Programmbereich Asthma und Allergie

Klinische und Molekulare Allergologie

Mission   Projekte   Drittmittel   Methoden    Organisation Kongress/Symposien    Preise und Auszeichnungen    Publikationen  Mitarbeiter/innen

Publikationen

2021

Behrends J, Schwager C, Hein M, Scholzen T, Kull S, Jappe U. Innovative robust basophil activation test using a novel gating strategy reliably diagnosing allergy with full automation. Allergy  2021 (online ahead of print)

Gülsen, A, König, IR, Jappe, U & Drömann, D 2021, 'Effect of comorbid pulmonary disease on the severity of COVID-19: A systematic review and meta-analysis', Respirology (Carlton, Vic.). https://doi.org/10.1111/resp.14049

Gülsen, A, Wallis, S & Jappe, U 2021, 'Combination of immunotherapies for severe allergic asthma', Journal of Asthma, Jg. 58, Nr. 1, S. 75-78. https://doi.org/10.1080/02770903.2019.1658204

Gülsen, A, Ruëff, F & Jappe, U 2021, 'Omalizumab ensures compatibility to bee venom immunotherapy (VIT) after VIT-induced anaphylaxis in a patient with systemic mastocytosis', Allergologie select, Jg. 5, S. 128-132. https://doi.org/10.5414/ALX02196E

Jappe, U, Beckert, H, Bergmann, K-C, Gülsen, A, Klimek, L, Philipp, S, Pickert, J, Rauber-Ellinghaus, MM, Renz, H, Taube, C, Treudler, R, Wagenmann, M, Werfel, T, Worm, M & Zuberbier, T 2021, 'Biologics for atopic diseases:Indication, side effect management, and new developments', Allergologie select, Jg. 5, S. 1-25. https://doi.org/10.5414/ALX02197E

Jappe, U, Karstedt, A, Warneke , D, Hellmig, S, Böttger, M, Riffelmann , FW, Treudler, R, Lange, L, Abraham, S, Dölle-Bierke, S, Worm, M, Wagner, N, Ruëff, F, Reese, G, Knulst, AC & Becker, W-M 2021, 'Identification and Purification of Novel Low-Molecular-Weight Lupine Allergens as Components for Personalized Diagnostics', Nutrients, Jg. 13, Nr. 2. https://doi.org/10.3390/nu13020409

Jappe, U, Schwager, C & Gadermaier, G 2021, 'Neue Allergene in der Erdnuss als Ursache einer Anaphylaxie', ALLERGOLOGIE, Jg. 44, Nr. 4, S. 271-276.

Kraft, M, Dölle-Bierke, S, Renaudin, J-M, Ruëff, F, Hofmeier, KS, Treudler, R, Pföhler, C, Hawranek, T, Poziomkowska-Gęsicka, I, Jappe, U, Christoff, G, Müller, S, Fernandez-Rivas, M, García, BE, De Vicente Jiménez, TM, Cardona, V, Kleinheinz, A, Kreft, B, Bauer, A, Wagner, N, Wedi, B, Wenzel, M, Bilò, MB & Worm, M 2021, 'Wheat anaphylaxis in adults differs from reactions to other types of food', Journal of Allergy and Clinical Immunology in Clinical Practice. https://doi.org/10.1016/j.jaip.2021.03.037

Platts-Mills, TA, Hilger, C, Jappe, U, van Hage, M, Gadermaier, G, Spillner, E, Lidholm, J, Keshavarz, B, Aalberse, RC, van Ree, R, Goodman, RE & Pomés, A 2021, 'Carbohydrate Epitopes Currently Recognized as Targets for IgE Antibodies', ALLERGY. https://doi.org/https://onlinelibrary.wiley.com/doi/10.1111/all.14802

Recke A, Becker M, Jappe U. Neu erworbene Milchallergie im Erwachsenenalter. Allergologie 2021; 44: 592-595.

