Klinisches Studienzentrum

Mission    Projekte    Methoden    Publikationen    Mitarbeiter/innen 



Herzmann, C, Ernst, M, Lange, C, Stenger, S, Kaufmann, SHE, Reiling, N, Schaberg, T, van der Merwe, L, Maertzdorf, J & Tb or not Tb consortium 2017, 'Pulmonary immune responses to Mycobacterium tuberculosis in exposed individuals' PLOS ONE, Bd 12, Nr. 11, S. e0187882. DOI: 10.1371/journal.pone.0187882

Bahmer, T, Waschki, B, Schatz, F, Herzmann, C, Zabel, P, Kirsten, A-M, Rabe, KF, Watz, H & ERA-Study Group 2017, 'Physical activity, airway resistance and small airway dysfunction in severe asthma' The European respiratory journal, Bd 49, Nr. 1, S. pii 1601827. DOI: 10.1183/13993003.01827-2016

Herzmann, C, Golakov, M, Malekzada, F, Lonnroth, K & Kranzer, K 2017, 'Radiological screening of refugees in Germany' The European respiratory journal, Bd 49, Nr. 5. DOI: 10.1183/13993003.02487-2016

Labugger, I, Heyckendorf, J, Dees, S, Häussinger, E, Herzmann, C, Kohl, TA, Richter, E, Rivera-Milla, E & Lange, C 2017, 'Detection of transrenal DNA for the diagnosis of pulmonary tuberculosis and treatment monitoring' INFECTION, Bd 45, Nr. 3, S. 269-276. DOI: 10.1007/s15010-016-0955-2

Nakiwala, D, Kellgren, L, Herzmann, C, Olaru, ID, Brown, M, Ferrand, RA, Khan, P & Kranzer, K 2017, 'Language discordance between tuberculosis patients and healthcare providers challenging universal access' The European respiratory journal, Bd 49, Nr. 4. DOI: 10.1183/13993003.00116-2017

Silkoff, PE, Flavin, S, Gordon, R, Loza, MJ, Sterk, PJ, Lutter, R, Diamant, Z, Turner, RB, Lipworth, BJ, Proud, D, Singh, D, Eich, A, Backer, V, Gern, JE, Herzmann, C, Halperin, SA, Mensinga, TT, Del Vecchio, AM, Branigan, P, San Mateo, L, Baribaud, F, Barnathan, ES & Johnston, SL 2017, 'TLR3 Blockade in Rhinovirus-Induced Experimental Asthma Exacerbations: A Randomized Controlled Study' The Journal of allergy and clinical immunology. DOI: 10.1016/j.jaci.2017.06.027




Busch, M, Herzmann, C, Kallert, S, Zimmermann, A, Höfer, C, Mayer, D, Zenk, SF, Muche, R, Lange, C, Bloom, BR, Modlin, RL, Stenger, S & TBornotTB Network 2016, 'Lipoarabinomannan-responsive Polycytotoxic T Cells are Associated With Protection in Human Tuberculosis' American journal of respiratory and critical care medicine, Bd 194, Nr. 3, S. 345-55. DOI: 10.1164/rccm.201509-1746OC

Herzmann, C, Sotgiu, G, Bellinger, O, Diel, R, Gerdes, S, Goetsch, U, Heykes-Uden, H, Schaberg, T, Lange, C & TB or not TB consortium 2016, 'Risk for latent and active tuberculosis in Germany' INFECTION. DOI: 10.1007/s15010-016-0963-2

Salzer, HJF, Wassilew, N, Köhler, N, Olaru, ID, Günther, G, Herzmann, C, Kalsdorf, B, Sanchez-Carballo, P, Terhalle, E, Rolling, T, Lange, C & Heyckendorf, J 2016, 'Personalized Medicine for Chronic Respiratory Infectious Diseases: Tuberculosis, Nontuberculous Mycobacterial Pulmonary Diseases, and Chronic Pulmonary Aspergillosis' RESPIRATION, Bd 92, Nr. 4, S. 199-214. DOI: 10.1159/000449037



Herzmann C, Sotgiu G, Schaberg T, Ernst M, Stenger S, Lange C; TB or not TB Consortium. Childhood BCG vaccination does not influence control of Mycobacterium tuberculosis growth by human bronchoalveolar lavage cells. TUBERCULOSIS (Edinb). 2015 May;95(3):321-7. doi: 10.1016/ Epub 2015 Feb 28.



