Programmbereich Infektionen

Zelluläre Mikrobiologie

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen



Kos, O, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Khatri, I, Mach, JP, Rietschel, ET, Tersikh, A, Ulmer, AJ, Waelli, T, Yu, K, Zähringer, U & Gorczynski, RM 2018, 'Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis' INTERNATIONAL IMMUNOPHARMACOLOGY , Bd 57, S. 112-120. DOI: 10.1016/j.intimp.2018.02.010

Binsker, U, Palankar, R, Wesche, J, Kohler, TP, Prucha, J, Burchhardt, G, Rohde, M, Schmidt, F, Bröker, BM, Mamat, U, Pané-Farré, J, Graf, A, Ebner, P, Greinacher, A & Hammerschmidt, S 2018, 'Secreted Immunomodulatory Proteins of Staphylococcus aureus Activate Platelets and Induce Platelet Aggregation' Thrombosis and Haemostasis, Bd 118, Nr. 4, S. 745-757. DOI: 10.1055/s-0038-1637735

Malm, S, Maaß, S, Schaible, UE, Ehlers, S & Niemann, S 2018, 'In vivo virulence of Mycobacterium tuberculosis depends on a single homologue of the LytR-CpsA-Psr proteins' Scientific Reports, Bd 8, Nr. 1, S. 3936. DOI: 10.1038/s41598-018-22012-6

Steinmann, J, Mamat, U, Abda, EM, Kirchhoff, L, Streit, WR, Schaible, UE, Niemann, S & Kohl, TA 2018, 'Analysis of Phylogenetic Variation of Reveals Human-Specific Branches' Frontiers in Microbiology, Bd 9, S. 806. DOI: 10.3389/fmicb.2018.00806

Herzmann, C, Dallenga, T & Kalinke, U 2018, 'Pulmonale Immunität bei Tuberkulose' PNEUMOLOGIE, Bd 72, S. 1-10. DOI: 10.1055/s-0043-122961



Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Rietschel, ET, Ulmer, AJ, Zähringer, U, Yu, K & Khatri, I 2017, 'An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression' INTERNATIONAL IMMUNOPHARMACOLOGY , Bd 50, Nr. (2017), S. 69-76.

Groeger, S, Jarzina, F, Mamat, U & Meyle, J 2017, 'Induction of B7-H1 receptor by bacterial cells fractions of Porphyromonas gingivalis on human oral epithelial cells: B7-H1 induction by Porphyromonas gingivalis fractions' IMMUNOBIOLOGY, Bd 222, Nr. 2, S. 137-147. DOI: 10.1016/j.imbio.2016.10.011

Dallenga, T, Repnik, U, Corleis, B, Eich, J, Reimer, R, Griffiths, GW & Schaible, UE 2017, 'M. tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages' Cell Host & Microbe, Bd 22, Nr. 4, S. 519-530.e3. DOI: 10.1016/j.chom.2017.09.003

Dallenga, T, Linnemann, L, Paudyal, B, Repnik, U, Griffiths, G & Schaible, UE 2017, 'Targeting neutrophils for host-directed therapy to treat tuberculosis' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. DOI: 10.1016/j.ijmm.2017.10.001

Haas, A, Hensel, M, Lührmann, A, Rudel, T, Saftig, P & Schaible, UE 2017, 'Intracellular compartments of pathogens: Highways to hell or stairways to heaven?' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. DOI: 10.1016/j.ijmm.2017.10.009

Patin, EC, Orr, SJ & Schaible, UE 2017, 'Macrophage Inducible C-Type Lectin As a Multifunctional Player in Immunity' Frontiers in Immunology, Bd 8, S. 861. DOI: 10.3389/fimmu.2017.00861

Jeschke, A, Zehethofer, N, Schwudke, D & Haas, A 2017, 'Quantification of Phosphatidylinositol Phosphate Species in Purified Membranes' Methods in Enzymology, Bd 587, S. 271-291. DOI: 10.1016/bs.mie.2016.10.037

Singh, S, Dallenga, T, Winkler, A, Roemer, S, Maruschak, B, Siebert, H, Brück, W & Stadelmann, C 2017, 'Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis' Journal of Neuroinflammation, Bd 14, Nr. 1, S. 57. DOI: 10.1186/s12974-017-0831-8

Schaible, UE, Linnemann, L, Redinger, N, Patin, E & Dallenga, T 2017, 'Strategies to improve vaccine efficacy againts tuberculosis by targeting innate immunity' Frontiers in Immunology, Bd 8, Nr. 1755, 1755. DOI: 10.3389/fimmu.2017.01755

