Forschungszentrum Borstel
Forschungszentrum Borstel

2014

PEER-REVIEWED ARTICLES

Claes AK, Steck N, Schultz D, Zähringer U, Lipinski S, Rosenstiel P, Geddes K, Philpott DJ, Heine H, Grassl GA. Salmonella enterica serovar Typhimurium ΔmsbB Triggers Exacerbated Inflammation in Nod2 Deficient Mice. PLoS One. 2014 Nov 25;9(11):e113645. doi: 10.1371/journal.pone.0113645.

Zehethofer N, Bermbach S, Hagner S, Garn H, Müller J, Goldmann T, Lindner B, Schwudke D*, König P*. Lipid Analysis of Airway Epithelial Cells for Studying Respiratory Diseases. Chromatographia. Nov 2014, DOI 10.1007/s10337-014-2787-5; * corresponding authors
Published in the topical collection Recent Developments in Clinical Omics with guest editors Martin Giera and Manfred Wuhrer.

Silipo A, Vitiello G, Gully D, Sturiale L, Chaintreuil C, Fardoux J, Gargani D, Lee HI, Kulkarni G, Busset N, Marchetti R, Palmigiano A, Moll H, Engel R, Lanzetta R, Paduano L, Parrilli M, Chang WS, Holst O, Newman DK, Garozzo D, D'Errico G, Giraud E, Molinaro A. Covalently linked hopanoid-lipid A improves outer-membrane resistance of a Bradyrhizobium symbiont of legumes. Nat Commun. 2014 Oct 30;5:5106. doi: 10.1038/ncomms6106.

Komaniecka I, Choma A, Mazur A, Duda KA, Lindner B, Schwudke D, Holst O. Occurrence of an unusual hopanoid-containing lipid A among lipopolysaccharides from Bradyrhizobium species. J Biol Chem. 2014 Nov 3. pii: jbc.M114.614529. [Epub ahead of print]

Diercks H, Semeniuk A, Gisch N, Moll H, Duda KA, Hölzl G. Accumulation of novel Glycolipids and Ornithine Lipids in Mesorhizobium loti under Phosphate Deprivation. J Bacteriol. 2014 Nov 17. pii: JB.02004-14. [Epub ahead of print]

Vassal-Stermann E, Lacroix M, Gout E, Laffly E, Pedersen CM, Martin L, Amoroso A, Schmidt RR, Zähringer U, Gaboriaud C, Di Guilmi AM, Thielens NM. Human L-Ficolin Recognizes Phosphocholine Moieties of Pneumococcal Teichoic Acid. J Immunol. 2014 Oct 24. pii: 1400127. [Epub ahead of print]

Hogendorf WFJ, Gisch N, Schwudke D, Heine H, Bols M, Pedersen CM, Total Synthesis of Five Lipoteichoic acids of Clostridium difficile, Chemistry - A European Journal. 2014 20(42): 13511-13516.

Böcking C, Harb H, Ege MJ, Zehethofer N, Fischer K, Krauß J, Holst O, Nüsing RM, Lindner B, von Mutius E, Renz H, Garn H, Pfefferle PI. Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation. Int Arch Allergy Immunol. 2014;163(3):234-42. doi: 10.1159/000358523.

Jäger J, Marwitz S, Tiefenau J, Rasch J, Shevchuk O, Kugler C, Goldmann T, Steinert M. Human lung tissue explants reveal novel interactions during Legionella pneumophila infections. Infect Immun. 2014 Jan;82(1):275-85. doi: 10.1128/IAI.00703-13. Epub 2013 Oct 28.

Bermbach S, Weinhold K, Roeder T, Petersen F, Kugler C, Goldmann T, Rupp J, König P. Mechanisms of cilia-driven transport in the airways in the absence of mucus. Am J Respir Cell Mol Biol. 2014 Jul;51(1):56-67. doi: 10.1165/rcmb.2012-0530OC.