Herzmann, C, Sotgiu, G, Schaberg, T, Ernst, M, Stenger, S, Lange, C & Consortium for the German TB or Not TB9 2014, 'Early BCG vaccination is unrelated to pulmonary immunity against Mycobacterium tuberculosis in adults' The European respiratory journal., 10.1183/09031936.00086514



Reiling N, Homolka S, Walter K, Brandenburg J, Niwinski L, Ernst M, Herzmann C, Lange C, Diel R, Ehlers S, Niemann S. Clade-specific virulence patterns of Mycobacterium tuberculosis complex strains in human primary macrophages and aerogenically infected mice. MBio. 2013 Jul 30;4(4). pii: e00250-13. doi: 10.1128/mBio.00250-13.



Herzmann C, Lange C, Schaberg T, Ernst M, Ehlers S; for The TB or Not TB Consortium. Immunological Evidence of Incipient Pulmonary Tuberculosis. J Infect Dis. 2012 Nov;206(10):1630-1631. Epub 2012 Sep 10

Günther G, Heyckendorf J, Herzmann C, Lange C. [Tuberculosis]. Dtsch Med Wochenschr. 2012 May;137(18):947-58; quiz 959-62. Epub 2012 Apr 26. Review.

Heyckendorf J, Kalsdorf B, Herzmann C, Günther G, Lange C, Tuberkulose – State of the Art. Kompendium Pneumologie 2012(1) 1, Georg Thieme Verlag KG

Günther G, Heyckendorf J, Herzmann C, Lange C. Tuberculosis. Dtsch Med Wochenschr. 2012 May;137(18):947-62. Epub 2012 Apr 26.

Herzmann C, Ernst M, Ehlers S, Stenger S, Maertzdorf J, Sotgiu G, Lange C. Increased frequencies of pulmonary Treg cells in latent M. tuberculosis infection. Eur Respir J. 2012 Mar 22.



Lange C, Herzmann C, Migliori GB, Gori A. Tuberculosis. p354-69 In: Hoffmann C, Rockstroh J. HIV Book 2011. Medizin Fokus Verlag, Hamburg. ISBN 978-3-941727-08-3

Herzmann C, Lange C, Stenger S, Maertzdorf J, Schaberg T, Sotgiu G, Ernst M. Latent tuberculosis infection is associated with an increased frequency of Treg cells in the bronchoalveolar lavage. Europ Respir Soc, Ann Congress 2011, Sep 24-28, Amsterdam, Poster 1809

Lange C, Herzmann C, Tuberkulose. P350-62. In: Hoffmann C, Rochstroh J. HIV Buch 2011. Medizin Fokus Verlag, Hamburg. ISBN-13: 978-3-941727-03-8

Herzmann C, Esser S, Lange C. Infections with non-tuberculous mycobacteria in HIV-infected patients. Hautarzt. 2011 Apr;62(4):272-9



Herzmann C, Smith C, Johnson MA, Byrne P, Terenghi G, et al. A Prospective, Double Blind, Randomised, Placebo Controlled Trial Evaluating Acetyl-L-Carnitine (ALCAR) for the Prevention of Distal Symmetric Polyneuropathy in HIV Infected Individuals. J AIDS Clinic Res 2010; 1:108. doi:10.4172/2155-6113.1000108

Herzmann C., Lange C. Infections with non-tuberculous mycobacteria and HIV. Dtsch Med Wochenschr. 2010 Jun;135(23):1192-7. Epub 2010 May 31.



Herzmann C., Arastéh K., Efavirenz induced osteomalacia. AIDS. 2009 Jan 14;23(2):274-5



Herzmann C., Jansen V. and Lichey J.. Bronchial cast formation associated with loss of immunoglobulin and calcium. Thorax, Aug 2008; 63: 754.

