Wissenschaftliche Publikationen 2005

Publikationen 2005

Akkerdaas JH, Schocker F, Vieths S, Versteeg S, Zuidmeer L, Hefle SL, Aalberse RC, Richter K, Ferreira F, van Ree R. Cloning of oleosin, a putative new hazelnut allergen, using a hazelnut cDNA library. Mol Nutr Food Res 2005 (Epub ahead of print).

Amadio A, Romano MI, Bigi F, Etchechoury I, Kubica T, Niemann S, Cataldi A, Caimi K. Identification and characterization of genomic variations between Mycobacterium bovis and M. tuberculosis H37Rv. J Clin Microbiol 2005, 43(5):2481-4.

Andrä J, de Cock H, Garidel P, Howe J, Schromm AB, Brandenburg K. Investigation into the interaction of the phosphoporin PhoE with outer membrane lipids: Physicochemical characterization and biological activity. Medicin Chem 2005; 1:537-546.

Andrä J, Lohner K, Blondelle SE, Jerala R, Moriyon I, Koch MHJ, Garidel P, Brandenburg K. Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem J 2005; 385: 135-143.

Andrä J, Rademann J, Howe J, Koch MHJ, Heine H, Zähringer U, Brandeburg K. Physicochemical characterization and endotoxin-related activity of a rhamnolipid exotoxin from Burkholderia plantarii. Biol Chem. In press.

Anisimov AP, Dentovskaya SV, Titareva GM, Bakhteeva IV, Shaikhutdinova RZ, Balakhonov SV, Lindner B, Kocharova NA, Senchenkova SN, Holst O, Pier GB, Knirel YA. Intraspecies and temperature-dependent variations in susceptibility of Yersinia pestis to the bactericidal action of serum and to polymyxin B. Infect Immun 2005; 73:7324-7331.

Bade S, Baier M, Boetel T, Frey A. Intranasal immunization of balb/c mice against prion protein attenuates orally acquired transmissible spongiform encephalopathy. Vaccine. In press.

Badugu R, Yoo Y, Singh PB, Kellum R. HP1 mutants mimicking hypo- and hyper-phosphorylated isoforms display distinct activities in heterochromatin assembly. Chromosoma 2005; 113(7):370-84.

Becker WM, Schocker R, Boldt A. Allergene der Erdnussstruktur und Charakteristika. Allergologie 2005; 28: 359-66.

Bergeron C, Hauber HP, Gotfried M, Newman K, Dhanda R, Servi RJ et al. Evidence of remodelling in peripheral airways of patients with mild to moderate asthma: effect of hydrofluoroalkane-flunisolide. J Allergy Clin Immunol 2005; 116:983-898.

Bonnet M, Sizaire V, Kebede Y, Janin A, Doshetov D, Mirzoian B, Arzumanian A, Muminov T, Iona E, Rigouts L, Rüsch-Gerdes S, Varaine F. Does one size fit all? Drug resistance and standard treatments: results of six tuberculosis programmes in former Soviet countries. Int J Tuberc Lung Dis 2005; 9:1147-54.

Blumenthal A, Lauber J, Hoffmann R, Ernst M, Keller C, Buer J, Ehlers S, Reiling N. Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics. Infect Immun 2005; 73(6):3330-41.

Boldt A, Fortunato D, Conti A, Petersen A, Ballmer-Weber B, Lepp U, Reese G, Becker WM. Analysis of the composition of an immunoglobulin E reactive high molecular weight protein complex of peanut extract containing Ara h 1 and Ara h 3/4. Proteomics 2005; 5:675-686.

Brandenburg K, David A, Howe J, Koch MHJ, Andrä J, Garidel P. Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide. Biophys J 2005; 88: 1845-1858.

Brandenburg K, Garidel P, Schromm AB, Andrä J, Kramer A, Egmond M, Wiese A. Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes. Eur Biophys J 2005; 34: 28-41.

Braun SG, Meyer A, Holst O, Pühler A, Niehaus K. Characterization of the Xanthomonas campestris pv. campestris lipopolysaccharide substructures essential for elicitation of an oxidative burst in tobacco cells. Mol Plant Microbe Interact 2005; 18:674-681.

Brecker L, Wicklein D, Moll H, Fuchs EC, Becker WM, Petersen A. Structural and immunological properties of arabinogalactan polysaccharides from pollen of timothy grass (Phleum pratense L.). Carbohydr Res 2005; 340:657-63.

Bruhn H, Winkelmann J, Andersen C, Andrä J, Leippe M. Dissection of the mechanisms of cytolytic and antibacterial activity of lysenin, a defence protein of the annelid Eisenia fetida. Dev Comp Immunol. In press.

Bullwinkel J., Baron-Lühr B., Lüdemann A., Wohlenberg C., Gerdes J., Scholzen T. The Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells. J Cell Physiol 2006; 206:624-635.

Busche A, Goldmann T, Naumann U, Steinele A, Brandau S. MICA NK-dependent rejection of experimental human lung cancer by genetic overexpression of MICA. Hum Gene Ther. 2005 Dec 28 [Epub ahead of print ].

Buwitt-Beckmann U, Heine H, Wiesmuller KH, Jung G, Brock R, Akira S, Ulmer AJ. Toll-like receptor 6-independent signaling by diacylated lipopeptides. Eur J Immunol 2005; 35:282-289.

Buwitt-Beckmann U, Heine H, Wiesmüller KH, Jung G, Brock R, Ulmer AJ. Lipopeptide structure determines TLR2 dependent cell activation level. FEBS J 2005; 272:6354-6364.

Casal M, Vaquero M, Rinder H, Tortoli E, Grosset J, Rüsch-Gerdes S, Gutierrez J, Jarlier V. A case-control study for multidrug-resistant tuberculosis: risk factors in four European countries. Microb Drug Resist 2005; 11(1):62-7.

