Programmbereich Asthma und Allergie

Experimentelle Pneumologie

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen

Publikationen

2021

El-Merhie, N, Krüger, A, Uliczka, K, Papenmeier, S, Roeder, T, Rabe, KF, Wagner, C, Angstmann, H & Krauss-Etschmann, S 2021, 'Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways', Scientific Reports, Jg. 11, Nr. 1, S. 4441. https://doi.org/10.1038/s41598-021-81607-8

Wagner C, Uliczka K, Bossen J, Niu X, Fink C, Thiedmann M, Knop M, Vock C, Abdelsadik A, Zissler UM, Isermann K, Garn H, Pieper M, Wegmann M, Koczulla AR, Vogelmeier CF, Schmidt-Weber CB, Fehrenbach H, König P, Silverman N, Renz H, Pfefferle P, Heine H, Roeder T. Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways. Cell Rep. 2021 Apr 6;35(1), https://doi.org/10.1016/j.celrep.2021.108956

 

2020

El-Faham MH, Gai F, Igetei JE, Richter S, Falcone FH, Schramm G, Doenhoff MJ.  Antigenic cross-reactivity between Schistosoma mansoni and allergenic invertebrates putatively due to shared glycanic epitopes. Sci Rep. 2020 Feb 25;10(1):3350. doi: 10.1038/s41598-020-59892-6

Frey A, Lunding LP, Ehlers JC,  Weckmann M, Zissler UM, Wegmann M (2020) More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis.
Front Immunol  2020 Apr 28;11:761. doi: 10.3389/fimmu.2020.00761.

H. G. Fehrenbach. Machtmissbrauch in der Wissenschaft. Fünf Mythen. Forschung & Lehre, Ausgabe 4/20: 322-324.

Orinska, Z, Hagemann, PM, Halova, I & Draber, P 2020, 'Tetraspanins in the regulation of mast cell function', MEDICAL MICROBIOLOGY AND IMMUNOLOGY, Jg. 209, Nr. 4, S. 531-543. https://doi.org/10.1007/s00430-020-00679-x

 

2019

Dudeck A, Köberle M, Goldmann O, Meyer N, Dudeck J, Lemmens S, Rohde M, Roldán NG, Dietze-Schwonberg K, Orinska Z, Medina E, Hendrix S, Metz M, Zenclussen AC, von Stebut E, Biedermann T. Mast cells as protectors of health. J Allergy Clin Immunol. 2019 Oct;144(4S):S4-S18. doi: 10.1016/j.jaci.2018.10.054.

González Roldán N, Engel R, Düpow S, Jakob K, Koops F, Orinska Z, Vigor C, Oger C, Galano JM, Durand T, Jappe U, Duda KA. Lipid Mediators From Timothy Grass Pollen Contribute to the Effector Phase of Allergy and Prime Dendritic Cells for Glycolipid Presentation. Front Immunol. 2019 May 7;10:974. doi: 10.3389/fimmu.2019.00974.

Hagemann PM, Nsiah-Dosu S, Hundt JE, Hartmann K, Orinska Z. Modulation of Mast Cell Reactivity by Lipids: The Neglected Side of Allergic Diseases. Front Immunol. 2019 May 29;10:1174. doi: 10.3389/fimmu.2019.01174.

Kordowski A, Reinicke AT, Wu D, Orinska Z, Hagemann P, Huber-Lang M, Lee JB, Wang YH, Hogan SP, Köhl J. C5a receptor 1-/- mice are protected from the development of IgE-mediated experimental food allergy. Allergy. 2019 Apr;74(4):767-779. doi: 10.1111/all.13637

Sarker RSJ, Conlon TM, Morrone C, Srivastava B, Konyalilar N, Verleden SE, Bayram H, Fehrenbach H, Yildirim AÖ. CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis. Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L602-L614. doi: 10.1152/ajplung.00441.2018.

Webering S, Lunding LP, Vock C, Schröder A, Gaede KI, Herzmann C, Fehrenbach H, Wegmann M. The alpha-melanocyte-stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma. Clin Exp Allergy. 2019 Jul;49(7):1026-1039. doi: 10.1111/cea.13400.

 

2018

Schramm G, Suwandi A, Galeev A , Sharma S, Braun J, Claes A-K, Braubach P, Grassl GA. Schistosome eggs impair protective Th1/Th17 Immune Responses against Salmonella infection. Front. Immunol. (accepted on 24 October 2018) doi: 10.3389/fimmu.2018.02614.

Dudeck A., Köberle M., Goldmann O., Meyer N.,  Dudeck J., Lemmens S., Rohde M., González Roldán N., Dietze-Schwonberg K., Orinska Z., Medina E., Hendrix S., Metz M., Zenclussen A.C., von Stebut E., Biedermann T. Mast cells as protectors of health. J Allergy Clinical Immunol. (accepted on 9 October 2018).

Kordowski A, Reinicke AT, Wu D, Orinska Z, Hagemann PM, Huber-Lang M, Lee J-B, Wang Y-H, Hogan SP, Köhl J. C5a receptor 1-/- mice are protected from the development of IgE-mediated experimental food allergy. Allergy (accepted on 28 September2018).

Knuhr K, Langhans K, Nyenhuis S, Viertmann K, Kildemoes AMO, Doenhoff MJ, Haas H, Schramm G. Schistosoma mansoni egg-released IPSE/alpha-1 dampens inflammatory cytokine responses via basophil interleukin (IL)-4 and IL-13. Front. Immunol. 2018 Oct 10; 9:2293. doi: 10.3389/fimmu.2018.02293.

