Forschungszentrum Borstel
Forschungszentrum Borstel

Programmbereich Infektionen

Mikrobielle Grenzflächenbiologie



Brandenburg, J & Reiling, N 2016, 'The Wnt blows: On the functional role of Wnt signaling in Mycobacterium tuberculosis infection and beyond' Frontiers in Immunology, Bd 7, S. 635. DOI: 10.3389/fimmu.2016.00635

Lentz, F, Hemmer, M, Reiling, N & Hilgeroth, A 2016, 'Discovery of novel N-phenyl 1,4-dihydropyridines with a dual mode of antimycobacterial activity' BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , Bd 26, Nr. 24, S. 5896-5898. DOI: 10.1016/j.bmcl.2016.11.010

Prosser, G, Brandenburg, J, Reiling, N, Barry, CE, Wilkinson, RJ & Wilkinson, KA 2016, 'The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition' MICROBES AND INFECTION . DOI: 10.1016/j.micinf.2016.10.001

Lehmann, J, Vomacka, J, Esser, K, Nodwell, M, Kolbe, K, Rämer, P, Protzer, U, Reiling, N & Sieber, SA 2016, 'Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases' MedChemComm. DOI: 10.1039/C6MD00231E

Moulakakis, C, Steinhäuser, C, Biedziak, D, Freundt, K, Reiling, N & Stamme, C 2016, 'Surfactant Protein A Enhances Constitutive Immune Functions of Clathrin Heavy Chain and Clathrin Adaptor Protein AP2' AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY , Bd 55, Nr. 1, S. 92-104. DOI: 10.1165/rcmb.2015-0219OC

Meyer, CG, Reiling, N, Ehmen, C, Ruge, G, Owusu-Dabo, E, Horstmann, RD & Thye, T 2016, 'TLR1 Variant H305L Associated with Protection from Pulmonary Tuberculosis' PLOS ONE, Bd 11, Nr. 5, S. e0156046. DOI: 10.1371/journal.pone.0156046

Kaufmann, E, Spohr, C, Battenfeld, S, De Paepe, D, Holzhauser, T, Balks, E, Homolka, S, Reiling, N, Gilleron, M & Bastian, M 2016, 'BCG Vaccination Induces Robust CD4+ T Cell Responses to Mycobacterium tuberculosis Complex-Specific Lipopeptides in Guinea Pigs' JOURNAL OF IMMUNOLOGY, Bd 196, Nr. 6, S. 2723-2732. DOI: 10.4049/jimmunol.1502307

Ganbat, D, Seehase, S, Richter, E, Vollmer, E, Reiling, N, Fellenberg, K, Gaede, KI, Kugler, C & Goldmann, T 2016, 'Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells' BMC PULMONARY MEDICINE, Bd 16, Nr. 1, S. 19. DOI: 10.1186/s12890-016-0185-5


Shima K, Klinger M, Schütze S, Kaufhold I, Solbach W, Reiling N et al. The role of ER-related BiP/GRP78 in IFN-γ induced persistent Chlamydia pneumoniae infection. CELLULAR MICROBIOLOGY. 2015 Jan 15;17(7):923-34.

Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T et al. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. PLOS ONE. 2015;10(7):e0133291.


Menck K, Behme D, Pantke M, Reiling N, Binder C, Pukrop T et al. Isolation of human monocytes by double gradient centrifugation and their differentiation to macrophages in teflon-coated cell culture bags. Journal of visualized experiments : JoVE. 2014 Sep 9;(91):e51554. Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T et al. Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLOS ONE. 2014 Mai 1;9(5):e96015.

Steinhäuser, C, Dallenga, T, Tchikov, V, Schaible, UE, Schütze, S & Reiling, N 2014, 'Immuno-magnetic isolation of pathogen-containing phagosomes and apoptotic blebs from primary phagocytes' Current Protocols in Immunology 2014 Apr 2;105:14.36.1-14.36.26.

Helm, O, Held-Feindt, J, Grage-Griebenow, E, Reiling, N, Ungefroren, H, Vogel, I, Krüger, U, Becker, T, Ebsen, M, Röcken, C, Kabelitz, D, Schäfer, H & Sebens, S 2014, 'Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis' International Journal of Cancer 2014;135(4):843-861. doi:10.1002/ijc.28736. [Epub ahead of print]


Schaale K, Brandenburg J, Kispert A, Leitges M, Ehlers S, Reiling N. Wnt6 Is Expressed in Granulomatous Lesions of Mycobacterium tuberculosis-Infected Mice and Is Involved in Macrophage Differentiation and Proliferation. J Immunol. 2013
Nov 15;191(10):5182-95.