Patin, EC, Geffken, AC, Willcocks, S, Leschczyk, C, Haas, A, Nimmerjahn, F, Lang, R, Ward, TH & Schaible, UE 2017, 'Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling' PLOS ONE, Bd 12, Nr. 4, S. e0174973. DOI: 10.1371/journal.pone.0174973, 10.1371/journal.pone.0174973




Hauptmann, M & Schaible, UE 2016, 'Linking microbiota and respiratory disease' FEBS LETTERS , Bd 590, Nr. 21, S. 3721-3738. DOI: 10.1002/1873-3468.12421

Dallenga, T & Schaible, UE 2016, 'Neutrophils in tuberculosis-first line of defence or booster of disease and targets for host-directed therapy?' Pathogens and Disease, Bd 74, Nr. 3., 10.1093/femspd/ftw012

Klionsky DJ, Abdelmohsen K, ....., Schaible, UE, , ...., Schneider BE, et al. 2016 'Guidelines for the use and interpretation of assays for monitoring autophagy' (3rd edition). Autophagy, Bd 12, S. 1-222.

Ulmer, AJ, Kaconis, Y, Heinbockel, L, Correa, W, Alexander, C, Rietschel, ET, Mach, J-P, Gorczynski, RM, Heini, A, Rössle, M, Richter, W, Gutsmann, T & Brandenburg, K 2016, 'Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A' INNATE IMMUNITY, Bd 22, Nr. 3, S. 168-80., 10.1177/1753425916632304

Patin, EC, Willcocks, S, Orr, S, Ward, TH, Lang, R & Schaible, UE 2016, 'Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro' INNATE IMMUNITY, Bd 22, Nr. 3, S. 181-185., 10.1177/1753425916636671



Leidinger P, Treptow J, Hagens K, Eich J, Zehethofer N, Schwudke D, Oehlmann W, Lünsdorf H, Goldmann O, Schaible UE, Dittmar KE, Feldmann C. Isoniazid@Fe2 O3 Nanocontainers and Their Antibacterial Effect on Tuberculosis Mycobacteria. Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12597-601. doi: 10.1002/anie.201505493. Epub 2015 Aug 31.

Weiss G, Schaible UE. Macrophage defense mechanisms against intracellular bacteria. Immunol Rev. 2015 Mar;264(1):182-203. doi: 10.1111/imr.12266. Review.

Jeschke A, Zehethofer N, Lindner B, Krupp J, Schwudke D, Haneburger I et al. Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015 Apr 14;112(15):4636-41.

Heinbockel L, Palacios-Chaves L, Alexander C, Rietschel E, Behrends J, Correa W et al. Mechanism of Hbγ-35-induced an increase in the activation of the human immune system by endotoxins. INNATE IMMUNITY. 2015 Apr;21(3):305-13.

Zehethofer N, Bermbach S, Hagner S, Garn H, Müller J, Goldmann T et al. Lipid Analysis of Airway Epithelial Cells for Studying Respiratory Diseases. Chromatographia. 2015 Mrz 10;78(5-6):403-413.

Weiss G, Schaible UE. Macrophage defense mechanisms against intracellular bacteria. IMMUNOLOGICAL REVIEWS . 2015 Mrz 1;264(1):182-203.

Dallenga T, Corleis B, Schaible UE. Infection of Human Neutrophils to Study Virulence Properties of Mycobacterium tuberculosis. Methods in Molecular Biology. 2015 Jan 1;1285:343-55.

Geffken AC, Patin EC, Schaible UE. Isolation of bead phagosomes to study virulence function of M. tuberculosis cell wall lipids. Methods in Molecular Biology. 2015;1285:357-68.

Kallsen K, Zehethofer N, Abdelsadik A, Lindner B, Kabesch M, Heine H et al. ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways. The Journal of allergy and clinical immunology. 2015. Erhältlich von: 10.1016/j.jaci.2015.04.009

Herweg J-A, Hansmeier N, Otto A, Geffken AC, Subbarayal P, Prusty BK et al. Purification and proteomics of pathogen-modified vacuoles and membranes. Frontiers in Cellular and Infection Microbiology. 2015;5:48. Erhältlich von: 10.3389/fcimb.2015.00048



Böcking, C, Harb, H, Ege, MJ, Zehethofer, N, Fischer, K, Krauß, J, Holst, O, Nüsing, RM, Lindner, B, von Mutius, E, Renz, H, Garn, H & Pfefferle, PI 2014, 'Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation' International archives of allergy and immunology, Bd 163, Nr. 3, S. 234-42.

