Forschungszentrum Borstel
Forschungszentrum Borstel

Priority Research Area Infections

Bioanalytical Chemistry

Publications

2017

Corsaro, MM, Casillo, A, Ziaco, M, Lindner, B, Parrilli, E, Schwudke, D, Holgado, A, Verstrepen, L, Sannino, F, Beyaert, R, Lanzetta, R, Tutino, ML. Unusual Lipid A from a cold adapted bacterium: detailed structural characterization. Chembiochem. 2017 Jun 26. doi: 10.1002/cbic.201700287. [Epub ahead of print]

Mehlitz, A, Eylert, E, Huber, C, Lindner, B, Vollmuth, N, Karunakaran, K, Goebel, W, Eisenreich, W, Rudel, T. Metabolic adaptation of Chlamydia trachomatis to mammalian host cells. Mol Microbiol. 2017 Mar;103(6):1004-1019. doi: 10.1111/mmi.13603. Epub 2017 Jan 31.

Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Neumann, D, Mach, JP, Rietschel, ET, Tersikh, A, Ulmer, AJ, Yu, K, Zähringer, U, Khatri, I. An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression. Int Immunopharmacol. 2017 Jun 19;50:69-76. doi: 10.1016/j.intimp.2017.06.003. [Epub ahead of print]

Steffens, T, Duda, K, Lindner, B, Vorhölter, F-J, Bednarz, H, Niehaus, K & Holst, O 2017, 'The lipopolysaccharide of the crop pathogen Xanthomonas translucens pv. translucens: chemical characterization and determination of signaling events in plant cells' GLYCOBIOLOGY, Bd 27, Nr. 3, S. 264-274. DOI: 10.1093/glycob/cww093

Hindle, SJ, Hebbar, S, Schwudke, D, Elliott, CJ & Sweeney, ST 2017, 'A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline' Neurobiology of disease, Nr. 98, S. 77-87. DOI: 10.1016/j.nbd.2016.11.012

Sezin, T, Krajewski, M, Wutkowski, A, Mousavi, S, Chakievska, L, Bieber, K, Ludwig, RJ, Dahlke, M, Rades, D, Schulze, FS, Schmidt, E, Kalies, K, Gupta, Y, Schilf, P, Ibrahim, SM, König, P, Schwudke, D, Zillikens, D & Sadik, CD 2017, 'The Leukotriene B4 and Its Receptor BLT1 Act as Critical Drivers of Neutrophil Recruitment in Murine Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita' Journal of Investigative Dermatology. DOI: 10.1016/j.jid.2016.12.021

Jeschke, A, Zehethofer, N, Schwudke, D & Haas, A 2017, 'Quantification of Phosphatidylinositol Phosphate Species in Purified Membranes' Methods in Enzymology, Bd 587, S. 271-291. DOI: 10.1016/bs.mie.2016.10.037

Casillo, A, Ziaco, M, Lindner, B, Merino, S, Mendoza-Barberá, E, Tomás, JM & Corsaro, MM 2017, 'Structural Characterization of Core Region in Erwinia amylovora Lipopolysaccharide' INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Bd 18, Nr. 3. DOI: 10.3390/ijms18030559

2016

Wohnig S, Spork AP, Koppermann S, Mieskes G, Gisch N, Jahn R, Ducho C. Total Synthesis of Dansylated Park's Nucleotide for High-Throughput MraY Assays. Chemistry. 2016 Dec 5;22(49):17813-17819. doi: 10.1002/chem.201604279. Epub 2016 Oct 28.

Carillo S, Pieretti G, Casillo A, Lindner B, Romano I, Nicolaus B, Parrilli M, Giuliano M, Cammarota M, Lanzetta R, Corsaro MM. Structural characterization of the lipid A from the LPS of the haloalkaliphilic bacterium Halomonas pantelleriensis. Extremophiles. 2016 Sep;20(5):687-94.

Klein G, Stupak A, Biernacka D, Wojtkiewicz P, Lindner B, Raina S. Multiple transcriptional factors regulate transcription of the rpoE gene in Escherichia coli under different growth conditions and when the lipopolysaccharide biosynthesis is defective. J Biol Chem. 2016 Sep 14. pii: jbc.M116.748954. [Epub ahead of print]

M. Palusińska-Szysz, A. Zdybicka-Barabas, E. Reszczyńska, R. Luchowski, M. Kania, N. Gisch, F. Waldow, P. Mak, W. Danikiewicz, W. I. Gruszecki, M. Cytryńska. The lipid composition of Legionella dumoffii membrane modulates the interaction with Galleria mellonella apolipophorin III. Biochim Biophys Acta. 2016 Jul;1861(7):617-29. doi: 10.1016/j.bbalip.2016.04.011. Epub 2016 Apr 17.

Brandenburg, K, Heinbockel, L, Correa-Vargas, W, Fukuoka, S, Gutsmann, T, Zähringer, U & Koch, MHJ 2016, 'Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5' Journal of Structural Biology., 10.1016/j.jsb.2016.01.014

Book Chapters

Encyclopedia of Lipidomics (Springer, 2016)
Lars F. Eggers, Dominik Schwudke; Liquid Extraction: Folch
doi:10.1007/978-94-007-7864-1_89-1

Annika Sündermann, Lars F. Eggers, Dominik Schwudke; Liquid Extraction: Bligh and Dyer
doi:10.1007/978-94-007-7864-1_88-1

Lars F. Eggers, Dominik Schwudke; Lipid Extraction: Basics of the Methyl-tert-Butyl Ether Extraction
doi:10.1007/978-94-007-7864-1_96-1

2015

F. Renzi, U. Zähringer, C. E. Chandler, R. K. Ernst, G. R. Cornelis, S. J. Ittig. Modification of the 1-Phosphate Group during Biosynthesis of Capnocytophaga canimorsus Lipid A. Infect Immun. 2015 Dec 7;84(2):550-61. doi: 10.1128/IAI.01006-15. PMID: 26644381

Hebbar, S, Sahoo, I, Matysik, A, Argudo Garcia, I, Osborne, KA, Papan, C, Torta, F, Narayanaswamy, P, Fun, XH, Wenk, MR, Shevchenko, A, Schwudke, D, Kraut, R. Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants. Sci Rep. 2015 Dec 7;5:15926. doi: 10.1038/srep15926.

Gisch, N, Schwudke, D, Thomsen, S, Heß, N, Hakenbeck, R, Denapaite, D. Lipoteichoic acid of Streptococcus oralis Uo5: a novel biochemical structure comprising an unusual phosphorylcholine substitution pattern compared to Streptococcus pneumoniae. Sci Rep. 2015 Nov 18;5:16718. doi: 10.1038/srep16718.

Marella, C, Torda, AE, Schwudke, D. The LUX Score: A Metric for Lipidome Homology. PLoS Comput Biol 2015, 11(9): e1004511. doi: 10.1371/journal.pcbi.1004511

de Tejada, GM, Heinbockel, L, Ferrer-Espada, R, Heine, H, Alexander, C, Bárcena-Varela, S, Goldmann, T, Correa, W,  Wiesmüller, K-H, Gisch, N, Sánchez-Gómez, S, Fukuoka, S, Schürholz, T, Gutsmann, T, Brandenburg, K. Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides. Scientific Reports 5, Article number: 14292 (2015). doi:10.1038/srep14292

Leidinger P, Treptow J, Hagens K, Eich J, Zehethofer N, Schwudke D, Oehlmann W, Lünsdorf H, Goldmann O, Schaible UE, Dittmar KE, Feldmann C. Isoniazid@Fe2O3 Nanocontainers and Their Antibacterial Effect on Tuberculosis Mycobacteria. Angew Chem Int Ed Engl. 2015 Aug 31. doi: 10.1002/anie.201505493. [Epub ahead of print]

Casillo A, Parrilli E, Filomena S, Lindner B, Lanzetta R, Parrilli M, Tutino ML, Corsaro MM. Structural Investigation of the Oligosaccharide Portion Isolated from the Lipooligosaccharide of the Permafrost Psychrophile Psychrobacter arcticus 273-4. Mar Drugs. 2015 Jul 22;13(7):4539-55. doi: 10.3390/md13074539.