Shevchuk O, Abidi N, Klawonn F, Wissing J, Nimtz M, Kugler C, Steinert M, Goldmann T, Jänsch L. HOPE-Fixation of Lung Tissue Allows Retrospective Proteome and Phosphoproteome Studies. J Proteome Res. 2014 Apr 28. [Epub ahead of print]

Kolb J, Hillemann D, Möbius P, Reetz J, Lahiri A, Lewin A, Rüsch-Gerdes S, Richter E. Genetic characterization of German Mycobacterium avium strains isolated from different hosts and specimens by multilocus sequence typing. Int J  Med Microbiol. 2014 Jun 28. pii: S1438-4221(14)00063-0. doi: 10.1016/j.ijmm.2014.06.001. [Epub ahead of print]

Sanchini A, Fiebig L, Drobniewski F, Haas W, Richter E, Katalinic-Jankovic V,  Pimkina E, Skenders G, Cirillo DM; European Reference Laboratory Network for TB Members, Balabanova Y. Laboratory diagnosis of paediatric tuberculosis in the European Union/European Economic Area: analysis of routine laboratory data, 2007  to 2011. Euro Surveill. 2014 Mar 20;19(11). pii: 20744.

Lange C, Abubakar I, Alffenaar JW, Bothamley G, Caminero JA, Carvalho AC, Chang KC, Codecasa L, Correia A, Crudu V, Davies P, Dedicoat M, Drobniewski F, Duarte R, Ehlers C, Erkens C, Goletti D, Günther G, Ibraim E, Kampmann B, Kuksa L, de Lange W, van Leth F, van Lunzen J, Matteelli A, Menzies D, Monedero I, Richter E, Rüsch-Gerdes S, Sandgren A, Scardigli A, Skrahina A, Tortoli E, Volchenkov G, Wagner D, van der Werf MJ, Williams B, Yew WW, Zellweger JP, Cirillo DM; TBNET. Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement. Eur Respir J. 2014 Jul;44(1):23-63. doi: 10.1183/09031936.00188313. Epub 2014 Mar 23. PubMed
PMID: 24659544

Heitmann L, Abad Dar M, Schreiber T, Erdmann H, Behrends J, Mckenzie AN, Brombacher F, Ehlers S, Hölscher C. The IL-13/IL-4R-alpha axis is involved in tuberculosis-associated pathology. J Pathol. 2014 Jun 30. doi: 10.1002/path.4399. [Epub ahead of print] PubMed PMID: 24979482.

Maiwald F, Benítez D, Charquero D, Dar MA, Erdmann H, Preu L, Koch O, Hölscher C, Loaëc N, Meijer L, Comini MA, Kunick C. 9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma. Eur J Med Chem. 2014  Aug 18;83:274-83. doi: 10.1016/j.ejmech.2014.06.020. Epub 2014 Jun 11. PubMed PMID: 24973661.

Eickmeier O, Kim SY, Herrmann E, Döring C, Duecker R, Voss S, Wehner S, Hölscher C, Pietzner J, Zielen S, Schubert R. Altered mucosal immune response after acute lung injury in a murine model of Ataxia Telangiectasia. BMC Pulm Med. 2014 May 29;14:93. doi: 10.1186/1471-2466-14-93. PubMed PMID: 24884546; PubMed Central PMCID: PMC4050222.

Ma Y, Podinovskaia M, Evans PJ, Emma G, Schaible UE, Porter J, Hider RC. A Novel Method for Non-Transferrin-Bound Iron Quantification by Chelatable Fluorescent Beads Based on Flow Cytometry. Biochem J. 2014 Aug 5. [Epub ahead of  print] PubMed PMID: 25093426.

Kolonko M, Geffken AC, Blumer T, Hagens K, Schaible UE, Hagedorn M. WASH-driven actin polymerization is required for efficient mycobacterial phagosome maturation arrest. Cell Microbiol. 2014 Feb;16(2):232-46. doi: 10.1111/cmi.12217. Epub 2013 Oct 24. PubMed PMID: 24119059.

