kasper, L, Vizcay, G, Iancu, SI, Kichik, N, Häder, A, Kurzai, O, Luo, T, Krüger, T, Kniemeyer, O, Cota, E, Bader, O, Wheeler, RT, Gutsmann, T, Hube, B & Naglik, JR 2016, 'Candidalysin is a fungal peptide toxin critical for mucosal infection' NATURE, Bd 532, Nr. 7597, S. 64-8. DOI: 10.1038/nature17625

Ulmer, AJ, Kaconis, Y, Heinbockel, L, Correa, W, Alexander, C, Rietschel, ET, Mach, J-P, Gorczynski, RM, Heini, A, Rössle, M, Richter, W, Gutsmann, T & Brandenburg, K 2016, 'Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A' INNATE IMMUNITY, Bd 22, Nr. 3, S. 168-80. DOI: 10.1177/1753425916632304

Brandenburg, K, Heinbockel, L, Correa-Vargas, W, Fukuoka, S, Gutsmann, T, Zähringer, U & Koch, MHJ 2016, 'Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5' Journal of Structural Biology, Bd 194, Nr. 1, S. 68-77. DOI: 10.1016/j.jsb.2016.01.014

Blodkamp, S, Kadlec, K, Gutsmann, T, Quiblier, C, Naim, HY, Schwarz, S & von Köckritz-Blickwede, M 2016, 'Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus' Veterinary Microbiology. DOI: 10.1016/j.vetmic.2016.03.021

Sommer, A, Kordowski, F, Büch, J, Maretzky, T, Evers, A, Andrä, J, Düsterhöft, S, Michalek, M, Lorenzen, I, Somasundaram, P, Tholey, A, Sönnichsen, FD, Kunzelmann, K, Heinbockel, L, Nehls, C, Gutsmann, T, Grötzinger, J, Bhakdi, S & Reiss, K 2016, 'Phosphatidylserine exposure is required for ADAM17 sheddase function' Nature communications, Bd 7, S. 11523. DOI: 10.1038/ncomms11523

Pfalzgraff, A, Heinbockel, L, Su, Q, Gutsmann, T, Brandenburg, K & Weindl, G 2016, 'Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration' Scientific Reports, Bd 6, S. 31577. DOI: 10.1038/srep31577


Schmidt T, Brodesser A, Schnitzler N, Grüger T, Brandenburg K, Zinserling J, Zündorf J. CD66b Overexpression and Loss of C5a Receptors as Surface Markers for Staphylococcus aureus-Induced Neutrophil Dysfunction. PLoS One. 2015 Jul 15;10(7):e0132703. doi: 10.1371/journal.pone.0132703. eCollection 2015

Blodkamp S, Kadlec K, Gutsmann T, Naim HY, von Köckritz-Blickwede M, Schwarz S. In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus. Vet Microbiol. 2015 Sep 28. pii: S0378-1135(15)30036-5. doi: 10.1016/j.vetmic.2015.09.018.

Martinez de Tejada G, Heinbockel L, Ferrer-Espada R, Heine H, Alexander C, Bárcena-Varela S, Goldmann T, Correa W, Wiesmüller KH, Gisch N, Sánchez-Gómez S, Fukuoka S, Schürholz T, Gutsmann T, Brandenburg K. Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides. Sci Rep. 2015 Sep 22;5:14292. doi: 10.1038/srep14292.

Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T, Gutsmann T, Mier W, Schürholz T, Drömann D, Brandenburg K, Martinez de Tejada G. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. PLoS One. 2015 Jul 21;10(7):e0133291. doi: 10.1371/journal.pone.0133291. eCollection 2015.

Tilly AK, Thiede J, Metwally N, Lubiana P, Bachmann A, Roeder T, Rockliffe N, Lorenzen S, Tannich E, Gutsmann T, Bruchhaus I. Type of in vitro cultivation influences cytoadhesion, knob structure, protein localization and transcriptome profile of Plasmodium falciparum. Sci Rep. 2015 Nov 16;5:16766. doi:10.1038/srep16766.

Dupont, A, Kaconis, Y, Yang, I, Albers, T, Woltemate, S, Heinbockel, L, Andersson, M, Suerbaum, S, Brandenburg, K & Hornef, MW 2015, 'Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide' Gut, Bd 64, Nr. 2, S. 222-32.

Gutsmann, T, Heimburg, T, Keyser, U, Mahendran, KR & Winterhalter, M 2015, 'Protein reconstitution into freestanding planar lipid membranes for electrophysiological characterization' Nature protocols, Bd 10, Nr. 1, S. 188-98..

Petersen A, Kull S, Rennert S, Becker WM, Krause S, Ernst M, Gutsmann T, Bauer J, Lindner B, Jappe U. Peanut defensins: Novel allergens isolated from lipophilic peanut extract. J Allergy Clin Immunol. 2015 Nov;136(5):1295-1301. pii: S0091-6749(15)00570-9.

Herrmann, M, Schneck, E, Gutsmann, T, Brandenburg, K & Tanaka, M 2015, 'Bacterial lipopolysaccharides form physically cross-linked, two-dimensional gels in the presence of divalent cations' SOFT MATTER, Bd 11, Nr. 30, S. 6037-44.

Ito, H, Kuss, N, Rapp, BE, Ichikawa, M, Gutsmann, T, Brandenburg, K, Pöschl, JMB & Tanaka, M 2015, 'Quantification of the Influence of Endotoxins on the Mechanics of Adult and Neonatal Red Blood Cells' Journal of Physical Chemistry. B, Bd 119, Nr. 25, S. 7837-45.

