Priority Research Area Chronic Lung Diseases

Immunology and Cell Biology

Mission    Project    Funding    Techniques    Publications    Staff



Chen, J, Wang, X, Schmalen, A, Haines, S, Wolff, M, Ma, H, Zhang, H, Stoleriu, MG, Nowak, J, Nakayama, M, Bueno, M, Brands, J, Mora, AL, Lee, JS, Krauss-Etschmann, S, Dmitrieva, A, Frankenberger, M, Hofer, TP, Noessner, E, Moosmann, A, Behr, J, Milger, K, Deeg, CA, Staab-Weijnitz, CA, Hauck, SM, Adler, H, Goldmann, T, Gaede, KI, Behrends, J, Kammerl, IE & Meiners, S 2023, 'Antiviral CD8+ T cell immune responses are impaired by cigarette smoke and in COPD', The European respiratory journal, Jg. 62, Nr. 2, 2201374.

Farr, A, Cuevas Ocaña, S, Gille, T, Pinnock, H, Bonsignore, MR, Roche, N, Laveneziana, P, Costello, RW, Harari, S, Meiners, S, Loukides, S & Cruz, J 2023, 'What to expect from the ERS International Congress 2023', Breathe, Jg. 19, Nr. 2, S. 230107.

Javitt, A, Shmueli, MD, Kramer, MP, Kolodziejczyk, AA, Cohen, IJ, Radomir, L, Sheban, D, Kamer, I, Litchfield, K, Bab-Dinitz, E, Zadok, O, Neiens, V, Ulman, A, Wolf-Levy, H, Eisenberg-Lerner, A, Kacen, A, Alon, M, Rêgo, AT, Stacher-Priehse, E, Lindner, M, Koch, I, Bar, J, Swanton, C, Samuels, Y, Levin, Y, da Fonseca, PCA, Elinav, E, Friedman, N, Meiners, S & Merbl, Y 2023, 'The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC', Nature cancer, Jg. 4, Nr. 5, S. 629-647.

Wang, X, Zhang, H, Wang, Y, Bramasole, L, Guo, K, Mourtada, F, Meul, T, Hu, Q, Viteri, V, Kammerl, I, Konigshoff, M, Lehmann, M, Magg, T, Hauck, F, Fernandez, IE & Meiners, S 2023, 'DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T-cell immunity', EMBO JOURNAL , Jg. 42, Nr. 8, S. e110597.



Bramasole, L & Meiners, S 2022, 'Profiling Proteasome Activities in Peripheral Blood – A Novel Biomarker Approach', Journal of cellular Immunology, Jg. 4, Nr. 5, S. 171-179.

Kammerl, IE, Hardy, S, Flexeder, C, Urmann, A, Peierl, J, Wang, Y, Vosyka, O, Frankenberger, M, Milger, K, Behr, J, Koch, A, Merl-Pham, J, Hauck, SM, Pilette, C, Schulz, H & Meiners, S 2022, 'Activation of immune cell proteasomes in peripheral blood of smokers and COPD patients - implications for therapy', The European respiratory journal, Jg. 59, Nr. 3, 2101798.

Meiners, S, Yazgili, A & Ebstein, F 2022, 'The proteasome activator PA200/PSME4: an emerging new player in health and disease', Biomolecules, Jg. 12, Nr. 8, S. 1150.

Nsiah-Dosu, S, Scholz, C, Orinska, Z, Sadik, CD, Ludwig, RJ, Schmidt, E, Zillikens, D & Hartmann, K 2022, 'Mast cell-deficient mice Mcpt5Cre/Dicerfl/fl redefine the role of mast cells in experimental bullous pemphigoid', Skin Health and Disease, Jg. 2, Nr. 1, e70, S. e70.

Schlesser, C, Meul, T, Stathopoulos, G & Meiners, S 2022, 'Metformin Induces Resistance of Cancer Cells to the Proteasome Inhibitor Bortezomib', Biomolecules, Jg. 12, Nr. 6, 756.

Zambusi, A, Novoselc, KT, Hutten, S, Kalpazidou, S, Koupourtidou, C, Schieweck, R, Aschenbroich, S, Silva, L, Yazgili, AS, van Bebber, F, Schmid, B, Möller, G, Tritscher, C, Stigloher, C, Delbridge, C, Sirko, S, Günes, ZI, Liebscher, S, Schlegel, J, Aliee, H, Theis, F, Meiners, S, Kiebler, M, Dormann, D & Ninkovic, J 2022, 'TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury', Nature neuroscience, Jg. 25, Nr. 12, S. 1608-1625.



Laveneziana P, Straus C, Meiners S. How and to What Extent Immunological Responses to SARS-CoV-2 Shape Pulmonary Function in COVID-19 Patients. Front Physiol. 2021 Jun 29;12:628288.

