Programmbereich Chronische Lungenerkrankungen

Lungen-Immunologie

Mission    Projekte    Drittmittel    Methoden    Publikationen    Auszeichnungen    Mitarbeiter/innen

Publikationen

2022

Raspe J, Wegmann M. Neue Therapeutika und Angriffspunkte in der Behandlung von Asthma. Allergologie 2022;45:409-21.

Ritzmann F, Lunding LP, Bals R, Wegmann M, Beisswenger C. IL-17 cytokines and chronic lung diseases. Cells 2022;11:2132.

Rønnow SR, Sand JMB, Staunstrup LM, Bahmer T, Wegmann M, Lunding L, Burgess J, Rabe K, Sorensen GL, Fuchs O, Mutius EV, Hansen G, Kopp MV, Karsdal M, Leeming DJ, Weckmann M; ALLIANCE Study Group as part of the German Center of Lung Research (DZL). A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype. Asthma Res Pract. 2022 Apr 13;8(1):2.

Schröder A*, Lunding LP*, Zissler UM, Vock C, Webering S, Ehlers JC, Orinska Z, Chaker A, Schmidt-Weber CB, Lang NJ, Schiller HB, Mall MA, Fehrenbach H, Dinarello CA, Wegmann M. IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33.
Allergy. 2022 Mar;77(3):856-869.

Lunding LP, Skouras DB, Vock C, Dinarello CA, Wegmann M. The NLRP3 inflammasome inhibitor, OLT1177® , ameliorates experimental allergic asthma in mice. Allergy. 2022 Mar;77(3):1035-1038.

2021

Lunding LP, Krause D, Stichtenoth G, Stamme C, Lauterbach N, Hegermann J, Ochs M, Schuster B, Sedlacek R, Saftig P, Schwudke D, Wegmann M*, Damme M*. LAMP3 deficiency affects surfactant homeostasis in mice. PLoS Genet. 2021 Jun 23;17(6):e1009619. https://doi.org/10.1371/journal.pgen.1009619. *equal contribution

Wagner, C, Uliczka, K, Bossen, J, Niu, X, Fink, C, Thiedmann, M, Knop, M, Vock, C, Abdelsadik, A, Zissler, UM, Isermann, K, Garn, H, Pieper, M, Wegmann, M, Koczulla, AR, Vogelmeier, CF, Schmidt-Weber, CB, Fehrenbach, H, König, P, Silverman, N, Renz, H, Pfefferle, P, Heine, H & Roeder, T 2021, 'Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways', Cell reports, Jg. 35, Nr. 1, S. 108956. https://doi.org/10.1016/j.celrep.2021.108956

Weckmann M, Bahmer T, Bülow Sand JM, Rank Rønnow S, Pech M, Vermeulen C, Faiz A, Leeming DJ, Karsdal MA, Lunding L, Oliver BGG, Wegmann M, Ulrich-Merzenich G, Juergens UR, Duhn J, Laumonnier Y, Danov O, Sewald K, Zissler U, Jonker M, König I, Hansen G, von Mutius E, Fuchs O, Dittrich AM, Schaub B, Happle C, Rabe KF, van de Berge M, Burgess JK, Kopp MV; ALLIANCE Study Group as part of the German Centre for Lung Research (DZL). COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy. <https://pubmed.ncbi.nlm.nih.gov/34326188/>Eur Respir J. 2021 Jul 29:2003969. https://doi.org/10.1183/13993003.03969-2020

2020

Frey, A, Lunding, L, Ehlers, JC, Weckmann, M, Zissler, UM & Wegmann, M 2020, 'More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis', FRONTIERS IN IMMUNOLOGY, Jg. 11, Nr. 11, 761, S. 761. https://doi.org/10.3389/fimmu.2020.00761

Vella, G, Lunding, L, Ritzmann, F, Honecker, A, Herr, C, Wegmann, M, Bals, R & Beisswenger, C 2020, 'The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma', RESPIRATORY RESEARCH , Jg. 21, Nr. 1, S. 176. https://doi.org/10.1186/s12931-020-01434-9

Wenzel, J, Hansen, CE, Bettoni, C, Vogt, MA, Lembrich, B, Natsagdorj, R, Huber, G, Brands, J, Schmidt, K, Assmann, JC, Stölting, I, Saar, K, Sedlacik, J, Fiehler, J, Ludewig, P, Wegmann, M, Feller, N, Richter, M, Müller-Fielitz, H, Walther, T, König, GM, Kostenis, E, Raasch, W, Hübner, N, Gass, P, Offermanns, S, de Wit, C, Wagner, CA & Schwaninger, M 2020, 'Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jg. 117, Nr. 3, S. 1753-1761. https://doi.org/10.1073/pnas.1907467117

Zazara, DE, Wegmann, M, Giannou, A, Hierweger, A, Alawi, M, Thiele, K, Huber, S, Pincus, M, Muntau, A, Solano, M-E & Arck, PC 2020, 'A prenatally disrupted airway epithelium orchestrates the fetal origin of asthma in mice.', The Journal of allergy and clinical immunology, Jg. 145, Nr. 6, S. 1641-1654. https://doi.org/10.1016/j.jaci.2020.01.050