Cox HS, Kubica T, Male R, Doshetov D, Kebede Y, Rüsch-Gerdes S, Niemann S. The Beijing genotype and drug resistant tuberculosis in the Aral Sea region of Central Asia. Resp Res 2005. In press.

Csernok E, MaiXing A, Gross WL, Wicklein D, Petersen A, Lindner B, Lamprecht P, Hellmich B. Wegener’s autoantigen induces maturation of dendritic cells and licences them for Th1 priming via the protease-activated receptor-2 pathway. Blood. In press.

Darcan Y, Petersen A, Becker WM, Galle J, Ernst M, Ahmed J, Seitzer U. Immunoprophylaxis with DNA vaccination inhibits Th2-mediated responses and airway inflammation in mice sensitised with the major timothy grass pollen allergen Phl p 5b. Vaccine 2005; 23:4203-4211.

Darcan Y, Seitzer U, Galle J, Becker WM, Ahmed JS, Petersen A. Allergy prophylaxis by DNA vaccination inhibits specific IgE response and lung pathologic parameters in a mouse model. Allergy Clin Immunol. In press.

De Castro C, Molinaro A, Lanzetta R, Holst O, Parrilli M. The linkage between O-specific caryan and core region in the lipopolysaccharide of Burkholderia caryophylli is furnished by a primer monosaccharide. Carbohydr Res 2005; 340:1802-1807.

Dennison SR, Haubeta T, Dante S, Brandeburg K, Harris F, Phoenix DA. Deuteration can affect the conformational behaviour of amphiphilic alpha-helical structures. Biophys Chem 2005. In press.

Dennison SR, Dante S, Hauss T, Brandeburg K, Harris F, Phoenix DA. Investigations into the membrane interactions of m-calpain domain V. Biophys J 2005; 88:3008-3017.

Diel R, Seidler A, Nienhaus A, Rüsch-Gerdes S, Niemann S. Occupational risk of tuberculosis transmission in a low incidence area. Resp Res 2005, 6:35.

Dmitriev B, Toukach F, Ehlers S. Towards a comprehensive view of the bacterial cell wall. Trends Microbiol 2005; 13:569-574.

Domergue F, Abbadi A, Zähringer U, Moreau H, Heinz E. In vivo-characterisation of the first acyl-CoA Δ6-desaturase from the plant kingdom. Biochem J 2005; 389:483-90.

Droemann D, Albrecht D, Gerdes J, Ulmer AJ, Branscheid D, Vollmer E, Dalhoff K, Zabel P, Goldmann T. Human lung cancer cells express functionally active Toll-like receptor 9. Respir Res 2005; 6(1):1-10.

Droemann D, Goldmann T, Tiedje T, Zabel P, Dalhoff K, Schaaf B. Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients. Respir Res 2005; 6:68.

Droemann D, Rupp J, Goldmann T, Maass M, Vollmer E, Zabel P, Dalhoff K. Pulmonale Infektionen im humanen Lungengewebsmodell. Pneumologie. 2005 Jun;59(6):422-4. German.

Droemann D, Hansen F, Aries SP, Braun J, Zabel P, Dalhoff K, Schaaf B. Neutrophil apoptosis, activation and antiinflammatory cytokine response in G-CSF treated patients with CAP. Respiration. In press.

Drosten C, Muller-Kunert E, Dietrich M, Gerdes J, Schmitz H. Topographic and quantitative display of integrated human immunodeficiency virus-1 provirus DNA in human lymph nodes by real-time polymerase chain reaction. J Mol Diagn 2005; 7(2):219-25.

Ehlers S. Tumor necrosis factor and its blockade in granulomatous infections: differential modes of action of infliximab and etanercept? Clin Infect Dis 2005; 41 S3: S199-203.

Ehlers S. Why does TNF-targeted therapy reactivate tuberculosis? J Rheumatol 2005; 74: 35-39.

Ehlers S, Lehmann J, Mossmann H, Alber G, Hölscher C. Interleukin-12p40 mediates transient protection against Mycobacterium avium infection in the abscence of interleukin-12. Immunbiology 2005; 210:217-227. *GA and CH contributed equally.

Eder W, Klimecki W, Yu L, von Mutius E, Riedler J, Braun-Fahrländer C, Nowak D, Holst O, Martinez FD, the ALEX Study Team. Association between exposure to farming, allergies and genetic variation in CARD4/NOD1. J Allergy Clin Immun 2005. In press.

Fautner GE, Oroudjev E, Schitter G, Golde LS, Thurner PJ, Finch MM, Thurner P, Gutsmann T, Morse DE, Hansma PK. Sacrificial bonds and hidden length: Unraveling molecular mesostructures in tough materials. Biohys J. In press.

Fitzsimmons CM, Schramm G, Jones FM, Chalmers IW, Hoffmann KF, Grevelding CG, Wuhrer M, Hokke CH, Haas H, Doenhoff MJ, Dunne DW. Molecular characterization of omega-1 (ω1); a hepatotoxic ribonuclease from Schistosoma mansoni eggs. Mol Biochem Parasitol 2005; 144:123-127.

Fraysse N, Lindner B, Kaczynski Z, Sharypova L, Holst O, Niehaus K, Poinsot V. Sinorhizobium meliloti strain 1021 produces a low-molecular mass capsular polysaccharide that is a homopolymer of 3-deoxy-D-manno-oct-2-ulosonic acid harbouring a phospholipidic anchor. Glycobiol 2005; 15:101-108.

Gaede KI, Amicosante M, Schurmann M, Fireman E, Saltini C, Muller-Quernheim J. Abstract Function associated transforming growth factor-beta gene polymorphism in chronic beryllium disease. J Mol Med 2005; 83(5):397-405.

