Priority Research Area Infections


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Lubiana, P, Bouws, P, Roth, LK, Dörpinghaus, M, Rehn, T, Brehmer, J, Wichers, JS, Bachmann, A, Höhn, K, Roeder, T, Thye, T, Gutsmann, T, Burmester, T, Bruchhaus, I & Metwally, NG 2020, 'Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions', Scientific Reports, Jg. 10, Nr. 1, S. 4548.

Nehls, C, Böhling, A, Podschun, R, Schubert, S, Grötzinger, J, Schromm, A, Fedders, H, Leippe, M, Harder, J, Kaconis, Y, Gronow, S & Gutsmann, T 2020, 'Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria', BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jg. 1862, Nr. 8, S. 183273.

Paulowski, L, Donoghue, A, Nehls, C, Groth, S, Koistinen, M, Hagge, SO, Böhling, A, Winterhalter, M & Gutsmann, T 2020, 'The Beauty of Asymmetric Membranes: Reconstitution of the Outer Membrane of Gram-Negative Bacteria', Frontiers in cell and developmental biology, Jg. 8, S. 586.

Pfrommer, E, Dreier, C, Gabriel, G, Dallenga, T, Reimer, R, Schepanski, K, Scherließ, R, Schaible, UE & Gutsmann, T 2020, 'Enhanced tenacity of mycobacterial aerosols from necrotic neutrophils', Scientific Reports, Jg. 10, Nr. 1, S. 9159.

Subh, L, Correa, W, Pinkvos, T-J, Behrens, P, Brandenburg, K, Gutsmann, T, Stiesch, M, Doll, K & Winkel, A 2020, 'Synthetic anti-endotoxin peptides interfere with Gram-positive and Gram-negative bacteria, their adhesion and biofilm formation on titanium', Journal of applied microbiology.

Thoma, J, Abuillan, W, Furikado, I, Habe, T, Yamamoto, A, Gierlich, S, Kaufmann, S, Brandenburg, K, Gutsmann, T, Konovalov, O, Inoue, S & Tanaka, M 2020, 'Specific localisation of ions in bacterial membranes unravels physical mechanism of effective bacteria killing by sanitiser', Scientific Reports, Jg. 10, Nr. 1, S. 12302.



Bleibaum, F, Sommer, A, Veit, M, Rabe, B, Andrä, J, Kunzelmann, K, Nehls, C, Correa, W, Gutsmann, T, Grötzinger, J, Bhakdi, S & Reiss, K 2019, 'ADAM10 sheddase activation is controlled by cell membrane asymmetry', Journal of molecular cell biology, Jg. 11, Nr. 11, S. 979-993.

Byrd-Leotis, L, Jia, N, Dutta, S, Trost, JF, Gao, C, Cummings, SF, Braulke, T, Müller-Loennies, S, Heimburg-Molinaro, J, Steinhauer, DA & Cummings, RD 2019, 'Influenza binds phosphorylated glycans from human lung', Science advances, Jg. 5, Nr. 2, S. eaav2554.

Correa, W, Brandenburg, J, Behrends, J, Heinbockel, L, Reiling, N, Paulowski, L, Schwudke, D, Stephan, K, Martinez-de-Tejada, G, Brandenburg, K & Gutsmann, T 2019, 'Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides', Biophysical journal, Jg. 117, Nr. 10, S. 1805-1819.

Correa, W, Heinbockel, L, Behrends, J, Kaconis, Y, Barcena-Varela, S, Gutsmann, T, Mauss, K, Schürholz, T, Schromm, AB, Martinez de Tejada, G & Brandenburg, K 2019, 'Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane-bound and free toxins', The FEBS journal, Jg. 286, Nr. 8, S. 1576-1593.

de Miguel Catalina, A, Forbrig, E, Kozuch, J, Nehls, C, Paulowski, L, Gutsmann, T, Hildebrandt, P & Mroginski, MA 2019, 'The C-Terminal VPRTES Tail of LL-37 Influences the Mode of Attachment to a Lipid Bilayer and Antimicrobial Activity', BIOCHEMISTRY, Jg. 58, Nr. 19, S. 2447-2462.