Schocker, F, Fehrenbach, H & Schromm, AB 2021, 'Mission impossible? A cultural change to support scientific integrity', EMBO REPORTS , Jg. 22, Nr. 7, S. e52334. https://doi.org/10.15252/embr.202052334

Wanka, L & Jappe, U 2021, 'Trained Immunity and Allergy: State of the Art and Future Perspectives', ALLERGY, Jg. 76, Nr. 4, S. 1265-1267. https://doi.org/10.1111/all.14617

Worm, M, Reese, I, Ballmer-Weber, B, Beyer, K, Bischoff, SC, Bohle, B, Brockow, K, Claßen, M, Fischer, PJ, Hamelmann, E, Jappe, U, Kleine-Tebbe, J, Klimek, L, Koletzko, B, Lange, L, Lau, S, Lepp, U, Mahler, V, Nemat, K, Raithel, M, Saloga, J, Schäfer, C, Schnadt, S, Schreiber, J, Szépfalusi, Z, Treudler, R, Wagenmann, M, Werfel, T & Zuberbier, T 2021, 'Update of the S2k guideline on the management of IgE-mediated food allergies', Allergologie select, Jg. 5, S. 195-243. https://doi.org/10.5414/ALX02257E

 

2020

Dölle-Bierke S, Plank-Habibi S, Schäfer C, Ahrens B, Ballmer-Weber B, Beyer K, Blümchen K, Hutteger I, Jappe U, Kleine-Tebbe J, Lange L, Lau S, Lepp U, Mahler V, Müller S, Saloga J, Schnadt S, Szepfalusi Z, Treudler R, Wassmann-Otto A, Werfel T, Zuberbier T, Reese I, Worm M. Diätetische Implikationen bei ASS-Unverträglichkeit. Stellungnahme der AG Nahrungsmittelallergie der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI). Allergo Journal Int 2020 Allergo J Int 2020; 29: 93–6

Ferastraoaru D, Bax HJ, Bergmann C, Capron M, Castells M, Dombrowicz D, Fiebiger E, Gould HJ, Hartmann K, Jappe U, Jordakieva G, Josephs DH, Levi-Schaffer F, Mahler V, Poli A, Rosenstreich D, Roth-Walter F, Shamji M, Steveling-Klein EH, Turner MC, Untersmayr E, Karagiannis SN, Jensen-Jarolim E. AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer-A Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI). Clin Transl Allergy. 2020 Jul 17;10:32. doi: 10.1186/s13601-020-00335-w. eCollection 2020.

Gülsen A, Wedi B, Jappe U. Hypersensitivity reactions to biologics (Part I): allergy as an important differential diagnosis in complex immune-derived adverse events. Allergo Journal International 20 May online DOI: 10.1007/s40629-020-00126-6

Gülsen A, Wedi B, Jappe U 2020, 'Hypersensitivity reactions to Biologics (Part II): classifications and current diagnostic and treatment approaches', Allergo Journal International. https://doi.org/doi.org/10.1007/s40629-020-00127-5

Gülsen, A, Wedi, B & Jappe, U 2020, 'Hypersensitivity reactions to biologics (Part I) allergy as an important differential diagnosis in complex immune-derived adverse events', Allergo Journal, Jg. 29, Nr. 4, S. 32-61. https://doi.org/10.1007/s15007-020-2550-1

Kaiser, A, Wanka, L, Ziffert, I & Beck-Sickinger, AG 2020, 'Biased Agonists at the Human Y1 Receptor Lead to Prolonged Membrane Residency and Extended Receptor G-Protein Interaction', CELLULAR AND MOLECULAR LIFE SCIENCES , Jg. 77, Nr. 22, S. 4675-4691. https://doi.org/DOI:10.1007/s00018-019-03432-7