Herzmann C., Cuthbertson Z., Fosdick L., Fisher M., Nelson M., Perry N., Law M., Wand H., Janossy G., Johnson M.A., Youle M. Long-term clinical and surrogate marker effects of subcutaneous intermittent interleukin-2 without antiretroviral therapy in HIV-infected patients. J Antimicrob Chemother. 2008 Jun 27

Herzmann C., Whiting S.J., Thomas M., Byrne P., Johnson M.A., Youle M. Pharmacokinetics of Acetyl-L-Carnitine Given in Single or Multiple Doses to HIV-1 Infected Patients with Toxic Peripheral Polyneuropathy. The Open AIDS J 2008;2:39-42(4)



Stocker H., Herzmann C., Breske A., Kruse G., Berger M., Schulbin H., Hill A., Steinmüller J., Becker M., Arastéh K., Kurowski M., Saquinavir, Nelfinavir and M8 pharmacokinetics following Ritonavir and Nelfinavir administration. J Antimicrob Chemother. 2007 Mar;59(3):560-4



Youle M., Emery S., Fisher M., Nelson M., Fosdick L., Janossy G., Loveday C., Sullivan A., Herzmann C., et al., A randomised trial of subcutaneous intermittent interleukin-2 without antiretroviral therapy in HIV-infected patients: The UK-Vanguard study. PLoS Clin Trials 1(1): e3. DOI: 10. 1371/journal.pctr.0010003, 2006 May

Stocker H, Kloft C, Plock N, Breske A, Kruse G, Herzmann C, Schulbin H, Kreckel P, Weber C, Goebel F, Roeling J, Staszewski S, Plettenberg A, Moecklinghoff C, Arasteh K, Kurowski M. Pharmacokinetics of enfuvirtide in patients treated in typical routine clinical settings. Antimicrob Agents Chemother. 2006 Feb;50(2):667-73.



Herzmann C, Johnson MA, Youle M, Long-term effect of acetyl-L-carnitine for antiretroviral toxic neuropathy. HIV Clinical Trials 2005 Nov/Dec; 6(6): 344-350

Herzmann C, Kinloch S, Johnson MA (2005) Rash in an HIV-positive patient. HIV Medicine 2005 Nov; 6(6): 379

Herzmann C, Arastèh K, Murphy RL, Schulbin H, Kreckel P, Drauz D, Schinazi RF,  Beard A, Cartee L, Otto MJ. Safety, Pharmacokinetics and Efficacy of Racivir with Efavirenz and Stavudine in antiretroviral-naïve HIV-infected patients (AAC00901-04) Antimicrob Agents Chemother. 2005 Jul;49(7): 2828-33



Stocker, H., Kruse, G., Kreckel, P., Herzmann, C., Arasteh, K., Claus, J., Jessen, H., Cordes, C., Hintsche, B., Schlote, F., Schneider, L., Kurowski, M., (2004) Nevirapine significantly reduces the levels of racemic methadone and (R)-methadone in human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 2004 Nov;48(11):4148-53

Herzmann, C., Karcher, H., (2004) Nevirapine plus zidovudine to prevent mother-to-child transmission of HIV (Correspondence). N Engl J Med. 351(19):2013-5
Stocker, H., Kruse, G., Arastéh, A., Breske, A., Herzmann, C., Izbicki, D., Möcklinghoff, C., Hill, A., Kurowski, M., (2004) Pharmacokinetic interaction between Saquinavir/r and Nelfinavir in HIV-infected patients. (Poster 2058 at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy, ICAAC, Washington DC)



Stocker, H., Kruse, G., Kreckel, P., Herzmann, C., Arastéh, K., Eskoetter, H., Claus, J., Jessen, H., Cordes, C., Hintsche, B., Schlote, F., Schneider, L., Kurowski, M. (2003) Nevirapine (NVP) significantly reduces methadone levels in HIV infected patients. (Poster for the  2nd International AIDS-Society Conference on HIV Pathogenesis and Treatment, Paris)



Herzmann, C., (2002) Interferon assay compared to tuberculin skin testing for latent tuberculosis detection. (Correspondence). JAMA. 2002 Jan 23-30; 287(4): 451-2.