Programmbereich Infektionen
Biophysik
Mission
Projekte
Drittmittel
Methoden
Publikationen
Mitarbeiter/innen
Publikationen
2023
Donoghue, A, Winterhalter, M & Gutsmann, T 2023, 'Influence of Membrane Asymmetry on OmpF Insertion, Orientation and Function', Membranes, Jg. 13, Nr. 5, 517. https://doi.org/10.3390/membranes13050517
2022
Al Nahas, K, Fletcher, M, Hammond, K, Nehls, C, Cama, J, Ryadnov, MG & Keyser, UF 2022, 'Measuring Thousands of Single-Vesicle Leakage Events Reveals the Mode of Action of Antimicrobial Peptides', ANALYTICAL CHEMISTRY , Jg. 94, Nr. 27, S. 9530-9539. https://doi.org/10.1021/acs.analchem.1c03564
Bachmann, A, Metwally, NG, Allweier, J, Cronshagen, J, Del Pilar Martinez Tauler, M, Murk, A, Roth, LK, Torabi, H, Wu, Y, Gutsmann, T & Bruchhaus, I 2022, 'CD36-A Host Receptor Necessary for Malaria Parasites to Establish and Maintain Infection', Microorganisms, Jg. 10, Nr. 12, S. 2356. https://doi.org/10.3390/microorganisms10122356
Blackler, RJ, Müller-Loennies, S, Pokorny-Lehrer, B, Legg, MSG, Brade, L, Brade, H, Kosma, P & Evans, SV 2022, 'Antigen binding by conformational selection in near-germline antibodies', The Journal of biological chemistry, Jg. 298, Nr. 5, S. 101901. https://doi.org/10.1016/j.jbc.2022.101901
Hansen, J, Kolbe, K, König, IR, Scherließ, R, Hellfritzsch, M, Malm, S, Müller-Loennies, S, Zallet, J, Hillemann, D, Wiesmüller, K-H, Herzmann, C, Brandenburg, J & Reiling, N 2022, 'Lipobiotin-capture magnetic bead assay for isolation, enrichment and detection of Mycobacterium tuberculosis from saliva', PLOS ONE, Jg. 17, Nr. 7, S. e0265554. https://doi.org/10.1371/journal.pone.0265554
Lagune, M, Le Moigne, V, Johansen, MD, Vásquez Sotomayor, F, Daher, W, Petit, C, Cosentino, G, Paulowski, L, Gutsmann, T, Wilmanns, M, Maurer, FP, Herrmann, J-L, Girard-Misguich, F & Kremer, L 2022, 'The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness', PLOS PATHOGENS, Jg. 18, Nr. 8, S. e1010771. https://doi.org/10.1371/journal.ppat.1010771
Mogavero, S, Höfs, S, Lauer, AN, Müller, R, Brunke, S, Allert, S, Gerwien, F, Groth, S, Dolk, E, Wilson, D, Gutsmann, T & Hube, B 2022, 'Candidalysin Is the Hemolytic Factor of Candida albicans', Toxins, Jg. 14, Nr. 12, 874. https://doi.org/10.3390/toxins14120874
Möller, C, Heinbockel, L, Garidel, P, Gutsmann, T, Mauss, K, Weindl, G, Fukuoka, S, Loser, D, Danker, T & Brandenburg, K 2022, 'Toxicological and Safety Pharmacological Profiling of the Anti-Infective and Anti-Inflammatory Peptide Pep19-2.5', Microorganisms, Jg. 10, Nr. 12, S. 2412. https://doi.org/10.3390/microorganisms10122412
Palusińska-Szysz, M, Jurak, M, Gisch, N, Waldow, F, Zehethofer, N, Nehls, C, Schwudke, D, Koper, P & Mazur, A 2022, 'The human LL-37 peptide exerts antimicrobial activity against Legionella micdadei interacting with membrane phospholipids', BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jg. 1867, Nr. 6, S. 159138. https://doi.org/10.1016/j.bbalip.2022.159138
Roeckendorf, N, Nehls, C & Gutsmann, T 2022, 'Design of Membrane Active Peptides Considering Multi-Objective Optimization for Biomedical Application', Membranes, Jg. 12, Nr. 2, 12020180. https://doi.org/10.3390/membranes12020180