Petersen A, Kull S, Rennert S, Becker WM, Krause S, Ernst M, Gutsmann T, Bauer J, Lindner B, Jappe U. Peanut defensins: Novel allergens isolated from lipophilic peanut extract. J Allergy Clin Immunol. 2015 May 30. pii: S0091-6749(15)00570-9. [Epub ahead of print]

Jeschke, A, Zehethofer, N, Lindner, B, Krupp, J, Schwudke, D, Haneburger, I, Jovic, M, Backer, JM, Balla, T, Hilbi, H & Haas, A 2015, 'Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis' PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Bd 112, Nr. 15, S. 4636-41.

Zehethofer, N, Bermbach, S, Hagner, S, Garn, H, Müller, J, Goldmann, T, Lindner, B, Schwudke, D & König, P 2015, 'Lipid Analysis of Airway Epithelial Cells for Studying Respiratory Diseases' Chromatographia, Bd 78, Nr. 5-6, S. 403-413., 10.1007/s10337-014-2787-5

Ranf, S, Gisch, N, Schäffer, M, Illig, T, Westphal, L, Knirel, YA, Sánchez-Carballo, PM, Zähringer, U, Hückelhoven, R, Lee, J & Scheel, D 2015, 'A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana' NATURE IMMUNOLOGY , Bd 16, Nr. 4, S. 426-33.

Diercks, H, Semeniuk, A, Gisch, N, Hermann, M, Duda, KA & Hölzl, G 2015, 'Accumulation of novel Glycolipids and Ornithine Lipids in Mesorhizobium loti under Phosphate Deprivation' JOURNAL OF BACTERIOLOGY, Bd 197, Nr. 3, S. 497-509.

Johnston, C, Bootsma, HJ, Aldridge, C, Manuse, S, Gisch, N, Schwudke, D, Hermans, PWM, Grangeasse, C, Polard, P, Vollmer, W & Claverys, J-P 2015, 'Co-Inactivation of GlnR and CodY Regulators Impacts Pneumococcal Cell Wall Physiology' PLOS ONE, Bd 10, Nr. 4, S. e0123702.

Mamat, U, Wilke, K, Bramhill, D, Schromm, AB, Lindner, B, Kohl, TA, Corchero, JL, Villaverde, A, Schaffer, L, Head, SR, Souvignier, C, Meredith, TC & Woodard, RW 2015, 'Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins' Microbial Cell Factories, Bd 14, S. 57.

Kallsen, K, Zehethofer, N, Abdelsadik, A, Lindner, B, Kabesch, M, Heine, H & Roeder, T 2015, 'ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways' The Journal of allergy and clinical immunology 2015 May 12, pii: S0091-6749(15)00549-7. doi: 10.1016/j.jaci.2015.04.009.

Book Chapters

Gisch, N., Peters, K., Zähringer, U. & Vollmer, W. The pneumococcal cell wall. In: Streptococcus pneumoniae: Molecular mechanisms of host-pathogen interactions (eds J. S. Brown, S. Hammerschmidt, & C. J. Orihuela) Chapter 8, 145-167 (Elsevier, 2015).

2014

Gronbach, K, Flade, I, Holst, O, Lindner, B, Ruscheweyh, HJ, Wittmann, A, Menz, S, Schwiertz, A, Adam, P, Stecher, B, Josenhans, C, Suerbaum, S, Gruber, AD, Kulik, A, Huson, D, Autenrieth, IB & Frick, J-S. Endotoxicity of lipopolysaccharide as a determinant of T-cell-mediated colitis induction in mice. Gastroenterology 2014, 146 (3), 765-775.

Correa, W, Manrique-Moreno, M, Behrends, J, Patiño, E, Chakravarty, M, Peláez-Jaramillo, C, Garidel, P, Gutsmann, T, Brandenburg, K & Heinbockel, L.  Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) anti-bacterial and anti-endotoxic effects. Biochimica et Biophysica Acta 2014, 1838 (10), 2739-2744.

Hilmi D, Parcina M, Stollewerk D, Ostrop J, Josten M, Meilaender A, Zaehringer U, Wichelhaus TA, Bierbaum G, Heeg K, Wolz C, Bekeredjian-Ding I. Heterogeneity of host TLR2 stimulation by Staphylocoocus aureus isolates. PLoS One. 2014 May 8;9(5):e96416. doi: 10.1371/journal.pone.0096416. eCollection 2014.

Claes AK, Steck N, Schultz D, Zähringer U, Lipinski S, Rosenstiel P, Geddes K, Philpott DJ, Heine H, Grassl GA. Salmonella enterica serovar Typhimurium ΔmsbB Triggers Exacerbated Inflammation in Nod2 Deficient Mice. PLoS One. 2014 Nov 25;9(11):e113645. doi: 10.1371/journal.pone.0113645.

Silipo A, Vitiello G, Gully D, Sturiale L, Chaintreuil C, Fardoux J, Gargani D, Lee HI, Kulkarni G, Busset N, Marchetti R, Palmigiano A, Moll H, Engel R, Lanzetta R, Paduano L, Parrilli M, Chang WS, Holst O, Newman DK, Garozzo D, D'Errico G, Giraud E, Molinaro A. Covalently linked hopanoid-lipid A improves outer-membrane resistance of a Bradyrhizobium symbiont of legumes. Nat Commun. 2014 Oct 30;5:5106. doi: 10.1038/ncomms6106.

Komaniecka I, Choma A, Mazur A, Duda KA, Lindner B, Schwudke D, Holst O. Occurrence of an unusual hopanoid-containing lipid A among lipopolysaccharides from Bradyrhizobium species. J Biol Chem. 2014 Dec 19;289(51):35644-55. doi:10.1074/jbc.M114.614529. Epub 2014 Nov 3.

Vassal-Stermann E, Lacroix M, Gout E, Laffly E, Pedersen CM, Martin L, Amoroso A, Schmidt RR, Zähringer U, Gaboriaud C, Di Guilmi AM, Thielens NM. Human L-Ficolin Recognizes Phosphocholine Moieties of Pneumococcal Teichoic Acid. J Immunol. 2014 Dec 1; 193(11):5699-708. doi:10.4049/jimmunol.14001127. Epub Oct 2014.

Hogendorf WFJ, Gisch N, Schwudke D, Heine H, Bols M, Pedersen CM, Total Synthesis of Five Lipoteichoic acids of Clostridium difficile, Chemistry - A European Journal. 2014 20(42): 13511-13516.

Böcking C, Harb H, Ege MJ, Zehethofer N, Fischer K, Krauß J, Holst O, Nüsing RM, Lindner B, von Mutius E, Renz H, Garn H, Pfefferle PI. Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation. Int Arch Allergy Immunol. 2014;163(3):234-42. doi: 10.1159/000358523.

Zähringer U, Ittig S, Lindner B, Moll H, Schombel U, Gisch N, Cornelis GR. NMR Based Structural Analysis of the Complete Rough-type LPS Isolated From Capnocytophaga canimorsus. J Biol Chem. 2014 289(34): 23963-23976.

Abdullah MR, Gutiérrez-Fernández J, Pribyl T, Gisch N, Saleh M, Rohde M, Petruschka L, Burchhardt G, Schwudke D, Hermoso JA, Hammerschmidt S. Structure of the pneumococcal l,d-carboxypeptidase DacB and pathophysiological effects of disabled cell wall hydrolases DacA and DacB. Mol Microbiol. 2014 93(6): 1183–1206.