Haji-Ghassemi, O, Müller-Loennies, S, Brooks, CL, MacKenzie, CR, Caveney, N, Van Petegem, F, Brade, L, Kosma, P, Brade, H & Evans, SV 2019, 'Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude', BIOCHEMISTRY, Jg. 58, Nr. 6, S. 714-726.

Jannadi, H, Correa, W, Zhang, Z, Brandenburg, K, Oueslati, R & Rouabhia, M 2019, 'Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation', MICROBIAL PATHOGENESIS , Jg. 133, S. 103546.

Pfalzgraff, A, Correa, W, Heinbockel, L, Schromm, AB, Lübow, C, Gisch, N, Martinez-de-Tejada, G, Brandenburg, K & Weindl, G 2019, 'LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses', BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jg. 1864, Nr. 10, S. 1503-1513.

von Bargen, K, Scraba, M, Krämer, I, Ketterer, M, Nehls, C, Krokowski, S, Repnik, U, Wittlich, M, Maaser, A, Zapka, P, Bunge, M, Schlesinger, M, Huth, G, Klees, A, Hansen, P, Jeschke, A, Bendas, G, Utermöhlen, O, Griffiths, G, Gutsmann, T, Wohlmann, J & Haas, A 2019, 'Virulence-associated protein A from Rhodococcus equi is an intercompartmental pH-neutralising virulence factor', CELLULAR MICROBIOLOGY, Jg. 21, Nr. 1, S. e12958.



Pfalzgraff, A, Bárcena-Varela, S, Heinbockel, L, Gutsmann, T, Brandenburg, K, Martinez-de-Tejada, G & Weindl, G 2018, 'Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo' BRITISH JOURNAL OF PHARMACOLOGY, Jg. 175, Nr. 17, S. 3581-3593. DOI: 10.1111/bph.14425

Pfalzgraff, A, Brandenburg, K & Weindl, G 2018, 'Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds' Frontiers in pharmacology, Jg. 9, S. 281. DOI: 10.3389/fphar.2018.00281

Di Lorenzo, G, Voltolini Velho, R, Winter, D, Thelen, M, Ahmadi, S, Schweizer, M, De Pace, R, Cornils, K, Yorgan, TA, Grüb, S, Hermans-Borgmeyer, I, Schinke, T, Müller-Loennies, S, Braulke, T & Pohl, S 2018, 'Lysosomal proteome and secretome analysis identifies missorted enzymes and their non-degraded substrates in mucolipidosis III mouse cells' MOLECULAR & CELLULAR PROTEOMICS , Jg. 17, Nr. 8, S. 1612-1626. DOI: 10.1074/mcp.RA118.000720

Yamada, N, Martin, LB, Zechendorf, E, Purvis, GSD, Chiazza, F, Varrone, B, Collino, M, Shepherd, J, Heinbockel, L, Gutsmann, T, Correa Vargas, WA, Brandenburg, K, Marx, G, Schuerholz, T, Brohi, K & Thiemermann, C 2018, 'Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock' American journal of surgical pathology, Jg. 268, Nr. 2, S. 348-356. DOI: 10.1097/SLA.0000000000002186

Kuhlmann, N, Heinbockel, L, Correa, W, Gutsmann, T, Goldmann, T, Englisch, U & Brandenburg, K 2018, 'Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation' European journal of pharmaceutical sciences, Jg. 115, S. 240-247. DOI: 10.1016/j.ejps.2018.01.022

Kos, O, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Khatri, I, Mach, JP, Rietschel, ET, Tersikh, A, Ulmer, AJ, Waelli, T, Yu, K, Zähringer, U & Gorczynski, RM 2018, 'Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis' INTERNATIONAL IMMUNOPHARMACOLOGY , Jg. 57, S. 112-120. DOI: 10.1016/j.intimp.2018.02.010


Gorczynski, RM, Alexander, C, Brandenburg, K, Chen, Z, Heini, A, Heumann, D, Mach, J-P, Rietschel, ET, Ulmer, AJ, Zähringer, U, Yu, K & Khatri, I 2017, 'An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression' INTERNATIONAL IMMUNOPHARMACOLOGY , Bd 50, Nr. (2017), S. 69-76.