2021
Brandenburg, K, Schromm, AB, Weindl, G, Heinbockel, L, Correa, W, Mauss, K, Martinez de Tejada, G & Garidel, P 2021, 'An update on endotoxin neutralization strategies in Gram-negative bacterial infections', Expert Review of Anti-Infective Therapy , Jg. 19, Nr. 4, S. 495-517. https://doi.org/10.1080/14787210.2021.1834847
Heinbockel, L, Weindl, G, Correa, W, Brandenburg, J, Reiling, N, Wiesmüller, K-H, Schürholz, T, Gutsmann, T, Martinez de Tejada, G, Mauss, K & Brandenburg, K 2021, 'Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 22, Nr. 3. https://doi.org/10.3390/ijms22031465
Jumde, RP, Guardigni, M, Gierse, RM, Alhayek, A, Zhu, D, Hamid, Z, Johannsen, S, Elgaher, WAM, Neusens, PJ, Nehls, C, Haupenthal, J, Reiling, N & Hirsch, AKH 2021, 'Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase', Chemical Science, Jg. 12, Nr. 22, S. 7775-7785. https://doi.org/10.1039/D1SC00330E
Kuhlmann, N, Nehls, C, Heinbockel, L, Correa, W, Moll, R, Gutsmann, T, Hübner, C, Englisch, U & Brandenburg, K 2021, 'Encapsulation and release of As pidasept peptides in polysaccharide formulation for oral application', European journal of pharmaceutical sciences, Jg. 158, S. 105687. https://doi.org/10.1016/j.ejps.2020.105687
Mohammad, S, Al Zoubi, S, Collotta, D, Krieg, N, Wissuwa, B, Ferreira Alves, G, Purvis, GSD, Norata, GD, Baragetti, A, Catapano, AL, Solito, E, Zechendorf, E, Schürholz, T, Correa-Vargas, W, Brandenburg, K, Coldewey, SM, Collino, M, Yaqoob, MM, Martin, L & Thiemermann, C 2021, 'A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 701275. https://doi.org/10.3389/fimmu.2021.701275
Schromm, AB, Paulowski, L, Kaconis, Y, Kopp, F, Koistinen, M, Donoghue, A, Keese, S, Nehls, C, Wernecke, J, Garidel, P, Sevcsik, E, Lohner, K, Sanchez-Gomez, S, Martinez-de-Tejada, G, Brandenburg, K, Brameshuber, M, Schütz, GJ, Andrä, J & Gutsmann, T 2021, 'Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jg. 118, Nr. 27. https://doi.org/10.1073/pnas.2101721118
Wang, C, Nehls, C, Baabe, D, Burghaus, O, Hurwitz, R, Gutsmann, T, Bröring, M & Kolbe, M 2021, 'Flagellin lysine methyltransferase FliB catalyzes a [4Fe-4S] mediated methyl transfer reaction', PLOS PATHOGENS, Jg. 17, Nr. 11, S. e1010052. https://doi.org/10.1371/journal.ppat.1010052
Wohlfart, S, Kilian, M, Storck, P, Gutsmann, T, Brandenburg, K & Mier, W 2021, 'Mass Spectrometric Quantification of the Antimicrobial Peptide Pep19-2.5 with Stable Isotope Labeling and Acidic Hydrolysis', Pharmaceutics, Jg. 13, Nr. 9. https://doi.org/10.3390/pharmaceutics13091342
2020
Lubiana, P, Bouws, P, Roth, LK, Dörpinghaus, M, Rehn, T, Brehmer, J, Wichers, JS, Bachmann, A, Höhn, K, Roeder, T, Thye, T, Gutsmann, T, Burmester, T, Bruchhaus, I & Metwally, NG 2020, 'Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions', Scientific Reports, Jg. 10, Nr. 1, S. 4548. https://doi.org/10.1038/s41598-020-61388-2
Nehls, C, Böhling, A, Podschun, R, Schubert, S, Grötzinger, J, Schromm, A, Fedders, H, Leippe, M, Harder, J, Kaconis, Y, Gronow, S & Gutsmann, T 2020, 'Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria', BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jg. 1862, Nr. 8, S. 183273. https://doi.org/10.1016/j.bbamem.2020.183273