Zähringer U, Ittig S, Lindner B, Moll H, Schombel U, Gisch N, Cornelis GR. NMR Based Structural Analysis of the Complete Rough-type LPS Isolated From Capnocytophaga canimorsus. J Biol Chem. 2014 Jul 2. pii: jbc.M114.571489. [Epub ahead of print]

Abdullah MR, Gutiérrez-Fernández J, Pribyl T, Gisch N, Saleh M, Rohde M, Petruschka L, Burchhardt G, Schwudke D, Hermoso JA, Hammerschmidt S. Structure of the pneumococcal l,d-carboxypeptidase DacB and pathophysiological effects of disabled cell wall hydrolases DacA and DacB. Mol Microbiol. 2014 Jul 24. doi: 10.1111/mmi.12729. [Epub ahead of print]

Hanuszkiewicz A, Pittock P, Humphries F, Moll H, Roa Rosales A, Molinaro A, Moynagh PN, Lajoie G, Valvano MA. Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune response. J Biol Chem. 2014 Jul 4;289(27):19231-44. doi: 10.1074/jbc.M114.562603. Epub 2014 May 19.

Ghosh D, Mueller GA, Schramm G, Edwards LI, Petersen A, London RE, Haas H, Gupta-Bhattacharya S. Primary identification, biochemical characterization, and immunologic properties of the allergenic pollen cyclophilin Cat r 1 J. Biol. Chem. jbc.M114.559971. First Published on June 17, 2014, doi:10.1074/jbc.M114.559971

Becker WM, Jappe U. Peanut allergens. Chem Immunol Allergy 2014; 100:256-67. doi: 10.1159/000359916. Epub 2014 May 22.

Napiórkowska A, Rüsch-Gerdes S, Hillemann D, Richter E, Augustynowicz-Kopeć E. Characterisation of pyrazinamide-resistant Mycobacterium tuberculosis strains isolated in Poland and Germany. Int J Tuberc Lung Dis. 2014 Apr;18(4):454-60. doi: 10.5588/ijtld.13.0457.

Macheras E, Konjek J, Roux AL, Thiberge JM, Bastian S, Leão SC, Palaci M, Sivadon-Tardy V, Gutierrez C, Richter E, Rüsch-Gerdes S, Pfyffer GE, Bodmer T, Jarlier V, Cambau E, Brisse S, Caro V, Rastogi N, Gaillard JL, Heym B.Multilocus sequence typing scheme for the Mycobacterium abscessus complex. Res Microbiol. 2014 Feb-Mar;165(2):82-90. doi: 10.1016/j.resmic.2013.12.003. Epub 2013 Dec 31.

Andres, S, Hillemann, D, Rüsch-Gerdes, S & Richter, E 2014, 'Occurence of rpoB mutations in German isoniazid resistant but rifampicin susceptible M. tuberculosis isolates' ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Bd 58, Nr. 1, S. 590-592., dx.doi.org/10.1128/AAC.01752-13

Marwitz S, Kolarova J, Reck M, Reinmuth N, Kugler C, Schädlich I, Haake A, Zabel P, Vollmer E, Siebert R, Goldmann T, Ammerpohl O. The tissue is the issue: improved methylome analysis from paraffin-embedded tissues by application of the HOPE technique. Lab Invest. 2014 Jun 16. doi: 10.1038/labinvest.2014.79. [Epub ahead of print]

Schmidt A, Belaaouaj A, Bissinger R, Koller G, Malleret L, D'Orazio C, Facchinelli M, Schulte-Hubbert B, Molinaro A, Holst O, Hammermann J, Schniederjans M, Meyer KC, Damkiaer S, Piacentini G, Assael B, Bruce K, Häußler S, Lipuma JJ, Seelig J, Worlitzsch D, Döring G.Neutrophil elastase-mediated increase in airway temperature during inflammation. J Cyst Fibros. 2014 Apr 5. pii: S1569-1993(14)00073-3. doi: 10.1016/j.jcf.2014.03.004. [Epub ahead of print]

Jasna Nikolic, Ivan Mrkic, Milica Grozdanovic, Milica Popovic, Arnd Petersen, Uta Jappe, Marija Gavrovic-Jankulovic. Protocol for simultaneous isolation of three important banana allergens. Journal of Chromatography B 2014; 962:30-36.