Klimek, L, Pfaar, O, Worm, M, Eiwegger, T, Hagemann, J, Ollert, M, Untersmayr, E, Hoffmann-Sommergruber, K, Vultaggio, A, Agache, I, Bavbek, S, Bossios, A, Casper, I, Chan, S, Chatzipetrou, A, Vogelberg, C, Firinu, D, Kauppi, P, Kolios, A, Kothari, A, Matucci, A, Palomares, O, Szépfalusi, Z, Pohl, W, Hötzenecker, W, Rosenkranz, A, Bergmann, K-C, Bieber, T, Buhl, R, Buters, J, Darsow, U, Keil, T, Kleine-Tebbe, J, Lau, S, Maurer, M, Merk, H, Mösges, R, Saloga, J, Staubach, P, Jappe, U, Rabe, C, Rabe, U, Vogelmeier, C, Biedermann, T, Jung, K, Schlenter, W, Ring, J, Chaker, A, Wehrmann, W, Becker, S, Freudelsperger, L, Mülleneisen, N, Nemat, K, Czech, W, Wrede, H, Brehler, R, Fuchs, T, Tomazic, P-V, Aberer, W, Fink Wagner, A, Horak, F, Wöhrl, S, Niederberger-Leppin, V, Pali-Schöll, I, Roller-Wirnsberger, R, Spranger, O, Valenta, R, Akdis, M, Matricardi, PM, Spertini, F, Khaltaev, N, Michel, J-P, Nicod, L, Schmid-Grendelmeier, P, Idzko, M, Hamelmann, E, Jakob, T, Werfel, T, Wagenmann, M, Taube, C, Jensen-Jarolim, E, Korn, S, Hentges, F, Schwarze, J, O Mahony, L, Knol, E, Del Giacco, S, Chivato, T, Bousquet, J, Zuberbier, T, Akdis, C & Jutel, M 2020, 'Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemie: Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI)D, der Luxemburgischen Gesellschaft für Allergologie und Immunologie (LGAI)E, der Österreichischen Gesellschaft für Pneumologie (ÖGP)F in Kooperation mit der deutschen, österreichischen, und schweizerischen ARIA-GruppeG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H', Allergo Journal, Jg. 29, Nr. 4, S. 14-27. https://doi.org/10.1007/s15007-020-2553-y

Kraft, M, Hofmeier, KS, Ruëff, F, Pföhler, C, Renaudin, J-M, Bilò, MB, Treudler, R, Lang, R, Cichoka-Jarosz, E, Fernandez-Rivas, M, Christoff, G, Papadopoulus, NG, Ensina, LF, O'B Hourihane, J, Maris, I, Köhli, A, García, BE, Jappe, U, Vogelberg, C, Ott, H, Lange, L, Spindler, T, Dölle-Bierke, S & Worm, M 2020, 'Risk factors and characteristics of biphasic anaphylaxis', Journal of Allergy and Clinical Immunology in Clinical Practice. https://doi.org/10.1016/j.jaip.2020.07.036

Krause T, Niels Röckendorf, Meckelein B, Sinnecker H, Schwager C, Möckel S, Jappe U, Frey A. IgE epitope profiling for allergy diagnosis and therapy – in parallel-analysis of a multitude of potential linear epitopes using a high throughput screening platform. Front. Immunol., 30 September 2020 | https://doi.org/10.3389/fimmu.2020.565243

Ramírez Caballero L, Kny C, Treudler R, Simon JC, Kern K, Jappe U, Szardenings M. 2020, 'Identification of seasonal variations of antibodies against PR-10 specific epitopes can be improved using peptide-phage display', International archives of allergy and immunology. https://doi.org/10.1159/000509995

Thomas A.E. Platts-Mills, Scott P. Commins, Tilo Biedermann, Marianne van Hage, Michael Levin, Lisa A. Beck, Maria Diuk-Wasser, Uta Jappe, Danijela Apostolovic, Michael Minnicozzi, Marshall Plaut, Jeffrey M. Wilson & Jappe, U 2020, 'On the cause and consequences of IgE to galactose-α-1,3-galactose: A Report from the National Institute of Allergy and Infectious Disease Workshop on Understanding IgE-Mediated Mammalian Meat Allergy', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Jg. 145, Nr. 4, S. 1061-1071. https://doi.org/10.1016/j.jaci.2020.01.047

 

2019

González Roldán N, Engel R, Düpow S, Jakob K, Koops F, Orinska Z, Vigor C, Oger C, Galano J-M, Durand T, Jappe U and Duda KA (2019) Lipid Mediators From Timothy Grass Pollen Contribute to the Effector Phase of Allergy and Prime Dendritic Cells for Glycolipid Presentation. Front. Immunol. 10:974. doi: 10.3389/fimmu.2019.00974

Gülsen A, Jappe U. Lipid transfer protein sensitization in an apple-allergic patient: a case report from northern Europe. Eur Ann Allergy Clin Immunol 2019; 51: 38-41.