Paulowski, L, Donoghue, A, Nehls, C, Groth, S, Koistinen, M, Hagge, SO, Böhling, A, Winterhalter, M & Gutsmann, T 2020, 'The Beauty of Asymmetric Membranes: Reconstitution of the Outer Membrane of Gram-Negative Bacteria', Frontiers in cell and developmental biology, Jg. 8, S. 586. https://doi.org/10.3389/fcell.2020.00586
Pfrommer, E, Dreier, C, Gabriel, G, Dallenga, T, Reimer, R, Schepanski, K, Scherließ, R, Schaible, UE & Gutsmann, T 2020, 'Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils', Scientific Reports, Jg. 10, Nr. 1, S. 9159. https://doi.org/10.1038/s41598-020-65781-9
Subh, L, Correa, W, Pinkvos, T-J, Behrens, P, Brandenburg, K, Gutsmann, T, Stiesch, M, Doll, K & Winkel, A 2020, 'Synthetic anti-endotoxin peptides interfere with Gram-positive and Gram-negative bacteria, their adhesion and biofilm formation on titanium', Journal of applied microbiology. https://doi.org/10.1111/jam.14701
Thoma, J, Abuillan, W, Furikado, I, Habe, T, Yamamoto, A, Gierlich, S, Kaufmann, S, Brandenburg, K, Gutsmann, T, Konovalov, O, Inoue, S & Tanaka, M 2020, 'Specific localisation of ions in bacterial membranes unravels physical mechanism of effective bacteria killing by sanitiser', Scientific Reports, Jg. 10, Nr. 1, S. 12302. https://doi.org/10.1038/s41598-020-69064-1
2019
Bleibaum, F, Sommer, A, Veit, M, Rabe, B, Andrä, J, Kunzelmann, K, Nehls, C, Correa, W, Gutsmann, T, Grötzinger, J, Bhakdi, S & Reiss, K 2019, 'ADAM10 sheddase activation is controlled by cell membrane asymmetry', Journal of molecular cell biology, Jg. 11, Nr. 11, S. 979-993. https://doi.org/10.1093/jmcb/mjz008
Byrd-Leotis, L, Jia, N, Dutta, S, Trost, JF, Gao, C, Cummings, SF, Braulke, T, Müller-Loennies, S, Heimburg-Molinaro, J, Steinhauer, DA & Cummings, RD 2019, 'Influenza binds phosphorylated glycans from human lung', Science advances, Jg. 5, Nr. 2, S. eaav2554. https://doi.org/10.1126/sciadv.aav2554
Correa, W, Brandenburg, J, Behrends, J, Heinbockel, L, Reiling, N, Paulowski, L, Schwudke, D, Stephan, K, Martinez-de-Tejada, G, Brandenburg, K & Gutsmann, T 2019, 'Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides', Biophysical journal, Jg. 117, Nr. 10, S. 1805-1819. https://doi.org/10.1016/j.bpj.2019.10.012
Correa, W, Heinbockel, L, Behrends, J, Kaconis, Y, Barcena-Varela, S, Gutsmann, T, Mauss, K, Schürholz, T, Schromm, AB, Martinez de Tejada, G & Brandenburg, K 2019, 'Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane-bound and free toxins', The FEBS journal, Jg. 286, Nr. 8, S. 1576-1593. https://doi.org/10.1111/febs.14805
de Miguel Catalina, A, Forbrig, E, Kozuch, J, Nehls, C, Paulowski, L, Gutsmann, T, Hildebrandt, P & Mroginski, MA 2019, 'The C-Terminal VPRTES Tail of LL-37 Influences the Mode of Attachment to a Lipid Bilayer and Antimicrobial Activity', BIOCHEMISTRY, Jg. 58, Nr. 19, S. 2447-2462. https://doi.org/10.1021/acs.biochem.8b01297
Haji-Ghassemi, O, Müller-Loennies, S, Brooks, CL, MacKenzie, CR, Caveney, N, Van Petegem, F, Brade, L, Kosma, P, Brade, H & Evans, SV 2019, 'Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude', BIOCHEMISTRY, Jg. 58, Nr. 6, S. 714-726. https://doi.org/10.1021/acs.biochem.8b00318