Gangloff SC, Zähringer U, Blondin C, Guenounou M, Silver J, Goyert SM. Influence of CD14 on ligand interactions between LPS and its receptor complex. J Immunol 2005; 175:3940-3945.

Garidel P, Rappolt M, Schromm AB, Howe J, Lohner K, Andrä J, Koch MHJ, Brandenburg K. Divalent cations affect chain mobility and aggregate structure of lipopolysaccharides from Salmonella minnesota reflected in a decrease of its biological activity. Biochim. Biophys Acta-Biomembranes 2005; 1715:122-131.

Geiss HK, Feldhues R, Niemann S, Nolte O, Rieker R. Landouzy Septicemia (Sepsis Tuberculosa Acutissima) due to Mycobacterium microti in an immunocompetent man. Infection 2005; 33:393-396.

Gerdes J. Taxing questionb of when ethics go up in smoke. Nature 2005; 438:914.

Gerlach D, Schlott B, Zähringer U, Schmidt KH. N-acetyl-D-galactosamine/N-acetyl-D-glucosamine - recognizing lectin from the snail Cepaea hortensis. Purification, chemical characterization, cloning, and expression in E. coli. FEMS Immunology & Medical Microbiology 2005; 43:223-232.

Göggel R, Uhlig S. The IP3-pathway mediates platelet-activating factor-induced pulmonary edema. Eur Respir J 2005; 25: 849-857.

Goldmann T, Dromann D, Marzouki M, Schimmel U, Debel K, Branscheid D, Zeiser T, Rupp J, Gerdes J, Zabel P, Vollmer E. Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded materials. Pathol Res Pract 2005; 201:599-602.

Gorczynski RM, Alexander C, Bessler W, Fournier K, Hoffmann P, Mach JP, Rietschel ET, Song L, Waelli T, Westphal O, Zähringer U, Khatri I. Analysis of interaction of cloned human and/or sheep fetal hemoglobin gamma-chain and LPS in augmenting induction of inflammatory cytokine production in vivo and in vitro. Immunol Lett. 2005;100:120-129.

Groneberg DA, Poutanen SM, Low DE, Lode H, Welte T, Zabel P. Treatment and vaccines for severe acute respiratory syndrome. Lancet Infect Dis 2005; 5:147-155.

Groneberg DA, Hilgenfeld R, Zabel P. Molecular mechanisms of severe acute respiratory syndrome (SARS). Respir Res 2005; 6:8.

Gronow S, Brabetz W, Lindner B, Brade H. OpsX from Haemophilus influenzae represents a novel type of heptosyltransferase I in lipopolysaccharide biosynthesis. J Bacteriol 2005; 187:6242-6247.

Guo YL, Kurz U, Schultz A, Linder JU, Dittrich D, Keller C, Ehlers S, Sander P, Schultz JE. Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener. Mol Microbiol 2005; 57(3):667-77.

Gutsmann T, Hassenkam T, Cutroni JA, Hansma PK. Sacrificial bonds in polymer brushes from rat tail tendon functioning as nanoscale velcro. Biophys J 2005; 89: 536-542.

Gutsmann T, Hagge SO, David A, Roes S, Bohling A, Hammer MU et al. Lipid-mediated resistance of Gram-negative bacteria against various pore-forming antimicrobial peptides. J endotoxin Res 2005; 11:167-173.

Hamann L, Alexander C, Stamme C, Zähringer U, Schumann RR. Acute-phase concentrations of Lipopolysaccharide (LPS) Binding Protein (LBP) inhibit innate immune cell activation by different LPS chemotypes via different mechanisms. Infect Immun 2005;73:193-200.

Hamann L, Gomma A, Schröder NWJ, Stamme C, Glaeser C, Schulz S, Gross M, Anker SD, Fox K, Schumann RR. A frequent Toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis. J Mol Med 2005; 83:478-485.

Hauber HP, Bergeron C, Tsicopoulos A, Wallaert B, Olivenstein R, Holroyd KJ, Levitt RC, Hamid Q. Increased expression of the calcium-activated chloride channel hCLCA1 in airways of patients with obstructive chronic bronchitis. Can Respir J. 2005;12(3):143-6.

Hauber HP, Tulic MK, Tsicopoulos A, Wallaert B, Olivenstein R, Daigneault P, Hamid Q. Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosis. Can Respir J. 2005; 12(1):13-8.

Hauber HP, Daigneault P, Frenkiel S, Lavigne F, Hung HL, Levitt RC, Hamid Q. Niflumic acid and MSI-2216 reduce TNF-alpha-induced mucin expression in human airway mucosa. J Allergy Clin Immunol. 2005;115(2):266-71.

Hauber HP, Galle J, Chiodini PL. Rupp J, Birke R, Vollmer E, Zabel P, Lange C. Fatal outcome of a hyperinfection syndrome despite successful eradication of stronyloides with subcutaneous ivermectin. Infection 2005; 33:383-386.

Hauer B, Mauch H, Loddenkemper R, Forssbohm M, Fruh J, Loytved G, Magdorf K, Priwitzer M, Rüsch-Gerdes S, Schaberg T. The tuberculosis rapid assay from DiaVita – no alternative to the tuberculin skin test. Pneumologie 2005; 59:681-684.

Hillemann D, Kubica T, Agzamova R, Venera B, Rüsch-Gerdes S, Niemann S. Rifampicin and isoniazid resistance mutations in Mycobacterium tuberculosis strains isolated from patients in Kazakhstan. Int J Tuber Lung Dis 2005, 9:1168-1170

Hillemann D, Kubica T, Rüsch-Gerdes S, Niemann S. Disequilibrium in Distribution of Resistance Mutations among Mycobacterium tuberculosis Beijing and Non-Beijing Strains Isolated from Patients in Germany. Antimicrob Agents Chemother 2005; 49(3):1229-31.

