Programmbereich Infektionen

2023

Donoghue, A, Winterhalter, M & Gutsmann, T 2023, 'Influence of Membrane Asymmetry on OmpF Insertion, Orientation and Function', Membranes, Jg. 13, Nr. 5, 517. https://doi.org/10.3390/membranes13050517

 

2022

Al Nahas, K, Fletcher, M, Hammond, K, Nehls, C, Cama, J, Ryadnov, MG & Keyser, UF 2022, 'Measuring Thousands of Single-Vesicle Leakage Events Reveals the Mode of Action of Antimicrobial Peptides', ANALYTICAL CHEMISTRY , Jg. 94, Nr. 27, S. 9530-9539. https://doi.org/10.1021/acs.analchem.1c03564

Bachmann, A, Metwally, NG, Allweier, J, Cronshagen, J, Del Pilar Martinez Tauler, M, Murk, A, Roth, LK, Torabi, H, Wu, Y, Gutsmann, T & Bruchhaus, I 2022, 'CD36-A Host Receptor Necessary for Malaria Parasites to Establish and Maintain Infection', Microorganisms, Jg. 10, Nr. 12, S. 2356. https://doi.org/10.3390/microorganisms10122356

Blackler, RJ, Müller-Loennies, S, Pokorny-Lehrer, B, Legg, MSG, Brade, L, Brade, H, Kosma, P & Evans, SV 2022, 'Antigen binding by conformational selection in near-germline antibodies', The Journal of biological chemistry, Jg. 298, Nr. 5, S. 101901. https://doi.org/10.1016/j.jbc.2022.101901

Hansen, J, Kolbe, K, König, IR, Scherließ, R, Hellfritzsch, M, Malm, S, Müller-Loennies, S, Zallet, J, Hillemann, D, Wiesmüller, K-H, Herzmann, C, Brandenburg, J & Reiling, N 2022, 'Lipobiotin-capture magnetic bead assay for isolation, enrichment and detection of Mycobacterium tuberculosis from saliva', PLOS ONE, Jg. 17, Nr. 7, S. e0265554. https://doi.org/10.1371/journal.pone.0265554

Lagune, M, Le Moigne, V, Johansen, MD, Vásquez Sotomayor, F, Daher, W, Petit, C, Cosentino, G, Paulowski, L, Gutsmann, T, Wilmanns, M, Maurer, FP, Herrmann, J-L, Girard-Misguich, F & Kremer, L 2022, 'The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness', PLOS PATHOGENS, Jg. 18, Nr. 8, S. e1010771. https://doi.org/10.1371/journal.ppat.1010771

Mogavero, S, Höfs, S, Lauer, AN, Müller, R, Brunke, S, Allert, S, Gerwien, F, Groth, S, Dolk, E, Wilson, D, Gutsmann, T & Hube, B 2022, 'Candidalysin Is the Hemolytic Factor of Candida albicans', Toxins, Jg. 14, Nr. 12, 874. https://doi.org/10.3390/toxins14120874

Möller, C, Heinbockel, L, Garidel, P, Gutsmann, T, Mauss, K, Weindl, G, Fukuoka, S, Loser, D, Danker, T & Brandenburg, K 2022, 'Toxicological and Safety Pharmacological Profiling of the Anti-Infective and Anti-Inflammatory Peptide Pep19-2.5', Microorganisms, Jg. 10, Nr. 12, S. 2412. https://doi.org/10.3390/microorganisms10122412

Palusińska-Szysz, M, Jurak, M, Gisch, N, Waldow, F, Zehethofer, N, Nehls, C, Schwudke, D, Koper, P & Mazur, A 2022, 'The human LL-37 peptide exerts antimicrobial activity against Legionella micdadei interacting with membrane phospholipids', BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jg. 1867, Nr. 6, S. 159138. https://doi.org/10.1016/j.bbalip.2022.159138

Roeckendorf, N, Nehls, C & Gutsmann, T 2022, 'Design of Membrane Active Peptides Considering Multi-Objective Optimization for Biomedical Application', Membranes, Jg. 12, Nr. 2, 12020180. https://doi.org/10.3390/membranes12020180

 

2021

Brandenburg, K, Schromm, AB, Weindl, G, Heinbockel, L, Correa, W, Mauss, K, Martinez de Tejada, G & Garidel, P 2021, 'An update on endotoxin neutralization strategies in Gram-negative bacterial infections', Expert Review of Anti-Infective Therapy , Jg. 19, Nr. 4, S. 495-517. https://doi.org/10.1080/14787210.2021.1834847

Heinbockel, L, Weindl, G, Correa, W, Brandenburg, J, Reiling, N, Wiesmüller, K-H, Schürholz, T, Gutsmann, T, Martinez de Tejada, G, Mauss, K & Brandenburg, K 2021, 'Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 22, Nr. 3. https://doi.org/10.3390/ijms22031465

Jumde, RP, Guardigni, M, Gierse, RM, Alhayek, A, Zhu, D, Hamid, Z, Johannsen, S, Elgaher, WAM, Neusens, PJ, Nehls, C, Haupenthal, J, Reiling, N & Hirsch, AKH 2021, 'Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase', Chemical Science, Jg. 12, Nr. 22, S. 7775-7785. https://doi.org/10.1039/D1SC00330E

Kuhlmann, N, Nehls, C, Heinbockel, L, Correa, W, Moll, R, Gutsmann, T, Hübner, C, Englisch, U & Brandenburg, K 2021, 'Encapsulation and release of As pidasept peptides in polysaccharide formulation for oral application', European journal of pharmaceutical sciences, Jg. 158, S. 105687. https://doi.org/10.1016/j.ejps.2020.105687

Mohammad, S, Al Zoubi, S, Collotta, D, Krieg, N, Wissuwa, B, Ferreira Alves, G, Purvis, GSD, Norata, GD, Baragetti, A, Catapano, AL, Solito, E, Zechendorf, E, Schürholz, T, Correa-Vargas, W, Brandenburg, K, Coldewey, SM, Collino, M, Yaqoob, MM, Martin, L & Thiemermann, C 2021, 'A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 701275. https://doi.org/10.3389/fimmu.2021.701275

Schromm, AB, Paulowski, L, Kaconis, Y, Kopp, F, Koistinen, M, Donoghue, A, Keese, S, Nehls, C, Wernecke, J, Garidel, P, Sevcsik, E, Lohner, K, Sanchez-Gomez, S, Martinez-de-Tejada, G, Brandenburg, K, Brameshuber, M, Schütz, GJ, Andrä, J & Gutsmann, T 2021, 'Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jg. 118, Nr. 27. https://doi.org/10.1073/pnas.2101721118

Wang, C, Nehls, C, Baabe, D, Burghaus, O, Hurwitz, R, Gutsmann, T, Bröring, M & Kolbe, M 2021, 'Flagellin lysine methyltransferase FliB catalyzes a [4Fe-4S] mediated methyl transfer reaction', PLOS PATHOGENS, Jg. 17, Nr. 11, S. e1010052. https://doi.org/10.1371/journal.ppat.1010052

Wohlfart, S, Kilian, M, Storck, P, Gutsmann, T, Brandenburg, K & Mier, W 2021, 'Mass Spectrometric Quantification of the Antimicrobial Peptide Pep19-2.5 with Stable Isotope Labeling and Acidic Hydrolysis', Pharmaceutics, Jg. 13, Nr. 9. https://doi.org/10.3390/pharmaceutics13091342

 

2020

Lubiana, P, Bouws, P, Roth, LK, Dörpinghaus, M, Rehn, T, Brehmer, J, Wichers, JS, Bachmann, A, Höhn, K, Roeder, T, Thye, T, Gutsmann, T, Burmester, T, Bruchhaus, I & Metwally, NG 2020, 'Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions', Scientific Reports, Jg. 10, Nr. 1, S. 4548. https://doi.org/10.1038/s41598-020-61388-2

Nehls, C, Böhling, A, Podschun, R, Schubert, S, Grötzinger, J, Schromm, A, Fedders, H, Leippe, M, Harder, J, Kaconis, Y, Gronow, S & Gutsmann, T 2020, 'Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria', BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jg. 1862, Nr. 8, S. 183273. https://doi.org/10.1016/j.bbamem.2020.183273

Paulowski, L, Donoghue, A, Nehls, C, Groth, S, Koistinen, M, Hagge, SO, Böhling, A, Winterhalter, M & Gutsmann, T 2020, 'The Beauty of Asymmetric Membranes: Reconstitution of the Outer Membrane of Gram-Negative Bacteria', Frontiers in cell and developmental biology, Jg. 8, S. 586. https://doi.org/10.3389/fcell.2020.00586

Pfrommer, E, Dreier, C, Gabriel, G, Dallenga, T, Reimer, R, Schepanski, K, Scherließ, R, Schaible, UE & Gutsmann, T 2020, 'Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils', Scientific Reports, Jg. 10, Nr. 1, S. 9159. https://doi.org/10.1038/s41598-020-65781-9

Subh, L, Correa, W, Pinkvos, T-J, Behrens, P, Brandenburg, K, Gutsmann, T, Stiesch, M, Doll, K & Winkel, A 2020, 'Synthetic anti-endotoxin peptides interfere with Gram-positive and Gram-negative bacteria, their adhesion and biofilm formation on titanium', Journal of applied microbiology. https://doi.org/10.1111/jam.14701

Thoma, J, Abuillan, W, Furikado, I, Habe, T, Yamamoto, A, Gierlich, S, Kaufmann, S, Brandenburg, K, Gutsmann, T, Konovalov, O, Inoue, S & Tanaka, M 2020, 'Specific localisation of ions in bacterial membranes unravels physical mechanism of effective bacteria killing by sanitiser', Scientific Reports, Jg. 10, Nr. 1, S. 12302. https://doi.org/10.1038/s41598-020-69064-1

 

2019

Bleibaum, F, Sommer, A, Veit, M, Rabe, B, Andrä, J, Kunzelmann, K, Nehls, C, Correa, W, Gutsmann, T, Grötzinger, J, Bhakdi, S & Reiss, K 2019, 'ADAM10 sheddase activation is controlled by cell membrane asymmetry', Journal of molecular cell biology, Jg. 11, Nr. 11, S. 979-993. https://doi.org/10.1093/jmcb/mjz008

Byrd-Leotis, L, Jia, N, Dutta, S, Trost, JF, Gao, C, Cummings, SF, Braulke, T, Müller-Loennies, S, Heimburg-Molinaro, J, Steinhauer, DA & Cummings, RD 2019, 'Influenza binds phosphorylated glycans from human lung', Science advances, Jg. 5, Nr. 2, S. eaav2554. https://doi.org/10.1126/sciadv.aav2554

Correa, W, Brandenburg, J, Behrends, J, Heinbockel, L, Reiling, N, Paulowski, L, Schwudke, D, Stephan, K, Martinez-de-Tejada, G, Brandenburg, K & Gutsmann, T 2019, 'Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides', Biophysical journal, Jg. 117, Nr. 10, S. 1805-1819. https://doi.org/10.1016/j.bpj.2019.10.012

Correa, W, Heinbockel, L, Behrends, J, Kaconis, Y, Barcena-Varela, S, Gutsmann, T, Mauss, K, Schürholz, T, Schromm, AB, Martinez de Tejada, G & Brandenburg, K 2019, 'Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane-bound and free toxins', The FEBS journal, Jg. 286, Nr. 8, S. 1576-1593. https://doi.org/10.1111/febs.14805

de Miguel Catalina, A, Forbrig, E, Kozuch, J, Nehls, C, Paulowski, L, Gutsmann, T, Hildebrandt, P & Mroginski, MA 2019, 'The C-Terminal VPRTES Tail of LL-37 Influences the Mode of Attachment to a Lipid Bilayer and Antimicrobial Activity', BIOCHEMISTRY, Jg. 58, Nr. 19, S. 2447-2462. https://doi.org/10.1021/acs.biochem.8b01297

Haji-Ghassemi, O, Müller-Loennies, S, Brooks, CL, MacKenzie, CR, Caveney, N, Van Petegem, F, Brade, L, Kosma, P, Brade, H & Evans, SV 2019, 'Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude', BIOCHEMISTRY, Jg. 58, Nr. 6, S. 714-726. https://doi.org/10.1021/acs.biochem.8b00318

Jannadi, H, Correa, W, Zhang, Z, Brandenburg, K, Oueslati, R & Rouabhia, M 2019, 'Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation', MICROBIAL PATHOGENESIS , Jg. 133, S. 103546. https://doi.org/10.1016/j.micpath.2019.103546

Pfalzgraff, A, Correa, W, Heinbockel, L, Schromm, AB, Lübow, C, Gisch, N, Martinez-de-Tejada, G, Brandenburg, K & Weindl, G 2019, 'LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses', BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jg. 1864, Nr. 10, S. 1503-1513. https://doi.org/10.1016/j.bbalip.2019.05.018

von Bargen, K, Scraba, M, Krämer, I, Ketterer, M, Nehls, C, Krokowski, S, Repnik, U, Wittlich, M, Maaser, A, Zapka, P, Bunge, M, Schlesinger, M, Huth, G, Klees, A, Hansen, P, Jeschke, A, Bendas, G, Utermöhlen, O, Griffiths, G, Gutsmann, T, Wohlmann, J & Haas, A 2019, 'Virulence-associated protein A from Rhodococcus equi is an intercompartmental pH-neutralising virulence factor', CELLULAR MICROBIOLOGY, Jg. 21, Nr. 1, S. e12958. https://doi.org/10.1111/cmi.12958

 

2018

Pfalzgraff, A, Bárcena-Varela, S, Heinbockel, L, Gutsmann, T, Brandenburg, K, Martinez-de-Tejada, G & Weindl, G 2018, 'Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo' BRITISH JOURNAL OF PHARMACOLOGY, Jg. 175, Nr. 17, S. 3581-3593. DOI: 10.1111/bph.14425

Pfalzgraff, A, Brandenburg, K & Weindl, G 2018, 'Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds' Frontiers in pharmacology, Jg. 9, S. 281. DOI: 10.3389/fphar.2018.00281

Di Lorenzo, G, Voltolini Velho, R, Winter, D, Thelen, M, Ahmadi, S, Schweizer, M, De Pace, R, Cornils, K, Yorgan, TA, Grüb, S, Hermans-Borgmeyer, I, Schinke, T, Müller-Loennies, S, Braulke, T & Pohl, S 2018, 'Lysosomal proteome and secretome analysis identifies missorted enzymes and their non-degraded substrates in mucolipidosis III mouse cells' MOLECULAR & CELLULAR PROTEOMICS , Jg. 17, Nr. 8, S. 1612-1626. DOI: 10.1074/mcp.RA118.000720

Yamada, N, Martin, LB, Zechendorf, E, Purvis, GSD, Chiazza, F, Varrone, B, Collino, M, Shepherd, J, Heinbockel, L, Gutsmann, T, Correa Vargas, WA, Brandenburg, K, Marx, G, Schuerholz, T, Brohi, K & Thiemermann, C 2018, 'Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock' American journal of surgical pathology, Jg. 268, Nr. 2, S. 348-356. DOI: 10.1097/SLA.0000000000002186

Kuhlmann, N, Heinbockel, L, Correa, W, Gutsmann, T, Goldmann, T, Englisch, U & Brandenburg, K 2018, 'Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation' European journal of pharmaceutical sciences, Jg. 115, S. 240-247. DOI: 10.1016/j.ejps.2018.01.022