Metwally, NG, Tilly, A-K, Lubiana, P, Roth, LK, Dörpinghaus, M, Lorenzen, S, Schuldt, K, Witt, S, Bachmann, A, Tidow, H, Gutsmann, T, Burmester, T, Roeder, T, Tannich, E & Bruchhaus, I 2017, 'Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151' Scientific Reports, Bd 7, Nr. 1, S. 4069. DOI: 10.1038/s41598-017-04241-3

Blodkamp, S, Kadlec, K, Gutsmann, T, Quiblier, C, Naim, HY, Schwarz, S & von Köckritz-Blickwede, M 2017, 'Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus' Veterinary Microbiology, Nr. 200, S. 52-58. DOI: 10.1016/j.vetmic.2016.03.021

Bang, C, Vierbuchen, T, Gutsmann, T, Heine, H & Schmitz, RA 2017, 'Immunogenic properties of the human gut-associated archaeon Methanomassiliicoccus luminyensis and its susceptibility to antimicrobial peptides' PLOS ONE, Bd 12, Nr. 10, S. e0185919. DOI: 10.1371/journal.pone.0185919

Ito, H, Murakami, R, Sakuma, S, Tsai, C-HD, Gutsmann, T, Brandenburg, K, Pöschl, JMB, Arai, F, Kaneko, M & Tanaka, M 2017, 'Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling' Scientific Reports, Bd 7, S. 43134. DOI: 10.1038/srep43134

de Buhr, N, Reuner, F, Neumann, A, Stump-Guthier, C, Tenenbaum, T, Schroten, H, Ishikawa, H, Müller, K, Beineke, A, Hennig-Pauka, I, Gutsmann, T, Valentin-Weigand, P, Baums, CG & von Köckritz-Blickwede, M 2017, 'Neutrophil extracellular trap formation in the Streptococcus suis-infected cerebrospinal fluid compartment' CELLULAR MICROBIOLOGY, Bd 19, Nr. 2. DOI: 10.1111/cmi.12649

Yamada, N, Martin, LB, Zechendorf, E, Purvis, GSD, Chiazza, F, Varrone, B, Collino, M, Shepherd, J, Heinbockel, L, Gutsmann, T, Correa Vargas, WA, Brandenburg, K, Marx, G, Schuerholz, T, Brohi, K & Thiemermann, C 2017, 'Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock' American journal of surgical pathology. DOI: 10.1097/SLA.0000000000002186

Haji-Ghassemi, O, Gagnon, SML, Müller-Loennies, S & Evans, SV 2017, 'Polyspecificity of Anti-lipid A Antibodies and Its Relevance to the Development of Autoimmunity'  Advances in Experimental Medicine and Biology , Bd 966, S. 181-202. DOI: 10.1007/5584_2017_94

Pfalzgraff, A, Heinbockel, L, Su, Q, Brandenburg, K & Weindl, G 2017, 'Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses' BIOCHEMICAL PHARMACOLOGY , Bd 140, S. 64-72. DOI: 10.1016/j.bcp.2017.05.015

Langer, MN, Blodkamp, S, Bayerbach, M, Feßler, AT, de Buhr, N, Gutsmann, T, Kreienbrock, L, Schwarz, S & von Köckritz-Blickwede, M 2017, 'Testing cathelicidin susceptibility of bacterial mastitis isolates: Technical challenges and data output for clinical isolates' Veterinary Microbiology, Bd 210, S. 107-115. DOI: 10.1016/j.vetmic.2017.08.022


Martin, L, Horst, K, Chiazza, F, Oggero, S, Collino, M, Brandenburg, K, Hildebrand, F, Marx, G, Thiemermann, C & Schuerholz, T 2016, 'The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis' Scientific Reports, Bd 6, S. 37277. DOI: 10.1038/srep37277

Blodkamp, S, Kadlec, K, Gutsmann, T, Naim, HY, von Köckritz-Blickwede, M & Schwarz, S 2016, 'In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus' Veterinary Microbiology. DOI: 10.1016/j.vetmic.2015.09.018

Malgorzata-Miller, G, Heinbockel, L, Brandenburg, K, van der Meer, JWM, Netea, MG & Joosten, LAB 2016, 'Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications' Scientific Reports, Bd 6, S. 34221. DOI: 10.1038/srep34221

Martin, L, Peters, C, Heinbockel, L, Moellmann, J, Martincuks, A, Brandenburg, K, Lehrke, M, Müller-Newen, G, Marx, G & Schuerholz, T 2016, 'The synthetic antimicrobial peptide 19-2.5 attenuates mitochondrial dysfunction in cardiomyocytes stimulated with human sepsis serum' INNATE IMMUNITY. DOI: 10.1177/1753425916667474

Manrique-Moreno, M, Heinbockel, L, Suwalsky, M, Garidel, P & Brandenburg, K 2016, 'Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes' Biochimica et biophysica acta, Bd 1858, Nr. 9, S. 2123-31. DOI: 10.1016/j.bbamem.2016.06.009

Gutsmann, T 2016, 'Interaction between antimicrobial peptides and mycobacteria' BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Bd 1858, Nr. 5, S. 1034-43. DOI: 10.1016/j.bbamem.2016.01.031

Brandenburg, K, Heinbockel, L, Correa-Vargas, W & Lohner, K 2016, 'Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis' BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Bd 1858, Nr. 5, S. 971-979. DOI: 10.1016/j.bbamem.2016.01.011

Moyes, DL, Wilson, D, Richardson, JP, Mogavero, S, Tang, SX, Wernecke, J, Höfs, S, Gratacap, RL, Robbins, J, Runglall, M, Murciano, C, Blagojevic, M, Thavaraj, S, Förster, TM, Hebecker, B, Kasper, L, Vizcay, G, Iancu, SI, Kichik, N, Häder, A, Kurzai, O, Luo, T, Krüger, T, Kniemeyer, O, Cota, E, Bader, O, Wheeler, RT, Gutsmann, T, Hube, B & Naglik, JR 2016, 'Candidalysin is a fungal peptide toxin critical for mucosal infection' NATURE, Bd 532, Nr. 7597, S. 64-8. DOI: 10.1038/nature17625

Ulmer, AJ, Kaconis, Y, Heinbockel, L, Correa, W, Alexander, C, Rietschel, ET, Mach, J-P, Gorczynski, RM, Heini, A, Rössle, M, Richter, W, Gutsmann, T & Brandenburg, K 2016, 'Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A' INNATE IMMUNITY, Bd 22, Nr. 3, S. 168-80. DOI: 10.1177/1753425916632304

Brandenburg, K, Heinbockel, L, Correa-Vargas, W, Fukuoka, S, Gutsmann, T, Zähringer, U & Koch, MHJ 2016, 'Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5' Journal of Structural Biology, Bd 194, Nr. 1, S. 68-77. DOI: 10.1016/j.jsb.2016.01.014

Sommer, A, Kordowski, F, Büch, J, Maretzky, T, Evers, A, Andrä, J, Düsterhöft, S, Michalek, M, Lorenzen, I, Somasundaram, P, Tholey, A, Sönnichsen, FD, Kunzelmann, K, Heinbockel, L, Nehls, C, Gutsmann, T, Grötzinger, J, Bhakdi, S & Reiss, K 2016, 'Phosphatidylserine exposure is required for ADAM17 sheddase function' Nature communications, Bd 7, S. 11523. DOI: 10.1038/ncomms11523

Pfalzgraff, A, Heinbockel, L, Su, Q, Gutsmann, T, Brandenburg, K & Weindl, G 2016, 'Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration' Scientific Reports, Bd 6, S. 31577. DOI: 10.1038/srep31577