Hanuszkiewicz A, Pittock P, Humphries F, Moll H, Roa Rosales A, Molinaro A, Moynagh PN, Lajoie G, Valvano MA. Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune response. J Biol Chem. 2014 Jul 4;289(27):19231-44. doi: 10.1074/jbc.M114.562603. Epub 2014 May 19.

Hebbar S, Schulz WD, Sauer U, Schwudke D. Laser Capture Microdissection coupled with on-column extraction LC-MS(n) enables lipidomics of fluorescently labeled Drosophila neurons. Anlay Chem 2014 jun 3; 86 (11): 5245-52. doi:10.1021/ac500276r. PMID 24820458

Turska-Szewczuk A, Duda KA, Schwudke D, Pekala A, Kozinska A, Holst O. Structural studies of the lipopolysaccharide from the fish pathogen Aeromonas veronii strain Bs19, serotype O16. Mar Drugs. 2014 Mar 7;12(3):1298-316. doi: 10.3390/md12031298.

Kohler T, Gisch N, Binsker U, Schlag M, Darm K, Völker U, Zähringer U & Hammerschmidt S. Repeating structures of the major staphylococcal autolysin are essential for the interaction with human thrombospondin-1 and vitronectin.
J Biol Chem 2014 Feb 14;289(7):4070-82.

2013

Zähringer U, Kawahara K, & Kosma P. 2013. ‘Isolation and structural characterization of a (Kdo-isosteric) D-glycero-alpha-D-talo-oct-2-ulopyranosidic acid (Ko) interlinking the lipid A and core oligosaccharide in the lipopolysaccharide of Acinetobacter calcoaceticus NCTC 10305’. Carbohydr Res. Bd. 378: S. 63-70. 

Scior T, Lozano-Aponte J, Figueroa-Vazquez V, Yunes-Rojas JA, Zähringer U & Alexander C. 2013. ‘Three-dimensional mapping of differential amino acids of human, murine, canine and equine TLR4/MD-2 receptor complexes conferring endotoxic activation by lipid A,  Antagonism by eritoran and species-dependent activities of lipid IVA in the mammalian LPS sensor system’. Comp Struct Biotechnol  J. 7 (9), p. 1-11 (online article).

Scior, T, Alexander, C & Zähringer, U. 2013. 'Reviewing and identifying amino acids of human, murine, canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid A, or antagonistic effects by Eritoran'. Comp Struct Biotechnol  J. 5 (6), p. 1-13 (online article).

Gronbach, K, Flade, I, Holst, O, Lindner, B, Ruscheweyh, HJ, Wittmann, A, Menz, S, Schwiertz, A, Adam, P, Stecher, B, Josenhans, C, Suerbaum, S, Gruber, A, Kulik, A, Huson, D, Autenrieth, I & Frick, J-S 2013, 'Endotoxicity of Lipopolysaccharide as a determinant of T-cell mediated colitis induction in mice' Gastroenterology, Nr. doi: 10.1053/j.gastro. 2013.11.033 [Epub ahead of print].

Popovic, M, Andjelkovic, U, Burazer, L, Lindner, B, Petersen, A & Gavrovic-Jankulovic, M 2013, 'Biochemical and immunological characterization of a recombinantly-produced antifungal cysteine proteinase inhibitor from green kiwifruit (Actinidia deliciosa)' Phytochemistry. Bd. 94. S. 53-59. doi:10.1016/j.phytochem.2013.06.006. Epub 2013 Jul 3.

Posch, G, Andrukhov, O, Vinogradov, E, Lindner, B, Messner, P, Holst, O & Schäffer, C 2013, 'Structure and immunogenicity of the rough-type lipopolysaccharide from the periodontal pathogen Tannerella forsythia' Clinical and Vaccine Immunology : CVI, Bd 20, Nr. 6, S. 945-53., dx.doi.org/10.1128/CVI.00139-13.

Turska-Szewczuk, A, Lindner, B, Komaniecka, I, Kozinska, A, Pekala, A, Choma, A & Holst, O 2013, 'Structural and immunochemical studies of the lipopolysaccharide from the fish pathogen, Aeromonas bestiarum strain K296, serotype O18'. Marine drugs, Bd 11, Nr. 4, S. 1235-55., dx.doi.org/10.3390/md11041235.

Carillo, S, Pieretti, G, Lindner, B, Romano, I, Nicolaus, B, Lanzetta, R, Parrilli, M & Corsaro, MM 2013, 'Structural characterization of the core oligosaccharide isolated from the lipopolysaccharide of the haloalkaliphilic bacterium Salinivibrio sharmensis strain BAG(T)' Carbohydrate Research, Bd 368, S. 61-7., dx.doi.org/10.1016/j.carres.2012.12.013.

Sydor, T, von Bargen, K, Hsu, F-F, Huth, G, Holst, O, Wohlmann, J, Becken, U, Dykstra, T, Söhl, K, Lindner, B, Prescott, JF, Schaible, UE, Utermöhlen, O & Haas, A 2013, 'Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length' Cellular Microbiology, Bd 15, Nr. 3, S. 458-473., dx.doi.org/10.1111/cmi.12050.

Pupo, E, Lindner, B, Brade, H & Schromm, AB 2013, 'Intact rough- and smooth-form lipopolysaccharides from Escherichia coli separated by preparative gel electrophoresis exhibit differential biological activity in human macrophages' FEBS Journal, Bd 280, Nr. 4, S. 1095-1111., dx.doi.org/10.1111/febs.12104.

Carillo, S, Pieretti, G, Lindner, B, Romano, I, Nicolaus, B, Lanzetta, R, Parrilli, M & Corsaro, MM 2013, 'The lipid A from the haloalkaliphilic bacterium Salinivibrio sharmensis strain BAG(T)' Marine drugs, Bd 11, Nr. 1, S. 184-93., dx.doi.org/10.3390/md11010184.

Klein, G, Müller-Loennies, S, Lindner, B, Kobylak, N, Brade, H & Raina, S. 2013, 'Molecular and structural basis of inner core lipopolysaccharide alterations in Escherichia coli: incorporation of glucuronic acid and phosphoethanolamine in the heptose region' The Journal of Biological Chemistry, Bd 288, S. 8111-8127., dx.doi.org/10.1074/jbc.M112.445981.

Herzog R, Schwudke D, Shevchenko A. LipidXplorer: Software for Quantitative Shotgun Lipidomics Compatible with Multiple Mass Spectrometry Platforms. CURRENT PROTOCOLS in BIOINFORMATICS 2013 14.12.1–14.12.30.

Sanderson JP, Brennan PJ, Mansour S, Matulis G, Patel O, Lissin N, Kawahara K, Zähringer U, Rossjohn J, Brenner MB, Gadola SD. CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells. EUROPEAN JOURNAL of  IMMUNOLOGY 2013; 43:815-825.
   
Gisch N, Kohler T, Ulmer AJ, Müthing J, Pribyl T, Fischer K, Lindner G, Hammerschmidt S, Zähringer U. Structural reevaluation of Streptococcus pneumoniae lipoteichoic acid and new insights into its immunostimulatory potency. JOURNAL BIOLOGICAL CHEMISTRY 2013; 288: 15654-1567.               

Gasulla F, Vom Dorp K, Dombrink I, Zähringer U, Gisch N, Bartels D. The role of lipid metabolism in the acquisition of desiccation-tolerance in Craterostigma plantagineum: a comparative approach. PLANT JOURNAL 2013 May 15. doi:10.1111/tpj.12241 [Epub ahead of print]               

Subramanian M, Metya SK, Sadaf S, Kumar S, Schwudke D, Hasan G. Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia. DISEASE MODEL & MECHANISMS 2013 May;6(3):734-44.

