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Priority Research Area Infections

The Programm Area Infections studies bacterial infections of the lung with a focus on tuberculosis with the goal to improve CONTROL and CARE

CONTROL includes studies on global Surveillance of bacterial lung pathogens, developing effective control programs, diagnostic and therapy guidelines, high resolution and quick monitoring of outbreaks, analysis of global transmission and evolution of drug resistant bacteria. This agenda pursues evolutionary medicine approaches.

CARE combines studies on virulence properties of pathogenic lung bacteria to identify targets for new drugs, development and testing of new anti-bacterial compounds and novel treatment regimens, biomarker based individualized therapies such through genome based resistome analysis and quantitative drug monitoring in patients with studies on the identification of host response pathways and molecules as targets for host-directed therapies. The term "host" includes also its microbiota. This agenda pursues personalized medicine approaches.

 

Konzept des Programmbereichs zur Kontrolle der TB

Concepts to control tuberculosis

  • Bacterial genotype and host biomarker based early detection of latent tuberculosis to reduce the risk of reactivation
  • Biomarker-guided host-directed therapy: Immune modulation, inflammation control
  • Novel compounds, resistome- and biomarker guided, individualized antibiotic therapy
  • Quick global surveillance through whole genome sequencing and resistome prediction straight from patient samples
  • New vaccination strategies to improve pulmonary immunity and barrier function

 

 

 

Program Director

Prof. Dr. Stefan Niemann
Prof. Dr. Stefan Niemann
+49 4537 / 188-7620
+49 4537 / 188-2091
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Deputy Director

Prof. Dr. Thomas Gutsmann
Prof. Dr. Thomas Gutsmann
+49 4537 / 188-2910
+49 4537 / 188-2091
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Assistant

Silke Luckow
Silke Luckow
+49 4537 / 188-4811
+49 4537 / 188-4060
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Research Groups in the Priority Research Area Infections

Bioanalytical Chemistry

Biophysics

Diagnostic Mycobacteriology

Evolution of the Resistome

Immunobiophysics

Infection Immunology

Clinical Infectious Diseases

Microbial Interface Biology

Molecular and Experimental Mycobacteriology

Host ­Determinants in Lung Infections

Host-Microbe Interactome

Cellular Microbiology

Cellular Pneumology