Priority Research Area Infections
Host Determinants in Lung Infections
Mission Projects Funding Techniques Publications Staff
Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is one of the most deadly infectious diseases worldwide. The rate of progression to disease is driven by a complex interplay of pathogen and host-related factors. The current poor understanding of protective versus non-protective host responses hampers the development of new treatments, particularly those based on immunomodulatory strategies. The overall goal of our research is to understand how host-related factors regulate anti-tuberculosis defenses, focusing on two major aspects, which are likely to play a crucial role in the pathogenesis of TB: the biological sex and viral coinfections.