Heinbockel, L, Palacios-Chaves, L, Alexander, C, Rietschel, E, Behrends, J, Correa, W, Fukuoka, S, Gutsmann, T, Ulmer, AJ & Brandenburg, K 2015, 'Mechanism of Hbγ-35-induced an increase in the activation of the human immune system by endotoxins' INNATE IMMUNITY, Bd 21, Nr. 3, S. 305-13.

Martin L, De Santis R, Koczera P, Simons N, Haase H, Heinbockel L, Brandenburg K, Marx G, Schuerholz T. The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis. PLoS One. 2015 Nov 23;10(11):e0143583. doi: 10.1371/journal.pone.0143583. eCollection 2015.

Garidel P, Kaconis Y, Heinbockel L, Wulf M, Gerber S, Munk A, Vill V, Brandenburg K. Self-Organisation, Thermotropic and Lyotropic Properties of Glycolipids Related to their Biological Implications. Open Biochem J. 2015 Aug 31;9:49-72. doi: 10.2174/1874091X01509010049. eCollection 2015.

Brandenburg KS, Calderon DF, Kierski PR, Brown AL, Shah NM, Abbott NL, Schurr MJ, Murphy CJ, McAnulty JF, Czuprynski CJ. Inhibition of Pseudomonas aeruginosa biofilm formation on wound dressings. Wound Repair Regen. 2015 Nov 12;23(6):842-54. doi: 10.1111/wrr.12365.

Brandenburg K, Schürholz T. Lack of new antiinfective agents: Passing into the pre-antibiotic age? World J Biol Chem. 2015 Aug 26;6(3):71-7. doi:10.4331/wjbc.v6.i3.71.

Brandenburg K, Marx G, Schuerholz T. Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum. PLoS One. 2015 May 29;10(5):e0127584. doi:10.1371/journal.pone.0127584. eCollection 2015.

Sandetskaya N, Engelmann B, Brandenburg K, Kuhlmeier D. Application of immobilized synthetic anti-lipopolysaccharide peptides for the isolation and detection of bacteria. Eur J Clin Microbiol Infect Dis. 2015 Aug;34(8):1639-45. doi: 10.1007/s10096-015-2399-5. Epub 2015 May 19.


Bang, C, Weidenbach, K, Gutsmann, T, Heine, H & Schmitz, RA 2014, 'The Intestinal Archaea Methanosphaera stadtmanae and Methanobrevibacter smithii Activate Human Dendritic Cells' PLOS ONE, Bd 9, Nr. 6, S. e99411., 10.1371/journal.pone.0099411

Correa, W, Manrique-Moreno, M, Patiño, E, Peláez-Jaramillo, C, Kaconis, Y, Gutsmann, T, Garidel, P, Heinbockel, L & Brandenburg, K 2014, 'Galleria mellonella native and analogue peptides Gm1 and ΔGm1. I) Biophysical characterization of the interaction mechanisms with bacterial model membranes' Biochimica et biophysica acta, Bd 1838, Nr. 10, S. 2728-38., 10.1016/j.bbamem.2014.07.006

Correa, W, Manrique-Moreno, M, Behrends, J, Patiño, E, Chakravarty, M, Peláez-Jaramillo, C, Garidel, P, Gutsmann, T, Brandenburg, K & Heinbockel, L 2014, 'Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) anti-bacterial and anti-endotoxic effects' Biochimica et biophysica acta, Bd 1838, Nr. 10, S. 2739-44., 10.1016/j.bbamem.2014.07.005

Gries, A, Prassl, R, Fukuoka, S, Rössle, M, Kaconis, Y, Heinbockel, L, Gutsmann, T & Brandenburg, K 2014, 'Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide' FEBS open bio, Bd 4, S. 432-40., 10.1016/j.fob.2014.04.008

Hoffmann, J, Schneider, C, Heinbockel, L, Brandenburg, K, Reimer, R & Gabriel, G 2014, 'A new class of synthetic anti-lipopolysaccharide peptides inhibits influenza A virus replication by blocking cellular attachment' Antiviral research, Bd 104, S. 23-33., 10.1016/j.antiviral.2014.01.015

Zuzuarregui, A, Souto, D, Pérez-Lorenzo, E, Arizti, F, Sánchez-Gómez, S, Martínez de Tejada, G, Brandenburg, K, Arana, S & Mujika, M 2014, 'Novel integrated and portable endotoxin detection system based on an electrochemical biosensor' The Analyst, Bd 140, Nr. 2, S. 654-60., 10.1039/c4an01324g


Keese, SP, Brandenburg, K, Roessle, M & Schromm, AB 2013, 'Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages' INNATE IMMUNITY, 10.1177/1753425913506269

Dannehl, C, Gutsmann, T & Brezesinski, G 2013, 'Surface activity and structures of two fragments of the human antimicrobial LL-37' Colloids and surfaces. B, Biointerfaces, Bd 109, S. 129-35., 10.1016/j.colsurfb.2013.03.030

Gross, S, Wilms, D, Krause, J, Brezesinski, G & Andrä, J 2013, 'Design of NK-2-derived peptides with improved activity against equine sarcoid cells' Journal of peptide science : an official publication of the European Peptide Society., 10.1002/psc.2540

Abuillan, W, Schneck, E, Körner, A, Brandenburg, K, Gutsmann, T, Gill, T, Vorobiev, A, Konovalov, O & Tanaka, M 2013, 'Physical interactions of fish protamine and antisepsis peptide drugs with bacterial membranes revealed by combination of specular x-ray reflectivity and grazing-incidence x-ray fluorescence' Physical review. E, Statistical, nonlinear, and soft matter physics, Bd 88, Nr. 1, S. 012705.

