Programmbereich Chronische Lungenerkrankungen

Universitäre Liaisongruppe Epigenetik chronischer Lungenerkrankungen

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen

Publikationen

2022

Kopp MV, Weckmann M, Nissen G, Ricklefs I, Härtel C. Two Beer(s) or Not Two Beer(s): The eNose as an Instrument to Pacify the World. Klin Padiatr. 2022 Feb 9. doi: 10.1055/a-1714-8895. Online ahead of print. PMID: 35139542 English.https://pubmed.ncbi.nlm.nih.gov/35210326/

Maison N, Omony J, Illi S, Thiele D, Skevaki C, Dittrich AM, Bahmer T, Rabe KF, Weckmann M, Happle C, Schaub B, Meier M, Foth S, Rietschel E, Renz H, Hansen G, Kopp MV, von Mutius E, Grychtol R; ALLIANCE Study Group. T-high asthma phenotypes across life span. Eur Respir J. 2022 Feb 24:2102288. doi: 10.1183/13993003.02288-2021. Online ahead of print. PMID: 35210326

Rønnow SR, Sand JMB, Staunstrup LM, Bahmer T, Wegmann M, Lunding L, Burgess J, Rabe K, Sorensen GL, Fuchs O, Mutius EV, Hansen G, Kopp MV, Karsdal M, Leeming DJ, Weckmann M; ALLIANCE Study Group as part of the German Center of Lung Research (DZL). A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype. Asthma Res Pract. 2022 Apr 13;8(1):2. doi: 10.1186/s40733-022-00084-6.PMID: 35418159 Free PMC article.

2021

Twisselmann N, Pagel J, Künstner A, Weckmann M, Hartz A, Glaser K, Hilgendorff A, Göpel W, Busch H, Herting E, Weinberg JB, Härtel C. Hyperoxia/Hypoxia Exposure Primes a Sustained Pro-Inflammatory Profile of Preterm Infant Macrophages Upon LPS Stimulation. Frontiers Immunol. 2021 Nov 18;12:762789

Maison N, Herbrüggen H, Schaub B, Schauberger C, Foth S, Grychtol R, ... ALLIANCE Study Group et al. Impact of imposed social isolation and use of face masks on asthma course and mental health in pediatric and adult patients with recurrent wheeze and asthma. Allergy Asthma Clin Immunol. 2021 Sep 16;17(1):93

Weckmann M, Bahmer T, Bülow Sand JM, Rank Rønnow S, Pech M, Vermeulen C, et al. COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy. Eur Respir J. European Respiratory Society; 2021 Jul 29

Skevaki C, Tafo P, Eiringhaus K, Timmesfeld N, Weckmann M, Happle C, et al. Allergen extract- and component-based diagnostics in children of the ALLIANCE asthma cohort. Clin Exp Allergy. John Wiley & Sons, Ltd; 2021 Jun 15

Abdo M, Uddin M, Goldmann T, Marwitz S, Bahmer T, Holz O, ... ALLIANCE Study Group et al. Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma. Respir Res. BioMed Central; 2021 Jun 3;22(1):167–11

Nemani SSP, Vermeulen CJ, Pech M, Faiz A, Oliver BGG, Van den Berge M, ...Weckmann M. COL4A3 expression in asthmatic epithelium depends on intronic methylation and ZNF263 binding. ERJ Open Res. European Respiratory Society; 2021 Jan 1.

Abdo M, Waschki B, Kirsten A-M, Trinkmann F, Biller H, Herzmann C, ... ALLIANCE Study Group et al. Persistent Uncontrolled Asthma: Long-Term Impact on Physical Activity and Body Composition. J Asthma Allergy. Dove Press; 2021;14:229–40

Abdo M, Trinkmann F, Kirsten A-M, Biller H, Pedersen F, Waschki B, … ALLIANCE Study Group et al. The Relevance of Small Airway Dysfunction in Asthma with Nocturnal Symptoms. J Asthma Allergy. Dove Press; 2021;14:897–905

2020

Weckmann M, Thiele D, Liboschik L, Bahmer T, Pech M, Dittrich A-M, ...Kopp M. Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time. Clin Exp Immunol. John Wiley & Sons, Ltd; 2020 Nov 17;6:204800401772927

