Programmbereich Asthma und Allergie

Angeborene Immunität

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen



Herster, F, Bittner, Z, Archer, NK, Dickhöfer, S, Eisel, D, Eigenbrod, T, Knorpp, T, Schneiderhan-Marra, N, Löffler, MW, Kalbacher, H, Vierbuchen, T, Heine, H, Miller, LS, Hartl, D, Freund, L, Schäkel, K, Heister, M, Ghoreschi, K & Weber, ANR 2020, 'Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis', Nature communications, Jg. 11, Nr. 1, S. 1-13.

Komaniecka, I, Susniak, K, Chroma, A, Heine, H & Holst, O 2020, 'The Lipid A from the Lipopolysaccharide of the Phototrophic Bacterium Rhodomicrobium vannielii ATCC 17100 Revisited', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 22, Nr. 1.

Wang, Z, Minarsch, E-ML, Kublik, S, Heine, H, Schloter, M & Foesel, BU 2020, 'Complete Genome Sequence of Lactococcus lactis subsp. lactis G121, an Isolate with Allergy-Protective Features Derived from a Farming Environment', Microbiology resource announcements, Jg. 9, Nr. 41.

Zamyatina, A & Heine, H 2020, 'Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways', FRONTIERS IN IMMUNOLOGY, Jg. 11, S. 585146.



Bossen J, Uliczka K, Steen L, Pfefferkorn R, Mai MM, Burkhardt L, Spohn M, Bruchhaus I, Fink C, Heine H, Roeder T: An EGFR-Induced Drosophila Lung Tumor Model Identifies Alternative Combination Treatments. Mol Cancer Ther 2019, 18(9):1659-1668.

Freund I, Buhl DK, Boutin S, Kotter A, Pichot F, Marchand V, Vierbuchen T, Heine H, Motorin Y, Helm M, Dalpke AH, Eigenbrod T: 2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms. Rna 2019, 25(7):869-880.

Jappe U, Schwager C, Schromm AB, Gonzalez Roldan N, Stein K, Heine H, Duda KA: Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy. Front Immunol 2019, 10:122.

Vierbuchen T, Stein K, Heine H: RNA is taking its Toll: Impact of RNA-specific Toll-like receptors on health and disease. Allergy 2019, 74(2):223-235.



Adanitsch, F, Shi, J, Shao, F, Beyaert, R, Heine, H & Zamyatina, A 2018, 'Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics' Journal of Physical Chemistry B, Bd 9, Nr. 16, S. 3957-3963. DOI: 10.1039/c7sc05323a

Borio A, Holgado A, Garate JA, Beyaert R, Heine H, Zamyatina A, ‘Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation’. ChemMedChem 2018, 13(21):2317-2331.

Vierbuchen, T., Stein, K., Hein, H., ‘RNA is taking its Toll - Impact of RNA-specific Toll-like receptors on health and disease’. Allergy 2018 Nov 26. doi: 10.1111/all.13680. [Epub ahead of print].



Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Rietschel, ET, Ulmer, AJ, Zähringer, U, Yu, K & Khatri, I 2017, 'An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression' INTERNATIONAL IMMUNOPHARMACOLOGY , Bd 50, Nr. (2017), S. 69-76.

Lindner, K, Ströbele, M, Schlick, S, Webering, S, Jenckel, A, Kopf, J, Danov, O, Sewald, K, Buj, C, Creutzenberg, O, Tillmann, T, Pohlmann, G, Ernst, H, Ziemann, C, Hüttmann, G, Heine, H, Bockhorn, H, Hansen, T, König, P & Fehrenbach, H 2017, 'Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons' Particle and Fibre Toxicology, Bd 14, Nr. 1, S. 8. DOI: 10.1186/s12989-017-0189-1

Stein, K, Brand, S, Jenckel, A, Sigmund, A, Chen, ZJ, Kirschning, CJ, Kauth, M & Heine, H 2017, 'Endosomal recognition of Lactococcus lactis G121 and its RNA by dendritic cells is key to its allergy-protective effects' The Journal of allergy and clinical immunology, Bd 139, Nr. 2, S. 667-678. DOI: 10.1016/j.jaci.2016.06.018

Bang, C, Vierbuchen, T, Gutsmann, T, Heine, H & Schmitz, RA 2017, 'Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides' PLOS ONE, Bd 12, Nr. 10, S. e0185919. DOI: 10.1371/journal.pone.0185919

Jatzlauk, G, Bartel, S, Heine, H, Schloter, M & Krauss-Etschmann, S 2017, 'Influences of environmental bacteria and their metabolites on allergies, asthma and host microbiota' ALLERGY, Bd 72, Nr. 12, S. 1859-1867. DOI: 10.1111/all.13220

Pooe, OJ, Köllisch, G, Heine, H & Shonhai, A 2017, 'Plasmodium falciparum heat shock protein 70 lacks immune modulatory activity' PROTEIN AND PEPTIDE LETTERS, Bd 24, Nr. 6, S. 503-510. DOI: 10.2174/0929866524666170214141909