Programmbereich Infektionen


Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen



Gräb, J, Suarez, I, van Gumpel, E, Winter, S, Schreiber, F, Esser, A, Hölscher, C, Fritsch, M, Herb, M, Schramm, M, Wachsmuth, L, Pallasch, C, Pasparakis, M, Kashkar, H & Rybniker, J. 2019, ‘Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition’ NAT COMMUN, Bd 10, S 688, DOI: 10.1038/s41467-019-08405-9.


Chakievska, L, Holtsche, MM, Künstner, A, Goletz, S, Petersen, BS, Thaci, D, Ibrahim, SM, Ludwig, RJ, Franke, A, Sadik, CD, Zillikens, D, Hölscher, C, Busch, H & Schmidt, E 2018, „IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid“, J AUTOIMMUN. doi: 10.1016/j.jaut.2018.09.003.

Erdmann, H, Behrends, J, Ritter, K, Hölscher, A, Volz, J, Rosenkrands, I & Hölscher, C 2018, 'The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells' Mucosal immunology. DOI: 10.1038/s41385-018-0026-3

Holz, K, Prinz, M, Brendecke, SM, Hölscher, A, Deng, F, Mitrücker, H-W, Rose-John, S & Hölscher, C 2018, 'Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice' FRONTIERS IN IMMUNOLOGY, Bd 9, S. 836. DOI: 10.3389/fimmu.2018.00836

Mahin Abad Dar and Christoph Hölscher. Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection. Front Immunol 2018; Volume 9: 2790; doi: 10.3389/fimmu.2018.02790

Stüve, P, Minarrieta, L, Erdmann, H, Arnold-Schrauf, C, Swallow, M, Guderian, M, Krull, F, Hölscher, A, Ghorbani, P, Behrends, J, Abraham, W-R, Hölscher, C, Sparwasser, TD & Berod, L 2018, 'Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages' FRONTIERS IN IMMUNOLOGY, Bd 9, S. 495. DOI: 10.3389/fimmu.2018.00495

Uwe Müller, Günter A. Schaub, Horst Mossmann, Gabriele Köhler, Rita Carsetti and Christoph Hölscher. Immunosuppression in Experimental Chagas Disease Is Mediated by an Alteration of Bone Marrow Stromal Cell Function During the Acute Phase of Infection. Front Immunol 2018; Volume 9: 2794; doi: 10.3389/fimmu.2018.02794


Deng, F, Chen, Y, Zheng, J, Huang, Q, Cao, X, Zillikens, D, Petersen, F & Yu, X 2017, 'CD11b-deficient mice exhibit an increased severity in the late phase of antibody transfer-induced experimental epidermolysis bullosa acquisita' EXPERIMENTAL DERMATOLOGY , Bd 26, Nr. 12, 12, S. 1175-1178. DOI: 10.1111/exd.13434

Schmok, E, Abad Dar, M, Behrends, J, Erdmann, H, Rückerl, D, Endermann, T, Heitmann, L, Hessmann, M, Yoshimura, A, Rose-John, S, Scheller, J, Schaible, UE, Ehlers, S, Lang, R & Hölscher C 2017 „Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis“ FRONT IMMUNOL Bd 8, S 1537. doi: 10.3389/fimmu.2017.01537. eCollection 2017.

Zheng, J, Huang, Q, Huang, R, Deng, F, Yue, X, Yin, J, Zhao, W, Chen, Y, Wen, L, Zhou, J, Huang, R, Riemekasten, G, Liu, Z, Petersen, F & Yu, X 2017, 'B Cells Are Indispensable for a Novel Mouse Model of Primary Sjögren's Syndrome' Frontiers in Immunology, Bd 8, S. 1384. DOI: 10.3389/fimmu.2017.01384


Erdmann, H, Behrends, J & Hölscher, C 2016, 'During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection' Scientific Reports, Bd 6, S. 32927. DOI: 10.1038/srep32927