Hillemann D, Weizenegger M, Kubica T, Richter E, Niemann S. Use of the genotype MTBDR assay for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis complex isolates. J Clin Microbiol 2005; 43(8):3699-703.

Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K, Sovath S, Shamel L, Hartung T, Zähringer U, Beutler B. CD36 is a sensor of diacylglycerides. Nature 2005; 433: 523-527.

Hölscher C, Arendse B, Schwegmann A, Myburgh E, Brombacher F. Impairment of alternative macrophage activation delays cutaneous leishmaniasis in non-healing BALB/c mice. J Immunol. In press.

Hölscher C, Hölscher A, Rückerl D, Yoshimoto T, Yoshida H, Mak T, Saris C, Ehlers S. The IL-27 receptor chain WSX-1 differentially regulates atnibacterial immunity and survival during experimental tuberculosis. J Immunol 2005; 174:3534-3544.

Hölzl G, Leipelt M, Ott C, Zähringer U, Lindner B, Warnecke D, Heinz E. Processive lipid galactosyl/glucosyltransferases from Agrobacterium tumefaciens and Mesorhizobium loti display multiple specificities. Glycobiology 2005; 15:874-886.

Hölzl G, Zähringer U, Warnecke D, Heinz E. Glycoengineering of cyanobacterial thylakoid membranes for future studies on the role of glycolipids in photosynthesis. Plant Cell Physiol 2005; 46:1766-1778.

Hubmacher D, Tiedemann K, Bartels R, Brinckmann J, Vollbrandt T, Bätge B, Notbohm H, Reinhardt DP. Modification of the structure and function of fibrillin-1 by homocysteine suggests a potential pathogenic mechanism in homocystinuria. J. Biol. Chem. 2005. In press.

Hübner G, Crone C, Lindner B. Application of sustained off-resonance irradiation infrared multiphoton dissociation tandem mass spectrometry to the analysis of biomolecules. Eur J Mass Spectrom 2005; 11:483-487.

Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, Crackower MA, Fukamizu A, Hui CC, Hein L, Uhlig S, Slutsky A, Jiang C, Penninger JM. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature 2005; 436: 112-116.

Isola D, Pardini M, Varaine F, Niemann S, Rüsch-Gerdes S, Fattorini L, Orefici G, Meacci F, Trappetti C, Rinaldo Oggioni M, Orru G; the LONG-DRUG study group. A pyrosequencing assay for rapid recognition of SNPs in Mycobacterium tuberculosis embB306 region. J Microbiol Methods 2005; 62(1):113-20.

Ito T, Ito N, Saathoff M, Stampachiacchiere B, Bettermann A, Bulfone-Paus S, Takigawa M, Nickoloff BJ, Paus R. Immunology of the human nail apparatus: infantile mail matrix is a site of relative immune priviledge. J Invest Dermatol. In press.

Jacobs T, Andrä J, Gaworski I, Graefe S, Mellenthin K, Krömer M, Halter R, Borlak J, Clos J. Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection. Med Microbiol Immunol 2005; 194:143-149.

Jin J, Zeng H, Schmid KW, Toetsch M, Uhlig S, MöröyT. The zinc finger protein gfi 1 acts upstream of TNF to attenuate endotoxin-mediated inflammatory response in the lung. Eur J Immunol. In press.

Kanse SM, Liang O, Schubert U, Haas H, Preissner KT, Doenhoff MJ, Dennis RD. Characterization and partial purification of Schistosoma mansoni egg-derived pro-angiogenic factor. Mol Biochem Parasitol 2005; 144:76-85.

Kasper B, Brandt E, Ernst M, Petersen F. Neutrophil adhesion to endothelial cells induced by platelet factor 4 (PF-4, CXCL4) requires sequnetial activation of Ras, Syk, and JNK MAP kinases. Blood; prepublished online Novemer 2, 2005; DOI 10.11182/blood-2005-06.2501.

Karagiannidisa C, Hense G, Martin C, Epstein M, Rückert B, Mantel PY, Menz G, Uhlig S, Blaser K, Schmidt-Weber CB. Overlapping functions but differential expression of activin A and TGF-β in asthma. J Allergy Clin Invest. In press.

Kayser K, Kosjerina Z, Goldmann T, Kayser G, Kazmierczak B, Vollmer E. Lung carcinoma-associated atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosa. Lung Cancer J IASLC 2005; 47:205-214.

Kayser K, Kosjerina Z, Goldmann T, Kayser G, Kazmierczak B, Vollmer E. Phenotype and genotype associations of lung carcinoma with atypical adenomatoid hyperplasia, squamous cell dyplasia, and chromosme alterations in non-neoplastic bronchial mucosa. Rom J Morphol Embryol 2005; 46:5-10.

Kespohl S, Sander I, Merget R, Petersen A, Meyer HE, Sickmann A, Bruening T, Raulf-Heimsoth M. Identification of an obeche (Triplochiton scleroxylon) wood allergen as a class I chitinase. Allergy. 2005; 60: 808-14.

Knirel YA, Lindner B, Vinogradov E, Shaikhutdinova RZ, Senchenkova SN, Kocharova NA, Holst O, Pier GB, Anisimov AP. Cold temperature-induced modifications to the composition and structure of the lipopolysaccharide of Yersinia pestis. Carbohydr Res 2005; 340:1625-1630.

Knirel YA, Lindner B, Vinogradov EV, Kocharova NA, Senchenkova SN, Shaikhutdinova RZ, Dentovskaya SV, Fursova NK, Bakhteeva IV, Titareva GM, Balakhonov SV, Holst O, Gremyakova TA, Pier GB, Anisimov AP. Temperature.dependent variations and intraspecies diversity of the structure of the lipopolysaccharide of Yersinia pestis. Biochemistry 2005; 44:1731-1743.