Schmidt T, Brodesser A, Schnitzler N, Grüger T, Brandenburg K, Zinserling J, Zündorf J. CD66b Overexpression and Loss of C5a Receptors as Surface Markers for Staphylococcus aureus-Induced Neutrophil Dysfunction. PLoS One. 2015 Jul 15;10(7):e0132703. doi: 10.1371/journal.pone.0132703. eCollection 2015

Blodkamp S, Kadlec K, Gutsmann T, Naim HY, von Köckritz-Blickwede M, Schwarz S. In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus. Vet Microbiol. 2015 Sep 28. pii: S0378-1135(15)30036-5. doi: 10.1016/j.vetmic.2015.09.018.

Martinez de Tejada G, Heinbockel L, Ferrer-Espada R, Heine H, Alexander C, Bárcena-Varela S, Goldmann T, Correa W, Wiesmüller KH, Gisch N, Sánchez-Gómez S, Fukuoka S, Schürholz T, Gutsmann T, Brandenburg K. Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides. Sci Rep. 2015 Sep 22;5:14292. doi: 10.1038/srep14292.

Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T, Gutsmann T, Mier W, Schürholz T, Drömann D, Brandenburg K, Martinez de Tejada G. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. PLoS One. 2015 Jul 21;10(7):e0133291. doi: 10.1371/journal.pone.0133291. eCollection 2015.

Tilly AK, Thiede J, Metwally N, Lubiana P, Bachmann A, Roeder T, Rockliffe N, Lorenzen S, Tannich E, Gutsmann T, Bruchhaus I. Type of in vitro cultivation influences cytoadhesion, knob structure, protein localization and transcriptome profile of Plasmodium falciparum. Sci Rep. 2015 Nov 16;5:16766. doi:10.1038/srep16766.

Dupont, A, Kaconis, Y, Yang, I, Albers, T, Woltemate, S, Heinbockel, L, Andersson, M, Suerbaum, S, Brandenburg, K & Hornef, MW 2015, 'Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide' Gut, Bd 64, Nr. 2, S. 222-32.

Gutsmann, T, Heimburg, T, Keyser, U, Mahendran, KR & Winterhalter, M 2015, 'Protein reconstitution into freestanding planar lipid membranes for electrophysiological characterization' Nature protocols, Bd 10, Nr. 1, S. 188-98..

Petersen A, Kull S, Rennert S, Becker WM, Krause S, Ernst M, Gutsmann T, Bauer J, Lindner B, Jappe U. Peanut defensins: Novel allergens isolated from lipophilic peanut extract. J Allergy Clin Immunol. 2015 Nov;136(5):1295-1301. pii: S0091-6749(15)00570-9.

Herrmann, M, Schneck, E, Gutsmann, T, Brandenburg, K & Tanaka, M 2015, 'Bacterial lipopolysaccharides form physically cross-linked, two-dimensional gels in the presence of divalent cations' SOFT MATTER, Bd 11, Nr. 30, S. 6037-44.

Ito, H, Kuss, N, Rapp, BE, Ichikawa, M, Gutsmann, T, Brandenburg, K, Pöschl, JMB & Tanaka, M 2015, 'Quantification of the Influence of Endotoxins on the Mechanics of Adult and Neonatal Red Blood Cells' Journal of Physical Chemistry. B, Bd 119, Nr. 25, S. 7837-45.

Heinbockel, L, Palacios-Chaves, L, Alexander, C, Rietschel, E, Behrends, J, Correa, W, Fukuoka, S, Gutsmann, T, Ulmer, AJ & Brandenburg, K 2015, 'Mechanism of Hbγ-35-induced an increase in the activation of the human immune system by endotoxins' INNATE IMMUNITY, Bd 21, Nr. 3, S. 305-13.

Martin L, De Santis R, Koczera P, Simons N, Haase H, Heinbockel L, Brandenburg K, Marx G, Schuerholz T. The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis. PLoS One. 2015 Nov 23;10(11):e0143583. doi: 10.1371/journal.pone.0143583. eCollection 2015.