2012

Czabańska A, Neiwert O, Lindner B, Leigh J, Holst O, Duda KA. Structural analysis of the lipoteichoic acids isolated from bovine mastitis Streptococcus uberis 233, Streptococcus dysgalactiae 2023 and Streptococcus agalactiae 0250. CARBOHYDRATE RESEARCH 2012 Nov;361:200–205.

Krauel K, Weber C, Brandt S, Zähringer U, Mamat U, Greinacher A, Hammerschmidt S. Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes. BLOOD 2012 Oct;120(16):3345–3352.

Fischer K, Vinogradov E, Lindner B, Heine H, Holst O. The structure of the extracellular teichoic acids from the allergy-protective bacterium Lactococcus lactis G121. BIOLOGICAL CHEMISTRY 2012 Aug;393(8): 749-55.

Turska-Szewczuk A, Lindner B, Pękała A, Palusińska-Szysz M, Choma A, Russa R, Holst O. Structural analysis of the O-specific polysaccharide from the lipopolysaccharide of Aeromonas veronii bv. sobria strain K49. CARBOHYDRATE RESEARCH 2012 May;353:62–68.

Ittig S, Lindner B, Stenta M, Manfredi P, Zdorovenko E, Knirel YA, dal Peraro M, Cornelis GR, Zähringer U. The Lipopolysaccharide from Capnocytophaga canimorsus Reveals an Unexpected Role of the Core-Oligosaccharide in MD-2 Binding. PLOS PATHOGENS 2012 May;8(5):e1002667. Open Access

Grozdanovic M, Popovic M, Polovic N, Burazer L, Vuckovic O, Atanaskovic-Markovic M, Lindner B, Petersen A, Gavrovic-Jankulovic M. Evaluation of IgE reactivity of active and thermally inactivated actinidin, a biomarker of kiwifruit allergy. FOOD AND CHEMICAL TOXICOLOGY 2012 Apr;50(3-4):1013–1018.

Schmidt H, Hansen G, Singh S, Hanuszkiewicz A, Lindner B, Fukase K, Woodard RW, Holst O, Hilgenfeld R, Mamat U, Mesters JR. Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2012 Apr;109(16):6253–6258.

Pieretti G, Carillo S, Lindner B, Kim KK, Lee KC, Lee J-S, Lanzetta R, Parrilli M, Corsaro MM. Characterization of the Core Oligosaccharide and the O-Antigen Biological Repeating Unit from Halomonas stevensii Lipopolysaccharide: The First Case of O-Antigen Linked to the Inner Core. CHEMISTRY-A EUROPEAN JOURNAL 2012 Mar;18(12):3729–3735.

Aleksic I, Popovic M, Dimitrijevic R, Andjelkovic U, Vassilopoulou E, Sinaniotis A, Atanaskovic-Markovic M, Lindner B, Petersen A, Papadopoulos NG, Gavrovic-Jankulovic M. Molecular and immunological characterization of Mus a 5 allergen from banana fruit. MOLECULAR NUTRITION & FOOD RESEARCH 2012 Mar;56(3):446–453.

Grozdanovic M, Popovic M, Polovic N, Burazer L, Vuckovic O, Atanaskovic-Markovic M, Lindner B, Petersen A, Gavrovic-Jankulovic M. Evaluation of IgE reactivity of active and thermally inactivated actinidin, a biomarker of kiwifruit allergy. FOOD AND CHEMICAL TOXICOLOGY 2012 Mar;50(3-4):1013–8.

Guttsches A-K, Loseke S, Zahringer U, Sonnenborn U, Enders C, Gatermann S, Bufe A. Anti-inflammatory modulation of immune response by probiotic Escherichia coli Nissle 1917 in human blood mononuclear cells. INNATE IMMUNITY 2012 Mar;18(2):204–216.

Kondakova AN, Sevillano AM, Shaikhutdinova RZ, Lindner B, Komandrova NA, Dentovskaya SV, Shashkov AS, Anisimov AP, Skurnik M, Knirel YA. Revision of the O-polysaccharide structure of Yersinia pseudotuberculosis O:1a; confirmation of the function of WbyM as paratosyltransferase. CARBOHYDRATE RESEARCH 2012 Mar;350:98–102.

Pedersen CM, Figueroa-Perez I, Ulmer AJ, Zähringer U, Schmidt RR. Synthesis of the repeating unit of the lipoteichoic acid of Streptococcus pneumoniae. TETRAHEDRON 2012 Jan;68(4):1052–1061.



2011

Fischer K, Stein K, Ulmer AJ, Lindner B, Heine H, Holst O. Cytokine-inducing lipoteichoic acids of the allergy-protective bacterium Lactococcus lactis G121 do not activate via Toll-like receptor 2. GLYCOBIOLOGY 2011 Dec;21(12):1588-1595.

Klein G, Lindner B, Brade H, Raina S. Molecular basis of lipopolysaccharide heterogeneity in Escherichia coli: envelope stress responsive regulators control the incorporation of glycoforms with a third 3-deoxy-{alpha}-D-manno-oct-2-ulosonic acid and rhamnose. JOURNAL OF BIOLOGICAL CHEMISTRY 2011 Dec;286(50):42787-807.

Garcia-Alles LF, Collmann A, Versluis C, Lindner B, Guiard J, Maveyraud L, Huc E, Im JS, Sansano S, Brando T, Julien S, Prandi J, Gilleron M, Porcelli SA, de la Salle H, Heck AJR, Mori L, Puzo G, Mourey L, De Libero G. Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2011 Oct;108(43):17755-17760.

Stübs G, Fingerle V, Zähringer U, Schumann RR, Rademann J, Schröder NWJ. Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato. FEMS Immunology & Medical Microbiology 2011 Oct;63(1):140-143.

Dombrowsky H, Lautenschläger I, Zehethofer N, Lindner B, Schultz H, Uhlig S, Frerichs I, Weiler N. Ingestion of (n-3) Fatty Acids Augments Basal and Platelet Activating Factor-Induced Permeability to Dextran in the Rat Mesenteric Vascular Bed. JOURNAL OF NUTRITION 2011 Sep;141(9):1635-1642.

Duda KA, Lindner B, Brade H, Leimbach A, Brzuszkiewicz E, Dobrindt U, Holst O. The lipopolysaccharide of the mastitis isolate Escherichia coli strain 1303 comprises a novel O-antigen and the rare K-12 core type. MICROBIOLOGY 2011 Jun;157(Pt 6):1750-60.

Dentovskaya SV, Anisimov AP, Kondakova AN, Lindner B, Bystrova OV, Svetoch TE, Shaikhutdinova RZ, Ivanov SA, Bakhteeva IV, Titareva GM, Knirel YA. Functional characterization and biological significance of Yersinia pestis lipopolysaccharide biosynthesis genes. BIOCHEMISTRY-MOSCOW 2011 Jul;76(7):808-822.

Knirel YA, Kondakova AN, Vinogradov E, Lindner B, Perepelov AV, Shashkov AS. Lipopolysaccharide core structures and their correlation with genetic groupings of Shigella strains. A novel core variant in Shigella boydii type 16. GLYCOBIOLOGY 2011 Jul;21(10):1362-1372.

Turska-Szewczuk A, Guz L, Lindner B, Pietras H, Russa R, Holst O. Structural characterization of the O-specific polysaccharide from the lipopolysaccharide of the fish pathogen Aeromonas bestiarum strain P1S. CARBOYDRATE RESEARCH 2011 May;346(6):815-821.

Keck M, Gisch N, Moll H, Vorhölter F-J, Gerth K, Kahmann U, Lissel M, Lindner B, Niehaus K, Holst O. Unusual outer membrane lipid composition of the gram-negative, lipopolysaccharide-lacking myxobacterium Sorangium cellulosum So ce56. The Journal of Biological Chemistry 2011 Apr;286(15):12850-12859.