Worm M, Jappe U, Kleine-Tebbe J, Schäfer C, Reese I, Saloga J, Treudler R, Zuberbier T, Waßmann A, Dölle S, Raithel M, Ballmer-Weber B, Niggemann B, Werfel T. Nahrungsmittelallergie infolge immunologischer Kreuzreaktivitäten mit Inhalationsallergenen Leitlinien-Nummer: 061-019, Klassifizierung: S1. Allergologie AllergoJournal Int 2014; 23: 16-31

Petersen A, Rennert S, Kull S, Becker WM, Notbohm H, Goldmann T, Jappe U. Roasting and lipid binding provide allergenic and proteolytic stability to the peanut allergen Ara h 8.Biol Chem. 2014 Feb;395(2):239-50

Bratu VA, Erpenbeck VJ, Fehrenbach A, Rausch T, Rittinghausen S, Krug N, Hohlfeld JM, Fehrenbach H. Cell Counting in Human Endobronchial Biopsies - Disagreement of 2D versus 3D Morphometry. PLoS One. 2014 Mar 24;9(3):e92510. Open Access

Madurga A, Mizikova I, Ruiz-Camp J, Vadász I, Herold S, Mayer K, Fehrenbach H, Seeger W, Morty RE. Systemic hydrogen sulfide administration partially restores normal alveolarization in an experimental animal model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014 Feb 7. [Epub ahead of print]

Jordakieva G, Wallmann J, Schmutz R, Lemell P, Wegmann M, Nittke T, Mittlböck M, Fehrenbach H, Godnic-Cvar J, Zieglmayer R, Jensen-Jarolim E. Peripheral Erythrocytes Decrease upon Specific Respiratory Challenge with Grass Pollen Allergen in Sensitized Mice and in Human Subjects. PLoS One. 2014 Jan 22;9(1):e86701. Open Access

Zheng, J, Petersen, F & Yu, X 2014, 'The role of PTPN22 in autoimmunity: Learning from mice' Autoimmunity reviews, Bd 13, Nr. 3, S. 266-271., http://dx.doi.org/10.1016/j.autrev.2013.10.011

Bermbach S, Weinhold K, Roeder T, Petersen F, Kugler C, Goldmann T et al. Mechanisms of Cilia-Driven Transport in the Airways in the Abscence of Mucus. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2014 jan 27, 10.2265/rcmb.2012-0530O0

Yu X, Zheng J.Collin M, SChmidt E, Zilikens D, Petersen F. EndoS reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils. PLOS ONE 2014;9. 10.1371/journal.pone.0085317

Schneider BE, Behrends J, Hagens K, Harmel N, Shayman JA, Schaible UE. Lysosomal phospholipase A2 : A novel player in host immunity to Mycobacterium tuberculosis. Eur J Immunol. 2014 May 13. doi: 10.1002/eji.201344383. [Epub ahead of print]

Steinhäuser C, Dallenga T, Tchikov V, Schaible UE, Schütze S, Reiling N. Immunomagnetic isolation of pathogen-containing phagosomes and apoptotic blebs from primary phagocytes. Curr Protoc Immunol. 2014 Apr 2;105:14.36.1-14.36.26. doi: 10.1002/0471142735.im1436s105.