Garidel P, Kaconis Y, Heinbockel L, Wulf M, Gerber S, Munk A, Vill V, Brandenburg K. Self-Organisation, Thermotropic and Lyotropic Properties of Glycolipids Related to their Biological Implications. Open Biochem J. 2015 Aug 31;9:49-72. doi: 10.2174/1874091X01509010049. eCollection 2015.

Brandenburg KS, Calderon DF, Kierski PR, Brown AL, Shah NM, Abbott NL, Schurr MJ, Murphy CJ, McAnulty JF, Czuprynski CJ. Inhibition of Pseudomonas aeruginosa biofilm formation on wound dressings. Wound Repair Regen. 2015 Nov 12;23(6):842-54. doi: 10.1111/wrr.12365.

Brandenburg K, Schürholz T. Lack of new antiinfective agents: Passing into the pre-antibiotic age? World J Biol Chem. 2015 Aug 26;6(3):71-7. doi:10.4331/wjbc.v6.i3.71.

Brandenburg K, Marx G, Schuerholz T. Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum. PLoS One. 2015 May 29;10(5):e0127584. doi:10.1371/journal.pone.0127584. eCollection 2015.

Sandetskaya N, Engelmann B, Brandenburg K, Kuhlmeier D. Application of immobilized synthetic anti-lipopolysaccharide peptides for the isolation and detection of bacteria. Eur J Clin Microbiol Infect Dis. 2015 Aug;34(8):1639-45. doi: 10.1007/s10096-015-2399-5. Epub 2015 May 19.



Bang, C, Weidenbach, K, Gutsmann, T, Heine, H & Schmitz, RA 2014, 'The Intestinal Archaea Methanosphaera stadtmanae and Methanobrevibacter smithii Activate Human Dendritic Cells' PLOS ONE, Bd 9, Nr. 6, S. e99411., 10.1371/journal.pone.0099411

Correa, W, Manrique-Moreno, M, Patiño, E, Peláez-Jaramillo, C, Kaconis, Y, Gutsmann, T, Garidel, P, Heinbockel, L & Brandenburg, K 2014, 'Galleria mellonella native and analogue peptides Gm1 and ΔGm1. I) Biophysical characterization of the interaction mechanisms with bacterial model membranes' Biochimica et biophysica acta, Bd 1838, Nr. 10, S. 2728-38., 10.1016/j.bbamem.2014.07.006

Correa, W, Manrique-Moreno, M, Behrends, J, Patiño, E, Chakravarty, M, Peláez-Jaramillo, C, Garidel, P, Gutsmann, T, Brandenburg, K & Heinbockel, L 2014, 'Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) anti-bacterial and anti-endotoxic effects' Biochimica et biophysica acta, Bd 1838, Nr. 10, S. 2739-44., 10.1016/j.bbamem.2014.07.005

Gries, A, Prassl, R, Fukuoka, S, Rössle, M, Kaconis, Y, Heinbockel, L, Gutsmann, T & Brandenburg, K 2014, 'Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide' FEBS open bio, Bd 4, S. 432-40., 10.1016/j.fob.2014.04.008

Hoffmann, J, Schneider, C, Heinbockel, L, Brandenburg, K, Reimer, R & Gabriel, G 2014, 'A new class of synthetic anti-lipopolysaccharide peptides inhibits influenza A virus replication by blocking cellular attachment' Antiviral research, Bd 104, S. 23-33., 10.1016/j.antiviral.2014.01.015

Zuzuarregui, A, Souto, D, Pérez-Lorenzo, E, Arizti, F, Sánchez-Gómez, S, Martínez de Tejada, G, Brandenburg, K, Arana, S & Mujika, M 2014, 'Novel integrated and portable endotoxin detection system based on an electrochemical biosensor' The Analyst, Bd 140, Nr. 2, S. 654-60., 10.1039/c4an01324g



