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Department Immunology and Cell Biology

Cellular Allergology

Publications

2013

Hussaarts L, Smits HH, Schramm G, van der Ham AJ, van der Zon GC, Haas H, Guigas B, Yazdanbakhsh M.Rapamycin and omega-1: mTOR-dependent and -independent Th2 skewing by human dendritic cells. IMMUNOLOGY AND CELL BIOLOGY 2013 Aug;91(7):486-9.

2012

Everts B, Hussaarts L, Driessen NN, Meevissen MHJ, Schramm G, Van der Ham AJ, Van der Hoeven B, Scholzen T, Burgdorf S, Mohrs M, Pearce EJ, Hokke CH, Haas H, Smits HH, Yazdanbakhsh M. Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. JOURNAL OF EXPERIMENTAL MEDICINE 2012 Sep;209(10):1753–1767.

Böhm M, Apel M, Sugawara K, Brehler R, Jurk K, Luger TA, Haas H, Paus R, Eiz-Vesper B, Walls AF, Ponimaskin E, Gehring M, Kapp A, Raap U. Modulation of basophil activity: A novel function of the neuropeptide α-melanocyte–stimulating hormone. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2012 Apr;129(4):1085–1093.

2011

Meevissen MHJ, Driessen NN, Smits HH, Versteegh R, van Vliet SJ, van Kooyk Y, Schramm G, Deelder AM, Haas H, Yazdanbakhsh M, Hokke CH. Specific Glycan Elements Determine Differential Binding of Individual Egg Glycoproteins of the Human Parasite Schistosoma mansoni by Host C-type Lectin Receptors. INTERNATIONAL JOURNAL OF PARASITOLOGY 2012 February 16;42(3):269-77.

Meyer NH, Schramm G, Sattler M. 1H, 13C and 15N chemical shift assignments of IPSEΔNLS. BIOMOL NMR ASSIGN. 2011 Oct;5(2):225-7. Epub 2011 Apr 24.

Zaccone P, Burton OT, Gibbs SE, Miller N, Jones FM, Schramm G, Haas H, Doenhoff MJ, Dunne DW, Cooke A. The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4+ T cells. EUROPEAN JOURNAL OF IMMUNOLOGY 2011 Sep;41(9):2709-2718.

Meevissen MHJ, Balog CIA, Koeleman CAM, Doenhoff MJ, Schramm G, Haas H, Deelder AM, Wuhrer M, Hokke CH. Targeted glycoproteomic analysis reveals that kappa-5 is a major, uniquely glycosylated component of Schistosoma mansoni egg antigens. MOLECULAR & CELLULAR PROTEOMICS: MCP 2011 May;10(5):M110.005710.

Kaur I, Schramm G, Everts B, Scholzen T, Kindle KB, Beetz C, Montiel-Duarte C, Blindow S, Jones AT, Haas H, Stolnik S, Heery DM, Falcone FH. Interleukin-4 Inducing Principle from Schistosoma mansoni Eggs (IPSE/alpha-1) contains a functional C-terminal nuclear localization signal necessary for nuclear translocation in mammalian cells but not for its uptake. INFECTION AND IMMUNITY 2011 Jan;79(4):1779-88.

2010

Schramm G, Haas H. Th2 immune response against Schistosoma mansoni infection. MICROBES AND INFECTION 2010 Nov; 12(12-13):881-8.

Bligh J, Schramm G, Chiodini PL, Doenhoff MJ. Serological analysis of the outcome of treatment of Schistosoma mansoni infections with praziquantel. ANNALS OF TROPICAL MEDICINE & PARASITOLOGY 2010; 104(6):511-520.

Meevissen MH, Wuhrer M, Doenhoff MJ, Schramm G, Haas H, Deelder AM, Hokke CH. Structural characterization of glycans on omega-1, a major Schistosoma mansoni egg glycoprotein that drives Th2 responses. JOURNAL OF PROTEOME RESEARCH 2010 May; 9(5):2630-2642.