Köser CU, Comas I, Feuerriegel S, Niemann S, Gagneux S, Peacock SJ. Genetic diversity within Mycobacterium tuberculosis complex impacts on the accuracy of genotypic pyrazinamide drug-susceptibility assay. Tuberculosis (Edinb). 2014 Jul;94(4):451-3. doi: 10.1016/j.tube.2014.04.002. Epub 2014 Apr 24

Kohl TA, Diel R, Harmsen D, Rothgänger J, Meywald Walter K, Merker M, Weniger T, Niemann S. Whole genome based Mycobacterium tuberculosis surveillance: A standardized, portable and expandable approach. J Clin Microbiol. 2014 Apr 30. [Epub ahead of print]

De Beer JL, Kodmon C, van der Werf MJ, van Ingen J, van Soolingen D; ECDC MDR-TB Molecular Surveillance Project Participants. Molecular surveillance of multi- and extensively drug-resistant tuberculosis transmission in the European Union from 2003 to 2011. Euro Surveill. 2014 Mar 20;19(11). pii: 20742.

Knobloch JK, Niemann S, Kohl TA, Lindner U, Nitschke M, Sayk F, Solbach W. Whole-Genome Sequencing for Risk Assessment of Long-term Shiga Toxin-producing Escherichia coli. Emerg Infect Dis. 2014 Apr;20(4):732-3. doi: 10.3201/eid2004.131782.

Feuerriegel S, Köser CU, Niemann S. Phylogenetic polymorphisms in antibiotic resistance genes of the Mycobacterium tuberculosis complex. J Antimicrob Chemother. 2014 May;69(5):1205-10. doi: 10.1093/jac/dkt535. Epub 2014 Jan 23.

Allix-Béguec C, Wahl C, Hanekom M, Nikolayevskyy V, Drobniewski F, Maeda S, Campos-Herrero I, Mokrousov I, Niemann S, Kontsevaya I, Rastogi N, Samper S, Sng LH, Warren RM, Supply P. Proposal of a Consensus Set of Hypervariable Mycobacterial Interspersed Repetitive-Unit-Variable-Number Tandem-Repeat Loci for Subtyping of Mycobacterium tuberculosis Beijing Isolates. J Clin Microbiol. 2014  Jan;52(1):164-72. doi: 10.1128/JCM.02519-13. Epub 2013 Oct 30.

Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T, Ames L, Zubiria Barrera C, Mansour MK, Becken U, Barz D, Vyas JM, Reiling N, Haas A, Haynes K, Kuchler K and Hube B. Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PloS One 2014 (in press)

Menck K, Behme D, Pantke M, Reiling N, Binder C, Pukrop T,  Klemm F. Isolation of human monocytes by double gradient centrifugation and their differentiation to macrophages in Teflon-coated cell culture bags. J Vis Exp (in press)

Yew WW, Lange C. Linezolid in the treatment of drug-resistant tuberculosis: the way forward? Int J Tuberc Lung Dis. 2014 Jun;18(6):631-2. doi: 10.5588/ijtld.14.0191.

Kaufmann SH, Lange C, Rao M, Balaji KN, Lotze M, Schito M, Zumla AI, Maeurer M. Progress in tuberculosis vaccine development and host-directed therapies-a state of the art review. Lancet Respir Med. 2014 Apr;2(4):301-320. doi: 10.1016/S2213-2600(14)70033-5. Epub 2014 Mar 24. Review.

Dunkel N, Biswas K, Hiller E, Fellenberg K, Satheesh SV, Rupp S, Morschhäuser J. Control of morphogenesis, protease secretion and gene expression in Candida albicans by the preferred nitrogen source ammonium. Microbiology. 2014 May 19. pii: mic.0.078238-0. doi: 10.1099/mic.0.078238-0. [Epub ahead of print]

Mojibian M, Lam AW, Fujita Y, Asadi A, Grassl GA, Dickie P, Tan R, Cheung AT, Kieffer TJ. Insulin-Producing Intestinal K Cells Protect Nonobese Diabetic Mice From Autoimmune Diabetes. Gastroenterology. 2014 Mar 21. pii: S0016-5085(14)00369-2. doi: 10.1053/j.gastro.2014.03.020. [Epub ahead of print

Gries A, Prassl R, Fukuoka S, Rössle M, Kaconis Y, Heinbockel L, Gutsmann T, Brandenburg K. Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide. FEBS Open Bio. 2014 May 2;4:432-40. doi: 10.1016/j.fob.2014.04.008

Bang C, Weidenbach K, Gutsmann T, Heine H, Schmitz RA.The Intestinal Archaea Methanosphaera stadtmanae and Methanobrevibacter smithii Activate Human Dendritic Cells. PLoS One. 2014 Jun 10;9(6):e99411. doi: 10.1371/journal.pone.0099411.