Komarova B, Tsvetkov YE, KNirel YA, Zähringer U, Pier GB, Nifantiev NE. Synthesis of a common trisaccharide fragment of glycoforms of the outer core region of the Pseudomonas aeruginosa lipopolysacchariode. Highly stereoselective α-glucosylation assisted by remote participation. Tetrahedron Lett. In press.

Kondakov A, Lindnder B. Structural characterization of complex bacterial glycolipids by Fourier transform mass spectrometry. Eur J Mass Spectrom 2005; 11:535-546.

Kondakova AN, Vinogradov EV, Knirel YA, Lindner B. Application of electrospray ionization with Fourier transform ion cyclotron resonance mass spectrometry for structural screening of core oligosaccharides from lipopolysaccharides of the bacteria Proteus. Rapid Commun Mass Spectrom 2005; 19:2343-2349.

Kourmouli N, Sun Y, van der Sar S, Singh PB, Brown JP. Epigenetic regulation of mammalian pericentric heterochromatin in vivo by HP1. BBRC 2005; 337:901-907.

Kubica T, Agzamova R, Wright A, Aziz MA, Rakishev G, Bismilda V, Richter E, Rüsch-Gerdes S, Niemann S. The Beijing genotype is a major cause of drug resistant tuberculosis in Kazakhstan. Int J Tuber Lung Dis 2005; 9:646-653.

Kuperman DA, Huang X, Nguyenvu L, Hölscher C, Brombacher F, Erle DJ. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol 2005; 175:3746-3752.

Lange C, Schuett M, Brodt HR. Neue Krankheitsbilder durch pneumotrope Viren. Dtsch Med Wochenschr 2005; 130:1385-91.

Lehmann K, Schweimer K, Reese G, Randow S, Suhr M, Becker WM, Vieths S, Rosch P. Structure and stability of 2S albumin type peanut allergens: implications for the severity of peanut allergic reactions. Biochem J 2005; doi:10.1042/BJ20051728.

Lindner K, Uhlig U, Uhlig S. Ceramide alters endothelial cell permeability by a non-apoptotic mechanism. Brit J Pharmacol 2005; 145: 132-140.

Liu K, Xia Z, Zhang Z, Wen Y, Wang D, Brandenburg K, Harris F, Phoenix D. Interaction between the movement protein of barley yellow dwarf virus and the cell nuclear envelope: role of a putative amphiphilic [alpha]-helix at the N-terminus of the movement protein. Biopolymers 2005; 79:86-96.

Liu Y, Walter S, Stagi M, Cherny D, Letiembre M, Schulz-Schaeffer W, Heine H, Penke B, Neumann H, Fassbender K. LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide. Brain 2005; 128:1778-1789.

Loeschke S, Goldmann T, Vollmer E. Improved detection of mycobacterial DNA by PCR in formalin-fixed, paraffin-embedded tissues using thin sections. Pathol Res Pract 2005; 201:37-40.

Malathi K, Paranjapee J, Bulanova E, Shim M, Guenther JM, Faber PW, Eling TE, Williams BRG, Silverman RH. 2'-5'-Oligoadenylates initiate a unique transcriptional signaling pathway mediated by RNase L. Proc. Natl. Acad. Sci. USA. In press.

Manterola L, Moriyon I., Moreno E, Sola-Landa A, Weiss DS, Koch MHJ, Howe J, Brandenburg K, Lopez-Goni I. The lipopolysaccharide of Brucella abortus BvrS/BvrR mutants contains lipid A modifications and has higher affinity for bactericidal cationic peptides. J Bacteriol 2005; 187:5631-5639.

Manukyan M, Triantafilou K, Triantafilou M, Mackie A, Nilsen N, Espevik T, Wiesmuller KH, Ulmer AJ, Heine H. Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1. Eur J Immunol 2005; 35:911-921.

Milkereit G, Gerber S, Brandeburg K, Morr M, Vill V. Synthesis and mesomorphic properties of glycosyl dialkyl- and diacyl-glycerols bearing saturated, unsaturated and methyl branched fatty acid and fatty alcohol chains. Part I. Synthesis Chem Phys Lipids 21005; 135:1-14.

Milkereit G, Brandenburg K, Gerber S, Koch MHJ, Morr M, Andrä J, Seydel U, Vill V. Synthesis and mesomorphic properties of glycosyl dialkyl- and diacyl-glycerols bearing saturated, unsaturated and methyl branched fatty acid and fatty alcohol chains Part II. Mesomorphic properties. Chem Phys Lipids 2005; 135:15-26.

Mittag D, Vieths S, Vogel L, Wagner-Loew D, Starke A, Hunziker P, Becker WM, Ballmer-Weber BK. Birch pollen-related food allergy to legumes: identification and characterization of the Bet v 1 homologue in mungbean (Vigna radiata), Vig r 1. Clin Exp Allergy 2005.;35:1049-55.

Mueller-Loennies S, Di Padova F, Brade L, Brade H, Rietschel ET. Anti-endotoxin antibodies. A cross-reactive and cross-protective monoclonal antibody against a conserved epitope of Escherichia coli and Salmonella enterica. Intensivmed 2005; 42, 27-38.

Mueller-Loennies S, Gronow S, Brade L, Meckenzie R, Kosma P, Brade H. Monoclonal antibody against a carbohydrate epitope in lipopolysaccharide differentiates Chlamydophila psittaci from Chlamydophila percorum, Chlamydophila pneumoniae and Chlamydia trachomatis. Glycobiology Nov 2005 [Epub ahead of print].