Yazgili AS, Meul T, Welk V, Semren N, Kammerl IE, Meiners S. In-gel proteasome assay to determine the activity, amount, and composition of proteasome complexes from mammalian cells or tissues. STAR Protoc. 2021 May 4;2(2):100526.



Korfei M, MacKenzie B, Meiners S. The ageing lung under stress. Eur Respir Rev. 2020 Jul 7;29(156):200126.  Review

Hu C, Meiners S, Lukas C, Stathopoulos GT, Chen J. Role of exosomal microRNAs in lung cancer biology and clinical applications. Cell Prolif. 2020 May 11:e12828. Review

Coux O, Zieba BA, Meiners S. The Proteasome System in Health and Disease. Adv Exp Med Biol. 2020;1233:55-100. Book chapter

Wang X, Meul T, Meiners S. Exploring the proteasome system: A novel concept of proteasome inhibition and regulation. Pharmacol Ther. 2020 Mar 13:107526. Review

Ubags ND, Baker J, Boots A, Costa R, El-Merhie N, Fabre A, Faiz A, Heijink IH, Hiemstra PS, Lehmann M, Meiners S, Rolandsson Enes S, Bartel S. ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly. ERJ Open Res. 2020 Mar 2;6(1). pii: 00350-2019. Report

Meul T, Berschneider K, Schmitt S, Mayr CH, Mattner LF, Schiller H, Yazgili A, Wang W, Lukas C, Prehn C, Adamski J, Graf E, Schwarzmayr  T, Perocchi F, Kukat A, Trifunovic A, Kremer L, Prokisch H, Popper B; von Toerne C, Hauck SM, Zischka H, Meiners S. Mitochondrial regulation of the 26S proteasome. Cell Reports 2020, accepted for publication

Bölükbas DA, Datz S, Meyer-Schwickerath C, Morrone C, Doryab A, Gössl D, Vreka M, Yang L, Argyo C. van Rijt SH, Lindner M, Eickelberg O, Stoeger T, Schmid O, Lindstedt S, Stathopoulos GT, Bein T, Wagner DE, Meiners S. Organ-restricted vascular delivery of nanoparticles for lung cancer therapy. Advanced Therapeutics. 2020, 3: 2070016

Heitmeier T, Sydykov A, Lukas C, Vroom C, Korfei M, Petrovic A, Klingel K, Günther A, Eickelberg O, Weissmann N, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Meiners S‡, Kosanovic D‡. Altered proteasome function in right ventricular hypertrophy. Cardiovasc Res. 2020 Feb 1;116(2):406-415. ‡ equal contribution

Meul et al., Cell Rep. 2020 Aug 25;32(8):108059.  doi: 10.1016/j.celrep.2020.108059.



Welk V, Meul T, Lukas C, Kammerl IE, Mulay SR, Schamberger AC, Semren N, Fernandez IE, Anders HJ, Günther A, Behr J, Eickelberg O, Korfei M, Meiners S. Proteasome activator PA200 regulates myofibroblast differentiation. Scientific Rep. 2019 Oct 23;9(1):15224.

Kesireddy VS, Chillappagari S, Ahuja S, Knudsen L, Henneke I, Graumann J, Meiners S, Ochs M, Ruppert C, Korfei M, Seeger W, Mahavadi P. Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/ LC3B) knockout mice to lung injury and fibrosis. FASEB J. 2019 Nov;33(11):12392-12408.

Kammerl IE, Caniard A, Merl-Pham J, Ben-Nissan G, Mayr CH, Mossina A, Geerlof A, Eickelberg O, Hauck SM, Sharon M, Meiners S. Dissecting the molecular effects of cigarette smoke on proteasome function. J Proteomics. 2019 Feb 20;193:1-9.



Meiners S, Lloyd C, Chambers RC. Cell-matrix interactions in lung disease and regeneration: ERS Lung Science Conference 2018 report. Eur Respir Rev. 2018 Jun 27;27(148). pii: 180040. Report

Amatngalim GD, Vieira RP, Meiners S, Bartel S. Novel insights into the effects of cigarette smoke on the airway epithelial surface-lessons learned at the European Respiratory Society International Congress 2018 in Paris. J Thorac Dis. 2018 Sep;10(Suppl 25):S2977-S2982. Report

Meiners S, Evankovich J, Mallampalli RK. The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis. Transl Res. 2018 Aug;198:17-28. Review

Houssaini A, Breau M, Kebe K, Abid S, Marcos E, Lipskaia L, Rideau D, Parpaleix A, Huang J, Amsellem V, Vienney N, Validire P, Maitre B, Attwe A, Lukas C, Vindrieux D, Boczkowski J, Derumeaux G, Pende M, Bernard D, Meiners S, Adnot S. mTOR pathway activation drives lung cell senescence and emphysema. JCI Insight. 2018 Feb 8;3(3). pii: 93203.



Agalioti T, Giannou AD, Krontira AC, Kanellakis NI, Kati D, Vreka M, Pepe M, Spella M, Lilis I, Zazara DE, Nikolouli E, Spiropoulou N, Papadakis A, Papadia K, Voulgaridis A, Harokopos V, Stamou P, Meiners S, Eickelberg O, Snyder LA, Antimisiaris SG, Kardamakis D, Psallidas I, Marazioti A, Stathopoulos GT. Mutant KRAS promotes malignant pleural effusion formation. Nat Commun. 2017 May 16;8:15205.

Scherer K, Yaroshenko A, Bölükbas DA, Gromann LB, Hellbach K, Meinel FG, Braunagel M, Berg JV, Eickelberg O, Reiser MF, Pfeiffer F, Meiners S‡, Herzen J‡. X-ray Dark-field Radiography - In-Vivo Diagnosis of Lung Cancer in Mice. Scientific Rep. 2017 Mar 24;7(1):402. ‡ equal contribution

Mossina A, Lukas C, Merl-Pham J, Uhl FE, Mutze K, Schamberger A, Staab-Weijnitz C, Jia J, Yildirim AÖ, Königshoff M, Hauck SM, Eickelberg O, Meiners S. Cigarette smoke alters the secretome of lung epithelial cells. Proteomics. 2017 Jan;17(1-2).

Wuttke S, Zimpel A, Bein T, Braig S, Stoiber K, Vollmar A, Müller D, Haastert-Talini K, Schaeske J, Stiesch M, Zahn Z, Mohmeyer A, Behrens P, Eickelberg O, Bölükbas DA, Meiners S. Validating Metal-Organic Framework Nanoparticles for Their Nanosafety in Diverse Biomedical Applications. Adv Healthcare Mater. 2017 Jan;6(2).

Taggart C, Mall MA, Lalmanach G, Cataldo D, Ludwig A, Janciauskiene S, Heath N, Meiners S, Overall CM, Schultz C, Turk B, Borensztajn KS. Protean proteases: at the cutting edge of lung diseases. Eur Respir J. 2017 Feb 8;49(2). Review



Welk V, Coux O, Kleene V, Abeza C, Truembach D, Eickelberg O, Meiners S. Inhibition of Proteasome Activity Induces Formation of Alternative Proteasome Complexes. J Biol Chem. 2016 Jun 17;291(25):13147-59.

Kammerl IE, Dann A, Mossina A, Brech D, Lukas C, Vosyka O, Nathan P, Conlon TM, Wagner DE, Overkleeft HS, Prasse A, Rosas IO, Straub T, Krauss-Etschmann S, Königshoff M, Preissler G, Winter H, Lindner M, Hatz R, Behr J, Heinzelmann K, Yildirim AÖ, Noessner E, Eickelberg O, Meiners S. Impairment of Immunoproteasome Function by Cigarette Smoke and in COPD. Am J Respir Crit Care Med. 2016 Jun 1;193(11):1230-41.

Conlon TM, Bartel J, Ballweg K, Günter S, Prehn C, Krumsiek J, Meiners S, Theiss FJ, Adamski J, Eickelberg O, Yildirim AO. Metabolomics screening identifies reduced L-carnitine to be associated with progressive emphysema. Clin Sci (Lond). 2016 Feb 1;130(4):273-87.

van Rijt SH, Bölükbas DA, Argyo C, Wipplinger K, Naureen M, Datz S, Eickelberg O, Meiners S, Bein T, Schmid O, Stoeger T. Applicability of avidin protein coated mesoporous silica nanoparticles as drug carriers in the lung. Nanoscale. 2016 Apr 14;8(15):8058-69.

Chen S, Kammerl IE, Vosyka O, Baumann T, Yu Y, Wu Y, Irmler M, Overkleeft HS, Beckers J, Eickelberg O, Meiners S, Stoeger T. Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages. Cell Death Differ. 2016 Jun;23(6):1026-37.

Meiners S, Hilgendorff A. Early injury of the neonatal lung contributes to premature lung aging: a hypothesis. Mol Cell Pediatr. 2016 Dec;3(1):24. Review

Kammerl IE, Meiners S. Proteasome function shapes innate and adaptive immune responses. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L328-36. Review



Caniard A, Ballweg K, Lukas C, Yildirim AÖ, Eickelberg O, Meiners S. Proteasome function is not impaired in healthy aging of the lung. Aging (Albany NY). 2015 Oct;7(10):776-92.