Banković, J, Andrä, J, Todorović, N, Podolski-Renić, A, Milošević, Z, Miljković, D, Krause, J, Ruždijić, S, Tanić, N & Pešić, M 2013, 'The elimination of P-glycoprotein over-expressing cancer cells by antimicrobial cationic peptide NK-2: the unique way of multi-drug resistance modulation' Experimental cell research, Bd 319, Nr. 7, S. 1013-27., 10.1016/j.yexcr.2012.12.017

Steinhäuser, C, Heigl, U, Tchikov, V, Schwarz, J, Gutsmann, T, Seeger, K, Brandenburg, J, Fritsch, J, Schroeder, J, Wiesmüller, K-H, Rosenkrands, I, Walther, P, Pott, J, Krause, E, Ehlers, S, Schneider-Brachert, W, Schütze, S & Reiling, N 2013, 'Lipid-labeling facilitates a novel magnetic isolation procedure to characterize pathogen-containing phagosomes' Traffic (Copenhagen, Denmark), Bd 14, Nr. 3, S. 321-36., 10.1111/tra.12031

Heinbockel, L, Sánchez-Gómez, S, Martinez de Tejada, G, Dömming, S, Brandenburg, J, Kaconis, Y, Hornef, M, Dupont, A, Marwitz, S, Goldmann, T, Ernst, M, Gutsmann, T, Schürholz, T & Brandenburg, K 2013, 'Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors' ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Bd 57, Nr. 3, S. 1480-7., 10.1128/AAC.02066-12

Richter, W, Heinbockel, L, Kaconis, Y, Steiniger, F, Gutsmann, T, Brade, L & Brandenburg, K 2013, 'Cellular distribution of lipid A and LPS R595 after in vitro application to isolated human monocytes by freeze-fracture replica immunogold-labelling' INNATE IMMUNITY., 10.1177/1753425912473851

Schuerholz, T, Doemming, S, Hornef, M, Martin, L, Simon, T-P, Heinbockel, L, Brandenburg, K & Marx, G 2013, 'The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study' Critical care (London, England), Bd 17, Nr. 1, S. R3., 10.1186/cc11920

Sil, D, Heinbockel, L, Kaconis, Y, Rössle, M, Garidel, P, Gutsmann, T, David, SA & Brandenburg, K 2013, 'Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines' The open biochemistry journal, Bd 7, S. 82-93., 10.2174/1874091X01307010082

Michalek, M, Sonnichsen, FD, Wechselberger, R, Dingley, AJ, Hung, CW, Kopp, A, Wienk, H, Simanski, M, Herbst, R, Lorenzen, I, Marciano-Cabral, F, Gelhaus, C, Gutsmann, T, Tholey, A, Grotzinger, J & Leippe, M 2013, 'Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba' NATURE CHEMICAL BIOLOGY, Bd 9, Nr. 1, S. 37-42., 10.1038/nchembio.1116


Gross S, Andrä J. Anticancer peptide NK-2 targets cell surface sulphated glycans rather than sialic acids. BIOLOGICAL CHEMISTRY 2012 Aug;393(8): 817-27.

Brauser A, Schroeder I, Gutsmann T, Cosentino C, Moroni A, Hansen U-P, Winterhalter M. Modulation of enrofloxacin binding in OmpF by Mg2+ as revealed by the analysis of fast flickering single-porin current. THE JOURNAL OF GENERAL PHYSIOLOGY 2012 Jul;140(1):69–82.

Sommer A, Fries A, Cornelsen I, Speck N, Koch-Nolte F, Gimpl G, Andra J, Bhakdi S, Reiss K. Melittin Modulates Keratinocyte Function through P2 Receptor-dependent ADAM Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 2012 May;287(28):23678–23689.

Schuerholz T, Dömming S, Hornef M, Dupont A, Kowalski I, Kaconis Y, Heinbockel L, Andrä J, Garidel P, Gutsmann T, David S, Sánchez-Gómez S, de Tejada GM, Brandenburg K. Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects. CURRENT DRUG TARGETS 2012 Aug;13(9):1131-7.

de Tejada GM, Sánchez-Gómez S, Razquin-Olazaran I, Kowalski I, Kaconis Y, Heinbockel L, Andrä J, Schürholz T, Hornef M, Dupont A, Garidel P, Lohner K, Gutsmann T, David SA, Brandenburg K. Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines. CURRENT DRUG TARGETS 2012 Aug;13(9):1121-30.

Bang C, Schilhabel A, Weidenbach K, Kopp A, Goldmann T, Gutsmann T, Schmitz RA. Effects of Antimicrobial Peptides on Methanogenic Archaea. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2012 May;56(8):4123–4130.

Conde-Álvarez R, Arce-Gorvel V, Iriarte M, Manček-Keber M, Barquero-Calvo E, Palacios-Chaves L, Chacón-Díaz C, Chaves-Olarte E, Martirosyan A, von Bargen K, Grilló M-J, Jerala R, Brandenburg K, Llobet E, Bengoechea JA, Moreno E, Moriyón I, Gorvel J-P. The Lipopolysaccharide Core of Brucella abortus Acts as a Shield Against Innate Immunity Recognition. PLOS PATHOGENS 2012 May;8(5):e1002675. Open Access

Fukuoka S, Richter W, Howe J, Andrä J, Rössle M, Alexander C, Gutsmann T, Brandenburg K. Biophysical investigations into the interactions of endotoxins with bile acids. INNATE IMMUNITY 2012 Apr;18(2):307-17.

