Medicine

2023

Vierbuchen, T, Agarwal, S, Johnson, JL, Galia, L, Lei, X, Stein, K, Olagnier, D, Gaede, KI, Herzmann, C, Holm, CK, Heine, H, Pai, A, O'Hara Hall, A, Hoebe, K & Fitzgerald, KA 2023, 'The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jg. 120, Nr. 1, S. e2213715120. https://doi.org/10.1073/pnas.2213715120

 

2022

Brandenburg, J, Heyckendorf, J, Marwitz, F, Zehethofer, N, Linnemann, L, Gisch, N, Karaköse, H, Reimann, M, Kranzer, K, Kalsdorf, B, Sanchez-Carballo, P, Weinkauf, M, Scholz, V, Malm, S, Homolka, S, Gaede, KI, Herzmann, C, Schaible, UE, Hölscher, C, Reiling, N & Schwudke, D 2022, 'Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis', ACS infectious diseases, Jg. 8, Nr. 7, S. 1303-1315. https://doi.org/10.1021/acsinfecdis.2c00075

COVICAT study group, Aachen Study (COVAS) 2022, 'Detailed stratified GWAS analysis for severe COVID-19 in four European populations',  HUMAN MOLECULAR GENETICS , Jg. 31, Nr. 23, S. 3945-3966. https://doi.org/10.1093/hmg/ddac158

Freundt, K, Herzmann, C, Biedziak, D, Scheffzük, C, Gaede, KI & Stamme, C 2022, 'Surfactant protein A enhances the degradation of LPS-induced TLR4 in primary alveolar macrophages involving Rab7, β-arrestin2, and mTORC1', INFECTION AND IMMUNITY , Jg. 90, Nr. 2, S. e0025021. https://doi.org/10.1128/IAI.00250-21

Tran, F, Harris, DMM, Scharmacher, A, Graßhoff, H, Sterner, K, Schinke, S, Käding, N, Humrich, JY, Cabral-Marques, O, Bernardes, JP, Mishra, N, Bahmer, T, Franzenburg, J, Hoyer, BF, Glück, A, Guggeis, M, Ossysek, A, Küller, A, Frank, D, Lange, C, Rupp, J, Heyckendorf, J, Gaede, KI, Amital, H, Rosenstiel, P, Shoenfeld, Y, Halpert, G, Rosenberg, AZ, Schulze-Forster, K, Heidecke, H, Riemekasten, G & Schreiber, S 2022, 'Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19', ERJ Open Research, Jg. 8, Nr. 4. https://doi.org/10.1183/23120541.00379-2022

 

2021

ALLIANCE Study Group, Weckmann, M, Thiele, D, Liboschik, L, Bahmer, T, Pech, M, Dittrich, A-M, Fuchs, O, Happle, C, Schaub, B, Ricklefs, I, Rabe, KF, von Mutius, E, Hansen, G, König, IR, Kopp, MV & Gaede, KI 2021, 'Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time', CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Jg. 204, Nr. 1, S. 152-164. https://doi.org/10.1111/cei.13550

COVID-19 Host Genetics Initiative, Lange, C, Heyckendorf, J & Gaede, KI 2021, 'Mapping the human genetic architecture of COVID-19', NATURE. https://doi.org/10.1038/s41586-021-03767-x

Freundt, K, Herzmann, C, Biedziak, D, Scheffzük, C, Gaede, KI & Stamme, C 2021, 'Surfactant protein A enhances the degradation of LPS-induced TLR4 in primary alveolar macrophages involving Rab7, β-arrestin2, and mTORC1', INFECTION AND IMMUNITY , S. IAI0025021. https://doi.org/10.1128/IAI.00250-21

Frye, BC, Gaede, KI, Saltini, C, Rossman, MD, Monos, DS, Rosenman, KD, Schuler, CR, Weston, A, Wegner, R, Noth, R, Zissel, G, Schreiber, S, Nothnagel, M & Müller-Quernheim, J 2021, 'Analysis of single nucleotide polymorphisms in chronic beryllium disease', RESPIRATORY RESEARCH , Jg. 22, Nr. 1, S. 107. https://doi.org/10.1186/s12931-021-01691-2

Pfeiffer, S, Herzmann, C, Gaede, KI, Kovacevic, D, Krauss-Etschmann, S & Schloter, M 2021, 'Different responses of the oral, nasal and lung microbiomes to cigarette smoke', Thorax. https://doi.org/10.1136/thoraxjnl-2020-216153

 

2020

Jünger, C, Reimann, M, Krabbe, L, Gaede, KI, Lange, C, Herzmann, C & Rüller, S 2020, 'Non-invasive ventilation with pursed lips breathing mode for patients with COPD and hypercapnic respiratory failure: A retrospective analysis', PLOS ONE, Jg. 15, Nr. 9, S. e0238619. https://doi.org/10.1371/journal.pone.0238619