Müller M, Brandenburg K, Dedrick R, Schromm AB, Seydel U. Phospholipids inhibit lipopolysaccharide (LPS) induced cell activation: a role for LPS-binding protein. J Immunol 2005; 174: 1091-1096.

Müller M, Lindner B, Dedrick R, Schromm AB, Seydel U. Endotoxin: Physical requirements for cell activation. J Endotox Res 2005; 11:299-303.

Müller M, Lindner B, Kusumoto S, Fukase K, Schromm AB, Seydel U. Aggregates are the biologically active unit of endotoxin. J Biol Chem 2005; 279:26307-26313.

Müller S, Hoffmann O, von der Esche U, Mach JP, Gorczynski RM, Waelli T, Alexander C, Zähringer U, Rietschel Eth, Bessler WG, Westphal O. A fetal sheep liver extract acts as a leukocyte activator in cells of LPS responder and non responder mice. Int J Immunopharmaco 2005; 5:1809-1819.

Nandy A, Petersen A, Wald M, Suck R, Kahlert H, Weber B, Becker WM, Cromwell O, Fiebig H. Primary structure, recombinant expression, and molecular characterization of Phl p 4, a major allergen of timothy grass (Phleum pratense). Biochem Biophys Res Commun. 2005; 337: 563-570.

Orinska Z, Bulanova E, Budagian V, Metz M, Maurer M, Bulfone-Paus S. TLR3-induced activation of mast cells modulates CD8+ T cell-recruitment. Blood; 2005 106:978-987.

Pardini M, Iona E, Varaine F, Karkozian H, Arzumanian H, Brunori L, Orefici G, the Long Study Group (Niemann S, Rüsch-Gerdes S), Fattorini L. Mycobacterium tuberculosis drug resistance, Abkhazia. Emerg Infect Dis 2005; 3:501-503.

Pechkovsky DV, Goldmann T, Ludwig C, Prasse A, Vollmer E, Müller-Quernheim J, Zissel G. CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II. Resp Res. In press.

Pechkovsky D, Goldmann T, Vollmer E, Müller-Quernheim J, Zissel G. Interleukin-18 expression by alveolar epithelial cells type II in tuberculosis and sarcoidosis. FEMS Immunology & Medical Microbiology. In press.

Petersen A, Suck R, Lindner B, Georgieva D, Ernst M, Notbohm H, Wicklein D, Cromwell O, Becker WM. Phl p 3: Structural and immunological characterization of a major allergen of timothy grass pollen. Clin Exp Allergy. In press.

Prodinger WM, Brandstätter A, Naumann L, Pacciarini M, Kubica T, Boschiroli ML, Aranaz A, Nagy G, Cvetnic Z, Ocepek M, Skrypnyk A, Erler W, Niemann S, Pavlik I, Moser I. Characterization of Mycobacterium caprae isolates from Europe by mycobacterial interspersed repetitive unit genotyping. J Clin Microbiol 2005; 43: 4984-4992.

Raevsky O, Andreeva E, Raevskaja O, Skvortsov V, Schaper KJ. QSPR analysis of the partitioning of vaporous chemicals in a water-gas phase system and the water solubility of liquid and solid chemicals on the basis of fragment and physicochemical similarity and HYBOT descriptors. SAR and QSAR Environ Res 2005; 16:191-202.

Roes S, Mumm F, Seydel U, Gutsmann T. Localization of the lipopolysaccharides-binding protein (LBP) in phospholipid membranes by an atomic force microscope. J Biol Chem 2005. In press. Roes S, Seydel U, Gutsmann T. Probing the properties of lipopolysaccharide monolayers and their interaction with the antimicrobial peptide polymyxin B by atomic force microscopy. Langmuir 2005; 19: 6970-6978.

Rückert R, Brandt K, Braun A, Hoymann HG, Herz U, Budagian V, Durkop H, Renz H, Bulfone-Paus S. Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo. J Immunol 2005; 174:5507-15.

Rupp J, Koch M, Van Zandbergen G, Solbach W, Brandt E, Maass M. Transmission of Chlamydia pneumoniae infection from blood monocytes to vascular cells in a novel transendothelial migration model. FEMS Microbiol Lett 2005; 242:203-208.

Rupp R, Hellwig-Burgel T, Wobbe V, Seitzer U, Brandt E, Maass M. Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo. Proc Nat Acad Sci 2005; 102:3447-3452.

Salih DE, Ahmed JS, Bakheit MA, Ali EB, Hussein AM, Hassan SM, Shariff OE, Fadl M, Jongejan F. Validation of the indirect TaSP enzyme-linked immunosorbent assay for diagnosis of Theileria annulata infection in cattle. Parasitol Res. 2005; 97:302-308.

Schaaf B, Rupp J, Muller-Steinhardt M, Kruse J, Boehmke F, Maass M et al. The interleukin-6 -174 promoter polymorphism is associated with extrapulmonary bacterial dissemination in Streptococcus pneumoniae infection. Cytokine 2005; 31:324-328.

Schaper KJ, Schubert S, Dalhoff A. Kinetics and quantification of antibacterial effects of beta-lactams, macrolides and quinolones against gram-positive and gram-negative RTI pathogens. Infection. In press.

Scheller J, Schuster B, Hölscher C, Yoshimoto T, Rose-John S. No inhibition of IL-27 signaling by soluble gp130. Biochem Biophys Res Commun 2005; 326:724-728.

Schewe C, Goldmann T, GrosserM, Zink A, Pahl S, Nerlich A, Baretton G, Dietel M, Vollmer E, Petersen I. Inter-laboratory validation of PCR-based detection of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissues. Virchows Arch 2005; 447:573-585.