Gisch N, Buske B, Heine H, Lindner B, Zähringer U. Synthesis of biotinylated muramyl tripeptides with NOD2-stimulating activity. BIOORGANIC & MEDICINAL CHEMISTRY; 2011 Jun 21(11):3362-6. Epub 2011 Apr 9.

Schmidt RR, Pedersen CM, Qiao Y, Zähringer U. Chemical synthesis of bacterial lipoteichoic acids: an insight on its biological significance. ORGANIC & BIOMOLECULAR CHEMISTRY 2011 Apr;9(7):2040-2052.

 

2010

Zehethofer N, Scior T, Lindner B. Elucidation of the fragmentation pathways of different phosphatidylinositol phosphate species (PIPx) using IRMPD implemented on a FT-ICR MS. ANALYTICAL AND BIOANALYTICAL CHEMISTRY 2010 Dec;398(7-8):2843-2851.

Pieretti G, Carillo S, Lindner B, Lanzetta R, Parrilli M, Jimenez N, Regué M, Tomás JM, Corsaro MM. The complete structure of the core of the LPS from Plesiomonas shigelloides 302–73 and the identification of its O-antigen biological repeating unit. CARBOHYDRATE RESEARCH 2010 Nov;345(17):2523-2528.

Pedersen CM, Figueroa-Perez I, Boruwa J, Lindner B, Ulmer AJ, Zähringer U, Schmidt RR. Synthesis of the Core Structure of the Lipoteichoic Acid of Streptococcus pneumoniae. CHEMISTRY-A EUROPEAN JOURNAL 2010 Nov;16(42):12627-12641.

Pinta E, Duda KA, Hanuszkiewicz A, Salminen TA, Bengoechea JA, Hyytiainen H, Lindner B, Radziejewska-Lebrecht J, Holst O, Skurnik M. Characterization of the Six Glycosyltransferases Involved in the Biosynthesis of Yersinia enterocolitica Serotype O:3 Lipopolysaccharide Outer Core. JOURNAL OF BIOLOGICAL CHEMISTRY 2010 Sep;285(36):28333-28342.

Paściak M, Kaczyński Z, Lindner B, Holst O, Gamian A. Immunochemical studies of trehalose-containing major glycolipid from Tsukamurella pulmonis. CARBOHYDRATE RESEARCH 2010 Jul;345(11):1570-1574.

Paściak M, Sanchez-Carballo P, Duda-Madej A, Lindner B, Gamian A, Holst O. Structural characterization of the major glycolipids from Arthrobacter globiformis and Arthrobacter scleromae. CARBOHYDRATE RESEARCH 2010 Jul;345(10):1497-1503.

Suomalainen M, Lobo LA, Brandenburg K, Lindner B, Virkola R, Knirel YA, Anisimov AP, Holst O, Korhonen TK. Temperature-Induced Changes in the Lipopolysaccharide of Yersinia pestis Affect Plasminogen Activation by the Pla Surface Protease. INFECTION AND IMMUNITY 2010 Jun;78(6):2644-2652.

Qiao Y, Lindner B, Zähringer U, Truog P, Schmidt RR. Synthesis of the lipoteichoic acid of the Streptococcus species DSM 8747. BIOORGANIC & MEDICINAL CHEMISTRY 2010 Jun;18(11):3696-3702.

Kondakova AN, Vinogradov EV, Shekht ME, Markina AA, Lindner B, L’vov VL, Aparin PG, Knirel YA. Structure of the oligosaccharide region (core) of the lipopolysaccharides of Shigella flexneri types 2a and 5b. RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 2010 May;36(3):396-399.

Mokrievich A, Kondakova A, Valade E, Platonov M, Vakhrameeva G, Shaikhutdinova R, Mironova R, Blaha D, Bakhteeva I, Titareva G, Kravchenko T, Kombarova T, Vidal D, Pavlov V, Lindner B, Dyatlov I, Knirel Y. Biological properties and structure of the lipopolysaccharide of a vaccine strain of Francisella tularensis generated by inactivation of a quorum sensing system gene qseC. BIOCHEMISTRY-MOSCOW 2010 Apr;75(4):443-451.

Kahler D, Alexander C, Schultz H, Abdullah M, Branscheid D, Lindner B, Zabel P, Vollmer E, Goldmann T. Proteomics Out of the Archive: Two-dimensional Electrophoresis and Mass Spectrometry Using HOPE-fixed, Paraffin-embedded Tissues. JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY 2010 Mar;58(3):221-228.

Popovic M, Milovanovic M, Burazer L, Vuckovic O, Hoffmann-Sommergruber K, Knulst A, Lindner B, Petersen A, Jankov R, Gavrovic-Jankulovic M. Cysteine proteinase inhibitor Act d 4 is a functional allergen contributing to the clinical symptoms of kiwifruit allergy. MOLECULAR NUTRITION & FOOD RESEARCH 2010 Mar;54(3):373-380.

Pedersen C, Figueroa-Perez I, Lindner B, Ulmer A, Zahringer U, Schmidt R. Total Synthesis of Lipoteichoic Acid of Streptococcus pneumoniae. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2010 Mar;49(14):2585-2590.

Gutsmann T, Howe J, Zahringer U, Garidel P, Schromm AB, Koch MHJ, Fujimoto Y, Fukase K, Moriyon I, Martinez-de-Tejada G, Brandenburg K. Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells. INNATE IMMUNITY 2010 Feb;16(1):39-47.

Duda K, Lindner B, Brade H, Dobrindt U, Seyfert H, Holst O. Escherichia coli 1303 mastitis isolate carries a novel O-antigen and the rare K-12 core type in its lipopolysaccharide. REPRODUCTION IN DOMESTIC ANIMALS 2010 Feb;45(Suppl. 1):9-9.

Schmengler K, Goldmann T, Brade L, Sánchez Carballo PM, Albrecht S, Brade H, Kosma P, Sahly H, Hauber H, Länger F, Meyer R, Welte T, Zähringer U. Monoclonal antibody S60-4-14 reveals diagnostic potential in the identification of Pseudomonas aeruginosa in lung tissues of cystic fibrosis patients. EUROPEAN JOURNAL OF CELL BIOLOGY 2010 Jan;89(1):25-33.

Rohde H, Frankenberger S, Zähringer U, Mack D. Structure, function and contribution of polysaccharide intercellular adhesin (PIA) to Staphylococcus epidermidis biofilm formation and pathogenesis of biomaterial-associated infections. EUROPEAN JOURNAL OF CELL BIOLOGY 2010 Jan;89(1):103-111.

Komaniecka I, Choma A, Lindner B, Holst O. The Structure of a Novel Neutral Lipid A from the Lipopolysaccharide of Bradyrhizobium elkanii Containing Three Mannose Units in the Backbone. CHEMISTRY-A EUROPEAN JOURNAL 2010 Jan;16(9):2922-2929.

 

2009

Hübner G, Crone C, Lindner B. lipID - a software tool for automated assignment of lipids in mass spectra. JOURNAL OF MASS SPECTROMETRY 2009 Dec;44(12):1676-1683.

Bade S, Rockendorf N, Franek M, Gorris H, Lindner B, Olivier V, Schaper K, Frey A. Biolabeling with 2,4-Dichlorophenoxyacetic Acid Derivatives: The 2,4-D Tag. ANALYTICAL CHEMISTRY 2009 Dec;81(23):9695-9702.

Kerth A, Garidel P, Howe J, Alexander C, Mach J, Waelli T, Blume A, Th Rietschel E, Brandenburg K. An infrared reflection-absorption spectroscopic (IRRAS) study of the interaction of lipid A and lipopolysaccharide Re with endotoxin-binding proteins. MEDICINAL CHEMISTRY 2009 Nov;5(6):535-542.