Krepstakies M, Lucifora J, Nagel C-H, Zeisel MB, Holstermann B, Hohenberg H, Kowalski I, Gutsmann T, Baumert TF, Brandenburg K, Hauber J, Protzer U. A New Class of Synthetic Peptide Inhibitors Blocks Attachment and Entry of Human Pathogenic Viruses. JOURNAL OF INFECTIOUS DISEASES 2012 Mar;205(11):1654–1664.

Mancek-Keber M, Bencina M, Japelj B, Panter G, Andra J, Brandenburg K, Triantafilou M, Triantafilou K, Jerala R. MARCKS as a Negative Regulator of Lipopolysaccharide Signaling. JOURNAL OF IMMUNOLOGY 2012 Mar;188(8):3893–3902.

Paulmann M, Arnold T, Linke D, Ozdirekcan S, Kopp A, Gutsmann T, Kalbacher H, Wanke I, Schuenemann VJ, Habeck M, Burck J, Ulrich AS, Schittek B. Structure-Activity Analysis of the Dermcidin-derived Peptide DCD-1L, an Anionic Antimicrobial Peptide Present in Human Sweat. JOURNAL OF BIOLOGICAL CHEMISTRY 2012 Mar;287(11):8434–8443.


Richter W, Vogel V, Howe J, Steiniger F, Brauser A, Koch MH, Roessle M, Gutsmann T, Garidel P, Mantele W, Brandenburg K. Morphology, size distribution, and aggregate structure of lipopolysaccharide and lipid A dispersions from enterobacterial origin. INNATE IMMUNITY 2011 Oct;17(5):427-438.

Suwalsky M, Manrique-Moreno M, Howe J, Brandenburg K, Villena F. Molecular Interactions of Mefenamic Acid with Lipid Bilayers and Red Blood Cells. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY 2011;22(12):2243–2249.

Zweytick D, Deutsch G, Andrä J, Blondelle SE, Vollmer E, Jerala R, Lohner K. Studies on lactoferricin-derived Escherichia coli membrane-active peptides reveal differences in the mechanism of N-acylated versus nonacylated peptides. THE JOURNAL OF BIOLOGICAL CHEMISTRY 2011 Jun;286(24):21266-21276.

Kaconis Y, Kowalski I, Howe J, Brauser A, Richter W, Razquin-Olazarán I, Iñigo-Pestaña M, Garidel P, Rössle M, Martinez de Tejada G, Gutsmann T, Brandenburg K. Biophysical mechanisms of endotoxin neutralization by cationic amphiphilic peptides. BIOPHYSICAL JOURNAL 2011 Jun;100(11):2652-2661.

Jeworrek C, Evers F, Howe J, Brandenburg K, Tolan M, Winter R. Effects of specific versus nonspecific ionic interactions on the structure and lateral organization of lipopolysaccharides. BIOPHYSICAL JOURNAL 2011 May;100(9):2169-2177.

Brandenburg K, Andrä J, Garidel P, Gutsmann T. Peptide-based treatment of sepsis. Applied Microbiology and Biotechnology 2011 May;90(3):799-808.

Andra J, Goldmann T, Ernst CM, Peschel A, Gutsmann T. Multiple peptide resistance factor (MPRF)-mediated resistance of staphylococcus aureus against antimicrobial peptides coincides with a modulated peptide interaction with artificial membranes comprising lysyl-phosphatidylglycerol. JOURNAL OF BIOLOGICAL CHEMISTRY 2011 May 27;286(21):18692-700. Epub 2011 Apr 7.



Kowalski I, Kaconis Y, Andrä J, Razquin-Olazarán I, Gutsmann T, de Tejada GM, Brandenburg K. Physicochemical and Biological Characterization of Anti-Endotoxin Peptides and their Influence on Lipid Properties. PROTEIN AND PEPTIDE LETTERS 2010 Nov;17(11):1328-33.

Travkova OG, Andrä J, Möhwald H, Brezesinski G. Conformational Properties of Arenicins: From the Bulk to the Air-Water Interface. ChemPhysChem 2010 Oct;11(15):3262-3268.

Schromm AB, Reiling N, Howe J, Wiesmuller K, Roessle M, Brandenburg K. Influence of serum on the immune recognition of a synthetic lipopeptide mimetic of the 19-kDa lipoprotein from Mycobacterium tuberculosis. INNATE IMMUNITY 2010 Aug;16(4):213-25.

Brandenburg K, Garidel P, Fukuoka S, Howe J, Koch MH, Gutsmann T, Andrä J. Molecular basis for endotoxin neutralization by amphipathic peptides derived from the ?-helical cationic core-region of NK-lysin?. BIOPHYSICAL CHEMISTRY 2010 Aug;150(1-3):80-87.

Brandenburg K, Seydel U. Conformation and supramolecular structure of lipid a. ADVANCES IN EXPERIMENTAL MEDICINE 2010 Jul;667:25-38.

Andrä J, Gutsmann T, Müller M, Schromm AB. Interactions between Lipid A and Serum Proteins. ADVANCES IN EXPERIMENTAL MEDICINE 2010 Jul;667:39-51.

