Core Group

Biomolecular Data Science in Pneumology

 Mission    Projects    Funding    Techniques    Publications    Staff



North and East African mitochondrial genetic variation needs further characterization towards precision medicine.
A. Fähnrich*, I. Stephan*, M. Hirose, F. Haarich, M.A. Awadelkareem, S. Ibrahim, H. Busch*, Wohlers I*. J Adv Res. 2023:S2090-1232(23)00034-6. doi:

Editorial: Long-read sequencing-Pitfalls, benefits and success stories.
I. Wohlers, S. Garg, J.Y. Hehir-Kwa. Front Genet. 2023;13:1114542. doi:



R. Saurabh, C. Fouodo, I. König, H. Busch and I. Wohlers.
A survey of genome-wide association studies (GWAS), polygenic scores (PGS) and UK Biobank (UKB) highlights resources for autoimmune disease genetics.
Front. Immunol. 2022;5;13:972107. doi:

H. R. Gouda, I. M. Talaat, A. Bouzid, H. El Assi, A. Nabil, T. Venkatachalam, P. Bhamidimarri, I. Wohlers, A. Mahdami, S. El-Gendi, A. Elkoraie, H. Busch, M. M. Saber-Ayad, R. Hamoudi, N. Baddour.
Genetic Analysis of CFH and MCP in Egyptian Patients with Immune-Complex Proliferative Glomerulonephritis.
Front Immunol. 2022;13:960068. doi:

T. Lüth, J. Laβ, S. Schaake, I. Wohlers, J. Pozojevic, R. D. Jamora, R. L. Rosales, N. Brüggemann, G. Saranza, C. C. E. Diesta, K. Schlüter, R. Tse, C. J. Reyes, M. Brand, H. Busch, C. Klein, A. Westenberger, J. Trinh.
Elucidating hexanucleotide repeat number and methylation within the X-linked dystonia-parkinsonism (XDP)-related SVA retrotransposon in TAF1 with Nanopore sequencing.
Genes (Basel). 2022;13(1):126. doi:



M. Munz*, M. Khodaygani*, Z. Aherrahrou, H. Busch and I. Wohlers.
In silico candidate variant and gene identification using inbred mouse strains.
PeerJ. 2021;9:e11017. doi:

M. Ohms, C. Ferreira, H. Busch, I. Wohlers, A. C. Guerra de Souza, R. Silvestre and T. Laskay.
Enhanced glycolysis is required for antileishmanial functions of neutrophils upon infection with Leishmania donovani.
Front Immunol. 2021;12:632512. doi:

D. Prokopenko, S. L. Morgan, K. Mullin, O. Hofmann, B. Chapman, R. Kirchner, S. Amberkar, I. Wohlers, C. Lange, W. Hide, L. Bertram and R. E. Tanzi.
Whole-genome sequencing reveals new Alzheimer’s disease-associated rare variants in loci related to synaptic function and neuronal development.
Alzheimers Dement. 2021;17(9):1509-1527. doi:



I. Wohlers, A. Künstner, M. Munz, M. Olbrich, A. Fähnrich, V. Calonga-Solís, C. Ma, M. Hirose, S. El-Mosallamy, M. Salama, H. Busch* and S. Ibrahim*. (* joint last authors)
A personal and population-based Egyptian genome reference.
Nat Commun. 2020;11(1):4719. doi:

M. Munz, I. Wohlers, E. Simon, T. Reinberger, H. Busch, A. S. Schaefer and J. Erdmann.
Qtlizer: comprehensive QTL annotation of GWAS results.
Sci Rep. 2020;10(1):20417. doi:

S. T. Jünger, F. Andreiuolo, M. Mynarek, I. Wohlers, S. Rahmann, L. Klein-Hitpass, E. Dörner, A. Zur Mühlen, N. Velez-Char, K. von Hoff, M. Warmuth-Metz, R. D. Kortmann, B. Timmermann, A. von Bueren, S. Rutkowski, T. Pietsch.
CDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohort.
Acta Neuropathol. 2020;140(3):405-407. doi:

I. Wohlers, C. Schulz, F. Kilpert and L. Bertram.
Alzheimer's disease risk SNPs show no strong effect on miRNA expression in human lymphoblastoid cell lines.
Neurobiol Aging. 2020;86:202.e1-202.e3. doi: