Pathology of the University Hospital Schleswig-Holstein, Campus Lübeck and the Leibniz Research Center Borstel
location Borstel


Mission    Projects     Funding     Techniques    Publications    
Krankenversorgung     Diagnostik     Konsil- und Referenzzentrum für Pulmopathologie    Einsender    



Vlastos F, Hillas G, Vidal P, Lacomme S, Galateau-Salle F, Vollmer E, Guzman-Costabel J, Vignaud J, Martinet N. Survey and Biological Insights of Pemetrexed-Related Therapeutic Improvement in Mesothelioma The Nancy Centre of Biological Resources' Mesothelioma Cohort. JOURNAL OF THORACIC ONCOLOGY 2009 Oct;4(10):1259-1263.

Marwitz S, Zeiser T, Schultz H, Kahler D, Abdullah M, Hauber H, Zabel P, Vollmer E, Goldmann T. The human placenta releases substances that drive lung cancer into apoptosis. DIAGNOSTIC PATHOLOGY 2009 Aug;4(1):27. Open Access

Schramm G, Hamilton J, Balog C, Wuhrer M, Gronow A, Beckmann S, Wippersteg V, Grevelding C, Goldmann T, Weber E, Brattig N, Deelder A, Dunne D, Hokke C, Haas H, Doenhoff M. Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 2009 Jul;166(1):4-14.

Bohringer H, Lankenau E, Stellmacher F, Reusche E, Huttmann G, Giese A. Imaging of human brain tumor tissue by near-infrared laser coherence tomography. ACTA NEUROCHIRURGICA 2009 May;151(5):507-517.

Schaaf B, Luitjens K, Goldmann T, van Bremen T, Sayk F, Dodt C, Dalhoff K, Droemann D. Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytes. DIAGNOSTIC PATHOLOGY 2009 Apr;4(1):12. Open Access

Andra J, Hammer M, Grotzinger J, Jakovkin I, Lindner B, Vollmer E, Fedders H, Leippe M, Gutsmann T. Significance of the cyclic structure and of arginine residues for the antibacterial activity of arenicin-1 and its interaction with phospholipid and lipopolysaccharide model membranes. BIOLOGICAL CHEMISTRY 2009 Apr;390(4):337-349.

Goldmann T, Kahler D, Schultz H, Abdullah M, Lang D, Stellmacher F, Vollmer E. On the significance of Surfactant Protein-A within the human lungs. DIAGNOSTIC PATHOLOGY 2009 Mar;4(1):8. Open Access

Kayser K, Schultz H, Goldmann T, Gortler J, Kayser G, Vollmer E. Theory of sampling and its application in tissue based diagnosis. DIAGNOSTIC PATHOLOGY 2009 Feb;4(1):6. Open Access

Knopp U, Knopp A, Stellmacher F, Reusche E, Löning M, Kantelhardt SR, Domarus HV, Arnold H, Giese A. A non-midline spheno-orbital encephalocele in a newborn. CENTRAL EUROPEAN NEUROSURGERY 2009 Feb;70(1):43-47.

Kayser K, Görtler J, Bogovac M, Bogovac A, Goldmann T, Vollmer E, Kayser G. AI (artificial intelligence) in histopathology--from image analysis to automated diagnosis. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA / POLISH ACADEMY OF SCIENCES, POLISH HISTOCHEMICAL AND CYTOCHEMICAL SOCIETY 2009 Jan;47(3):355-361.

Abdullah M, Schultz H, Kahler D, Branscheid D, Dalhoff K, Zabel P, Vollmer E, Goldmann T. Expression of the acute phase protein haptoglobin in human lung cancer and tumor-free lung tissues. PATHOLOGY RESEARCH AND PRACTICE 2009;205(9):639-647.


Kayser K, Hoshang S, Metze K, Goldmann T, Vollmer E, Radziszowski D, Kosjerina Z, Mireskandari M, Kayser G. Texture- and Object-Related Automated Information Analysis in Histological Still Images of Various Organs. ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY 2008 Dec;30(6):323-335.

Hanuszkiewicz A, Kaczynski Z, Lindner B, Goldmann T, Vollmer E, Debarry J, Heine H, Holst O. Structural Analysis of the Capsular Polysaccharide from Acinetobacter lwoffii F78. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2008 Dec;(36):6183-6188.

Xu F, Droemann D, Rupp J, Shen H, Wu X, Goldmann T, Hippenstiel S, Zabel P, Dalhoff K. Modulation of the Inflammatory Response to Streptococcus pneumoniae in a Model of Acute Lung Tissue Infection. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2008 Nov;39(5):522-529.

Hauber H, Steffen A, Goldmann T, Vollmer E, Hung H, Wollenberg B, Zabel P. Effect of Steroids, Acetyl-cysteine and Calcium-Activated Chloride Channel Inhibitors on Allergic Mucin Expression in Sinus Mucosa. LARYNGOSCOPE 2008 Sep;118(9):1528-1533.

Schultz H, Kahler D, Branscheid D, Vollmer E, Zabel P, Goldmann T. TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens. DIAGNOSTIC PATHOLOGY 2008 Aug;3(1):35. Open Access

Vogel K, Blumer N, Korthals M, Mittelstadt J, Garn H, Ege M, von Mutius E, Gatermann S, Bufe A, Goldmann T, Schwaiger K, Renz H, Brandau S, Bauer J, Heine H, Holst O. Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2008 Aug;122(2):307-312.

Kayser K, Gortler J, Goldmann T, Vollmer E, Hufnagl P, Kayser G. Image standards in Tissue-Based Diagnosis (Diagnostic Surgical Pathology). DIAGNOSTIC PATHOLOGY 2008 Apr;3(1):17. Open Access

Goldmann T, Droemann D, Radtke J, Marwitz S, Lang D, Schultz H, Vollmer E. CXCR7 transcription in human non-small cell lung cancer and tumor-free lung tissues; possible regulation upon chemotherapy. VIRCHOWS ARCHIV 2008 Mar;452(3):347-348.

Andra J, Jakovkin I, Grotzinger J, Hecht O, Krasnosdembskaya A, Goldmann T, Gutsmann T, Leippe M. Structure and mode of action of the antimicrobial peptide arenicin. BIOCHEMICAL JOURNAL 2008 Feb;410:113-122.

Esendagli G, Bruderek K, Goldmann T, Busche A, Branscheid D, Vollmer E, Brandau S. Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer. LUNG CANCER 2008 Jan;59(1):32-40.


Hauber H, Goldmann T, Vollmer E, Wollenberg B, Zabel P. Effect of dexamethasone and ACC on bacteria-induced mucin expression in human airway mucosa. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 2007 Nov;37(5):606-616.

Welker L, Akkan R, Holz O, Schultz H, Magnussen H. Diagnostic outcome of two different CT-guided fine needle biopsy procedures. DIAGNOSTIC PATHOLOGY 2007 Aug;2(1):31. Open Access

Steffan A, Jafari C, Merz H, Galle J, Berger G. Subglottic MALT lymphoma of the larynx - More attention to the glottis. IN VIVO 2007 Aug;21(4):695-698.

Meyer B, Loeschke S, Schultze A, Weigel T, Sandkamp M, Goldmann T, Vollmer E, Bullerdiek J. HMGA2 overexpression in non-small cell lung cancer. MOLECULAR CARCINOGENESIS 2007 Jul;46(7):503-511.

Lin Z, Thomas N, Bibikova M, Seifart C, Wang Y, Guo X, Wang G, Vollmer E, Goldmann T, Garcia E, Zhou L, Fan J, Floros J. DNA methylation markers of surfactant proteins in lung cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 2007 Jul;31(1):181-191.

Lang D, Droemann D, Schultz H, Branscheid D, Martin C, Ressmeyer A, Zabel P, Vollmer E, Goldmann T. A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy. RESPIRATORY RESEARCH 2007 Jun;8:43. Open Access

Watz H, Engels K, Loeschke S, Amthor M, Kirsten D, Magnussen H. Lymphangioleiomyomatosis - presence of receptor tyrosine kinases and the angiogenesis factor VEGF-A as potential therapeutic targets. THORAX 2007 Jun;62(6):559-559.

Müller-Quernheim JM, Vollmer E, Galle J. Secondary bronchial botryomycosis due to foreign body aspiration. MONALDI ARCHIVES FOR CHEST DISEASE 2007 Jun;67(2):119-121.

Andra J, Monreal D, de Tejada G, Olak C, Brezesinski G, Gomez S, Goldmann T, Bartels R, Brandenburg K, Moriyon I. Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against gram-negative pathogens. JOURNAL OF BIOLOGICAL CHEMISTRY 2007 May;282(20):14719-14728.

Droemann D, Rupp J, Goldmann T, Uhlig U, Branscheid D, Vollmer E, Kujath P, Zabel P, Dalhoff K. Disparate innate immune responses to persistent and acute Chlamydia pneumoniae infection in chronic obstructive pulmonary disease. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2007 Apr;175(8):791-797.

Welker L, Muller M, Holz O, Vollmer E, Magnussen H, Jorres R. Cytological diagnosis of malignant mesothelioma-improvement by additional analysis of hyaluronic acid in pleural effusions. VIRCHOWS ARCHIV 2007 Apr;450(4):455-461.

Kähler, D, Schultz, H, Löschke, S, Branscheid, D, Zabel, P, Vollmer, E, Goldmann, T. Automatisierte Auswertung molekularer Hochdurchsatzanalysen an Tissue Microarrays. FOCUS MUL 2007 Mar;24(1):16-21.

Hauber H, Goldmann T, Vollmer E, Wollenberg B, Hung H, Levitt R, Zabel P. LPS-induced mucin expression in human sinus mucosa can be attenuated by hCLCA inhibitors. JOURNAL OF ENDOTOXIN RESEARCH 2007;13(2):109-116.

