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Department Immunology and Cell Biology




Sandig H, Jobbings CE, Roldan NG, Whittingham-Dowd JK, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S. IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur J Immunol. 2013 Apr;43(4):979-88.

Jobbings CE, Sandig H, Whittingham-Dowd JK, Roberts IS, Bulfone-Paus S. Listeria monocytogenes alters mast cell phenotype, mediator and osteopontin secretion in a listeriolysin-dependent manner. PLoS One 2013; 8(2):e57102.

D’Orlando O, Zhao F, Kasper B, Orinska Z, Müller J, Hermans-Borgmeyer I, Griffiths GM, Zur Stadt U, Bulfone-Paus S. Syntaxin 11 is required for NK and CD8(+) T-cell cytotoxicity and neutrophil degranulation. EUROPEAN JOURNAL OF IMMUNOLOGY 2013 Jan;43(1):194-20.


Bahri R, Bollinger A, Bollinger T, Orinska Z, Bulfone-Paus S. Ectonucleotidase CD38 Demarcates Regulatory, Memory-Like CD8(+) T Cells with IFN-γ-Mediated Suppressor Activities. PLoS ONE 2012;7(9):e45234. Open Access

Henningsson L, Jirholt P, Bogestal YR, Eneljung T, Adiels M, Lindholm C, McInnes I, Bulfone-Paus S, Lerner UH, Gjertsson I. Interleukin 15 Mediates Joint Destruction in Staphylococcus Aureus Arthritis. JOURNAL OF INFECTIOUS DISEASES 2012 Sep;206(5):687–696.

Sandig H, Bulfone-Paus S. TLR signaling in mast cells: common and unique features. FRONTIERS IN IMMUNOLOGY 2012 Jul;3:185. Open Access

Quinci AC, Vitale S, Parretta E, Soriani A, Iannitto ML, Cippitelli M, Fionda C, Bulfone-Paus S, Santoni A, Di Rosa F. IL-15 inhibits IL-7Rα expression by memory-phenotype CD8+T cells in the bone marrow. EUROPEAN JOURNAL OF IMMUNOLOGY 2012 May;42(5):1129–1139.

Wegmann M, Lunding L, Orinska Z, Wong DM, Manz RA, Fehrenbach H. Long-Term Bortezomib Treatment Reduces Allergen-Specific IgE but Fails to Ameliorate Chronic Asthma in Mice. International Archives of Allergy and Immunology 2012;158(1):43-53.


Nguyen X-H, Fattakhova G, Lang PA, Lang KS, Adam D, Föger N, Lee K-H. Response: Antiapoptotic function of Toso (Faim3) in death receptor signaling. BLOOD 2012 Feb;119(7):1790–1791.


Ketroussi F, Giuliani M, Bahri R, Azzarone B, Charpentier B, Durrbach A. Lymphocyte cell-cycle inhibition by HLA-G is mediated by phosphatase SHP-2 and acts on the mTOR pathway. PLoS ONE 2011 Aug;6(8):e22776. Open Access

Föger N, Jenckel A, Orinska Z, Lee K-H, Chan AC, Bulfone-Paus S. Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b. JOURNAL OF EXPERIMENTAL MEDICINE 2011 Aug;208(9):1777-87.

Duitman EH, Orinska Z, Bulfone-Paus S. Mechanisms of cytokine secretion: A portfolio of distinct pathways allows flexibility in cytokine activity. EUROPEAN JOURNAL OF CELL BIOLOGY 2011 Jun;90(6-7):476-83.

Nguyen X-H, Lang PA, Lang KS, Adam D, Fattakhova G, Föger N, Kamal MA, Prilla P, Mathieu S, Wagner C, Mak T, Chan AC, Lee K-H. Toso regulates the balance between apoptotic and non-apoptotic death receptor signaling by facilitating RIP1 ubiquitination. BLOOD. Epub May 25;118(3):598-608.


Bollinger T, Bollinger A, Naujoks J, Lange T, Solbach W. The influence of regulatory T cells and diurnal hormone rhythms on T helper cell activity. IMMUNOLOGY 2010 Dec;131(4):488-500.

Angelova-Fischer I, Fernandez IM, Donnadieu M, Bulfone-Paus S, Zillikens D, Fischer TW, Soumelis V. Injury to the Stratum Corneum Induces In Vivo Expression of Human Thymic Stromal Lymphopoietin in the Epidermis. JOURNAL OF INVESTIGATIVE DERMATOLOGY 2010 Oct;130(10):2505-2507.