Jannadi, H, Correa, W, Zhang, Z, Brandenburg, K, Oueslati, R & Rouabhia, M 2019, 'Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation', MICROBIAL PATHOGENESIS , Jg. 133, S. 103546. https://doi.org/10.1016/j.micpath.2019.103546
Pfalzgraff, A, Correa, W, Heinbockel, L, Schromm, AB, Lübow, C, Gisch, N, Martinez-de-Tejada, G, Brandenburg, K & Weindl, G 2019, 'LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses', BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jg. 1864, Nr. 10, S. 1503-1513. https://doi.org/10.1016/j.bbalip.2019.05.018
von Bargen, K, Scraba, M, Krämer, I, Ketterer, M, Nehls, C, Krokowski, S, Repnik, U, Wittlich, M, Maaser, A, Zapka, P, Bunge, M, Schlesinger, M, Huth, G, Klees, A, Hansen, P, Jeschke, A, Bendas, G, Utermöhlen, O, Griffiths, G, Gutsmann, T, Wohlmann, J & Haas, A 2019, 'Virulence-associated protein A from Rhodococcus equi is an intercompartmental pH-neutralising virulence factor', CELLULAR MICROBIOLOGY, Jg. 21, Nr. 1, S. e12958. https://doi.org/10.1111/cmi.12958
2018
Pfalzgraff, A, Bárcena-Varela, S, Heinbockel, L, Gutsmann, T, Brandenburg, K, Martinez-de-Tejada, G & Weindl, G 2018, 'Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo' BRITISH JOURNAL OF PHARMACOLOGY, Jg. 175, Nr. 17, S. 3581-3593. DOI: 10.1111/bph.14425
Pfalzgraff, A, Brandenburg, K & Weindl, G 2018, 'Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds' Frontiers in pharmacology, Jg. 9, S. 281. DOI: 10.3389/fphar.2018.00281
Di Lorenzo, G, Voltolini Velho, R, Winter, D, Thelen, M, Ahmadi, S, Schweizer, M, De Pace, R, Cornils, K, Yorgan, TA, Grüb, S, Hermans-Borgmeyer, I, Schinke, T, Müller-Loennies, S, Braulke, T & Pohl, S 2018, 'Lysosomal proteome and secretome analysis identifies missorted enzymes and their non-degraded substrates in mucolipidosis III mouse cells' MOLECULAR & CELLULAR PROTEOMICS , Jg. 17, Nr. 8, S. 1612-1626. DOI: 10.1074/mcp.RA118.000720
Yamada, N, Martin, LB, Zechendorf, E, Purvis, GSD, Chiazza, F, Varrone, B, Collino, M, Shepherd, J, Heinbockel, L, Gutsmann, T, Correa Vargas, WA, Brandenburg, K, Marx, G, Schuerholz, T, Brohi, K & Thiemermann, C 2018, 'Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock' American journal of surgical pathology, Jg. 268, Nr. 2, S. 348-356. DOI: 10.1097/SLA.0000000000002186
Kuhlmann, N, Heinbockel, L, Correa, W, Gutsmann, T, Goldmann, T, Englisch, U & Brandenburg, K 2018, 'Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation' European journal of pharmaceutical sciences, Jg. 115, S. 240-247. DOI: 10.1016/j.ejps.2018.01.022
Kos, O, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Khatri, I, Mach, JP, Rietschel, ET, Tersikh, A, Ulmer, AJ, Waelli, T, Yu, K, Zähringer, U & Gorczynski, RM 2018, 'Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis' INTERNATIONAL IMMUNOPHARMACOLOGY , Jg. 57, S. 112-120. DOI: 10.1016/j.intimp.2018.02.010
2017
Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Rietschel, ET, Ulmer, AJ, Zähringer, U, Yu, K & Khatri, I 2017, 'An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression' INTERNATIONAL IMMUNOPHARMACOLOGY , Bd 50, Nr. (2017), S. 69-76.