Roderfeld M, Padem S, Lichtenberger J, Quack T, Weiskirchen R, Longerich T, Schramm G, Churin Y, Irungbam K, Tschuschner A, Windhorst A, Grevelding CG, Roeb E. Schistosoma mansoni egg secreted antigens activate HCC-associated transcription factors c-Jun and STAT3 in hamster and human hepatocytes. Hepatology. 2018 Jul 27. doi: 10.1002/hep.30192. [Epub ahead of print].

Reitz M, Hartmann W, Rüdiger N, Orinska Z, Brunn ML, Breloer M. Interleukin-9 promotes early mast cell-mediated expulsion of Strongyloides ratti but is dispensable for generation of protective memory. Sci Rep. 2018 Jun 5;8(1):8636. doi: 10.1038/s41598-018-26907-2.

Nissen G, Hollaender H, Tang FSM, Wegmann M, Lunding L, Vock C, Bachmann A, Lemmel S, Bartels R, Oliver BG, Burgess JK, Becker T, Kopp MV, Weckmann M. Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation. Clin Exp Allergy. 2018 Jul 20. doi: 10.1111/cea.13236.

Bonniaud P, Fabre A, Frossard N, Guignabert C, Inman M, Kuebler WM, Maes T, Shi W, Stampfli M, Uhlig S, et al. Optimising experimental research in respiratory diseases: an ERS statement. Eur Respir J. 2018 May 17;51(5). pii: 1702133. doi: 10.1183/13993003.02133-2017.

Igetei JE, El-Faham M, Liddell S, Schramm G & Doenhoff MJ 2018, 'Antigenic cross-reactivity between Schistosoma mansoni and pollen allergens from the birch tree (Betula verrucosa) and Timothy grass (Phleum pratense): involvement of shared glycan epitopes and implications for the hygiene hypothesis' INTERNATIONAL JOURNAL FOR PARASITOLOGY, Bd 48, Nr. 5, S. 345-357. DOI: 10.1016/j.ijpara.2017.12.005

Kaisar MMM, Ritter M, Del Fresno C, Jónasdóttir HS, van der Ham AJ, Pelgrom LR, Schramm G, Layland LE, Sancho D, Prazeres da Costa C, Giera M, Yazdanbakhsh M & Everts B 2018, 'Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses' PLOS BIOLOGY , Bd 16, Nr. 4, S. e2005504. DOI: 10.1371/journal.pbio.2005504

Lindner K, Webering S, Stroebele M, Bockhorn H, Hansen T, König P & Fehrenbach H 2018, 'Low dose Carbon Black nanoparticle exposure does not aggravate allergic airway inflammation in mice irrespective of the presence of surface polycyclic aromatic hydrocarbons' Nanomaterials, Bd 8, Nr. 4. DOI: 10.3390/nano8040213

Spengler D, Winoto-Morbach S, Kupsch S, Vock C, Blöchle K, Frank S, Rintz N, Diekötter M, Janga H, Weckmann M, Fuchs S, Schromm AB, Fehrenbach H, Schütze S & Krause MF 2018, 'Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model. A translational study' AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY , Bd 314, Nr. 1, S. L32-L53. DOI: 10.1152/ajplung.00128.2017
 

2017

Fehrenbach H, Wagner C, Wegmann M. Airway remodeling in asthma: what really matters. Cell Tissue Res. 2017;367:551-569. https://www.ncbi.nlm.nih.gov/pubmed/28190087

Lindner, K, Ströbele, M, Schlick, S, Webering, S, Jenckel, A, Kopf, J, Danov, O, Sewald, K, Buj, C, Creutzenberg, O, Tillmann, T, Pohlmann, G, Ernst, H, Ziemann, C, Hüttmann, G, Heine, H, Bockhorn, H, Hansen, T, König, P & Fehrenbach, H 2017, 'Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons' Particle and Fibre Toxicology, Bd 14, Nr. 1, S. 8. DOI: 10.1186/s12989-017-0189-1

Abla, N, Keiser, J, Vargas, M, Reimers, N, Haas, H & Spangenberg, T 2017, 'Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model' PLoS Neglected Tropical Diseases, Bd 11, Nr. 9, S. e0005942. DOI: 10.1371/journal.pntd.0005942

Homann, A, Schramm, G & Jappe, U 2017, 'Glycans and Glycan-specific IgE in Clinical and Molecular Allergology - Sensitization, Diagnosis and Clinical Symptoms.' JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Bd 140, Nr. 2, S. 356-368.

Spengler, D, Winoto-Morbach, S, Kupsch, S, Vock, C, Blöchle, K, Frank, S, Rintz, N, Diekötter, M, Janga, H, Weckmann, M, Fuchs, S, Schromm, AB, Fehrenbach, H, Schütze, S & Krause, MF 2017, 'Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model. A translational study' AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY , S. ajplung.00128.2017. DOI: 10.1152/ajplung.00128.2017

Wilbers, RHP, Westerhof, LB, van Noort, K, Obieglo, K, Driessen, NN, Everts, B, Gringhuis, SI, Schramm, G, Goverse, A, Smant, G, Bakker, J, Smits, HH, Yazdanbakhsh, M, Schots, A & Hokke, CH 2017, 'Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants' Scientific Reports, Bd 7, S. 45910. DOI: 10.1038/srep45910

Haeberlein, S, Obieglo, K, Ozir-Fazalalikhan, A, Chayé, MAM, Veninga, H, van der Vlugt, LEPM, Voskamp, A, Boon, L, den Haan, JMM, Westerhof, LB, Wilbers, RHP, Schots, A, Schramm, G, Hokke, CH & Smits, HH 2017, 'Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells' PLOS PATHOGENS, Bd 13, Nr. 7, S. e1006539. DOI: 10.1371/journal.ppat.1006539