Semren N, Habel-Ungewitter NC, Fernandez IE, Königshoff M, Eickelberg O, Stöger T, Meiners S. Validation of the 2nd Generation Proteasome Inhibitor Oprozomib for Local Therapy of Pulmonary Fibrosis. PLoS One. 2015 Sep 4;10(9):e0136188.

Semren N, Welk V, Korfei M, Keller IE, Fernandez IE, Adler H, Günther A, Eickelberg O, Meiners S. Regulation of 26S Proteasome Activity in Pulmonary Fibrosis. Am J Respir Crit Care Med. 2015 Nov 1;192(9):1089-101.

Keller IE, Vosyka O, Takenaka S, Kloß A, Dahlmann B, Willems LI, Verdoes M, Overkleeft HS, Marcos E, Adnot S, Hauck SM, Ruppert C, Günther A, Herold S, Ohno S, Adler H, Eickelberg O, Meiners S. Regulation of immunoproteasome function in the lung. Scientific Rep. 2015 May 19;5:10230.

van Rijt SH, Bölükbas DA, Argyo C, Datz S, Lindner M, Eickelberg O, Königshoff M, Bein T, Meiners S. Protease-Mediated Release of Chemotherapeutics from Mesoporous Silica Nanoparticles to ex Vivo Human and Mouse Lung Tumors. ACS Nano. 2015 Mar 24;9(3):2377-89.

Oehrle B, Burgstaller G, Irmler M, Dehmel S, Grün J, Hwang T, Krauss-Etschmann S, Beckers J, Meiners S, Eickelberg O. Validated prediction of pro-invasive growth factors using a transcriptome-wide invasion signature derived from a complex 3D invasion assay. Scientific Rep. 2015 Aug 5;5:12673.

Uhl FE, Vierkotten S, Wagner DE, Burgstaller G, Costa R, Koch I, Lindner M, Meiners S, Eickelberg O, Königshoff M. Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures. Eur Respir J. 2015 Apr 30. pii: ERJ-01832-2014.

Bölükbas DA, Meiners S. Lung cancer nanomedicine: potentials and pitfalls. Nanomedicine (Lond). 2015;10(21):3203-12. Review

Meiners S, Eickelberg O, Königshoff M. Hallmarks of the ageing lung. Eur Respir J. 2015 Mar;45(3):807-27. Review

Thannickal VJ, Murthy M, Balch WE, Chandel NS, Meiners S, Eickelberg O, Selman M, Pardo A, White ES, Levy BD, Busse PJ, Tuder RM, Antony VB, Sznajder JI, Budinger GR.Blue Journal Conference. Aging and Susceptibility to Lung Disease. Am J Respir Crit Care Med. 2015 Feb 1;191(3):261-269. Review



Ballweg K, Mutze K, Königshoff M, Eickelberg O, Meiners S. Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 1;307(11):L895-907.

Schamberger AC, Mise N, Jia J, Genoyer E, Yildirim AO, Meiners S, Eickelberg O. Cigarette Smoke-Induced Disruption of Bronchial Epithelial Tight Junctions is Prevented by Transforming Growth Factor-Beta. Am J Respir Cell Mol Biol. 2014 Jun;50(6):1040-52.

Lenz AG, Stoeger T, Cei D, Schmidmeir M, Semren N, Burgstaller G, Lentner B, Eickelberg O, Meiners S‡, Schmid O‡. Efficient bioactive delivery of aerosolized drugs to human pulmonary epithelial cells cultured at air-liquid interface conditions. Am J Respir Cell Mol Biol. 2014 Oct;51(4):526-35. ‡ equal contribution

S Meiners "Protein Quality Control Coming of Age" in Molecular Aspects of Aging: Understanding Lung Aging M Rojas, S Meiners, CJ Le Saux, John Wiley & Sons, 2014, book chapter

Meiners S, Greene CM. Protein quality control in lung disease: it's all about cloud networking. Eur Respir J. 2014 Oct;44(4):846-9. Editorial

Schamberger AC, Mise N, Meiners S, Eickelberg O. Epigenetic mechanisms in COPD: implications for pathogenesis and drug discovery. Expert Opin Drug Discov. 2014 Jun;9(6):609-28. Review

van Rijt SH, Bein T, Meiners S. Medical nanoparticles for next generation drug delivery to the lungs. Eur Respir J. 2014 Sep;44(3):765-74.1. Review

Meiners S, Keller IE, Semren N, Caniard A. Regulation of the Proteasome: Evaluating the Lung Proteasome as a New Therapeutic Target. Antioxid Redox Signal. 2014 Dec 10;21(17):2364-82. Review

Meiners S, Ballweg K. Proteostasis in pediatric pulmonary pathology. Mol Cell Pediatr. 2014 Dec;1(1):11. Review