Hanuszkiewicz A, Pittock P, Humphries F, Molll H, Roa Rosales A, Molinaro A, Moynagh PN, Lajoie G, Valvano MA. Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune response. J Biol Chem 2014 May 19. pii:jbc.M1114.562603. (Epub ahead of print)

Hebbar S, Schulz WD, Sauer U, Schwudke D. Laser Capture Microsdissection coupled with on-column extraction LC-MS(n) enables lipidomics of fluorescently labeled Drosophila neurons. Anal Chem 2014 Jun3; 86(11):5345-52. doi:10.1021/ac500276r. PMID 24820458

Schneider BE, Behrends J, Hagens K, Harmel N, Shayman JA, Schaible UE. Lysosomal phospholipase A2: A novel player in host immunity to Mycbacterium tuberculosis. EUROPEAN JOURNAL of IMMUNOLOGY 2014; DOI: 10.1002/eji.201244383

Turska-Szewczuk A, Duda KA, Schwudke D, Pekala A, Kozinska A, Holst O. Structural studies of the lipopolysaccharide from the fish pathogen Aeromonas veronii strain Bs19, serotype O16. Mar Drugs. 2014 Mar 7;12(3):1298-316. doi: 10.3390/md12031298.open access

Kohler T, Gisch N, Binsker U, Schlag M, Darm K, Völker U, Zähringer U, Hammerschmidt S. Repeating structures of the major staphylococcal autolysin are essential for the interaction with human thrombospondin-1 and vitronectin. J Biol Chem 2014 Feb 14; 289(7):4070-82.

Mueller, A. K., Behrends, J., Blank, J., Schaible, U. E., Schneider, B. E. An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei. J. Vis. Exp. (84), e50829, doi:10.3791/50829.

Yew, W-W & Lange, C 2014, 'Fluoroquinolone resistance in Mycobacterium tuberculosis. What have we learnt? [Editorial]' THE INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Bd 18, Nr. 1, S. 1-2., dx.doi.org/10.5588/ijtld.13.0739

Jäger, J, Marwitz, S, Tiefenau, J, Rasch, J, Shevchuk, O, Kugler, C, Goldmann, T & Steinert, M 2014, 'Human lung tissue explants reveal novel interactions during Legionella pneumophila infections' Infection and immunity, Bd 82, Nr. 1, S. 275-285., dx.doi.org/10.1128/IAI.00703-13

Andres, S, Hillemann, D, Rüsch-Gerdes, S & Richter, E 2014, 'Occurence of rpoB mutations in German isoniazid resistant but rifampicin susceptible M. tuberculosis isolates' ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Bd 58, Nr. 1, S. 590-592., dx.doi.org/10.1128/AAC.01752-13Günther, G 2014, 'Delamanid - ein neues Tuberkulose- Medikament im Yin und Yang regulatorischer Erfordernisse und zunehmender Medikamentenresistenz' Der Pneumologe.Steinhäuser, C, Dallenga, T, Tchikov, V, Schaible, UE, Schütze, S & Reiling, N 2014, 'Immuno-magnetic isolation of pathogen-containing phagosomes and apoptotic blebs from primary phagocytes' Current Protocols in Immunology, Bd (in press).Helm, O, Held-Feindt, J, Grage-Griebenow, E, Reiling, N, Ungefroren, H, Vogel, I, Krüger, U, Becker, T, Ebsen, M, Röcken, C, Kabelitz, D, Schäfer, H & Sebens, S 2014, 'Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis' International Journal of Cancer, Bd (in press).