 

2019

Lieb, W, Jacobs, G, Wolf, A, Richter, G, Gaede, KI, Schwarz, J, Arnold, N, Böhm, R, Buyx, A, Cascorbi, I, Franke, A, Glinicke, C, Held-Feindt, J, Junker, R, Kalthoff, H, Kramer, H-H, Leypoldt, F, Maass, N, Maetzler, W, May, S, Mehdorn, HM, Röcken, C, Schafmayer, C, Schrappe, M, Schreiber, S, Sebens, S, Stephani, U, Synowitz, M, Weimer, J, Zabel, P, Nöthlings, U, Röder, C & Krawczak, M 2019, 'Linking pre-existing biorepositories for medical research: the PopGen 2.0 Network', Journal of community genetics, Jg. 10, Nr. 4, S. 523-530. https://doi.org/10.1007/s12687-019-00417-8

Webering, S, Lunding, LP, Vock, C, Schröder, A, Gaede, KI, Herzmann, C, Fehrenbach, H & Wegmann, M 2019, 'The alpha-melanocyte-stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma', Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Jg. 49, Nr. 7, S. 1026-1039. https://doi.org/10.1111/cea.13400

 

2018

Fuchs O, Bahmer T, Weckmann M, Dittrich AM, Schaub B, Rosler B, Happle C, Brinkmann F, Ricklefs I, Konig IR, Watz H, Rabe KF, Kopp MV, Hansen G, von Mutius E (2018) The all age asthma cohort (ALLIANCE) - from early beginnings to chronic disease: a longitudinal cohort study. BMC Pulm Med 18: 140 (ARCN, BREATH, CPC-M)

Heinbockel L, Marwitz S, Schromm AB, Watz H, Kugler C, Ammerpohl O, Schnepf K, Rabe KF, Droemann D, Goldmann T (2018) Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 13: 2255-2259 (ARCN)

Marwitz S, Heinbockel L, Scheufele S, Kugler C, Reck M, Rabe KF, Perner S, Goldmann T, Ammerpohl O (2018) Fountain of youth for squamous cell carcinomas? On the epigenetic age of NSCLC and corresponding tumor-free lung tissues. Int J Cancer (ARCN)

Schupp JC, Freitag-Wolf S, Bargagli E, Mihailović-Vučinić V, Rottoli P, Grubanovic A, Müller A, Jochens A, Tittmann L, Schnerch J, Olivieri C, Fischer A, Jovanovic D, Filipovic S, Videnovic-Ivanovic J, Bresser P, Jonkers R, O'Reilly K, Ho LP, Gaede KI, Zabel P, Dubaniewicz A, Marshall B, Kieszko R, Milanowski J, Günther A, Weihrich A, Petrek M, Kolek V, Keane MP, O'Beirne S, Donnelly S, Haraldsdottir SO, Jorundsdottir KB, Costabel U, Bonella F, Wallaert B, Grah C, Peroš-Golubičić T, Luisetti M, Kadija Z, Pabst S, Grohé C, Strausz J, Vašáková M, Sterclova M, Millar A, Homolka J, Slováková A, Kendrick Y, Crawshaw A, Wuyts W, Spencer L, Pfeifer M, Valeyre D, Poletti V, Wirtz H, Prasse A, Schreiber S, Krawczak M, Müller-Quernheim J. Phenotypes of organ involvement in sarcoidosis. Eur Respir J. 2018 Jan 25;51(1). pii: 1700991. doi: 10.1183/13993003.00991-2017.  Print 2018 Jan. PubMed PMID: 29371378.
 

2017

Bahmer, T., Waschki, B., Schatz, F., Herzmann, C., Zabel, P., Kirsten, A-M., Rabe, K. F., Watz, H. & ERA-Study Group (Gaede, KI Member of ERA-Study Group) Physical activity, airway resistance and small airway dysfunction in severe asthma . 04.01.2017 in : EUROPEAN RESPIRATORY JOURNAL. 49

Eggers LF, Julia Müller, Chakravarthy Marella, Verena Scholz, Henrik Watz, Christian Kugler, Klaus F. Rabe, Torsten Goldmann, and Dominik Schwudke. Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema. Sci Rep. 2017 Sep 11;7(1):11087.