Ma Y, Podinovskaia M, Evans PJ, Emma G, Schaible UE, Porter J et al. A Novel Method for Non-Transferrin-Bound Iron Quantification by Chelatable Fluorescent Beads Based on Flow Cytometry. BIOCHEMICAL JOURNAL . 2014 Nov 1;463(3):351-62.

Njuguna JT, von Koschitzky I, Gerhardt H, Lämmerhofer M, Choucry A, Pink M et al. Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS . 2014 Aug 1;22(15):4338-46.

Schneider BE, Behrends J, Hagens K, Harmel N, Shayman JA, Schaible UE. Lysosomal phospholipase A2: A novel player in host immunity to Mycobacterium tuberculosis. European journal of immunology. 2014 Mai 13;44(8):2394-404.

Steinhäuser C, Dallenga T, Tchikov V, Schaible UE, Schütze S, Reiling N. Immuno-magnetic isolation of pathogen-containing phagosomes and apoptotic blebs from primary phagocytes. Current Protocols in Immunology. 2014 Apr 2;105:14.36.1-14.36.26.

Kolonko M, Geffken AC, Blumer T, Hagens K, Schaible UE, Hagedorn M. WASH-driven actin polymerization is required for efficient mycobacterial phagosome maturation arrest. CELLULAR MICROBIOLOGY. 2014 Feb;(16(2)):232-46.

Mueller A-K, Behrends J, Blank J, Schaible UE, Schneider BE. An experimental model to study tuberculosis-malaria coinfection upon natural transmission of Mycobacterium tuberculosis and Plasmodium berghei. Journal of visualized experiments : JoVE. 2014 Jan 1;(84):e50829.

Yun YJ, Srinivas G, Kuenzel S, Linnenbrink M, Alnahas S, Bruce KD et al. Environmentally determined differences in the murine lung microbiota and their relation to alveolar architecture. PLOS ONE. 2014 Jan 1;9(12):e113466.



Weinhold M, Eisenblätter M, Jasny E, Fehlings M, Finke A, Gayum H, Rüschendorf U, Renner Viveros P, Moos V, Allers K, Schneider T, Schaible UE, Schumann RR, Mielke ME, Ignatius R. The Attenuated Brucella abortus Strain 19 Invades, Persists in, and Activates Human Dendritic Cells, and Induces the Secretion of IL-12p70 but Not IL-23. PLoS One. 2013 Jun 21;8(6):e65934.

Andreu N, Zelmer A, Sampson SL, Ikeh M, Bancroft GJ, Schaible UE, Wiles S, Robertson BD. Rapid in vivo assessment of drug efficacy against Mycobacterium tuberculosis using an improved firefly luciferase. J Antimicrob Chemother. 2013 Sep;68(9):2118-27.

Erdmann H, Roßnagel C, Böhme J, Iwakura Y, Jacobs T, Schaible UE, Hölscher C. IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment. Immunobiology. 2013 Jun;218(6):910-23.

Sydor T, von Bargen K, Hsu FF, Huth G, Holst O, Wohlmann J, Becken U, Dykstra T, Söhl K, Lindner B, Prescott JF, Schaible UE, Utermöhlen O, Haas A. Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length. Cell Microbiol. 2013 Mar;15(3):458-73.

Ehlers S, Schaible UE. The granuloma in tuberculosis: dynamics of a host-pathogen collusion. FRONTIERS IN IMMUNOLOGY 2012;3:411. Open Access



Mueller AK, Behrends J, Hagens K, Mahlo J, Schaible UE, Schneider BE. Natural transmission of Plasmodium berghei exacerbates chronic tuberculosis in an experimental co-infection model. PLOS ONE 2012 Oct; 7(10): e48110. Open Access



Corleis B, Korbel D, Wilson R, Bylund J, Chee R, Schaible UE. Escape of Mycobacterium tuberculosis from oxidative killing by neutrophils. CELLULAR MICROBIOLOGY 2012 Jul;14(7):1109-1121.

Zelmer A, Carroll P, Andreu N, Hagens K, Mahlo J, Redinger N, Robertson BD, Wiles S, Ward TH, Parish T, Ripoll J, Bancroft GJ, Schaible UE. A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2012 May;67(8):1948–1960.

Herbst S, Schaible UE, Schneider BE. Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis. PloS One 2011 May;6(5):e19105. Open Access


Nunes A, Podinovskaia M, Leite A, Gameiro P, Zhou T, Ma Y, Kong X, Schaible UE, Hider RC, Rangel M. Fluorescent 3-hydroxy-4-pyridinone hexadentate iron chelators: intracellular distribution and the relevance to antimycobacterial properties. JBIC Journal of Biological Inorganic Chemistry 2010 Aug;15(6):861-877.