Jappe U, Breiteneder H.Peanut allergy-Individual molecules as a key to precision medicine (Editorial) Allergy. 2019 Feb;74(2):216-219. doi: 10.1111/all.13625

Jappe U, Schwager C, Schromm AB, Gonzalez Roldan N, Stein K, Heine H, Duda K. Lipophilic allergens, different modes of allergen-lipid interaction and their impact on asthma and allergy. Frontiers in Immunology 2019;10:122-130

Recke A, Massalme EG, Jappe U, Steinmüller-Magin L, Schmidt J, Hellenbroich Y, Hüning I, Gillessen-Kaesbach G, Zillikens D, Hartmann K. Identification of the recently described plasminogen gene mutation in a family from Northern Germany with hereditary angioedema. Clinical Translational Allergy 2019 Feb 14;9:9. doi: 10.1186/s13601-019-0247-x.

Schocker, F.; Kull, S.; Schwager, C.; Behrends, J.; Jappe, U. Individual Sensitization Pattern Recognition to Cow’s Milk and Human Milk Differs for Various Clinical Manifestations of Milk Allergy. Nutrients 2019, 11, 1331.

 

2018

Anemüller W, Mohr M, Brans R, Homann A, Jappe U.Alpha-Gal-associated delayed red meat anaphylaxis as an occupational disease. Hautarzt. 2018; 69(10):848-852. doi: 10.1007/s00105-018-4224-4. German.

Jappe U. Nahrungsmittelallergie: Theorie und Praxis. Deutsche Medizinische Wochenschrift. 2018; 143(10): 713-721

M. McIntyre, U. Darsow, A. Zink. Ohrmuschel und Gehörgang: wann ist es eine Allergie? Allergologie, Jahrgang 41, Nr. 3/2018, S. 105-110.

Pomés A, Davies JM, Gadermaier G, Hilger C, Holzhauser T, Lidholm J, Lopata A, Mueller GA, Nandy A, Radauer C, Chan SK, Jappe U, Kleine-Tebbe J, Thomas WR, Chapman MD, van Hage M, van Ree R, Vieths S, Raulf M, Goodman RG* on behalf of the WHO/IUIS Allergen Nomenclature Sub-Committee WHO/IUIS Allergen Nomenclature: Providing a common language. Molecular Immunology 2018; 100:3-13.  doi: 10.1016/j.molimm.2018.03.003.

Nikolić J, Nešić A, Kull S, Schocker F, Jappe U#, Gavrović-Jankulović M#. Employment of combinatorial peptide ligand libraries for the identification of catalase as novel allergen from banana fruit. J Proteomics 2018; 175:87-94. doi: 10.1016/j.jprot.2018.01.007.

Cabanillas B, Jappe U, Novak N.Allergy to Peanut, Soybean, and Other Legumes: Recent Advances in Allergen Characterization, Stability to Processing and IgE Cross-Reactivity. Mol Nutr Food Res. 2018 Jan;62(1): 1-9. doi: 10.1002/mnfr.201700446. Epub 2017

Jappe U. Nomenklatur der Allergene. Der Hautarzt 2018; 69: 90-91 doi: 10.1007/s00105-017-4103-4.

Jappe U, Kull S, Opitz A, Zabel P. Anaphylaxis to vanilla ice cream: a near fatal cross reactivity phenomenon. Letter to the Editor. Journal of the European Academy of Dermatology and Venereology 2018; 32: e1-e2; doi: 10.1111/jdv.14445 

Jappe, U, Minge, S, Kreft, B, Ludwig, A, Przybilla, B, Walker, A, Varga, R, Seidel, P, Biedermann, T, Anemüller, W, Kromminga, A, Ruëff, F, Merk, H, Wagner, N, Treudler, R, Worm, M, Waldmann, I, Saloga, J, Becker, WM, Goldmann, T, Platts-Mills, TA & Homann, A 2018, 'Meat allergy associated with α-Gal - Closing diagnostic gaps by anti-α-Gal IgE immune profiling' ALLERGY, Bd 73, Nr. 1, S. 93-105. DOI: 10.1111/all.13238

Epp A, Hobusch J, Bartsch Y, Petry J, Lilienthal GM, Koeleman CAM, Eschweiler S, Möbs C, Hall A, Morris SC, Petzold D, Engellenner C, Bitterling J, Rahmöller J, Leliavskia A, Thurmann R, Collin M, Moremen KW, Strait RT, Blanchard V, Petersen A, Gemoll T, Habermann JK, Petersen F, Nandy A, Kahlert H, Hertl M, Wuhrer M, Pfützner W, Jappe U, Finkelman F, Marc Ehlers. Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions. J Allergy Clin Immunol (Letter to the Editor) 2018; 148: 399-402 doi: 10.1016/j.jaci.2017.06.021.

