Fluorescence Cytometry

Mission   Projects   Publications    Staff



ALLIANCE study group as part of the German Center for Lung Research (DZL) 2020, 'RNA-seq based profiling of extracellular vesicles in plasma reveals a potential role of miR-122-5p in asthma', ALLERGY.

Bartel, S, La Grutta, S, Cilluffo, G, Perconti, G, Bongiovanni, A, Giallongo, A, Behrends, J, Kruppa, J, Hermann, S, Chiang, D, Pfaffl, MW & Krauss-Etschmann, S 2020, 'Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development', ALLERGY, Jg. 75, Nr. 2, S. 346-356.

Ritter, K, Sodenkamp, J, Hölscher, A, Behrends, J, Hölscher, C, 'IL-6 is not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium Tuberculosis H37rv', PMID: 33375150, DOI: 10.3390/cells10010009

Schocker, F, Kull, S, Schwager, C, Behrends, J & Jappe, U 2020, Individual Sensitization Pattern Recognition to Cow’s Milk and Human Milk Differs for Various Clinical Manifestations of Milk Allergy. in Cow's Milk and Allergy. MDPI AG, Basel•Beijing•Wuhan•Barcelona•Belgrade, S. 95-105.

Witschkowski, J, Behrends, J, Frank, R, Eggers, L, von Borstel, L, Hertz, D, Mueller, A, Schneider, B,'BCG Provides Short-Term Protection from Experimental Cerebral Malaria in Mice', PMID: 33316929, DOI: 10.3390/vaccines8040745



Bartel S, La Grutta S, Cilluffo G, Perconti G, Bongiovanni A, Giallongo A, Behrends J, Kruppa J, Hermann S, Chiang D, Pfaffl MW, Krauss-Etschmann S. Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development. Allergy. 2019 Aug 6. doi: 10.1111/all.14008.

Correa W, Heinbockel L, Behrends J, Kaconis Y, Barcena-Varela S, Gutsmann T, Mauss K, Schürholz T, Schromm AB, Martinez de Tejada G, Brandenburg K. Antibacterial action of synthetic antilipopolysaccharide peptides (SALP) involves neutralization of both membrane-bound and free toxins. FEBS J. 2019 Apr;286(8):1576-1593. doi: 10.1111/febs.14805. Epub 2019 Mar 20. PubMed PMID: 30843356.

Correa W, Brandenburg J, Behrends J, Heinbockel L, Reiling N, Paulowski L, Schwudke D, Stephan K, Martinez-de-Tejada G, Brandenburg K, Gutsmann T. Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides. Biophys J. 2019 Oct 18. pii: S0006-3495(19)30859-8. doi: 10.1016/j.bpj.2019.10.012.

Ring S, Eggers L, Behrends J, Wutkowski A, Schwudke D, Kröger A, Hierweger AM, Hölscher C, Gabriel G, Schneider B. Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation. JCI Insight. 2019 Apr 18;5. pii: 126533. doi: 10.1172/jci.insight.126533. PubMed PMID: 30998505.

Schocker, F., Kull, S., Schwager, C., Behrends, J. & Jappe, U. Individual Sensitization Pattern Recognition to Cow’s Milk and Human Milk Differs for Various Clinical Manifestations of Milk Allergy. 14.06.2019, in : Nutrients. Nutrients 2019, 11, S. 1331 11 S., Nutrients 2019, 11(6), 1331;



Erdmann H, Behrends J, Ritter K, Hölscher A, Volz J, Rosenkrands I, Hölscher C. The increased protection and pathology in Mycobacterium tuberculosis-infected  IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the  IL-17A-induced expansion of multifunctional T cells. Mucosal Immunol. 2018 May 4.doi: 10.1038/s41385-018-0026-3. [Epub ahead of print] PubMed PMID: 29728641.

Stüve P, Minarrieta L, Erdmann H, Arnold-Schrauf C, Swallow M, Guderian M,  Krull F, Hölscher A, Ghorbani P, Behrends J, Abraham WR, Hölscher C, Sparwasser  TD, Berod L. De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a  Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages. Front Immunol. 2018 Apr 5;9:495. doi: 10.3389/fimmu.2018.00495. eCollection 2018. PubMed PMID: 29675017; PubMed Central PMCID: PMC5895737.

Schocker F, Recke A, Kull S, Worm M, Behrends J, Jappe U. Reply to Chirumbolo et al. Pediatr Allergy Immunol. 2018 Jun;29(4):461-462. doi: 10.1111/pai.12892. Epub 2018 Apr 22. PubMed PMID: 29542182.

Yu X, Akbarzadeh R, Pieper M, Scholzen T, Gehrig S, Schultz C, Zillikens D, König P, Petersen F.Neutrophil Adhesion Is a Prerequisite for Antibody-Mediated Proteolytic Tissue Damage in Experimental Models of Epidermolysis Bullosa Acquisita. J Invest Dermatol. 2018 Mar 17. pii: S0022-202X(18)31729-9. doi: 10.1016/j.jid.2018.03.1499. [Epub ahead of print] PubMed PMID: 29559343.