Andreu N, Zelmer A, Fletcher T, Elkington P, Ward T, Ripoll J, Parish T, Bancroft G, Schaible U, Robertson B, Wiles S. Optimisation of Bioluminescent Reporters for Use with Mycobacteria. PLOS ONE 2010 May;5(5): e10777. Open Access

Carroll P, Schreuder L, Muwanguzi-Karugaba J, Wiles S, Robertson B, Ripoll J, Ward T, Bancroft G, Schaible U, Parish T. Sensitive Detection of Gene Expression in Mycobacteria under Replicating and Non-Replicating Conditions Using Optimized Far-Red Reporters [Internet]. PLOS ONE 2010 Mar;5(3). Open Access
Schneider BE, Korbel D, Hagens K, Koch M, Raupach B, Enders J, Kaufmann SHE, Mittrücker H, Schaible UE. A role for IL-18 in protective immunity against Mycobacterium tuberculosis. EUROPEAN JOURNAL OF IMMUNOLOGY 2010 Feb;40(2):396-405.



Savy M, Edmond K, Fine P, Hall A, Hennig B, Moore S, Mulholland K, Schaible U, Prentice A. Landscape Analysis of Interactions between Nutrition and Vaccine Responses in Children. JOURNAL OF NUTRITION 2009 Nov;139(11):2154S-2218S.

Fakih S, Podinovskaia M, Kong X, Schaible U, Collins H, Hider R. Monitoring Intracellular Labile Iron Pools: A Novel Fluorescent Iron(III) Sensor as a Potential Non-Invasive Diagnosis Tool. JOURNAL OF PHARMACEUTICAL SCIENCES 2009 Juni;98(6):2212-2226.

Books / Book Chapters

Schaible UE, Haas A, (ed.). Intracellular niches of microbes : a pathogens guide through the host cell. Weinheim: Wiley-VCH-Verl.; 2009.



Fakih S, Podinovskaia M, Kong X, Collins H, Schaible U, Hider R. Targeting the lysosome: Fluorescent iron(III) chelators to selectively monitor endosomal/lysosomal labile iron pools. JOURNAL OF MEDICINAL CHEMISTRY 2008 Aug;51(15):4539-4552.

Korbel D, Schneider B, Schaible U. Innate immunity in tuberculosis: myths and truth. MICROBES AND INFECTION 2008 Juli;10(9):995-1004.

Axelrod S, Oschkinat H, Enders J, Schlegel B, Brinkmann V, Kaufmann S, Haas A, Schaible U. Delay of phagosome maturation by a mycobacterial lipid is reversed by nitric oxide. CELLULAR MICROBIOLOGY 2008 Juli;10(7):1530-1545.

Prentice A, Gershwin M, Schaible U, Keusch G, Victora C, Gordon J. New challenges in studying nutrition-disease interactions in the developing world. JOURNAL OF CLINICAL INVESTIGATION 2008 Apr;118(4):1322-1329.

Raftery M, Winau F, Giese T, Kaufmann S, Schaible U, Schonrich G. Viral danger signals control CD1d de novo synthesis and NKT cell activation. EUROPEAN JOURNAL OF IMMUNOLOGY 2008 März;38(3):668-679.

Holscher C, Reiling N, Schaible U, Holscher A, Bathmann C, Korbel D, Lenz I, Sonntag T, Kroger S, Akira S, Mossmann H, Kirschning C, Wagner H, Freudenberg M, Ehlers S. Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9. EUROPEAN JOURNAL OF IMMUNOLOGY 2008 März;38(3):680-694.

Niemeyer M, Darmoise A, Mollenkopf H, Hahnke K, Hurwitz R, Besra G, Schaible U, Kaufmann S. Natural killer T-cell characterization through gene expression profiling: an account of versatility bridging T helper type 1 (Th1), Th2 and Th17 immune responses. IMMUNOLOGY 2008 Jan;123(1):45-56.



Schaible U, Kaufmann S. Malnutrition and infection: Complex mechanisms and global impacts. PLOS MEDICINE 2007 Mai;4(5):806-812. Open Access
Mattow J, Siejak F, Hagens K, Schmidt F, Koehler C, Treumann A, Schaible U, Kaufmann S. An improved strategy for selective and efficient enrichment of integral plasma membrane proteins of mycobacteria. PROTEOMICS 2007 Mai;7(10):1687-1701.