Reiling N, Homolka S, Walter K, Brandenburg J, Niwinski L, Ernst M, Herzmann C, Lange C, Diel R, Ehlers S, Niemann, S. Clade-Specific Virulence Patterns of Mycobacterium tuberculosis Complex Strains in Human Primary Macrophages and Aerogenically Infected Mice. MBio. 2013 Jul 30;4(4). pii: e00250-13 Open Access

Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, et al. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7820-5. Open Access

Steinhäuser C, Heigl U, Tchikov V, Schwarz J, Gutsmann T, Seeger K, et al. Lipid-labeling facilitates a novel magnetic isolation procedure to characterize pathogen-containing phagosomes. TRAFFIC. 2013 Mar;(14):321–36.


Steinhäuser C, Heigl U, Tchikov V, Schwarz J, Gutsmann T, Seeger K, Brandenburg J, Fritsch J, Schroeder J, Wiesmüller K-H, Rosenkrands I, Walther P, Pott J, Krause E, Ehlers S, Schneider-Brachert W, Schütze S, Reiling N. Lipid-labeling facilitates a novel magnetic isolation procedure to characterize pathogen-containing phagosomes. TRAFFIC 2012 Dec (in press).

Ungefroren H, Hyder A, Hinz H, Reiling N, Grage-Griebenow E, Schulze M, Ehnert S, Nüssler A, Fändrich F. Peripheral Blood Monocytes Can Be Induced to Acquire Stem Cell-Like Properties. In: Hayat, M.A. (Ed.): Therapeutic Applications in Disease and Injury (Stem Cells and Cancer Stem Cells ; 6). 2012 p. 367–375.

Maertzdorf J, Weiner J 3rd, Mollenkopf H-J, TBornotTB Network, Bauer T, Prasse A, Müller-Quernheim J, Kaufmann SHE. Common patterns and disease-related signatures in tuberculosis and sarcoidosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2012 May 15;109(20):7853-8.

Abdullah M, Kähler D, Vock C, Reiling N, Kugler C, Dromann D, Rupp J, Hauber HP, Fehrenbach H, Zabel P, Vollmer E, Dalhoff K, Goldmann T. Pulmonary haptoglobin and CD163 are functional immunoregulatory elements in the human lung. RESPIRATION 2012 Jan;83(1):61-73.

Wenzel UA, Bank E, Florian C, Förster S, Zimara N, Steinacker J, Klinger M, Reiling N, Ritter U, van Zandbergen G. Leishmania major parasite stage-dependent host cell invasion and immune evasion. The FASEB Journal 2012 Jan;26(1):29-39.


Uciechowski P, Imhoff H, Lange C, Meyer CG, Browne EN, Kirsten DK, Schröder AK, Schaaf B, Al-Lahham A, Reinert RR, Reiling N, Haase H, Hatzmann A, Fleischer D, Heussen N, Kleines M, Rink L. Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression. J. Leukoc. Biol. 2011 Aug;90(2):377-388.

Klug K, Ehlers S, Uhlig S, Reiling N. Mitogen-activated protein kinases p38 and ERK1/2 regulated control of Mycobacterium avium replication in primary murine macrophages is independent of tumor necrosis factor-alpha and interleukin-10. INNATE IMMUNITY 2011 Aug;17(5):470-85.

Schaale K, Neumann J, Schneider D, Ehlers S, Reiling N. Wnt signaling in macrophages: Augmenting and inhibiting mycobacteria-induced inflammatory responses. EUROPEAN JOURNAL OF CELL BIOLOGY 2011 Jun;90(6-7):553-9.


Ungefroren H, Groth S, Hyder A, Thomsen N, Hinz H, Reiling N, Grage-Griebenow E, Held-Feindt J, Schulze M, Nüssler AK, Fändrich F. The generation of programmable cells of monocytic origin (PCMOs) involves partial repression of monocyte/macrophage markers and reactivation of pluripotency genes. STEM CELLS AND DEVELOPMENT 2010 Nov;19(11):1769-80.

Neumann J, Schaale K, Farhat K, Endermann T, Ulmer AJ, Ehlers S, Reiling N. Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages. FASEB JOURNAL 2010 Nov;24(11):4599-4612.