Žukovskaja, O, Ryabchykov, O, Straßburger, M, Heinekamp, T, Brakhage, AA, Hennings, JC, Hübner, CA, Wegmann, M, Cialla-May, D, Bocklitz, TW, Weber, K & Popp, J 2020, 'Towards Raman spectroscopy of urine as screening tool', Journal of Biophotonics, Jg. 13, Nr. 1, S. e201900143. https://doi.org/10.1002/jbio.201900143

 

2019

Højen JF, Vindva Kristensen ML, McKee AS, Taylor MK, Azam T, Lunding LP, De Graff DM, Swartzwelter BJ, Wegmann M, Tolstrup M, Beckmann K, Fujita M, Fischer S, Dinarello CA. A Blocking Antibody to IL-1R3 Broadly Attenuates Function of Six Members of the IL-1 Family and Reveals the Inflammatory Contribution of these Cytokines in vitro and in vivo. Nat Immunol. 2019;20:1138-49.

Webering S, Lunding L, Vock C, Schröder A, Gaede KI, Herzmann C, Fehrenbach, Wegmann M. The alpha-melanocyte-stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma. Clin Exp Allergy. 2019;49:1026-1039.

 

2018

Lindner, K, Webering, S, Stroebele, M, Bockhorn, H, Hansen, T, König, P & Fehrenbach, H 2018, 'Low Dose Carbon Black Nanoparticle Exposure Does Not Aggravate Allergic Airway Inflammation in Mice Irrespective of the Presence of Surface Polycyclic Aromatic Hydrocarbons' Nanomaterials, Bd 8, Nr. 4. DOI: 10.3390/nano8040213

Nissen G, Hollaender H, Tang FSM, Wegmann M, Lunding L, Vock C, Bachmann A, Lemmel S, Bartels R, Oliver BG, Burgess JK, Becker T, Kopp MV, Weckmann M. Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation. Clin Exp Allergy. 2018;48:1483-1493.

 

2017

Wegmann M. Targeting cytokines in asthma therapy: could IL-37 be a solution? Expert Rev Respir Med. 2017 Sep;11(9):675-677.

George L, Mitra A, Thimraj TA, Irmler M, Vishweswaraiah S, Lunding L, Hühn D, Madurga A, Beckers J, Fehrenbach H, Upadhyay S, Schulz H, Leikauf GD, Ganguly K. Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function. Respir Res. 2017 Aug 9;18(1):152.

Fehrenbach H, Wagner C, Wegmann M. Airway remodeling in asthma: what really matters. Cell Tissue Res. 2017;367:551-569. https://www.ncbi.nlm.nih.gov/pubmed/28190087

 

2016

Zimmer, J, Weitnauer, M, Boutin, S, Küblbeck, G, Thiele, S, Walker, P, Lasitschka, F, Lunding, L, Orinska, Z, Vock, C, Arnold, B, Wegmann, M & Dalpke, A 2016, 'Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung' Frontiers in Immunology, Bd 7, S. 514. DOI: 10.3389/fimmu.2016.00514

Lunding, L, Webering, S, Vock, C, Schröder, A, Raedler, D, Schaub, B, Fehrenbach, H & Wegmann, M 2016, 'Effect of IL-37 on Allergic Airway Inflammation. Ann Am Thorac Soc 2016;13:S95-6.

Körbelin J, Sieber T, Michelfelder S, Lunding L, Spies E, Hunger A, Alawi M, Rapti K, Indenbirken D, Müller OJ, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M. Pulmonary targeting of adeno-associated viral vectors by next-generation sequencing-guided screening of random capsid displayed peptide libraries.
Molecular therapy. 24, 6, S. 1050-61

Wegmann M, Fehrenbach H, Krauss-Etschmann S. Asthma Update 2015 - What Cell Biology in Basic Pulmonary Research Can Offer to the Pneumologist. Pneumologie. 2016;70:103-9.

 

2015

Lunding L, Schröder A, Wegmann M. Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR. Expert Rev Respir Med. 2015;11:1-12.

Lunding L, Wegmann M. NK cells in asthma exacerbation. Oncotarget. 2015 Aug 21;6:19932-3.

Voss M, Wolf L, Kamyschnikow A, Honecker A, Herr C, Lepper PM, Wegmann M, Menger MD, Bals R, Beisswenger C. IL-17A contributes to maintenance of pulmonary homeostasis in a murine model of cigarette smoke-induced emphysema. Am J Physiol Lung Cell Mol Physiol. 2015;309:L188-95.

Lunding LP, Webering S, Vock C, Behrends J, Wagner C, Hölscher C, Fehrenbach, Wegmann M. pIC-triggered exacerbation of experimental asthma depends on IL-17A produced by NK cells. J Immunol 2015;194:5615-25.

Vock C, Yildirim AÖ, Wagner C, Schlick S, Lunding LP, Lee CG, Elias JA, Fehrenbach H, Wegmann M. Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signaling components. Clin Exp Allergy. 2015;45:1447-1458.

Lunding L, Webering S, Vock C, Schröder A, Raedler D, Schaub B, Fehrenbach H, Wegmann M. IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice. Allergy. 2015;70:366-73.