Schiemann F, Brandt E, Gross R, Lindner B, Mittelstadt J, Sommerhoff C, Schulmistrat J, Petersen F. The Cathelicidin LL-37 Activates Human Mast Cells and Is Degraded by Mast Cell Tryptase: Counter-Regulation by CXCL4. JOURNAL OF IMMUNOLOGY 2009 Aug;183(4):2223-2231.

Mamat U, Schmidt H, Munoz E, Lindner B, Fukase K, Hanuszkiewicz A, Wu J, Meredith T, Woodard R, Hilgenfeld R, Mesters J, Holst O. WaaA of the Hyperthermophilic Bacterium Aquifex aeolicus Is a Monofunctional 3-Deoxy-D-manno-oct-2-ulosonic Acid Transferase Involved in Lipopolysaccharide Biosynthesis. JOURNAL OF BIOLOGICAL CHEMISTRY 2009 Aug;284(33):22248-22262.

Pinta E, Duda K, Hanuszkiewiez A, Kaczynski Z, Lindner B, Miller W, Hyytiainen H, Vogel C, Borowski S, Kasperkiewicz K, Lam J, Radziejewska-Lebrecht J, Skurnik M, Holst O. Identification and Role of a 6-Deoxy-4-Keto-Hexosamine in the Lipopolysaccharide Outer Core of Yersinia enterocolitica Serotype O:3. CHEMISTRY-A EUROPEAN JOURNAL 2009 Aug;15(38):9747-9754.

Klein G, Lindner B, Brabetz W, Brade H, Raina S. Escherichia coli K-12 Suppressor-free Mutants Lacking Early Glycosyltransferases and Late Acyltransferases MINIMAL LIPOPOLYSACCHARIDE STRUCTURE AND INDUCTION OF ENVELOPE STRESS RESPONSE. JOURNAL OF BIOLOGICAL CHEMISTRY 2009 Jun;284(23):15369-15389.

Shin H, Mally M, Meyer S, Fiechter C, Paroz C, Zaehringer U, Cornelis G. Resistance of Capnocytophaga canimorsus to Killing by Human Complement and Polymorphonuclear Leukocytes. INFECTION AND IMMUNITY 2009 Jun;77(6):2262-2271.

Stubs G, Fingerle V, Wilske B, Gobel U, Zahringer U, Schumann R, Schroder N. Acylated Cholesteryl Galactosides Are Specific Antigens of Borrelia Causing Lyme Disease and Frequently Induce Antibodies in Late Stages of Disease. JOURNAL OF BIOLOGICAL CHEMISTRY 2009 May;284(20):13326-13334.

Lotter H, Gonzalez-Roldan N, Lindner B, Winau F, Isibasi A, Moreno-Lafont M, Ulmer A, Holst O, Tannich E, Jacobs T. Natural Killer T Cells Activated by a Lipopeptidophosphoglycan from Entamoeba histolytica Are Critically Important To Control Amebic Liver Abscess. PLOS PATHOGENS 2009 May;5(5):e1000434. Open Access

Khatri I, Alexander C, Brandenburg K, Fournier K, Mach J, Rietschel E, Ulmer A, Terzioglu E, Waelli T, Gorczynski R. Induction of tolerogenic vs immunogenic dendritic cells (DCs) in the presence of GM-CSF is regulated by the strength of signaling from monophosphoryl lipid A (MPLA) in association with glutathione and fetal hemoglobin gamma-chain. IMMUNOLOGY LETTERS 2009 May;124(1):44-49.

Hubner G, Lindner B. Separation of R-form lipopolysaccharide and lipid A by CE-Fourier-transform ion cyclotron resonance MS. ELECTROPHORESIS 2009 May;30(10):1808-1816.

Feodorova VA, Pan'kina LN, Savostina EP, Kuznetsov OS, Konnov NP, Sayapina LV, Dentovskaya SV, Shaikhutdinova RZ, Ageev SA, Lindner B, Kondakova AN, Bystrova OV, Kocharova NA, Senchenkova SN, Holst O, Pier GB, Knirel YA, Anisimov AP, Motin VL. Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens. VACCINE 2009 Apr;27(16):2240-2250.

Andra J, Hammer M, Grotzinger J, Jakovkin I, Lindner B, Vollmer E, Fedders H, Leippe M, Gutsmann T. Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes. BIOLOGICAL CHEMISTRY 2009 Apr;390(4):337-349.

Reifenberg K, Lehr H, Fan J, Koike T, Wiese E, Kupper I, Sagban T, Schaefer S, Zahringer U, Torzewski M, Lackner K, Bhakdi S. Endotoxin accelerates atherosclerosis independent of complement activation. THROMBOSIS RESEARCH 2009 Feb;123(4):653-658.

Gronow S, Lindner B, Brade H, Müller-Loennies S. Kdo-(2 --> 8)-Kdo-(2 --> 4)-Kdo but not Kdo-(2 --> 4)-Kdo-(2 --> 4)-Kdo is an acceptor for transfer of L-glycero-alpha-D-manno-heptose by Escherichia coli heptosyltransferase I (WaaC). INNATE IMMUNITY 2009 Feb;15(1):13-23.

Feodorova V, Pan'kina L, Savostina E, Kuznetsov O, Konnov N, Sayapina L, Dentovskaya S, Shaikhutdinova R, Ageev S, Lindner B, Kondakova A, Kocharova N, Senchenkova S, Holst O, Pier G, Knirel Y, Anisimov A, Motin V. Yersinia pestis Live Vaccine with Improved Characteristics. PROCEDIA IN VACCINOLOGY 2009;1(1):97-100.

 

2008

Zauner S, Zahringer U, Lindner B, Warnecke D, Sperling P. Identification and Functional Characterization of the 2-Hydroxy Fatty N-Acyl-Delta 3(E)-desaturase from Fusarium graminearum. JOURNAL OF BIOLOGICAL CHEMISTRY 2008 Dec;283(52):36734-36742.

Hanuszkiewicz A, Kaczynski Z, Lindner B, Goldmann T, Vollmer E, Debarry J, Heine H, Holst O. Structural Analysis of the Capsular Polysaccharide from Acinetobacter lwoffii F78. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2008 Dec;(36):6183-6188.

Wang W, Sass H, Zahringer U, Grzesiek S. Structure and Dynamics of C-13,N-15-Labeled Lipopolysaccharides in a Membrane Mimetic. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2008 Nov;47(51):9870-9874.

Howe J, Richter W, Hawkins L, Rossle M, Alexander C, Fournier K, Mach J, Waelli T, Gorczynski R, Ulmer A, Brade H, Zamyatina A, Kosma P, Rietschel E, Brandenburg K. Hemoglobin Enhances the Biological Activity of Synthetic and Natural Bacterial (Endotoxic) Virulence Factors: A General Principle. MEDICINAL CHEMISTRY 2008 Nov;4(6):520-525.

Malm S, Walter K, Engel R, Maass S, Pfau S, Hubner G, Lindner B, Holst O, Ehlers S, Bange F. In vitro and in vivo characterization of a Mycobacterium tuberculosis mutant deficient in glycosyltransferase Rv1500. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 2008 Oct;298(7-8):645-655.

Hanuszkiewicz A, Hubner G, Vinogradov E, Lindner B, Brade L, Brade H, Debarry J, Heine H, Holst O. Structural and Immunochemical Analysis of the Lipopolysaccharide from Acinetobacter Iwoffii F78 Located Outside Chlamydiaceae with a Chlamydia-Specific Lipopolysaccharide Epitope. CHEMISTRY-A EUROPEAN JOURNAL 2008 Oct;14(33):10251-10258.

Parcina M, Wendt C, Goetz F, Zawatzky R, Zahringer U, Heeg K, Bekeredjian-Ding I. Staphylococcus aureus-induced plasmacytoid dendritic cell activation is based on an IgG-mediated memory response. JOURNAL OF IMMUNOLOGY 2008 Sep;181(6):3823-3833.