Noll, J, Helk, E, Fehling, H, Bernin, H, Marggraff, C, Jacobs, T, Huber, S, Pelczar, P, Ernst, T, Ittrich, H, Otto, B, Mittrücker, H-W, Hölscher, C, Tacke, F, Bruchhaus, I, Tannich, E & Lotter, H 2016, 'IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage' Journal of hepatology, Bd 64, Nr. 5, S. 1147-57. DOI: 10.1016/j.jhep.2016.01.013

Böhme, J, Roßnagel, C, Jacobs, T, Behrends, J, Hölscher, C & Erdmann, H 2016, 'Epstein-Barr virus-induced gene 3 suppresses T helper type 1, type 17 and type 2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation.' IMMUNOLOGY , Bd 147, Nr. 3, S. 338-348. DOI: 10.1111/imm.12565

Hölscher, C, Heitmann, L, Owusu-Dabo, E, Horstmann, RD, Meyer, CG, Ehlers, S & Thye, T 2016, 'A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients' Mediators of inflammation, Bd 2016, 4245028. DOI: 10.1155/2016/4245028

Chen, Y, Zheng, J, Huang, Q, Deng, F, Huang, R, Zhao, W, Yin, J, Song, L, Chen, J, Gao, X, Liu, Z, Petersen, F & Yu, X 2016, 'Autoantibodies against the Second Extracellular Loop of M3R Do neither Induce nor Indicate Primary Sjögren's Syndrome' PLOS ONE, Bd 11, Nr. 2, S. e0149485. DOI: 10.1371/journal.pone.0149485

Herrtwich, L, Nanda, I, Evangelou, K, Nikolova, T, Horn, V, [Unbekannt], S, Erny, D, Stefanowski, J, Rogell, L, Klein, C, Gharun, K, Follo, M, Seidl, M, Kremer, B, Münke, N, Senges, J, Fliegauf, M, Aschman, T, Pfeifer, D, Sarrazin, S, Sieweke, MH, Wagner, D, Dierks, C, Haaf, T, Ness, T, Zaiss, MM, Voll, RE, Deshmukh, SD, Prinz, M, Goldmann, T, Hölscher, C, Hauser, AE, Lopez-Contreras, AJ, Grün, D, Gorgoulis, V, Diefenbach, A, Henneke, P & Triantafyllopoulou, A 2016, 'DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas' CELL, Bd 167, Nr. 5, S. 1264. DOI: 10.1016/j.cell.2016.09.054



Hernández PP, Mahlakõiv T, Yang I, Schwierzeck V, Nguyen N, Guendel F et al. Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection. NATURE IMMUNOLOGY . 2015 Jul;16(7):698-707.

Speer A, Sun J, Danilchanka O, Meikle V, Rowland JL, Walter K et al. Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.  Mol Microbiol. 2015 Sep;97(5):881-97. doi:
10.1111/mmi.13073. Epub 2015 Jul 4.

Lunding LP, Webering S, Vock C, Behrends J, Wagner C, Hölscher C et al. Poly(inosinic-cytidylic) Acid-Triggered Exacerbation of Experimental Asthma Depends on IL-17A Produced by NK Cells. JOURNAL OF IMMUNOLOGY. 2015 Mai 13;194(12):5615-25.



Heitmann L, Abad Dar M, Schreiber T, Erdmann H, Behrends J, Mckenzie ANJ et al. The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology. JOURNAL OF PATHOLOGY . 2014 Nov 1;234(3):338-50.

Maiwald F, Benítez D, Charquero D, Dar MA, Erdmann H, Preu L et al. 9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY . 2014 Aug 18;83:274-83.

Berod L, Stüve P, Varela F, Behrends J, Swallow M, Kruse F et al. Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents the development of autoimmunity *CH and TS contributed equally. PLOS ONE. 2014 Jul 22;9(7):e10284.

Eickmeier O, Kim SY, Herrmann E, Döring C, Duecker R, Voss S et al. Altered mucosal immune response after acute lung injury in a murine model of Ataxia Telangiectasia. BMC PULMONARY MEDICINE. 2014 Jan 1;14(1):93.