Kos, O, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Khatri, I, Mach, JP, Rietschel, ET, Tersikh, A, Ulmer, AJ, Waelli, T, Yu, K, Zähringer, U & Gorczynski, RM 2018, 'Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis' INTERNATIONAL IMMUNOPHARMACOLOGY , Jg. 57, S. 112-120. DOI: 10.1016/j.intimp.2018.02.010

 

2017

Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Rietschel, ET, Ulmer, AJ, Zähringer, U, Yu, K & Khatri, I 2017, 'An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression' INTERNATIONAL IMMUNOPHARMACOLOGY , Bd 50, Nr. (2017), S. 69-76.

Metwally, NG, Tilly, A-K, Lubiana, P, Roth, LK, Dörpinghaus, M, Lorenzen, S, Schuldt, K, Witt, S, Bachmann, A, Tidow, H, Gutsmann, T, Burmester, T, Roeder, T, Tannich, E & Bruchhaus, I 2017, 'Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151' Scientific Reports, Bd 7, Nr. 1, S. 4069. DOI: 10.1038/s41598-017-04241-3

Blodkamp, S, Kadlec, K, Gutsmann, T, Quiblier, C, Naim, HY, Schwarz, S & von Köckritz-Blickwede, M 2017, 'Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus' Veterinary Microbiology, Nr. 200, S. 52-58. DOI: 10.1016/j.vetmic.2016.03.021

Bang, C, Vierbuchen, T, Gutsmann, T, Heine, H & Schmitz, RA 2017, 'Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides' PLOS ONE, Bd 12, Nr. 10, S. e0185919. DOI: 10.1371/journal.pone.0185919

Ito, H, Murakami, R, Sakuma, S, Tsai, C-HD, Gutsmann, T, Brandenburg, K, Pöschl, JMB, Arai, F, Kaneko, M & Tanaka, M 2017, 'Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling' Scientific Reports, Bd 7, S. 43134. DOI: 10.1038/srep43134

de Buhr, N, Reuner, F, Neumann, A, Stump-Guthier, C, Tenenbaum, T, Schroten, H, Ishikawa, H, Müller, K, Beineke, A, Hennig-Pauka, I, Gutsmann, T, Valentin-Weigand, P, Baums, CG & von Köckritz-Blickwede, M 2017, 'Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment' CELLULAR MICROBIOLOGY, Bd 19, Nr. 2. DOI: 10.1111/cmi.12649

Yamada, N, Martin, LB, Zechendorf, E, Purvis, GSD, Chiazza, F, Varrone, B, Collino, M, Shepherd, J, Heinbockel, L, Gutsmann, T, Correa Vargas, WA, Brandenburg, K, Marx, G, Schuerholz, T, Brohi, K & Thiemermann, C 2017, 'Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock' American journal of surgical pathology. DOI: 10.1097/SLA.0000000000002186

Haji-Ghassemi, O, Gagnon, SML, Müller-Loennies, S & Evans, SV 2017, 'Polyspecificity of Anti-lipid A Antibodies and Its Relevance to the Development of Autoimmunity'  Advances in Experimental Medicine and Biology , Bd 966, S. 181-202. DOI: 10.1007/5584_2017_94

Pfalzgraff, A, Heinbockel, L, Su, Q, Brandenburg, K & Weindl, G 2017, 'Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses' BIOCHEMICAL PHARMACOLOGY , Bd 140, S. 64-72. DOI: 10.1016/j.bcp.2017.05.015

Langer, MN, Blodkamp, S, Bayerbach, M, Feßler, AT, de Buhr, N, Gutsmann, T, Kreienbrock, L, Schwarz, S & von Köckritz-Blickwede, M 2017, 'Testing cathelicidin susceptibility of bacterial mastitis isolates: Technical challenges and data output for clinical isolates' Veterinary Microbiology, Bd 210, S. 107-115. DOI: 10.1016/j.vetmic.2017.08.022