Bollinger T, Bollinger A, Oster H, Solbach W. Sleep, Immunity, and Circadian Clocks: A Mechanistic Model. GERONTOLOGY 2010 Oct;56(6):574-580.

Orinska Z, Föger N, Huber M, Marschall J, Mirghomizadeh F, Du X, Scheller M, Rosenstiel P, Goldmann T, Bollinger A, Beutler BA, Bulfone-Paus S. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. BLOOD 2010 Oct;116(15):2665-2675.

Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J. Forced Homo- and Heterodimerization of all gp130-type Receptor Complexes Leads to Constitutive Ligand-independent Signaling, and Cytokine-independent Growth. MOL BIOL CELL. 2010 Aug 1;21(15):2797-807. Epub 2010 Jun 16.

Bulanova E, Bulfone-Paus S. P2 receptor-mediated signaling in mast cell biology. PURINERGIC SIGNALING 2010 Mar;6(1):3-17.

Koch M, Savvatis K, Scheeler M, Dhayat S, Bonaventura K, Pohl T, Riad A, Bulfone-Paus S, Schultheiss H, Tschöpe C. Immunosuppression with an interleukin-2 fusion protein leads to improved LV function in experimental ischemic cardiomyopathy. INTERNATIONAL IMMUNOPHARMACOLOGY 2010 Feb;10(2):207-212.


Bahri R, Naji A, Menier C, Charpentier B, Carosella E, Rouas-Freiss N, Durrbach A. Dendritic Cells Secrete the Immunosuppressive HLA-G Molecule upon CTLA4-Ig Treatment: Implication in Human Renal Transplant Acceptance. JOURNAL OF IMMUNOLOGY 2009 Dec;183(11):7054-7062.

Mirghomizadeh F, Bullwinkel J, Orinska Z, Janssen O, Petersen A, Singh P, Bulfone-Paus S. Transcriptional Regulation of Mouse Mast Cell Protease-2 by Interleukin-15. JOURNAL OF BIOLOGICAL CHEMISTRY 2009 Nov;284(47):32635-32641.

Carlens J, Wahl B, BallMayer M, Bulfone-Paus S, Forster R, Pabst O. Common gamma-Chain-Dependent Signals Confer Selective Survival of Eosinophils in the Murine Small Intestine. JOURNAL OF IMMUNOLOGY 2009 Nov;183(9):5600-5607.

Stelekati E, Bahri R, D'Orlando O, Orinska Z, Mittrucker H, Langenhaun R, Glatzel M, Bollinger A, Paus R, Bulfone-Paus S. Mast Cell-Mediated Antigen Presentation Regulates CD8(+) T Cell Effector Functions. IMMUNITY 2009 Oct;31(4):665-676.

Mirghomizadeh F, Winoto-Morbach S, Orinska Z, Lee K, Schutze S, Bulfone-Paus S. Intracellular IL-15 controls mast cell survival. EXPERIMENTAL CELL RESEARCH 2009 Oct;315(17):3064-3075.

Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M. Survival and Migration of Human Dendritic Cells Are Regulated by an IFN-alpha-Inducible Axl/Gas6 Pathway. JOURNAL OF IMMUNOLOGY 2009 Sep;183(5):3004-3013.

Foger N, Bulfone-Paus S, Chan A, Lee K. Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling. FEBS JOURNAL 2009 Aug;276(15):4256-4265.

Schroder J, Lullmann-Rauch R, Himmerkus N, Pleines I, Nieswandt B, Orinska Z, Koch-Nolte F, Schroder B, Bleich M, Saftig P. Deficiency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function. MOLECULAR AND CELLULAR BIOLOGY 2009 Feb;29(4):1083-1094.

Hirsch B, Brauer J, Fischdick M, Loddenkemper C, Bulfone-Paus S, Stein H, Durkop H. Anti-CD30 Human IL-2 Fusion Proteins Display Strong and Specific Cytotoxicity In Vivo. CURRENT DRUG TARGETS 2009 Feb;10(2):110-117.

Bollinger T, Bollinger A, Skrum L, Dimitrov S, Lange T, Solbach W. Sleep-dependent activity of T cells and regulatory T cells. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2009 Feb;155(2):231-238.

Ruckert R, Brandt K, Ernst M, Marienfeld K, Csernok E, Metzler C, Budagian V, Bulanova E, Paus R, Bulfone-Paus S. Interleukin-15 stimulates macrophages to activate CD4(+) T cells: a role in the pathogenesis of rheumatoid arthritis? IMMUNOLOGY 2009 Jan;126(1):63-73.