Heitmann, L, Schoenen, H, Ehlers, S, Lang, R & Hölscher, C. 2013, 'Mincle is not essential for controlling Mycobacterium tuberculosis infection' IMMUNOBIOLOGY, Bd 218, Nr. 4, S. 506-516.

Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Hölscher C, Müller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F & Prinz M. 2013, ‘Microglia emerge from erythromyeloid precursors via PU.1 and IRF-8 dependent pathways’ NATURE NEUROSICENCE 16:273-280.

Garbers, C, Spudy, B, Aparicio-Siegmund, S, Waetzig, GH, Sommer, J, Hölscher, C, Rose-John, S, Grötzinger, J, Lorenzen, I & Scheller, J 2013, 'An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer' The Journal of biological chemistry, vol 288, no. 6, pp. 4346-54.

Behrends J, Renauld JC, Ehlers S, Hölscher C. IL-22 is mainly produced by IFNγ-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection. PLoS One. 2013;8(2):e57379.

Erdmann H, Roßnagel C, Böhme J, Iwakura Y, Jacobs T, Schaible UE, Hölscher C. IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment. Immunobiology 2013 Jun;218(6):910-23.



Gelderblom M, Weymar A, Bernreuther C, Velden J, Arunachalam P, Steinbach K, Orthey E, Arumugam TV, Leypoldt F, Simova O, Thom V, Friese MA, Prinz I, Hölscher C, Glatzel M, Korn T, Gerloff C, Tolosa E, Magnus T. Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. BLOOD 2012 Nov;120(18):3793–3802.

Mueller A-K, Behrends J, Hagens K, Mahlo J, Schaible UE, Schneider BE. Natural Transmission of Plasmodium berghei Exacerbates Chronic Tuberculosis in an Experimental Co-Infection Model. PLOS ONE 2012 Oct;7(10):e48110. Open Access

Sodenkamp J, Waetzig GH, Scheller J, Seegert D, Grötzinger J, Rose-John S, Ehlers S, Hölscher C. Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis. IMMUNOBIOLOGY 2012 Oct;217(10):996–1004.

Erdmann H, Roßnagel C, Böhme J, Iwakura Y, Jacobs T, Schaible UE, Hölscher C. IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment. IMMUNOBIOLOGY 2012 Oct (in press).

Heitmann L, Rani R, Dawson L, Perkins C, Yang Y, Downey J, Hölscher C, Herbert DR. TGF-β-Responsive Myeloid Cells Suppress Type 2 Immunity and Emphysematous Pathology after Hookworm Infection. AMERICAN JOURNAL OF PATHOLOGY 2012 Sep;181(3):897–906.

Tchaptchet S, Gumenscheimer M, Kalis C, Freudenberg N, Hölscher C, Kirschning CJ, Lamers M, Galanos C, Freudenberg MA. TLR9-Dependent and Independent Pathways Drive Activation of the Immune System by Propionibacterium Acnes. PLoS ONE 2012 Jun;7(6):e39155. Open Access

Heitmann L, Schoenen H, Ehlers S, Lang R, Hölscher C. Mincle is not essential for controlling Mycobacterium tuberculosis infection. IMMUNOBIOLOGY 2012 Jun (in press).

Maertzdorf J, Weiner J 3rd, Mollenkopf H-J, TBornotTB Network, Bauer T, Prasse A, Müller-Quernheim J, Kaufmann SHE. Common patterns and disease-related signatures in tuberculosis and sarcoidosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2012 May;109(20):7853-8.

Carrasco-Marin E, Rodriguez-Del Rio E, Frande-Cabanes E, Tobes R, Pareja E, Lecea-Cuello MJ, Ruiz-Saez M, Madrazo-Toca F, Hölscher C, Alvarez-Dominguez C. Phagosomes induced by cytokines function as anti-listeria vaccines: a novel role for functional compartmentalization of STAT-1 and cathepsin-D. JOURNAL OF BIOLOGICAL CHEMISTRY 2012 Feb;287(18):14310–14324.