Gutsmann T, Razquin-Olazarán I, Kowalski I, Kaconis Y, Howe J, Bartels R, Hornef M, Schürholz T, Rössle M, Sanchez-Gómez S, Moriyon I, Martinez de Tejada G, Brandenburg K. New antiseptic peptides to protect from endotoxin-mediated shock. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2010 Sep;54(9):3817-24.

Brandenburg K, Schromm AB, Gutsmann T. Endotoxins: relationship between structure, function, and activity. SUBCELLULAR BIOCHEMISTRY 2010 Jun;53:53-67.

Suomalainen M, Lobo LA, Brandenburg K, Lindner B, Virkola R, Knirel YA, Anisimov AP, Holst O, Korhonen TK. Temperature-Induced Changes in the Lipopolysaccharide of Yersinia pestis Affect Plasminogen Activation by the Pla Surface Protease. INFECTION AND IMMUNITY 2010 Jun;78(6):2644-2652.

Schneck E, Schubert T, Konovalov OV, Quinn BE, Gutsmann T, Brandenburg K, Oliveira RG, Pink DA, Tanaka M. Quantitative determination of ion distributions in bacterial lipopolysaccharide membranes by grazing-incidence X-ray fluorescence. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2010 May;107(20):9147-9151.

Hammer MU, Brauser A, Olak C, Brezesinski G, Goldmann T, Gutsmann T, Andrä J. Lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide NK-2 against Escherichia coli and Proteus mirabilis. BIOCHEMICAL JOURNAL 2010 May;427(3):477-488.

Schuh E, Kramer J, Rohwedel J, Notbohm H, Muller R, Gutsmann T, Rotter N. Effect of Matrix Elasticity on the Mayntenance of the Chondrogenic Phenotype. TISSUE ENGINEERING PART A 2010 Apr;16(4):1281-1290.

Oliveira R, Schneck E, Quinn B, Konovalov O, Brandenburg K, Gutsmann T, Gill T, Hanna C, Pink D, Tanaka M. Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence x-ray structural characterizations and Monte Carlo simulations. PHYSICAL REVIEW E 2010 Apr;81(4). DOI: 10.1103/PhysRevE.81.041901

Gutsmann T, Howe J, Zahringer U, Garidel P, Schromm AB, Koch MHJ, Fujimoto Y, Fukase K, Moriyon I, Martinez-de-Tejada G, Brandenburg K. Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells. INNATE IMMUNITY 2010 Feb;16(1):39-47.

Brandenburg K, Howe J, Sanchez-Gomez S, Garidel P, Roessle M, Andra J, Jerala R, Zweytick D, Lohner K, Rappolt M, Blondelle S, Moriyon I, de Tejada G,  (. Effective Antimicrobial and Anti-Endotoxin Activity of Cationic Peptides Based on Lactoferricin: A Biophysical and Microbiological Study. ANTI-INFECTIVE AGENTS IN MEDICINAL CHEMISTRY (FORMERLY `CURRENT MEDICINAL CHEMISTRY - ANTI-INFECTIVE AGENTS) 2010 Jan;9(1):9-22.

Manrique-Moreno M, Howe J, Suwalsky M, Garidel P, Brandenburg K. Physicochemical Interaction Study of Non-Steroidal Anti-Inflammatory Drugs with Dimyristoylphosphatidylethanolamine Liposomes. LETTERS IN DRUG DESIGN & DISCOVERY 2010 Jan;7(1):50-56.

Gutsmann T, Seydel U. Impact of the glycostructure of amphiphilic membrane components on the function of the outer membrane of Gram-negative bacteria as a matrix for incorporated channels and a target for antimicrobial peptides or proteins. EUROPEAN JOURNAL OF CELL BIOLOGY 2010 Jan;89(1):11-23.


Kerth A, Garidel P, Howe J, Alexander C, Mach J, Waelli T, Blume A, Th Rietschel E, Brandenburg K. An infrared reflection-absorption spectroscopic (IRRAS) study of the interaction of lipid A and lipopolysaccharide Re with endotoxin-binding proteins. MEDICINAL CHEMISTRY 2009 Nov;5(6):535-542.

Schneck E, Oliveira R, Rehfeldt F, Deme B, Brandenburg K, Seydel U, Tanaka M. Mechanical properties of interacting lipopolysaccharide membranes from bacteria mutants studied by specular and off-specular neutron scattering. PHYSICAL REVIEW E 2009 Oct;80(4). DOI 10.1103/PhysRevE.80.041929

Garidel P, Brandenburg K. Current Understanding of Polymyxin B Applications in Bacteraemia/ Sepsis Therapy Prevention: Clinical, Pharmaceutical, Structural and Mechanistic Aspects. ANTI-INFECTIVE AGENTS IN MEDICINAL CHEMISTRY (FORMERLY `CURRENT MEDICINAL CHEMISTRY - ANTI-INFECTIVE AGENTS) 2009 Oct;8:367-385.

Brandenburg K, Howe J, Gutsman T, Garidel P. The Expression of Endotoxic Activity in the Limulus Test as Compared to Cytokine Production in Immune Cells. CURRENT MEDICINAL CHEMISTRY 2009 Jul;16(21):2653-2660.

Senyurek I, Paulmann M, Sinnberg T, Kalbacher H, Deeg M, Gutsmann T, Hermes M, Kohler T, Gotz F, Wolz C, Peschel A, Schittek B. Dermcidin-Derived Peptides Show a Different Mode of Action than the Cathelicidin LL-37 against Staphylococcus aureus. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2009 Jun;53(6):2499-2509.