Scholzen T, Gerlach C, Cattoretti G. An insider's view on how Ki-67, the bright beacon of cell proliferation, became very popular.A tribute to Johannes Gerdes (1950 - 2016). Histopathology. 2018 Mar 11. doi: 10.1111/his.13511. [Epub ahead of print] PubMed PMID: 29526027.


Offermann A, Vlasic I, Syring I, Vogel W, Ruiz C, Zellweger T, Rentsch CA, Hagedorn S, Behrends J, Nowak M, Merseburger A, Bubendorf L, Kirfel J, Duensing S, Shaikhibrahim Z, Perner S. MED15 overexpression in prostate cancer arises
during androgen deprivation therapy via PI3K/mTOR signaling. Oncotarget. 2017 Jan 31;8(5):7964-7976. doi: 10.18632/oncotarget.13860. PubMed PMID: 27974704; PubMed Central PMCID: PMC5352374.

Schmok E, Abad Dar M, Behrends J, Erdmann H, Rückerl D, Endermann T, Heitmann L, Hessmann M, Yoshimura A, Rose-John S, Scheller J, Schaible UE, Ehlers S, Lang R, Hölscher C. Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis. Front Immunol. 2017 Nov 10; 8:1537. doi: 10.3389/fimmu.2017.01537.

Schwager C, Kull S, Behrends J, Röckendorf N, Schocker F, Frey A, Homann A, Becker WM, Jappe U. Peanut oleosins associated with severe peanut allergy - Importance of lipophilic allergens for comprehensive allergy diagnostics. J Allergy Clin Immunol. 2017 Mar 22. pii: S0091-6749(17)30417-7. doi: 10.1016/j.jaci.2017.02.020. [Epub ahead of print] PubMed PMID: 28342912.



Offermann A, Vlasic I, Syring I, Vogel W, Ruiz C, Zellweger T, Rentsch CA, Hagedorn S, Behrends J, Nowak M, Merseburger A, Bubendorf L, Kirfel J, Duensing  S, Shaikhibrahim Z, Perner S. MED15 overexpression in prostate cancer arises  during androgen deprivation therapy via PI3K/mTOR signaling. Oncotarget. 2016 Dec 10. doi: 10.18632/oncotarget.13860. [Epub ahead of print] PubMed PMID: 27974704.

Wang S, Hüttmann G, Scholzen T, Zhang Z, Vogel A, Hasan T, Rahmanzadeh R. A light-controlled switch after dual targeting of proliferating tumor cells via the membrane receptor EGFR and the nuclear protein Ki-67. Sci Rep. 2016 Jun 1;6:27032. doi: 10.1038/srep27032. 

Erdmann H, Behrends J, Hölscher C. During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection. Scientific Reports. 2016;6:32927. doi:10.1038/srep32927.

Böhme J, Roßnagel C, Jacobs T, Behrends J, Hölscher C, Erdmann H. ‚Epstein-Barr virus-induced gene 3 suppresses T helper type 1, type 17 and type 2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation.‘, Immunology. 2016 Mar;147(3):338-48. doi: 10.1111/imm.12565.

Blank J, Eggers L, Behrends J, Jacobs T, Schneider BE., ‚One Episode of Self-Resolving Plasmodium yoelii Infection Transiently Exacerbates Chronic Mycobacterium tuberculosis Infection.‘, Front Microbiol. 2016 Feb 15;7:152. doi: 10.3389/fmicb.2016.00152. eCollection 2016.



Böhme J, Roßnagel C, Jacobs T, Behrends J, Hölscher C, Erdmann H. EBI3 suppresses Th1, Th17 and Th2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation. Immunology. 2015 Dec 23. doi: 10.1111/imm.12565. [Epub ahead of print]

Blank J, Behrends J, Jacobs T, Schneider BE. 2016. Mycobacterium tuberculosis coinfection has no impact on Plasmodium berghei ANKA-induced experimental cerebral malaria in C57BL/6 mice. Infect Immun. 2015 Dec 7;84(2):502-10. doi: 10.1128/IAI.01290-15.

Lewis MD, Behrends J, Sá E Cunha C, Mendes AM, Lasitschka F, Sattler JM, Heiss K, Kooij TW, Prudêncio M, Bringmann G, Frischknecht F, Mueller AK. Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression. J Immunol. 2015 May 15;194(10):4860-70. doi: 10.4049/jimmunol.1400863. Epub 2015 Apr 10.

