Priority Research Area Infections

Cellular Microbiology

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Prof. Dr. Ulrich Schaible
Prof. Dr. Ulrich Schaible
04537 / 188-6000
04537 / 188-2091
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Tuberculosis (TB) is worldwide the most important bacterial infection of humans. The TB agent, Mycobacterium tuberculosis, is a facultative intracellular pathogen able to survive and proliferate inside host macrophages and other phagocytes. We study host-pathogen interactions in tuberculosis on molecular, cellular, animal model and patient levels. Our focus question is how the intracellular niche of the tubercle bacillus determines the pathogens fate and transmission, innate and acquired immune responses as well as pathogenesis and, ultimately, anti-mycobacterial drug efficacy.


Research Topics

  • Virulence properties and intracellular trafficking of mycobacteria
  • Neutrophil - macrophage interactions in tuberculosis
  • Host-directed-therapies and Point-of Care diagnostics of tuberculosis
  • Nano-carrier based anti-tuberculosis drug delivery
  • Imaging of infection and immune processes
  • Respiratory tract microbiota functions in infection & immunity
  • Pathobiology of the emerging pulmonary pathogen, Stenotrophomonas maltophilia