Moreno M, Garidel P, Suwalsky M, Howe J, Brandenburg K. The membrane-activity of Ibuprofen, Diclofenac, and Naproxen: A physico-chemical study with lecithin phospholipids. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 2009 Jun;1788(6):1296-1303.

Mashburn-Warren L, Howe J, Brandenburg K, Whiteley M. Structural Requirements of the Pseudomonas Quinolone Signal for Membrane Vesicle Stimulation. JOURNAL OF BACTERIOLOGY 2009 May;191(10):3411-3414.

Khatri I, Alexander C, Brandenburg K, Fournier K, Mach J, Rietschel E, Ulmer A, Terzioglu E, Waelli T, Gorczynski R. Induction of tolerogenic vs immunogenic dendritic cells (DCs) in the presence of GM-CSF is regulated by the strength of signaling from monophosphoryl lipid A (MPLA) in association with glutathione and fetal hemoglobin gamma-chain. IMMUNOLOGY LETTERS 2009 May;124(1):44-49.

Gerber S, Wulf M, Milkereit G, Vill V, Howe J, Roessle M, Garidel P, Gutsmann T, Brandenburg K. Phase diagrams of monoacylated amide-linked disaccharide glycolipids. CHEMISTRY AND PHYSICS OF LIPIDS 2009 Apr;158(2):118-130.

Andra J, Hammer M, Grotzinger J, Jakovkin I, Lindner B, Vollmer E, Fedders H, Leippe M, Gutsmann T. Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes. BIOLOGICAL CHEMISTRY 2009 Apr;390(4):337-349.

Harrington J, Chou H, Gutsmann T, Gelhaus C, Stahlberg H, Leippe M, Armstrong P. Membrane activity of a C-reactive protein. FEBS LETTERS 2009 Mar;583(6):1001-1005.

Oliveira RG, Schneck E, Quinn BE, Konovalov OV, Brandenburg K, Seydel U, Gill T, Hanna CB, Pink DA, Tanaka M. Physical mechanisms of bacterial survival revealed by combined grazing-incidence X-ray scattering and Monte Carlo simulation. COMPTES RENDUS CHIMIE 2009 Feb;12(1-2):209-217.

Jung S, Dingley A, Augustin R, Anton-Erxleben F, Stanisak M, Gelhaus C, Gutsmann T, Hammer M, Podschun R, Bonvin A, Leippe M, Bosch T, Grotzinger J. Hydramacin-1, Structure and Antibacterial Activity of a Protein from the Basal Metazoan Hydra. JOURNAL OF BIOLOGICAL CHEMISTRY 2009 Jan;284(3):1896-1905.

Hanulova M, Andra J, Garidel P, Olak C, Howe J, Funari SS, Gutsmann T, Brandenburg K. Interaction of Melittin with Phospholipid- and Lipopolysaccharide- Containing Model Membranes. ANTI-INFECTIVE AGENTS IN MEDICINAL CHEMISTRY (FORMERLY `CURRENT MEDICINAL CHEMISTRY - ANTI-INFECTIVE AGENTS) 2009 Jan;8:17-27.


Sanchez-Gomez S, Lamata M, Leiva J, Blondelle S, Jerala R, Andra J, Brandenburg K, Lohner K, Moriyon I, Martinez-De-Tejada G. Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides. BMC MICROBIOLOGY 2008 Nov;8(196). Open Access

Howe J, Richter W, Hawkins L, Rossle M, Alexander C, Fournier K, Mach J, Waelli T, Gorczynski R, Ulmer A, Brade H, Zamyatina A, Kosma P, Rietschel E, Brandenburg K. Hemoglobin Enhances the Biological Activity of Synthetic and Natural Bacterial (Endotoxic) Virulence Factors: A General Principle. MEDICINAL CHEMISTRY 2008 Nov;4(6):520-525.

Garidel P, Howe J, Brandenburg K. Thermodynamic Analysis of the Interaction of Lipopolysaccharides with Cationic Compounds. ENGINEERING IN LIFE SCIENCES 2008 Oct;8(5):523-529.

Fukuoka S, Howe J, Andra J, Gutsmann T, Rossle M, Brandenburg K. Physico-chemical and biophysical study of the interaction of hexa- and heptaacyl lipid A from Erwinia carotovora with magainin 2-derived antimicrobial peptides. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 2008 Oct;1778(10):2051-2057.

Howe J, Garidel P, Wulf M, Gerber S, Milkereit G, Vill V, Roessle M, Brandenburg K. Structural polymorphism of hydrated monoacylated maltose glycolipids. CHEMISTRY AND PHYSICS OF LIPIDS 2008 Sep;155(1):31-37.

Andra J, Bohling A, Gronewold T, Schlecht U, Perpeet M, Gutsmann T. Surface acoustic wave biosensor as a tool to study the interaction of antimicrobial peptides with phospholipid and lipopolysaccharide model membranes. LANGMUIR 2008 Aug;24(16):9148-9153.

Khatri I, Alexander C, Brandenburg K, Fournier K, Lee L, Mach J, Rietschel E, Ulmer A, Waelli T, Gorczynski R. A role for altered TLR gene expression in association with increased expression of CD200R in the induction of mucosal tissue CD4(+) Treg in aged mice following gavage with a liver extract along with intramuscular monophosphoryl lipid A (MPLA) injection. EXPERIMENTAL GERONTOLOGY 2008 Aug;43(8):771-781.