Lunding LP, Webering S, Vock C, Behrends J, Wagner C, Hölscher C, Fehrenbach H, Wegmann M. Poly(inosinic-cytidylic) Acid-Triggered Exacerbation of Experimental Asthma Depends on IL-17A Produced by NK Cells. J Immunol. 2015 May 13. pii: 1402529. [Epub ahead of print]



Heinbockel L, Palacios-Chaves L, Alexander C, Rietschel E, Behrends J, Correa W, Fukuoka S, Gutsmann T, Ulmer AJ, Brandenburg K. Mechanism of Hbγ-35-induced anincrease in the activation of the human immune system by endotoxins. Innate Immun. 2014 Jul 16. pii: 1753425914535957. [Epub ahead of print]

Schneider BE, Behrends J, Hagens K, Harmel N, Shayman JA, Schaible UE. Lysosomal phospholipase A2: A novel player in host immunity to Mycbacterium tuberculosis. EUROPEAN JOURNAL of IMMUNOLOGY 2014; DOI: 10.1002/eji.201244383

Mueller AK, Behrends J, Blank J, Schaible UE, Schneider BE. An experimental model to study tuberculosis-malaria coinfection upon natural transmission of Mycobacterium tuberculosis and Plasmodium berghei. J Vis Exp. 2014 Feb 17;(84):e50829. doi: 10.3791/50829. PubMed PMID: 24637905

Correa W, Manrique-Moreno M, Behrends J, Patiño E, Marella C, Peláez-Jaramillo C, Garidel P, Gutsmann T, Brandenburg K, Heinbockel L. Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) Anti-bacterial and anti-endotoxic effects. Biochim Biophys Acta. 2014 Oct;1838(10):2739-44. doi: 10.1016/j.bbamem.2014.07.005. Epub 2014 Jul 10.

Berod L, Stüve P, Varela F, Behrends J, Swallow M, Kruse F, Krull F, Ghorbani P, Mayer CT, Hölscher C, Sparwasser T. Rapid Rebound of the Treg Compartment in DEREG Mice Limits the Impact of Treg Depletion on Mycobacterial Burden, but Prevents Autoimmunity. PLoS One. 2014 Jul 22;9(7):e102804. doi:10.1371/journal.pone.0102804. eCollection 2014.

Heitmann L, Abad Dar M, Schreiber T, Erdmann H, Behrends J, Mckenzie AN, Brombacher F, Ehlers S, Hölscher C. The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology. J Pathol. 2014 Jun 30. doi: 10.1002/path.4399. [Epub ahead of print]



Behrends J, Renauld JC, Ehlers S, Hölscher C. IL-22 is mainly produced by IFNγ-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection. PLoS One. 2013;8(2):e57379. doi: 10.1371/journal.pone.0057379. Epub 2013 Feb 27. PubMed PMID: 23460846; PubMed Central PMCID: PMC3583848.



Mueller AK, Behrends J, Hagens K, Mahlo J, Schaible UE, Schneider BE. Natural transmission of Plasmodium berghei exacerbates chronic tuberculosis in an experimental co-infection model. PLoS One. 2012;7(10):e48110. doi: 10.1371/journal.pone.0048110. Epub 2012 Oct 26. PubMed PMID: 23110184; PubMedCentral PMCID: PMC3482195.

Everts, B, Hussaarts, L, Driessen, NN, Meevissen, MHJ, Schramm, G, van der Ham, AJ, van der Hoeven, B, Scholzen, T, Burgdorf, S, Mohrs, M, Pearce, EJ, Hokke, CH, Haas, H, Smits, HH & Yazdanbakhsh, M 2012, 'Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor' JOURNAL OF EXPERIMENTAL MEDICINE, Bd 209, Nr. 10, S. 1753-1767., 10.1084/jem.20111381 



Kaur, I, Schramm, G, Everts, B, Scholzen, T, Kindle, KB, Beetz, C, Montiel-Duarte, C, Blindow, S, Jones, AT, Haas, H, Stolnik, S, Heery, DM & Falcone, FH 2011, 'Interleukin-4-inducing principle from Schistosoma mansoni eggs contains a functional C-terminal nuclear localization signal necessary for nuclear translocation in mammalian cells but not for its uptake' Infection and immunity, Bd 79, Nr. 4, S. 1779-88., 10.1128/IAI.01048-10

Sodenkamp J, Behrends J, Förster I, Müller W, Ehlers S, Hölscher C. gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis. Eur J Cell Biol. 2011 Jun-Jul;90(6-7):505-14. doi: 10.1016/j.ejcb.2010.10.010. Epub 2010 Dec 8. Review. PubMed PMID: 21144615.



Lindner, U, Kramer, J, Behrends, J, Driller, B, Wendler, N-O, Boehrnsen, F, Rohwedel, J & Schlenke, P 2010, 'Improved proliferation and differentiation capacity of human mesenchymal stromal cells cultured with basement-membrane extracellular matrix proteins' Cytotherapy, Bd 12, Nr. 8, S. 992-1005., 10.3109/14653249.2010.510503



Karsten CM, Behrends J, Wagner AK, Fuchs F, Figge J, Schmudde I, Hellberg L, Kruse A. DC within the pregnant mouse uterus influence growth and functional properties of uterine NK cells. Eur J Immunol. 2009 Aug;39(8):2203-14. doi: 10.1002/eji.200838844.


Behrends J, Karsten CM, Wilke S, Röbke A, Kruse A. Identification of ITGA4/ITGB7 and ITGAE/ITGB7 expressing subsets of decidual dendritic-like cells within distinct microdomains of the pregnant mouse uterus. Biol Reprod. 2008 Oct;79(4):624-32. doi: 10.1095/biolreprod.107.067041. Epub 2008 Jun 18.