Keese, SP, Brandenburg, K, Roessle, M & Schromm, AB 2013, 'Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages' INNATE IMMUNITY, 10.1177/1753425913506269

Dannehl, C, Gutsmann, T & Brezesinski, G 2013, 'Surface activity and structures of two fragments of the human antimicrobial LL-37' Colloids and surfaces. B, Biointerfaces, Bd 109, S. 129-35., 10.1016/j.colsurfb.2013.03.030

Gross, S, Wilms, D, Krause, J, Brezesinski, G & Andrä, J 2013, 'Design of NK-2-derived peptides with improved activity against equine sarcoid cells' Journal of peptide science : an official publication of the European Peptide Society., 10.1002/psc.2540

Abuillan, W, Schneck, E, Körner, A, Brandenburg, K, Gutsmann, T, Gill, T, Vorobiev, A, Konovalov, O & Tanaka, M 2013, 'Physical interactions of fish protamine and antisepsis peptide drugs with bacterial membranes revealed by combination of specular x-ray reflectivity and grazing-incidence x-ray fluorescence' Physical review. E, Statistical, nonlinear, and soft matter physics, Bd 88, Nr. 1, S. 012705.

Banković, J, Andrä, J, Todorović, N, Podolski-Renić, A, Milošević, Z, Miljković, D, Krause, J, Ruždijić, S, Tanić, N & Pešić, M 2013, 'The elimination of P-glycoprotein over-expressing cancer cells by antimicrobial cationic peptide NK-2: the unique way of multi-drug resistance modulation' Experimental cell research, Bd 319, Nr. 7, S. 1013-27., 10.1016/j.yexcr.2012.12.017

Steinhäuser, C, Heigl, U, Tchikov, V, Schwarz, J, Gutsmann, T, Seeger, K, Brandenburg, J, Fritsch, J, Schroeder, J, Wiesmüller, K-H, Rosenkrands, I, Walther, P, Pott, J, Krause, E, Ehlers, S, Schneider-Brachert, W, Schütze, S & Reiling, N 2013, 'Lipid-labeling facilitates a novel magnetic isolation procedure to characterize pathogen-containing phagosomes' Traffic (Copenhagen, Denmark), Bd 14, Nr. 3, S. 321-36., 10.1111/tra.12031

Heinbockel, L, Sánchez-Gómez, S, Martinez de Tejada, G, Dömming, S, Brandenburg, J, Kaconis, Y, Hornef, M, Dupont, A, Marwitz, S, Goldmann, T, Ernst, M, Gutsmann, T, Schürholz, T & Brandenburg, K 2013, 'Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors' ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Bd 57, Nr. 3, S. 1480-7., 10.1128/AAC.02066-12

Richter, W, Heinbockel, L, Kaconis, Y, Steiniger, F, Gutsmann, T, Brade, L & Brandenburg, K 2013, 'Cellular distribution of lipid A and LPS R595 after in vitro application to isolated human monocytes by freeze-fracture replica immunogold-labelling' INNATE IMMUNITY., 10.1177/1753425912473851

Schuerholz, T, Doemming, S, Hornef, M, Martin, L, Simon, T-P, Heinbockel, L, Brandenburg, K & Marx, G 2013, 'The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study' Critical care (London, England), Bd 17, Nr. 1, S. R3., 10.1186/cc11920

Sil, D, Heinbockel, L, Kaconis, Y, Rössle, M, Garidel, P, Gutsmann, T, David, SA & Brandenburg, K 2013, 'Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines' The open biochemistry journal, Bd 7, S. 82-93., 10.2174/1874091X01307010082

Michalek, M, Sonnichsen, FD, Wechselberger, R, Dingley, AJ, Hung, CW, Kopp, A, Wienk, H, Simanski, M, Herbst, R, Lorenzen, I, Marciano-Cabral, F, Gelhaus, C, Gutsmann, T, Tholey, A, Grotzinger, J & Leippe, M 2013, 'Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba' NATURE CHEMICAL BIOLOGY, Bd 9, Nr. 1, S. 37-42., 10.1038/nchembio.1116