Harrington J, Chou H, Gutsmann T, Gelhaus C, Stahlberg H, Leippe M, Armstrong P. Membrane pore formation by pentraxin proteins from Limulus, the American horseshoe crab. BIOCHEMICAL JOURNAL 2008 Jul;413:305-313.

Gelhaus C, Jacobs T, Andra J, Leippe M. The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic Plasmodium falciparum. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2008 May;52(5):1713-1720.

Olak C, Muenter A, Andrae J, Brezesinskia G. Interfacial properties and structural analysis of the antimicrobial peptide NK-2. JOURNAL OF PEPTIDE SCIENCE 2008 Apr;14(4):510-517.

Andra J, Jakovkin I, Grotzinger J, Hecht O, Krasnosdembskaya A, Goldmann T, Gutsmann T, Leippe M. Structure and mode of action of the antimicrobial peptide arenicin. BIOCHEMICAL JOURNAL 2008 Feb;410:113-122.

Howe J, Garidel P, Roessle M, Richter W, Alexander C, Fournier K, Mach J, Waelli T, Gorczynski R, Ulmer A, Zaehringer U, Hartmann A, Rietschel E, Brandenburg K. Structural investigations into the interaction of hemoglobin and part structures with bacterial endotoxins. INNATE IMMUNITY 2008 Feb;14(1):39-49.

Garidel P, Howe J, Milkereit G, Roessle M, Linser S, Gerber S, Willumeit R, Gutsmann T, Vill V, Brandenburg K. Structural polymorphism of hydrated ether-linked dimyristyl maltoside and melibioside. CHEMISTRY AND PHYSICS OF LIPIDS 2008 Jan;151(1):18-29.


Zughaier S, Lindner B, Howe J, Garidel P, Koch M, Brandenburg K, Stephens D. Physicochemical characterization and biological activity of lipooligosaccharides and lipid A from Neisseria meningitidis. JOURNAL OF ENDOTOXIN RESEARCH 2007 Dec;13(6):343-357.

Dennison S, Harris F, Brandenburg K, Phoenix D. Characterization of the N-terminal segment used by the barley yellow dwarf virus movement protein to promote interaction with the nuclear membrane of host plant cells. PEPTIDES 2007 Nov;28(11):2091-2097.

Howe J, von Minden M, Gutsmann T, Koch M, Wulf M, Gerber S, Milkereit G, Vill V, Brandenburg K. Structural preferences of dioleoyl glycolipids with mono- and disaccharide head groups. CHEMISTRY AND PHYSICS OF LIPIDS 2007 Oct;149(1-2):52-58.

Chen X, Howe J, Andra J, Roessle M, Richter W, da Silva A, Krensky A, Clayberger C, Brandenburg K. Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 2007 Oct;1768(10):2421-2431.

Andra J, Howe J, Garidel P, Rossle M, Richter W, Leiva-Leon J, Moriyon I, Bartels R, Gutsmann T, Brandenburg K. Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis. BIOCHEMICAL JOURNAL 2007 Sep;406:297-307.

Gutsmann T, Schromm A, Brandenburg K. The physicochemistry of endotoxins in relation to bioactivity. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 2007 Sep;297(5):341-352.

Patrick Garidel, Jorg Andra, Jorg Howe, Thomas Gutsmann, Klaus Brandenburg. Novel Antiinflammatory and Antiinfective Agents. ANTI-INFECTIVE AGENTS IN MEDICINAL CHEMISTRY (FORMERLY `CURRENT MEDICINAL CHEMISTRY - ANTI-INFECTIVE AGENTS) 2007 Jul;6:185-200.

Howe J, Hammer M, Brandenburg K. Calorimetric investigations of the effect of polymyxin B on different Gram-negative bacteria. THERMOCHIMICA ACTA 2007 Jun;458(1-2):34-37.

Andra J, Monreal D, de Tejada G, Olak C, Brezesinski G, Gomez S, Goldmann T, Bartels R, Brandenburg K, Moriyon I. Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against gram-negative pathogens. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 May;282(20):14719-14728.

Gorczynski R, Alexander C, Bessler W, Brandenburg K, Fournier K, Mach J, Mueller S, Rietschel E, Ulmer A, Waelli T, Zahringer U, Khatri I. An alteration in the levels of populations of CD4(+) Treg is in part responsible for altered cytokine production by cells of aged mice which follows injection with a fetal liver extract. IMMUNOLOGY LETTERS 2007 Apr;109(2):101-112.

Schromm A, Howe J, Ulmer A, Wiesmuller K, Seyberth T, Jung G, Rossle M, Koch M, Gutsmann T, Brandenburg K. Physicochemical and biological analysis of synthetic bacterial lipopeptides - Validity of the concept of endotoxic conformation. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 Apr;282(15):11030-11037.

Howe J, Andra J, Conde R, Iriarte M, Garidel P, Koch M, Gutsmann T, Moriyon I, Brandenburg K. Thermodynamic analysis of the lipopolysaccharide-dependent resistance of gram-negative bacteria against polymyxin B. BIOPHYSICAL JOURNAL 2007 Apr;92(8):2796-2805.

Japelj B, Zorko M, Majerle A, Pristovsek P, Sanchez-Gomez S, de Tejada G, Moriyon I, Blondelle S, Brandenburg K, Andra J, Lohner K, Jerala R. The acyl group as the central element of the structural organization of antimicrobial lipopeptide. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2007 Feb;129(5):1022-1023.