Metwally, NG, Tilly, A-K, Lubiana, P, Roth, LK, Dörpinghaus, M, Lorenzen, S, Schuldt, K, Witt, S, Bachmann, A, Tidow, H, Gutsmann, T, Burmester, T, Roeder, T, Tannich, E & Bruchhaus, I 2017, 'Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151' Scientific Reports, Bd 7, Nr. 1, S. 4069. DOI: 10.1038/s41598-017-04241-3
Blodkamp, S, Kadlec, K, Gutsmann, T, Quiblier, C, Naim, HY, Schwarz, S & von Köckritz-Blickwede, M 2017, 'Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus' Veterinary Microbiology, Nr. 200, S. 52-58. DOI: 10.1016/j.vetmic.2016.03.021
Bang, C, Vierbuchen, T, Gutsmann, T, Heine, H & Schmitz, RA 2017, 'Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides' PLOS ONE, Bd 12, Nr. 10, S. e0185919. DOI: 10.1371/journal.pone.0185919
Ito, H, Murakami, R, Sakuma, S, Tsai, C-HD, Gutsmann, T, Brandenburg, K, Pöschl, JMB, Arai, F, Kaneko, M & Tanaka, M 2017, 'Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling' Scientific Reports, Bd 7, S. 43134. DOI: 10.1038/srep43134
de Buhr, N, Reuner, F, Neumann, A, Stump-Guthier, C, Tenenbaum, T, Schroten, H, Ishikawa, H, Müller, K, Beineke, A, Hennig-Pauka, I, Gutsmann, T, Valentin-Weigand, P, Baums, CG & von Köckritz-Blickwede, M 2017, 'Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment' CELLULAR MICROBIOLOGY, Bd 19, Nr. 2. DOI: 10.1111/cmi.12649
Yamada, N, Martin, LB, Zechendorf, E, Purvis, GSD, Chiazza, F, Varrone, B, Collino, M, Shepherd, J, Heinbockel, L, Gutsmann, T, Correa Vargas, WA, Brandenburg, K, Marx, G, Schuerholz, T, Brohi, K & Thiemermann, C 2017, 'Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock' American journal of surgical pathology. DOI: 10.1097/SLA.0000000000002186
Haji-Ghassemi, O, Gagnon, SML, Müller-Loennies, S & Evans, SV 2017, 'Polyspecificity of Anti-lipid A Antibodies and Its Relevance to the Development of Autoimmunity' Advances in Experimental Medicine and Biology , Bd 966, S. 181-202. DOI: 10.1007/5584_2017_94
Pfalzgraff, A, Heinbockel, L, Su, Q, Brandenburg, K & Weindl, G 2017, 'Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses' BIOCHEMICAL PHARMACOLOGY , Bd 140, S. 64-72. DOI: 10.1016/j.bcp.2017.05.015
Langer, MN, Blodkamp, S, Bayerbach, M, Feßler, AT, de Buhr, N, Gutsmann, T, Kreienbrock, L, Schwarz, S & von Köckritz-Blickwede, M 2017, 'Testing cathelicidin susceptibility of bacterial mastitis isolates: Technical challenges and data output for clinical isolates' Veterinary Microbiology, Bd 210, S. 107-115. DOI: 10.1016/j.vetmic.2017.08.022