Letters / short communications:

Holz O, Waschki B, Watz H, Kirsten A, Abdo M, Pedersen F, Weckmann M, et al. Breath volatile organic compounds and inflammatory markers in adult asthma patients - negative results from the ALLIANCE cohort. Eur Respir J. European Respiratory Society; 2020 Oct 2;:2002127

Editorials / Reports

Skevaki C, Weckmann M. Activation of Group 2 Innate Lymphoid Cells via TL1A/DR3. A Solution to Corticosteroid Resistance? Am J Respir Crit Care Med. American Thoracic Society; 2020 Oct 15;202(8):1067–9

Übersichtsarbeiten:

Frey A, Lunding LP, Ehlers JC, Weckmann M, Zissler UM, Wegmann M. More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis. Front Immunol. Frontiers; 2020;11:761

Bahmer T, Sand JMB, Weckmann M. Lost in transition: biomarkers of remodeling in patients with asthma. Curr Opin Pulm Med. 2020 Jan;26(1):40–6

2019

Vermeulen CJ, Xu C-J, Vonk JM, Hacken Ten NHT, Timens W, Heijink IH, ... Weckmann M et al. Differential DNA methylation in bronchial biopsies between persistent asthma and asthma in remission. Eur Respir J. European Respiratory Society; 2019 Nov 14;:1901280  

Editorials / Reports

Burgess JK, Weckmann M, Karsdal MA. The message from the matrix-should we listen more closely? J Thorac Dis. 2019 Mar;11(Suppl 3):S230–3

2018

Pech M, Weckmann M, König IR, Franke A, Heinsen F-A, Oliver B, et al. Rhinovirus infections change DNA methylation and mRNA expression in children with asthma. Singanayagam A, editor. PLoS ONE. Public Library of Science; 2018;13(11):e0205275

Faiz A, Weckmann M, Tasena H, Vermeulen CJ, Van den Berge M, Hacken Ten NHT, et al. Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion. Eur Respir J. European Respiratory Society; 2018 Aug;52(2):1800310

Nissen G, Hollaender H, Tang FSM, Wegmann M, Lunding L, Vock C, ... Weckmann, M. Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation. Clin Exp Allergy. Wiley/Blackwell (10.1111); 2018 Jul 20

Conference Proceedings:

Combining morphological and migration profiles of in vitro time-lapse data. Tim Becker, Juan C Caicedo, Shantanu Singh, Markus Weckmann, and Anne E Carpenter. 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018), pp. 965-968. https://ieeexplore.ieee.org/document/8363731/

Editorials / Reports

Fuchs O, Bahmer T, Weckmann M, Dittrich A-M, Schaub B, Rösler B, et al. The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study. BMC Pulmonary Medicine 2005 5:1. BioMed Central; 2018 Aug 20;18(1):140

Letters / short communications:

Zissler UM, Ulrich M, Jakwerth CA, Rothkirch S, Guerth F, Weckmann M, et al. Biomatrix for upper and lower airway biomarker in allergic asthma. J Allergy Clin Immunol. 2018 Aug 16

2017

Spengler D, Winoto-Morbach S, Kupsch S, Vock C, Blöchle K, Frank S, … Weckmann, M, et al. Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model. A translational study. Am J Physiol Lung Cell Mol Physiol. American Physiological Society; 2017 Aug 31;:ajplung.00128.2017

Harkness LM, Weckmann M, Kopp M, Becker T, Ashton AW, Burgess JK. Tumstatin regulates the angiogenic and inflammatory potential of airway smooth muscle extracellular matrix. J Cell Mol Med. 2017 Jun 13;17:1520

Weckmann M, Becker T, Nissen G, Pech M, Kopp MV. SiMA: A simplified migration assay for analyzing neutrophil migration. Cytometry A. 2017 May 19;13:159

2016

Weckmann M, Schultheiss C, Hollaender A, Bobis I, Rupp J, Kopp MV. Treatment with rhDNase in patients with cystic fibrosis alters in‐vitro CHIT‐1 activity of isolated leucocytes. Clin Exp Immunol. 2016 Sep 1;185(3):382–91