Zdorovenko E, Vinogradov E, Wydra K, Lindner B, Knirel Y. Structure of the oligosaccharide chain of the SR-type lipopolysaccharide of Ralstonia solanacearum Toudk-2. BIOMACROMOLECULES 2008 Aug;9(8):2215-2220.

Khatri I, Alexander C, Brandenburg K, Fournier K, Lee L, Mach J, Rietschel E, Ulmer A, Waelli T, Gorczynski R. A role for altered TLR gene expression in association with increased expression of CD200R in the induction of mucosal tissue CD4(+) Treg in aged mice following gavage with a liver extract along with intramuscular monophosphoryl lipid A (MPLA) injection. EXPERIMENTAL GERONTOLOGY 2008 Aug;43(8):771-781.

Kondakova A, Ho N, Bystrova O, Shashkov A, Lindner B, Creuzenet C, Knirel Y. Structural studies of the O-antigens of Yersinia pseudotuberculosis O : 2a and mutants thereof with impaired 6-deoxy-D-manno-heptose biosynthesis pathway. CARBOHYDRATE RESEARCH 2008 Jun;343(8):1383-1389.

Kocharova N, Kondakova A, Vinogradov E, Ovchinnikova O, Lindner B, Shashkov A, Rozalski A, Knirel Y. Full structure of the carbohydrate chain of the lipopolysaccharide of Providencia rustigianii O34. CHEMISTRY-A EUROPEAN JOURNAL 2008 Jun;14(20):6184-6191.

Gavrovic-Jankulovic M, Spasic M, Velickovic T, Stojanovic M, Inic-Kanada A, Dimitrijevic L, Lindner B, Petersen A, Becker W, Jankov R. Quantification of the thaumatin-like kiwi allergen by a monoclonal antibody-based ELISA. MOLECULAR NUTRITION & FOOD RESEARCH 2008 Jun;52(6):701-707.

Jimenez N, Canals R, Lacasta A, Kondakova A, Lindner B, Knirel Y, Merino S, Regue M, Tomas J. Molecular analysis of three Aeromonas hydrophila AH-3 (serotype 034) lipopolysaccharide core biosynthesis gene clusters. JOURNAL OF BACTERIOLOGY 2008 May;190(9):3176-3184.

Riecken S, Lindner B, Petersen A, Jappe U, Becker W. Purification and characterization of natural Ara h 8, the Bet v 1 homologous allergen from peanut, provides a novel isoform. BIOLOGICAL CHEMISTRY 2008 Apr;389(4):415-423.

Zahringer U, Lindner B, Inamura S, Heine H, Alexander C. TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity. IMMUNOBIOLOGY 2008 Mar;213(3-4):205-224.

Pieretti G, Corsaro M, Lanzetta R, Parrilli M, Nicolaus B, Gambacorta A, Lindner B, Holst O. Structural characterization of the core region of the lipopolysaccharide from the haloalkaliphilic Halomonas pantelleriensis: Identification of the biological O-antigen repeating unit. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2008 Feb;(4):721-728.

Mamat U, Meredith T, Aggarwal P, Kuhl A, Kirchhoff P, Lindner B, Hanuszkiewicz A, Sun J, Holst O, Woodard R. Single amino acid substitutions in either YhjD or MsbA confer viability to 3-deoxy-D-manno-oct-2-ulosonic acid-depleted Escherichia coli. MOLECULAR MICROBIOLOGY 2008 Feb;67(3):633-648.

Howe J, Garidel P, Roessle M, Richter W, Alexander C, Fournier K, Mach J, Waelli T, Gorczynski R, Ulmer A, Zaehringer U, Hartmann A, Rietschel E, Brandenburg K. Structural investigations into the interaction of hemoglobin and part structures with bacterial endotoxins. INNATE IMMUNITY 2008 Feb;14(1):39-49.

Dentovskaya S, Bakhteeva I, Titareva G, Shaikhutdinova R, Kondakova A, Bystrova O, Lindner B, Knirel Y, Anisimov A. Structural diversity and endotoxic activity of the lipopolysaccharide of Yersinia pestis. BIOCHEMISTRY-MOSCOW 2008 Feb;73(2):192-199.

Gavrovic-Jankulovic M, Poulsen K, Brckalo T, Bobic S, Lindner B, Petersen A. A novel recombinantly produced banana lectin isoform is a valuable tool for glycoproteomics and a potent modulator of the proliferation response in CD3(+), CD4(+), and CD8(+) populations of human PBMCs. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2008;40(5):929-941.

Corsaro M, Pieretti G, Lindner B, Lanzetta R, Parrilli E, Tutino M, Parrilli M. Highly Phosphorylated Core Oligosaccaride Structures from Cold-Adapted Psychromonas arctica. CHEMISTRY-A EUROPEAN JOURNAL 2008;14(30):9368-9376.

 

2007

Zughaier S, Lindner B, Howe J, Garidel P, Koch M, Brandenburg K, Stephens D. Physicochemical characterization and biological activity of lipooligosaccharides and lipid A from Neisseria meningitidis. JOURNAL OF ENDOTOXIN RESEARCH 2007 Dec;13(6):343-357.

Kondakova A, Vinogradov E, Lindner B, Kocharova N, Rozalski A, Knirel Y. Mass-spectrometric studies of Providencia SR-Form lipopolysaccharides and elucidation of the biological repeating unit structure of Providencia rustigianii O14-polysaccharide. JOURNAL OF CARBOHYDRATE CHEMISTRY 2007 Dec;26(8-9):497-512.

Feodorova V, Pan'kina L, Savostina E, Sayapina L, Motin V, Dentovskaya S, Shaikhutdinova R, Ivanov S, Lindner B, Kondakova A, Bystrova O, Kocharova N, Senchenkova S, Holst O, Pier G, Knirel Y, Anisimov A. A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. VACCINE 2007 Nov;25(44):7620-7628.

Rennemeier C, Hammerschmidt S, Niemann S, Inamura S, Zahringer U, Kehrel B. Thrombospondin-1 promotes cellular adherence of Gram-positive pathogens via recognition of peptidoglycan. FASEB JOURNAL 2007 Oct;21(12):3118-3132.

Fedtke I, Mader D, Nicholson G, Henseler K, Goetz F, Zaehringer U, Peschel A. A Staphylococcus aureus mutant with strongly reduced lipoteichoic acid (LTA) content: LTA governs bacterial surface properties and autolysin activity. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 2007 Sep;297:122-122.

Wittkowski M, Mittelstadt J, Brandau S, Reiling N, Lindner B, Torrelles J, Brennan P, Holst O. Capsular arabinomannans from Mycobacterium avium with morphotype-specific structural differences but identical biological activity. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 Jun;282(26):19103-19112.

Gorczynski R, Alexander C, Bessler W, Brandenburg K, Fournier K, Mach J, Mueller S, Rietschel E, Ulmer A, Waelli T, Zahringer U, Khatri I. An alteration in the levels of populations of CD4(+) Treg is in part responsible for altered cytokine production by cells of aged mice which follows injection with a fetal liver extract. IMMUNOLOGY LETTERS 2007 Apr;109(2):101-112.

Bitter W, van Boxtel R, Groeneweg M, Carballo P, Zahringer U, Tommassen J, Koster M. Species-specific functioning of the Pseudomonas XcpQ secretin: Role for the C-terminal homology doMayn and lipopolysaccharide. JOURNAL OF BACTERIOLOGY 2007 Apr;189(8):2967-2975.

Anisimov A, Shaikhutdinova R, Pan'kina L, Feodorova V, Savostina E, Bystrova O, Lindner B, Mokrievich A, Bakhteeva I, Titareva G, Dentovskaya S, Kocharova N, Senchenkova S, Holst O, Devdarian Z, Popov Y, Pier G, Knirel Y. Effect of deletion of the IpxM gene on virulence and vaccine potential of Yersinia pestis in mice. JOURNAL OF MEDICAL MICROBIOLOGY 2007 Apr;56(4):443-453.