Howe J, Hammer M, Alexander C, Rossle M, Fournier K, Mach J, Waelli T, Gorczynski R, Ulmer A, Zahringer U, Rietschel E, Brandenburg K. Biophysical characterization of the interaction of endotoxins with hemoglobins. MEDICINAL CHEMISTRY 2007 Jan;3(1):13-20.

2006 (Selection)

Howe J, Bauer J, Andra J, Schromm A, Ernst M, Rossle M, Zahringer U, Rademann J, Brandenburg K. Biophysical characterization of synthetic rhamnolipids. FEBS JOURNAL 2006 Nov;273(22):5101-5112.

Wiedemann I, Bottiger T, Bonelli R, Wiese A, Hagge S, Gutsmann T, Seydel U, Deegan L, Hill C, Ross P, Sahl H. The mode of action of the lantibiotic lacticin 3147 - a complex mechanism involving specific interaction of two peptides and the cell wall precursor lipid II. MOLECULAR MICROBIOLOGY 2006 Jul;61(2):285-296.

Bohling A, Hagge S, Roes S, Podschun R, Sahly H, Harder J, Schroder J, Grotzinger J, Seydel U, Gutsmann T. Lipid-specific membrane activity of human beta-defensin-3. BIOCHEMISTRY 2006 May;45(17):5663-5670.

Hagge SO, Hammer MU, Wiese A, Seydel U, Gutsmann T. Calcium adsorption and displacement: characterization of lipid monolayers and their interaction with membrane-active peptides/proteins. BMC Biochemistry 2006 May;7:15. Open Access

Andra J, Rademann J, Howe J, Koch M, Heine H, Zahringer U, Brandenburg K. Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization. BIOLOGICAL CHEMISTRY 2006 Mar;387(3):301-310.

Roes S, Mumm F, Seydel U, Gutsmann T. Localization of the lipopolysaccharide-binding protein in phospholipid membranes by atomic force microscopy. JOURNAL OF BIOLOGICAL CHEMISTRY 2006 Feb;281(5):2757-2763.

2005 (Selection)

Schroder-Borm H, Bakalova R, Andra J. The NK-lysin derived peptide NK-2 preferentially kills cancer cells with increased surface levels of negatively charged phosphatidylserine. FEBS LETTERS 2005 Nov;579(27):6128-6134.

Roes S, Seydel U, Gutsmann T. Probing the properties of lipopolysaccharide monolayers and their interaction with the antimicrobial peptide polymyxin B by atomic force microscopy. LANGMUIR 2005 Jul;21(15):6970-6978.

Brandenburg K, David A, Howe J, Koch M, Andra J, Garidel P. Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide. BIOPHYSICAL JOURNAL 2005 Mar;88(3):1845-1858.

Brandenburg K, Garidel P, Schromm A, Andra J, Kramer A, Egmond M, Wiese A. Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT : lipopolysaccharide complexes. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 2005 Feb;34(1):28-41.

Mueller M, Brandenburg K, Dedrick R, Schromm A, Seydel U. Phospholipids inhibit lipopolysaccharide (LPS)-induced cell activation: A role for LPS-binding protein. JOURNAL OF IMMUNOLOGY 2005 Jan;174(2):1091-1096.

Andra J, Lohner K, Blondelle S, Jerala R, Moriyon I, Koch M, Garidel P, Brandenburg K. Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. BIOCHEMICAL JOURNAL 2005 Jan;385:135-143.

Mueller M, Lindner B, Dedrick R, Schromm A, Seydel U. Endotoxin: physical requirements for cell activation. JOURNAL OF ENDOTOXIN RESEARCH 2005;11(5):299-303.

Gutsmann T, Hagge S, David A, Roes S, Bohling A, Hammer M, Seydel U. Lipid-mediated resistance of Gram-negative bacteria against various pore-forming antimicrobial peptides. JOURNAL OF ENDOTOXIN RESEARCH 2005;11(3):167-173.


Rappolt M, Rössle M, Kaconis Y, Howe J, Andrä J, Gutsmann T, Brandenburg K. X-ray scattering of bacterial cell wall compounds and their neutralization. In: X-Ray Scattering. Nova Science; 2011 p. 133-48.

Olak C, Andrä J, Brezesinski G. Langmuir monolayers at the liquid-air interface: a useful tool to study the interaction of membrane-active peptides with phospholipids.  In: Castanho, Miguel A.R.B. (ed.): Membrane-Active Peptides: Methods and Results on Structure and Function.  La Jolla, CA : International University Line; 2009 p. 81-112.

Brandenburg K, Seydel U. Conformation and Supramolecular Structure of Lipid A.  In: Jeannin, Jean-Francois (Ed.): Lipid A in cancer therapy.  New York, NY: Springer New York; 2009 p. 25-38.

Andrä J, Gutsmann T, Müller M, Schromm AB. Interactions Between Lipid A and Serum Proteins.  In: Jeannin, Jean-Francois (Ed.): Lipid A in cancer therapy.  New York, NY: Springer New York; 2009 p. 39-52.

Schromm AB, Alexander C, Gutsmann T, Stamme C. Pathogens in Sepsis: Gram-negative Bacterial PAMPs and PRRs.  In: Cavaillon, Jean-Marc (Ed.): Sepsis and non-infectious systemic inflammation : from biology to critical care.  Weinheim: Wiley-VCH; 2009 p. 75-104.