Shiow L, Roadcap D, Paris K, Watson S, Grigorova I, Lebet T, An J, Xu Y, Jenne C, Foger N, Sorensen R, Goodnow C, Bear J, Puck J, Cyster J. The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. NATURE IMMUNOLOGY 2008 Nov;9(11):1307-1315.

Ullrich E, Bonmort M, Mignot G, Jacobs B, Bosisio D, Sozzani S, Jalil A, Louache F, Bulanova E, Geissman F, Ryffel B, Chaput N, Bulfone-Paus S, Zitvogel L. Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions. JOURNAL OF IMMUNOLOGY 2008 Jun;180(12):7887-7897.

Aoufouchi S, Faili A, Zober C, D'Orlando O, Weller S, Weill J, Reynaud C. Proteasomal degradation restricts the nuclear lifespan of AID. JOURNAL OF EXPERIMENTAL MEDICINE 2008 Jun;205(6):1357-1368.

Brandenburg S, Takahashi T, de la Rosa M, Janke M, Karsten G, Muzzulini T, Orinska Z, Bulfone-Paus S, Scheffold A. IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells. EUROPEAN JOURNAL OF IMMUNOLOGY 2008 Jun;38(6):1643-1653.

Giuliani M, Giron-Michel J, Negrini S, Vacca P, Durali D, Caignard A, Le Bousse-Kerdiles C, Chouaib S, Devocelle A, Bahri R, Durrbach A, Taoufik Y, Ferrini S, Croce M, Mingari M, Moretta L, Azzarone B. Generation of a Novel Regulatory NK Cell Subset from Peripheral Blood CD34(+) Progenitors Promoted by Membrane-Bound IL-15. PLOS ONE 2008 May;3(5). Open Access
Mignot G, Ullrich E, Bonmort M, Menard C, Apetoh L, Taieb J, Bosisio D, Sozzani S, Ferrantini M, Schmitz J, Mack M, Ryffel B, Bulfone-Paus S, Zitvogel L, Chaput N. The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2. JOURNAL OF IMMUNOLOGY 2008 May;180(10):6477-6483.

Ruckert R, Bulfone-Paus S, Brandt K. Interleukin-21 stimulates antigen uptake, protease activity, survival and induction of CD4(+) T cell proliferation by murine macrophages. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2008 Mar;151(3):487-495.

Bulfone-Paus S, Paus R. Osteopontin as a new player in mast cell biology. EUROPEAN JOURNAL OF IMMUNOLOGY 2008 Feb;38(2):338-341.

Merluzzi S, D'Orlando O, Leonardi A, Vitale G, Pucillo C. TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: A novel pathway in B cell activation. MOLECULAR IMMUNOLOGY 2008 Jan;45(1):76-86.


Ziegler E, Oberbarnscheidt M, Bulfone-Paus S, Forster R, Kunzendorf U, Krautwald S. CCR7 signaling inhibits T cell proliferation. JOURNAL OF IMMUNOLOGY 2007 Nov;179(10):6485-6493.

Orinska Z, Maurer M, Mirghomizadeh F, Bulanova E, Metz M, Nashkevich N, Schiemann F, Schulmistrat J, Budagian V, Giron-Michel J, Brandt E, Paus R, Bulfone-Paus S. IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. NATURE MEDICINE 2007 Aug;13(8):927-934.

Brandt K, Singh P, Bulfone-Paus S, Ruckert R. Interleukin-21: A new modulator of immunity, infection, and cancer. CYTOKINE & GROWTH FACTOR REVIEWS 2007 Aug;18(3-4):223-232.

Stelekati E, Orinska Z, Bulfone-Paus S. Mast cells in allergy: Innate instructors of adaptive responses. IMMUNOBIOLOGY 2007 Jun;212(6):505-519.

Duitman E, Wyczawski D, Boven L, Venema G, Kuipers O, Hamoen L. Novel methods for genetic transformation of natural Bacillus subtilis isolates used to study the regulation of the mycosubtilin and surfactin synthetases. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2007 Jun;73(11):3490-3496.

D'Orlando O, Gri G, Cattaruzzi G, Merluzzi S, Betto E, Gattei V, Pucillo C. Outside inside signalling in CD40-mediated B cell activation. JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS 2007;21(3-4):49-62.