Waknine-Grinberg J, Gold D, Ohayon A, Flescher E, Heyfets A, Doenhoff M, Schramm G, Haas H, Golenser J. Schistosoma mansoni infection reduces the incidence of murine cerebral malaria. MALARIA JOURNAL 2010 Jan;9(5). Open Access

2009

Everts B, Perona-Wright G, Smits H, Hokke C, van der Ham A, Fitzsimmons C, Doenhoff M, van der Bosch J, Mohrs K, Haas H, Mohrs M, Yazdanbakhsh M, Schramm G. Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. JOURNAL OF EXPERIMENTAL MEDICINE 2009 Aug;206(8):1673-1680.

Schramm G, Hamilton J, Balog C, Wuhrer M, Gronow A, Beckmann S, Wippersteg V, Grevelding C, Goldmann T, Weber E, Brattig N, Deelder A, Dunne D, Hokke C, Haas H, Doenhoff M. Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 2009 Jul;166(1):4-14.

Mayerhofer H, Schramm G, Hatzopoulos G, Mueller-Dieckmann C, Haas H, Mueller-Dieckmann J. Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/alpha-1). ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION 2009 Jun;65:594-596.

2008

Lichtenbergova L, Kolbekova P, Kourilova P, Kasny M, Mikes L, Haas H, Schramm G, Horak P, Kolarova L, Mountford A. Antibody responses induced by Trichobilharzia regenti antigens in murine and human hosts exhibiting cercarial dermatitis. PARASITE IMMUNOLOGY 2008 Dec;30(11-12):585-595.

2007

Lin J, Renault N, Haas H, Schramm G, Vieths S, Vogel L, Falcone F, Alcocer M. A novel tool for the detection of allergic sensitization combining protein microarrays with human basophils. CLINICAL AND EXPERIMENTAL ALLERGY 2007 Dec;37(12):1854-1862.

Schramm G, Mohrs K, Wodrich M, Doenhoff M, Pearce E, Haas H, Mohrs M. Cutting edge: IPSE/alpha-1, a glycoprotein from Scbistosoma mansoni eggs, induces IgE-dependent antigen-indenendent IL-4 production by murine basophils in vivo. JOURNAL OF IMMUNOLOGY 2007 May;178(10):6023-6027.


1996-2006 (Selection)

Gibbs BF, Räthling A, Zillikens D, Huber M, Haas H. Initial Fc epsilon RI-mediated signal strength plays a key role in regulating basophil signaling and deactivation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2006 Nov;118(5):1060-1067.

Wuhrer M, Balog CIA, Catalina MI, Jones FM, Schramm G, Haas H, Doenhoff MJ, Dunne DW, Deelder AM, Hokke CH. IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans. FEBS JOURNAL 2006 May;273(10):2276-2292.

Schramm G, Gronow A, Knobloch J, Wippersteg V, Grevelding CG, Galle J, Fuller H, Stanley RG, Chiodini PL, Haas H, Doenhoff MJ. IPSE/alpha-1: a major immunogenic component secreted from Schistosoma mansoni eggs. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 2006 May;147(1):9-19.

Fitzsimmons CM, Schramm G, Jones FM, Chalmers IW, Hoffmann KF, Grevelding CG, Wuhrer M, Hokke CH, Haas H, Doenhoff MJ, Dunne DW. Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 2005 Nov;144(1):123-127.

Aumüller E, Schramm G, Gronow A, Brehm K, Gibbs BF, Doenhoff MJ, Haas H. Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin-4. PARASITE IMMUNOLOGY 2004 Oct;26(10):387-395.

Schramm G, Falcone FH, Gronow A, Haisch K, Mamat U, Doenhoff MJ, Oliveira G, Galle J, Dahinden CA, Haas H. Molecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs. JOURNAL OF BIOLOGICAL CHEMISTRY 2003 May;278(20):18384-18392.

Falcone FH, Dahinden CA, Gibbs BF, Noll T, Amon U, Hebestreit H, Abrahamsen O, Klaucke J, Schlaak M, Haas H. Human basophils release interleukin-4 after stimulation with Schistosoma mansoni egg antigen. EUROPEAN JOURNAL OF IMMUNOLOGY 1996 May;26(5):1147-1155.

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