Gaber R, Watermann I, Kugler C, Vollmer E, Perner S, Reck M, Goldmann T (2017) Preselection of EGFR mutations in non-small-cell lung cancer patients by immunohistochemistry: comparison with DNA-sequencing, EGFR wild-type expression, gene copy number gain and clinicopathological data. Rom J Morphol Embryol 58: 1175-1184 (ARCN)

Hoppe J, Can Murat Ünal, Stefanie Thiem, Louisa Grimpe, Torsten Goldmann, Nikolaus Gaßler, Matthias Richter, Olga Shevchuk, Michael Steinert PilY1 promotes Legionella pneumophila infection of human lung tissue explants and contributes to bacterial adhesion, host cell invasion and twitching motility. Frontiers in Cellular and Infection Microbiology Front Cell Infect Microbiol. 2017 Mar 7;7:63.

Kaufhold I, Sünja Osbahr, Kensuke Shima, Sebastian Marwitz, Kristina Rohmann, Daniel Drömann, Torsten Goldmann, Klaus Dalhoff, Jan Rupp. Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells. Microbes Infect. 2017 Nov;19(11):560-566.

Krause T, Rockendorf N, Gaede KI, Ramaker K, Sinnecker H, Frey A (2017) Validation of antibody reagents for mucin analysis in chronic inflammatory airway diseases. MAbs 9: 333-341 (ARCN)

Marwitz S, Heinbockel L, Scheufele S, Nitschkowski D, Kugler C, Perner S, Reck M, Ammerpohl O, Goldmann T (2017) Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression. Clin Epigenetics 9: 123 (ARCN)

Marwitz S, Scheufele S, Perner S, Reck M, Ammerpohl O, Goldmann T (2017) Epigenetic modifications of the immune-checkpoint genes CTLA4 and PDCD1 in non-small cell lung cancer results in increased expression. Clin Epigenetics 9: 51 (ARCN)

Müller-Quernheim, J., Fischer, A., Krawczak, M., Freitag-Wolf, S., Bargagli, E., Schupp, J. C., Mihailovic-Vucinic , V., Rottoli, P., Grubanovic, A., Müller, A., Jochens, A., Tittmann, L., Schnerch, J., Olivieri, C., Prasse, A., Schreiber, S., GenPhenReSa consortium & Gaede, K. I. Morbidity and phenotypes of organ involvements in sarcoidosis. The European respiratory journal.  2017 (Accepted/In press)

Watz H, Uddin M, Pedersen F, Kirsten A, Goldmann T, Stellmacher F, Groth E, Larsson B, Böttcher G, Malmgren A, Kraan M, Rabe KF. Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma. Pulm Pharmacol Ther. 2017 Aug;45:121-123.

Zimmermann A, Knecht H, Hasler R, Zissel G, Gaede KI, Hofmann S, Nebel A, Muller-Quernheim J, Schreiber S, Fischer A (2017) Atopobium and Fusobacterium as novel candidates for sarcoidosis-associated microbiota. Eur Respir J 50 (ARCN)

 

2016

Ganbat D, Seehase S, Richter E, Vollmer E, Reiling N, Fellenberg K, Gaede KI, Kugler C, Goldmann T (2016) Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells. BMC Pulm Med 16: 19 (ARCN)

Goldmann T, Kugler C, Reinmuth N, Vollmer E, Reck M (2016) PD-L1 copy number gain in nonsmall-cell lung cancer defines a new subset of patients for anti PD-L1 therapy. Ann Oncol 27: 206-207 (ARCN)

Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar, Erny D, Stefanowski J, Rogell L, Klein C, Gharun K, Follo M, Seidl M, Kremer B, Münke N, Senges J, Fliegauf M, Aschman T, Pfeifer D, Sarrazin S, Sieweke MH, Wagner D, Dierks Ch, Haaf T, Ness T, Zaiss MM, Voll RE, Deshmukh SD, Prinz M, Goldmann T, Hölscher Ch, Hauser AE, Lopez-Contreras AJ, Grün D, Gorgoulis V, Diefenbach A, Henneke Ph, Triantafyllopoulo A. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell 167, 1–17, November 17, 2016. IF 28.710

Marwitz S, Depner S, Dvornikov D, Merkle R, Szczygiel M, Muller-Decker K, Lucarelli P, Wasch M, Mairbaurl H, Rabe KF, Kugler C, Vollmer E, Reck M, Scheufele S, Kroger M, Ammerpohl O, Siebert R, Goldmann T, Klingmuller U (2016) Downregulation of the TGFbeta Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFbeta Signaling and Invasion. Cancer Res 76: 3785-3801 (ARCN, TLRC)

Schnerch J, Prasse A, Vlachakis D, Schuchardt KL, Pechkovsky DV, Goldmann T, Gaede KI, Muller-Quernheim J, Zissel G (2016) Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis. Am J Respir Cell Mol Biol 55: 749-757 (ARCN)