Schiemann F, Grimm TA, Hoch J, Gross R, Petersen F, Lindner B, Bulfone-Paus S, Brandt E. Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are suject to counter-regulation by PF-4 through inhibition of chymase and cathepsin G. Blood; prepublished online November 29, 2005; DOI 10.1182/blood-2005-06-2424.

Schramm G, Gronow A, Knobloch J, Wippersteg V, Grevelding CG, HGalle J et al. IPSE/alpha-1: a major immunogenic component secreted from Schistosoma mansoni eggs. Mol Biochem Parasitol 2006. In press.

Schröder-Borm H, Bakalova R, Andrä J. The NK-lysin derived peptide NK-2 preferentially kills cancer cells with increased surface levels of negatively charged phosphatidylserine. FEBS Lett 2005; 579:6128-6134.

Seitzer U, Bussler H, Kullmann B, Petersen A, Becker W-M, Ahmed JS. Mouse strain specificity of the IgE response to the major allergens of Phleum pratense. Int Arch All Immunol 2005; 136:347-355.

Seydel U. Editorial. J Endoxin Res 2005; 11:131.

Seydel U. Editorial. J Endoxin Res 2005; 11:323.

Seydel U, Schromm AB, Brade L, Gronow S, Andrae J, Muller M, Koch MH, Fukase K, Kataoka M, Hashimoto M, Kusumoto S, Brandenburg K. Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity. FEBS J 2005; 272:327-340.

Stöcker M, Klockenbring T, Huhn M, Nachreiner T, Wicklein D, Petersen A, Bauer R, Görlich R, Fischer R, Barth S. Antigen-specific targeting and elimination of EBV-transformed B cells by allergen toxins. J Allergy Clin Immunol. 2005; 116:910-915.

Thon L, Möhlig H, Mathieu S, Lange A, Bulanova E, Schütze S, Bulfone-Paus S, Adam D. Ceramide mediates caspase-independent programmed cell death. FASEB J 2005; 19:1945-1956.

Valentonyte R, Hampe J, Huse K, Rosenstiel P, Albrecht M, Stenzel A, Nagy M, Gaede KI, Franke A, Haesler R, Koch A, Lengauer T, Seegert D, Reiling N, Ehlers S, Schwinger E, Platzer M, Krawczak M, Muller-Quernheim J, Schurmann M, Schreiber S. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet 2005; 37(4):357-64.

Vermi W, Facchetti F, Riboldi E, Heine H, Scutera S, Stornello S, Ravarino D, Cappello P, Giovarelli M, Badolato R, Zucca M, Gentili F, Chilosi M, Doglioni C, Negro PA, Sozzani S, Musso T. Role of dendritic cell-derived CXCL13 in the pathogenesis of Bartonella henselae B-rich granuloma. Blood 2005. [Epub ahead of print].

Vinogradov EV, Brade L, Brade H, Holst O. The structure of the O-specific polysaccharide of the lipopolysaccharide from Acinetobacter strain 44 (DNA group 3). Pol J Chem 2005; 79:267-273.

Visser L, Jan de Heer H, Boven LA, van Riel D, van Meurs M, Melief MJ, Zähringer U, van Strijp J, Lambrecht BN, Nieuwenhuis EE, Laman JD. Pro-inflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease. J Immunol 2005; 174:808-816.

Wallis RW, Ehlers S. TNF and granuloma biology: Explaining the differential infection risk to etanercept and infliximab. Sem Arthritis Rheum 2005; 34 S11: 34-38.

Willumeit R, Kumpugdee M, Funari SS, Lohner K, Navas BP, Brandenburg K, Linser S, Andrä J. Structural rearrangement of model membranes by the peptide antibiotic NK-2. Biochim Biophys Acta 2005; 1669:125-134.

Wrigge H, Uhlig U, Baumgarten G, Menzenbach J, Zinserling J, Ernst M, Drömann D, Welz A, Uhlig S, Putensen C. Mechanical ventilation strategies and inflammatory responses to cardiac surgery: a prospective randomized clinical trial. Intens Care Med 2005; 31:1379-87.

Wu R, Terry A, Singh PB, Gilbert DM. Subnuclear localisation and replication timing of methyl K9 epitopes. Mol Biol Cell. In press.

Yamane M, Liu M, Kaneda H, Uhlig S, Waddell TK, Keshavjee S. Reperfusion-induced gene expression profiles in rat lung transplantation. Am J Tansplant 2005; 5: 2160-2169.

Yamazaki V, Sirenko O, Schafer RJ, Nguyen L, Gutsmann T, Brade L, Groves JT. Cell membrane array fabrication and assay technology. BMC Biotechnol 2005; 5:18.

zur Stadt U, Schmidt S, Kasper B, Beutel K, Diler AS, Henter JI et al. Linkage of familial hemophagoctic lymphohistiocytosis (FHL) type-4 to chromosme 6q24 and identification of mutations in syntaxin 11. Hum Mol Genet 2005; 14:827-834.

Buch- und Übersichtsartikel

Becker WM, Klimek L. Inhalationsallergene. In: Allergologie-Handbuch, Grundlagen und klinische Praxis. Saloga J, KlimekL, Bugl R, Mann W, Knop J, Hrsg., Schattauer Verlag, Stuttgart 2005, pp112-127.

Becker WM, Schocker F, Boldt A. Allergene der Erdnuss: Struktur und Charakteristika. Allergologie 2005; 28:359-366.

Brandau S, Böhle A. Mode of action of BCG and rationale for combination immunotherapy. In: Bladder Cancer, Lerner S, Schoenberg MP, Sternberged CN, eds., Taylor & Francis. 2005; pp 359-366.

Brandenburg K, Garidel P, Howe J, Andrä J, Hawkins L, Koch MHJ, Seydel U. What can calorimetry tell us about changes of three-dimensional aggregate structures of phospho-and glycolipids? Thermochim Acta 2005. In press.

