Forschungszentrum Borstel
Forschungszentrum Borstel

Priority Research Area Asthma and Allergy

Asthma Exacerbation & Regulation

Techniques

Mouse models of allergic bronchial asthma with its different phenotypes and disease stages are the methodological basis of our research. Currently, models reflecting acute, sub-chronic and chronic allergic asthma phenotypes are available.

Furthermore, we have established mouse models of virus-induced, acute exacerbation of allergic asthma as well as neutrophil asthma. Genetically modified mouse strains (knock-out, transgene, etc.) and different biological (antibodies, siRNA, DNAzymdes, etc.) are applied in order to perform mechanistic studies. Thus, we use a variety of methods to characterize the inflammatory reaction and immune response underlying asthma and its effects on lung structure and physiology. Since the analysis of lung function represents the benchmark criteria for clinical diagnostics as well as for the development and success of new therapeuticals, we put considerable emphasis on this method:

Analyse der Lungenfunktion


Analysis of Lung Structure

 
Analysis of Lung Cell and Molecular Biology