Forschungszentrum Borstel
Forschungszentrum Borstel

Science

Priority Research Area Infections

Andra  Schromm

PD Dr. Andra Schromm

04537 - 188 - 2960
04537 - 188 - 6320

Mission

We investigate the molecular principles of the innate immune response to lipids and the specific mechanism to regulate the activation pathways involved. Bacterial membrane components are highly effective activators of innate immune responses such as inflammation and antimicrobial effector mechanisms. Dysregulation of these immune responses can lead to fatal diseases like pneumonia, acute respiratory distress syndrome, and sepsis. We analyze the mechanisms of initiation and regulation of inflammation in different projects with a special focus on the investigation of host defense peptides, proteins and lipids involved in anti-inflammatory immune regulation. The aim of these studies it to evaluate natural immune-response modifiers as candidates for therapeutic applications.