Priority Research Area Infections

2022

Kupsch S, Eggers LF, Spengler D, Gisch N, Goldmann T, Fehrenbach H, Stichtenoth G, Krause MF, Schwudke D, Schromm AB. Characterization of phospholipid-modified lung surfactant in vitro and in a neonatal ARDS model reveals anti-inflammatory potential and surfactant lipidome signatures. Eur J Pharm Sci. 2022 Aug 1;175:106216. doi: 10.1016/j.ejps.2022.106216

 

2021

Brandenburg, K, Schromm, AB, Weindl, G, Heinbockel, L, Correa, W, Mauss, K, Martinez de Tejada, G & Garidel, P 2021, 'An update on endotoxin neutralization strategies in Gram-negative bacterial infections', Expert Review of Anti-Infective Therapy, Jg. 19, Nr. 4, S. 495-517. https://doi.org/10.1080/14787210.2021.1834847

Schromm AB and Brandenburg K 2021, TLR4 ligands: Single Molecules and Aggregates. In: Rossetti C, Peri F. (eds) The Role of Toll-Like Receptor 4 in Infectious and Non Infectious Inflammation. Springer Nature Switzerland AG. https://doi.org/10.1007/978-3-030-56319-6

Schromm AB, Paulowski L, Kaconis Y, Kopp F, Koistinen M, Donoghue A, Keese S, Nehls C, Wernecke J, Garidel P, Sevcsik E, Lohner K, Sanchez-Gomez S, Martinez-de-Tejada G, Brandenburg K, Brameshuber M, Schütz GJ, Andrä J, Gutsmann T. Cathelicidin and PMB neutralize endotoxin by multifactorial mechanisms including LPS‑interaction and targeting of host cell membranes. Proc Natl Acad Sci USA. 2021 Jul 6;118(27):e2101721118. https://doi.org/10.1073/pnas.2101721118. PMID: 34183393

Schocker F, Fehrenbach H, Schromm AB. Mission impossible?: A cultural change to support scientific integrity. EMBO Rep. 2021 Jul 5;22(7):e52334. https://doi.org/10.15252/embr.202052334 <https://doi.org/10.15252/embr.202052334>. Epub 2021 Jul 2. PMID: 34212478

 

2020

Brandenburg K, Schromm AB, Weindl G, Heinbockel L, Correa W, Mauss K, Martinez de Tejada G, Garidel P 2020, An update on endotoxin neutralization strategies in Gram-negative bacterial infections. Expert Rev Anti Infect Ther. Nov 19:1-23. https://doi.org/10.1080/14787210.2021.1834847

Brandenburg K, Garidel P, Schromm AB, Gutsmann T 2020, Physico-chemistry of Lipopolysaccharides. In: Roberts G., Watts A., European Biophysical Societies (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35943-9_531-1

Nehls, C, Böhling, A, Podschun, R, Schubert, S, Grötzinger, J, Schromm, A, Fedders, H, Leippe, M, Harder, J, Kaconis, Y, Gronow, S & Gutsmann, T 2020, 'Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria', BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jg. 1862, Nr. 8, S. 183273. https://doi.org/10.1016/j.bbamem.2020.183273

 

2019

Correa, W, Heinbockel, L, Behrends, J, Kaconis, Y, Barcena-Varela, S, Gutsmann, T, Mauss, K, Schürholz, T, Schromm, AB, Martinez de Tejada, G & Brandenburg, K 2019, 'Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane-bound and free toxins', The FEBS journal, Jg. 286, Nr. 8, S. 1576-1593. https://doi.org/10.1111/febs.14805

Jappe, U, Schwager, C, Schromm, A, Gonzalez Roldan, N, Stein, K, Heine, H & Duda, K 2019, 'Lipophilic allergens, different modes of allergen-lipid interaction and their impact on asthma and allergy', FRONTIERS IN IMMUNOLOGY, Jg. 10, S. 122. https://doi.org/10.3389/fimmu.2019.00122

Pfalzgraff, A, Correa, W, Heinbockel, L, Schromm, AB, Lübow, C, Gisch, N, Martinez-de-Tejada, G, Brandenburg, K & Weindl, G 2019, 'LPS-neutralizing peptides reduce outer membrane vesicle-induced inflammatory responses', BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jg. 1864, Nr. 10, S. 1503-1513. https://doi.org/10.1016/j.bbalip.2019.05.018

 

2018

Heinbockel L, Marwitz S, Schromm AB, Watz H, Kugler C, Ammerpohl O, Schnepf K, Rabe KF, Droemann D, Goldmann T 2018. Identification of novel target genes in human lung tissue involved in Chronic Obstructive Pulmonary Disease. INTERNAT J COPD. Jul 26;13:2255-2259. doi: 10.2147/COPD.S161958.

Facchini, FA, Zaffaroni, L, Minotti, A, Rapisarda, S, Calabrese, V, Forcella, M, Fusi, P, Airoldi, C, Ciaramelli, C, Billod, J-M, Schromm, AB, Braun, H, Palmer, C, Beyaert, R, Lapenta, F, Jerala, R, Pirianov, G, Martin-Santamaria, S & Peri, F 2018, 'Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists' JOURNAL OF MEDICINAL CHEMISTRY, Jg. 61, Nr. 7, S. 2895-2909. DOI: 10.1021/acs.jmedchem.7b01803

Spengler, D, Winoto-Morbach, S, Kupsch, S, Vock, C, Blöchle, K, Frank, S, Rintz, N, Diekötter, M, Janga, H, Weckmann, M, Fuchs, S, Schromm, AB, Fehrenbach, H, Schütze, S & Krause, MF 2018, 'Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model. A translational study' AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY , Jg. 314, Nr. 1, S. L32-L53. DOI: 10.1152/ajplung.00128.2017