Dmitriev BA, Toukach PV, Ehlers S. Towards a comprehensive view of the bacterial cell wall. Trends Microbiol 2005. In press

Ehlers S, Bulfone-Paus S. Pathogens: Innate immune responses. In: Encyclopedia of Molecular Cell Biology and Molecular Medicine/, Wiley VCH Verlag, Weinheim. In press.

Ehlers S, Hölscher C. DTH-associated pathology. In Topley & Wilson´s Microbiology and Microbial Infections: Immunology, Vol. 10. S. H. E. Kaufmann and M. Steward, eds. Arnold Publishers, London, pp 705-730.

Frey A, Bade S, Petersen A. Protein-Blotting und Nachweis Membran-gebundener Proteine. In: Gentechnische Methoden: eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor, 4th ed. Schrimpf G, Hrsg., Elsevier-Spektrum Akademischer Verlag, Heidelberg. Germany. In press.

Gorris HH, Bade S, Frey A. Peptidarrays auf Cellulosemembranen. In: Gentechnische Methoden: eine Sammlung von Arbeitsanleitungen für das molekularbiologische Labor, 4th ed. Schrimpf G, Hrsg., Elsevier-Spektrum Akademischer Verlag, Heidelberg. Germany. In press.

Hamacher J, Heyder S, Lucas R, Schramm R, Sybrecht GW, Uhlig S. Brochoalveoläre Lavage beim Nager. Pneumologie 2005; 59:486-490.

Heine H, Ulmer AJ. Recognition of bacterial products by toll-like receptors. Chem Immunol Allergy 2005; 86:99-119.

Helfmann J, Bindig U, Meckelein B, Wehry K, Röckendorf N, Schädel D, Bürger M, Frey A. Early diagnosis of cancer. In: Biophotonics: Throwing a new light on life science. J. Popp, Hrsg., Wiley-VCH, Weinheim. In press.

Hölscher C. Targeting IL-23 in autoimmunity. Curr Opin Investig Drugs 2005; 6:489-495.

Klimek L, Becker WM. Inhalationsallergene: Vorkommen und klinische Bedeutung In: Allergologie-Handbuch, Grundlagen und klinische Praxis. Saloga J, KlimekL, Bugl R, Mann W, Knop J, Hrsg., Schattauer Verlag, Stuttgart 2005, pp127-141.

Lange C, Lederman MM. Infections Involving Bones and Joints. In: Cecil´s Essentials of medicine 7th (Eds. Andreoli TE, Carpenter CJ, Loscalzo J, Groggs RC) Elsevier. In press.

Lange C, Lederman MM. Infections of the Head and Neck. In: Cecil´s Essentials of medicine 7th (Eds. Andreoli TE, Carpenter CJ, Loscalzo J, Groggs RC) Elsevier. In press.

Lange C, Lederman MM. Infections of the Lower Respiratory Tract. In: Cecil´s Essentials of medicine 7th (Eds. Andreoli TE, Carpenter CJ, Loscalzo J, Groggs RC) Elsevier. In press.

Lange C, Lederman MM. Infections of the Urinary Tract. In: Cecil´s Essentials of medicine 7th (Eds. Andreoli TE, Carpenter CJ, Loscalzo J, Groggs RC) Elsevier. In press.

Lange C, Lederman MM. Infectious Diarrhea. In: Cecil´s Essentials of medicine 7th (Eds. Andreoli TE, Carpenter CJ, Loscalzo J, Groggs RC) Elsevier. In press.

Lange C, Lederman MM. Intra-Abdominal Abscess and Peritonitis. In: Cecil´s Essentials of medicine 7th (Eds. Andreoli TE, Carpenter CJ, Loscalzo J, Groggs RC) Elsevier. In press.

Lange C, Lederman MM. Skin and Soft Tissue Infections. In: Cecil´s Essentials of medicine 7th (Eds. Andreoli TE, Carpenter CJ, Loscalzo J, Groggs RC) Elsevier. In press.

Lange CG, Schieferstein C, Toossi Z. Tuberculosis. In: HIVMEDICINE 2005 (eds. Hoffmann C, Kamps BS) Steinhäuser Verlag Wuppertal.

Lange C. Bakteriell verursachte Exazerbation chronisch obstruktiver Lungenerkrankungen (COPD). Der Pneumologe 2005; 2:123-124.

Reese G, Vieths S, Becker WM. Gentechnik und Lebensmittelallergie. In GSF ‘Umwelt und Gesundheit’ 2005; 17:55.

Schieferstein C, Lange CG. Tuberkulose. In: HIV.NET 2005 (eds. Hoffmann C, Kamps BS) Steinhäuser Verlag Wuppertal.

Uhlig S, Göggel R, Engel S. Mechanisms of PAF-mediated responses in the lung. Pharmacol Reports 2005. In press.

Uhlig S, Held HD. Isolated perfused lung. In: van Schil P, ed. Lung metastases and isolated lung perfusion, Nova Science Publishers, Inc. In press.

Uhlig S. Who tidies up the lung? Ask Cox-2 and Nrf2. Am J Respir Crit Care Med 2005; 171:1198-1999.

Wallis RS, Ehlers S. Tumor necrosis factor and granuloma biology: explaining the differential infection risk of etanercept and infliximab. Semin Arthritis Rheum 2005; 34(5 Suppl1):34-8.

Zabel P. Endotoxinbindende Proteine, Antiendotoxinantikörper. In: Sepsis and MODS, 4. Aufl. Werdan K, Schuster HP, Müller-Werdan U, Hrsg, Springer Verlag, Berlin-Heidelberg-New York, 2005; pp 189-205.pdf