Schromm AB, Reiling N, Howe J, Wiesmuller K, Roessle M, Brandenburg K. Influence of serum on the immune recognition of a synthetic lipopeptide mimetic of the 19-kDa lipoprotein from Mycobacterium tuberculosis. INNATE IMMUNITY 2010 Aug;16(4):213-25.

Krummel B, Strassburg A, Ernst M, Reiling N, Eker B, Rath H, Hoerster R, Wappler W, Glaewe A, Schoellhorn V, Sotgiu G, Lange C. Potential Role for IL-2 ELISpot in Differentiating Recent and Remote Infection in Tuberculosis Contact Tracing. PLOS ONE 2010 Jul;5(7):e11670. Open Access

Selected Publications

Schaefer M, Reiling N, Fessler C, Stephani J, Taniuchi I, Hatam F, Yildirim A, Fehrenbach H, Walter K, Ruland J, Wagner H, Ehlers S, Sparwasser T. Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. JOURNAL OF IMMUNOLOGY 2008 May;180(10):6836-6845.

Holscher C, Reiling N, Schaible U, Holscher A, Bathmann C, Korbel D, Lenz I, Sonntag T, Kroger S, Akira S, Mossmann H, Kirschning C, Wagner H, Freudenberg M, Ehlers S. Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9. EUROPEAN JOURNAL OF IMMUNOLOGY 2008 Mar;38(3):680-694.

Reiling N, Ehlers S, Holscher C. MyDths and un-TOLLed truths: Sensor, instructive and effector immunity to tuberculosis. IMMUNOLOGY LETTERS 2008 Feb;116(1):15-23.

Wittkowski M, Mittelstadt J, Brandau S, Reiling N, Lindner B, Torrelles J, Brennan P, Holst O. Capsular arabinomannans from Mycobacterium avium with morphotype-specific structural differences but identical biological activity. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 Jun;282(26):19103-19112.

Reiling N, Schneider D, Ehlers S. Mycobacterium tuberculosis-induced cell death of primary human monocytes and macrohages is not significantly modulated by tumor necrosis factor-targeted biologicals. JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS 2007 May;12(1):26-33.

Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, Heine H, Brandt E, Reiling N. The Wingless homolog, WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. BLOOD 2006 Aug;108(3):965-973.

Blumenthal A, Lauber J, Hoffmann R, Ernst M, Keller C, Buer J, Ehlers S, Reiling N. Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics. INFECTION AND IMMUNITY 2005 Jun;73(6):3330-3341.

Valentonyte R, Hampe J, Huse K, Rosenstiel P, Albrecht M, Stenzel A, Nagy M, Gaede K, Franke A, Haesler R, Koch A, Lengauer T, Seegert D, Reiling N, Ehlers S, Schwinger E, Platzer M, Krawczak M, Muller-Quernheim J, Schurmann M, Schreiber S. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. NATURE GENETICS 2005 Apr;37(4):357-364.

Rupp J, Berger M, Reiling N, Gieffers J, Lindschau C, Haller H, Dalhofff K, Maass M. Cox-2 inhibition abrogates Chlamydia pneumoniae-induced PGE(2) and MMP-1 expression. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2004 Jul;320(3):738-744.

Mailaender C, Reiling N, Engelhardt H, Bossmann S, Ehlers S, Niederweis M. The MspA porin promotes growth and increases antibiotic susceptibility of both Mycobacterium bovis BCG and Mycobacterium tuberculosis. MICROBIOLOGY-SGM 2004 Apr;150:853-864.

Reiling N, Holscher C, Fehrenbach A, Kroger S, Kirschning C, Goyert S, Ehlers S. Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. JOURNAL OF IMMUNOLOGY 2002 Oct;169(7):3480-3484.

Blumenthal A, Ehlers S, Ernst M, Flad H, Reiling N. Control of mycobacterial replication in human macrophages: Roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways. INFECTION AND IMMUNITY 2002 Sep;70(9):4961-4967.

Reiling N, Klug K, Krallmann-Wenzel U, Laves R, Goyert S, Taylor M, Lindhorst T, Ehlers S. Complex encounters at the macrophage-mycobacterium interface: Studies on the role of the mannose receptor and CD14 in experimental infection models with Mycobacterium avium. IMMUNOBIOLOGY 2001 Dec;204(5):558-571.

Reiling N, Blumenthal A, Flad H, Ernst M, Ehlers S. Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity. JOURNAL OF IMMUNOLOGY 2001 Sep;167(6):3339-3345.