 

2017

Schiener, M, Eberlein, B, Moreno-Aguilar, C, Pietsch, G, Serrano, P, McIntyre, M, Schwarze, L, Russkamp, D, Biedermann, T, Spillner, E, Darsow, U, Ollert, M, Schmidt-Weber, CB & Blank, S 2017, 'Application of recombinant antigen 5 allergens from seven allergy-relevant Hymenoptera species in diagnostics' ALLERGY, Bd 72, Nr. 1, S. 98-108. DOI: 10.1111/all.13000

Treudler R, Franke A, Schmiedeknecht A, Ballmer-Weber B, Worm M, Werfel T, Jappe U, Biedermann T, Schmitt J, Brehler R, Kleinheinz A, Kleine-Tebbe J, Brüning H, Ruëff F, Ring J, Saloga J, Schäkel K, Holzhauser T, Vieths S, Simon JC. 2017, 'BASALIT trial: double-blind placebo-controlled allergen immunotherapy with rBet v 1-FV in birch-related soya allergy.' ALLERGY, Bd 72, Nr. 8, S. 1243-1253. DOI: 10.1111/all.13112

Schocker, F, Scharf , A, Kull, S & Jappe, U 2017, 'Detection of the Peanut Allergens Ara h 2 and Ara h 6 in Human Breast Milk: Development of Two Sensitive and Specific Sandwich ELISA Assays' International Archives of Allergy and Immunology, Bd 174 , DOI: 10.1159/000479388 , S. 17-25 . DOI: 10.1159/000479388

Homann, A, Röckendorf, N, Kromminga, A, Frey, A, Platts-Mills, TA & Jappe, U 2017, 'Glycan and Peptide IgE Epitopes of the TNF-alpha Blockers Infliximab and Adalimumab - Precision Diagnostics by Cross-Reactivity Immune Profiling of Patient Sera.' Theranostics, Bd 7, Nr. 19, S. 4699-4709.

Homann, A, Schramm, G & Jappe, U 2017, 'Glycans and Glycan-specific IgE in Clinical and Molecular Allergology - Sensitization, Diagnosis and Clinical Symptoms.' JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Bd 140, Nr. 2, S. 356-368.

Jappe, U 2017, 'Molekular-allergologische Aspekte der allergenspezifischen Immuntherapie.' HAUTARZT, Bd 68, Nr. 4, S. 271-281.

Schwager, C, Kull, S, Behrends, J, Röckendorf, N, Schocker, F, Frey, A, Homann, A, Becker, W-M & Jappe, U 2017, 'Peanut oleosins associated with severe peanut allergy - Importance of lipophilic allergens for comprehensive allergy diagnostics' JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Bd 140, Nr. 5, 10.1016/j.jaci.2017.02.020, S. 1331-1338. DOI: 10.1016/j.jaci.2017.02.020

Schocker F, Recke A, Kull S, Worm M, Jappe U. 2017, 'Persistent cow's milk anaphylaxis from early childhood monitored by IgE and BAT to cow's and human milk under therapy.' Pediatric Allergy and Immunology.

Jappe, U & Schwager, C 2017, 'Relevance of lipophilic allergens in food allergy diagnosis.' Current Allergy and Asthma Reports, Bd 17, Nr. 9, S. 61. DOI: 10.1007/s11882-017-0731-0

Holzhauser, T, Franke, A, Treudler, R, Schmiedeknecht, A, Randow, S, Becker, W-M, Lidholm, J, Vieths, S & Simon, J-C 2017, 'The BASALIT multicenter trial: Gly m 4 quantification for consistency control of challenge meal batches and toward Gly m 4 threshold data' MOLECULAR NUTRITION & FOOD RESEARCH, Bd 61, Nr. 3. DOI: 10.1002/mnfr.201600527