2013

Faiz A, Tjin G, Harkness L, Weckmann M, Bao S, Black JL, et al. The expression and activity of cathepsins D, H and K in asthmatic airways. PLoS ONE. 2013;8(3):e57245

2012

Weckmann M, Moir LM, Heckman CA, Black JL, Oliver BG, Burgess JK. Lamstatin - a novel inhibitor of lymphangiogenesis derived from collagen IV. J Cell Mol Med. 2012 Sep 21

Übersichtsarbeiten:

Burgess JK, Weckmann M. Matrikines and the lungs. Pharmacol Ther. 2012 Jun;134(3):317–37

2011

Weckmann M, Kopp MV, Heinzmann A, Mattes J. Haplotypes covering the TNFSF10 gene are associated with bronchial asthma. Pediatr Allergy Immunol. Blackwell Publishing Ltd; 2011 Feb 1;22(1‐Part‐I):25–30

2010

Burgess JK, Boustany S, Moir LM, Weckmann M, Lau JY, Grafton K, et al. Reduction of tumstatin in asthmatic airways contributes to angiogenesis, inflammation, and hyperresponsiveness. Am J Respir Crit Care Med. 2010 Jan 15;181(2):106–15

2009

Puthothu B, Bierbaum S, Kopp MV, Forster J, Heinze J, Weckmann M, et al. Association of TNF‐α with severe respiratory syncytial virus infection and bronchial asthma. Pediatr Allergy Immunol. Blackwell Publishing Ltd; 2009 Mar 1;20(2):157–63

Übersichtsarbeiten:

Bailey SR, Boustany S, Burgess JK, Hirst SJ, Sharma HS, Simcock DE, …, Weckmann, M. Airway vascular reactivity and vascularisation in human chronic airway disease. Pulm Pharmacol Ther. 2009 Oct;22(5):417–25

Weckmann M, Trian T, Oliver BG. Reconstruction is not renovation - the role of remodeling in asthma. J Asthma Allergy. 2009;2:33–42. 

2008

Walaschek C, Heinzmann A, Weckmann M, Kopp MV. Sulphidoleukotriene release of cord blood basophils in response to allergen stimulation correlates with neither a family history of atopy nor a subsequent development of atopic eczema. Clin Exp Allergy. 2008 Mar;38(3):458–65

2007

Puthothu B, Krueger M, Forster J, Heinze J, Weckmann M, Heinzmann A. Interleukin (IL)-18 Polymorphism 133C/G Is Associated With Severe Respiratory Syncytial Virus Infection. Pediatr Infect Dis J. 2007 Dec 1;26(12):1094–8

Weckmann M, Collison A, Simpson JL, Kopp MV, Wark PAB, Smyth MJ, et al. Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease. Nat Med. 2007 Nov;13(11):1308–15

Huck B, Neumann-Haefelin D, Schmitt-Graeff A, Weckmann M, Mattes J, Ehl S, et al. Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus. Respir Res. 2007;8:6

Conference Proceedings:

Weckmann M, Bustany S, Poniris M, Oliver B, Moir L, Black J, et al. Tumstatin, an anti-angiogenic factor is absent in airways from asthmatics. Stewart A, editor. Pulmonary pharmacology & therapeutics. Elsevier Ltd; 2009. 115 p. (Proceedings of the 6th Young Investigators' Symposium on Smooth Muscle. November 6-9, 2007. Sydney, Australia; vol. 22)

Preise/Auszeichnungen

2020 Johannes-Wenner Preis der Deutschen Gesellschaft Pädiatrische Pneumologie

2019 Teaser and Poster Award 2019 für das beste wissenschaftliche Poster ‘Lost and Found – COL4A3’s Fate In Asthma’ (DZL)

2012 Young Investigator Award 2012 der medizinischen Universität zu Lübeck

2010 LAM Foundation Travel Award (Amercian Thoracic Society) für das beste wissenschaftliche Poster 2010, Jahrestreffen der Amerikanischen Thoraxgesellschaft 2010, New Orleans, U.S.A.

2005 Hoffmann – La Roche Stiftung Freiburg, travel award 2005 für: „TRAIL – a key regulator in the development of allergic asthma“