Meredith T, Mamat U, Kaczynski Z, Lindner B, Holst O, Woodard R. Modification of lipopolysaccharide with colanic acid (M-antigen) repeats in Escherichia coli. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 Mar;282(11):7790-7798.

Bekeredjian-Ding I, Inamura S, Giese T, Moll H, Endres S, Sing A, Zahringer U, Hartmann G. Staphylococcus aureus protein A triggers T cell-independent B cell proliferation by sensitizing B cells for TLR2 ligands. JOURNAL OF IMMUNOLOGY 2007 Mar;178(5):2803-2812.

Fritz M, Lokstein H, Hackenberg D, Welti R, Roth M, Zahringer U, Fulda M, Hellmeyer W, Ott C, Wolter F, Heinz E. Channeling of eukaryotic diacylglycerol into the biosynthesis of plastidial phosphatidylglycerol. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 Feb;282(7):4613-4625.

Howe J, Hammer M, Alexander C, Rossle M, Fournier K, Mach J, Waelli T, Gorczynski R, Ulmer A, Zahringer U, Rietschel E, Brandenburg K. Biophysical characterization of the interaction of endotoxins with hemoglobins. MEDICINAL CHEMISTRY 2007 Jan;3(1):13-20.

Knirel Y, Dentovskaya S, Bystrova O, Kocharova N, Senchenkova S, Shaikhutdinova R, Titareva G, Bakhteeva I, Lindner B, Pier G, Anisimov A. Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors. GENUS YERSINIA: FROM GENOMICS TO FUNCTION 2007;603:88-96.

Kaczynski Z, Braun S, Lindner B, Niehaus K, Holst O. Investigation of the chemical structure and biological activity of oligosaccharides isolated from rough-type Xanthomonas campestris pv. campestris B100 lipopolysaccharide. JOURNAL OF ENDOTOXIN RESEARCH 2007;13(2):101-108.

 

2006 (Selection)

Lebrun A, Wunder C, Hildebrand J, Churin Y, Zahringer U, Lindner B, Meyer T, Heinz E, Warnecke D. Cloning of a cholesterol-alpha-glucosyltransferase from Helicobacter pylori. JOURNAL OF BIOLOGICAL CHEMISTRY 2006 Sep;281(38):27765-27772.

Wunder C, Churin Y, Winau F, Warnecke D, Vieth M, Lindner B, Zahringer U, Mollenkopf H, Heinz E, Meyer T. Cholesterol glucosylation promotes immune evasion by Helicobacter pylori. NATURE MEDICINE 2006 Sep;12(9):1030-1038.

Holzl G, Witt S, Kelly A, Zahringer U, Warnecke D, Dormannn P, Heinz E. Functional differences between galactolipids and glucolipids revealed in photosynthesis of higher plants. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF 2006 May;103(19):7512-7517.

Zacharowski K, Zacharowski P, Koch A, Baban A, Tran N, Berkels R, Papewalis C, Schulze-Osthoff K, Knuefermann P, Zahringer U, Schumann R, Rettori V, McCann S, Bornstein S. Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF 2006 Apr;103(16):6392-6397.

Knirel Y, Bystrova O, Kocharova N, Zahringer U, Pier G. Conserved and variable structural features in the lipopolysaccharide of Pseudomonas aeruginosa. JOURNAL OF ENDOTOXIN RESEARCH 2006;12(6):324-336.

2005 (Selection)

Holzl G, Zahringer U, Warnecke D, Heinz E. Glycoengineering of cyanobacterial thylakoid membranes for future studies on the role of glycolipids in photosynthesis. PLANT AND CELL PHYSIOLOGY 2005 Nov;46(11):1766-1778.

Gangloff S, Zahringer U, Blondin C, Guenounou M, Silver J, Goyert S. Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. JOURNAL OF IMMUNOLOGY 2005 Sep;175(6):3940-3945.

Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K, Sovath S, Shamel L, Hartung T, Zahringer U, Beutler B. CD36 is a sensor of diacylglycerides. NATURE 2005 Feb;433(7025):523-527.

 

2004-2001 (Selection)

Zeidler D, Zahringer U, Gerber I, Dubery I, Hartung T, Bors W, Hutzler P, Durner J. Innate immunity in Arabidopsis thaliana: Lipopolysaccharides activate nitric oxide synthase (NOS) and induce defense genes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF 2004 Nov;101(44):15811-15816.

Zahringer U, Lindner B, Knirel Y, van den Akker W, Hiestand R, Heine H, Dehio C. Structure and biological activity of the short-chain lipopolysaccharide from Bartonella henselae ATCC 49882(T). JOURNAL OF BIOLOGICAL CHEMISTRY 2004 May;279(20):21046-21054.

Weber J, Freyer D, Alexander C, Schroder N, Reiss A, Kuster C, Pfeil D, Tuomanen E, Schumann R. Recognition of pneumococcal peptidoglycan: An expanded, pivotal role for LPS binding protein. IMMUNITY 2003 Aug;19(2):269-279.

Girardin S, Boneca I, Carneiro L, Antignac A, Jehanno M, Viala J, Tedin K, Taha M, Labigne A, Zahringer U, Coyle A, Bertin J, Sansonetti P, Philpott D. Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan. SCIENCE 2003 Jun;300(5625):1584-1587.

Schroder N, Morath S, Alexander C, Hamann L, Hartung T, Zahringer U, Gobel U, Weber J, Schumann R. Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. JOURNAL OF BIOLOGICAL CHEMISTRY 2003 May;278(18):15587-15594.

Domergue F, Spiekermann P, Lerchl J, Beckmann C, Kilian O, Kroth P, Boland W, Zahringer U, Heinz E. New insight into Phaeodactylum tricornutum fatty acid metabolism. Cloning and functional characterization of plastidial and microsomal Delta 12-fatty acid desaturases. PLANT PHYSIOLOGY 2003 Apr;131(4):1648-1660.

ChaMayllard M, Philpott D, Girardin S, Zouali H, Lesage S, Chareyre F, Bui T, Giovannini M, Zaehringer U, Penard-Lacronique V, Sansonetti P, Hugot J, Thomas G. Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF 2003 Mar;100(6):3455-3460.

Alexander C, Rietschel E. Bacterial lipopolysaccharides and innate immunity. JOURNAL OF ENDOTOXIN RESEARCH 2001;7(3):167-202.



Book Chapters

Feodorova V, Pan’kina L, Savostina E, Kuznetsov O, Konnov N, Sayapina L, Dentovskaya S, Shaikhutdinova R, Ageev S, Lindner B, Kondakova A, Holst O, Pier G, Knirel Y, Anisimov A, Motin A. A Live Plaque Vaccine Candidate with Improved Safety and Immunogenecity [Internet].  In: Shafferman A, Ordentlich A, Velan B, (Eds): The Challenge of Highly Pathogenic Microorganisms : Mechanisms of Virulence and Novel Medical Countermeasures.  Dordrecht: Springer; 2010 p. 261-268.

Schromm AB, Alexander C, Gutsmann T, Stamme C. Pathogens in Sepsis: Gram-negative Bacterial PAMPs and PRRs.  In: Cavaillon, Jean-Marc (Ed.): Sepsis and non-infectious systemic inflammation : from biology to critical care.  Weinheim: Wiley-VCH; 2009 p. 75-104.

Alexander C, Haylett R, Schromm AB, Zähringer U, Rink L. Pathogens in Sepsis: Gram-positive Bacterial PAMPs, PRRs and Superantigens.  In: Cavaillon, Jean-Marc (Ed.): Sepsis and non-infectious systemic inflammation : from biology to critical care.  Weinheim: Wiley-VCH; 2009 p. 109-144.