2006 (Selection)

Opitz B, Vinzing M, van Laak V, Schmeck B, Heine G, Günther S, Preissner R, Slevogt H, N'Guessan PD, Eitel J, Goldmann T, Flieger A, Suttorp N, Hippenstiel S. Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication. JOURNAL OF BIOLOGICAL CHEMISTRY 2006 Nov;281(47):36173-36179.

Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, Heine H, Brandt E, Reiling N. The Wingless homolog, WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. BLOOD 2006 Aug;108(3):965-973.

Fricke I, Mitchell D, Mittelstadt J, Lehan N, Heine H, Goldmann T, Bohle A, Brandau S. Mycobacteria induce IFN-gamma production in human dendritic cells via triggering of TLR2. JOURNAL OF IMMUNOLOGY 2006 May;176(9):5173-5182.

Prasse A, Pechkovsky D, Toews G, Jungraithmayr W, Kollert F, Goldmann T, Vollmer E, Muller-Quernheim J, Zissel G. A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006 Apr;173(7):781-792.

Hillemann D, Galle J, Vollmer E, Richter E. Real-time PCR assay for improved detection of Mycobacterium tuberculosis complex in paraffin-embedded tissues. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 2006 Mar;10(3):340-342.

Droeman D, Rupp J, Goldmann T, Kujath P, Vollmer E, Zabel P, Dalhoff K. In vitro Infektion im humanen Lungengewebsmodell am Beispiel von Chlamydia pneumoniae. FOCUS MUL 2006 Mar;23(1):24-27.

Bibikova M, Lin Z, Zhou L, Chudin E, Garcia E, Wu B, Doucet D, Thomas N, Wang Y, Vollmer E, Goldmann T, Seifart C, Jiang W, Barker D, Chee M, Floros J, Fan J. High-throughput DNA methylation profiling using universal bead arrays. GENOME RESEARCH 2006 Mar;16(3):383-393. Open Access

Busche A, Goldmann T, Naumann U, Steinle A, Brandau S. Natural killer cell-mediated rejection of experimental human lung cancer by genetic overexpression of major histocompatibility complex class I chain-related gene A. HUMAN GENE THERAPY 2006 Feb;17(2):135-146.

Vollmer E, Galle J, Lang DS, Loeschke S, Schultz H, Goldmann T. The HOPE technique opens up a multitude of new possibilities in pathology. ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY = REVUE ROUMAINE DE MORPHOLOGIE ET EMBRYOLOGIE 2006;47(1):15-19.

Goldmann T, Burgemeister R, Sauer U, Loeschke S, Lang D, Branscheid D, Zabel P, Vollmer E. Enhanced molecular analyses by combination of the HOPE-technique and laser microdissection. DIAGNOSTIC PATHOLOGY 2006;1(2). DOI: 10.1186/1746-1596-1-2 Open Access

2005 (Selection)

Droemann D, Goldmann T, Tiedje T, Zabel P, Dalhoff K, Schaaf B. Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients [Internet]. RESPIRATORY RESEARCH 2005 Jul;6(68). DOI: 10.1186/1465-9921-6-68 Open Access

Kayser K, Kosjerina Z, Goldmann T, Gian K, Kazmierczak B, Vollmer E. Lung carcinoma-associated atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosa. LUNG CANCER 2005 Feb;47(2):205-214.

Droemann D, Albrecht D, Gerdes J, Ulmer A, Branscheid D, Vollmer E, Dalhoff K, Zabel P, Goldmann T. Human lung cancer cells express functionally active Toll-like receptor 9 [Internet]. RESPIRATORY RESEARCH 2005 Jan;6(1). DOI: 10.1186/1465-9921-6-1 Open Access

Loeschke S, Goldmann T, Vollmer E. Improved detection of mycobacterial DNA by PCR in formalin-fixed, paraffin-embedded tissues using thin sections. PATHOLOGY RESEARCH AND PRACTICE 2005;201(1):37-40.

Kayser K, Kosjerina Z, Goldmann T, Kayser G, Kazmierczak B, Vollmer E. Phenotype and genotype associations of lung carcinoma with atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosa. ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY = REVUE ROUMAINE DE MORPHOLOGIE ET EMBRYOLOGIE 2005;46(1):5-10.

Goldmann T, Dromann D, Marzouki M, Schimmel U, Debel K, Branscheid D, Zeiser T, Rupp J, Gerdes J, Zabel P, Vollmer E. Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material. PATHOLOGY RESEARCH AND PRACTICE 2005;201(8-9):599-602.

2004 (Selection)

Rupp J, Droemann D, Goldmann T, Zabel P, Solbach W, Vollmer E, Branscheid D, Dalhoff K, Maass M. Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infection. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY 2004 Jul;41(3):197-203.

Goldmann T, Flohr AM, Murua Escobar H, Gerstmayer B, Janssen U, Bosio A, Loeschke S, Vollmer E, Bullerdiek J. The HOPE-technique permits Northern blot and microarray analyses in paraffin-embedded tissues. PATHOLOGY RESEARCH AND PRACTICE 2004;200(7-8):511-515.