Programmbereich Infektionen


Mission   Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen

Publikationen von 2000 bis 2010


Schromm AB, Reiling N, Howe J, Wiesmuller K, Roessle M, Brandenburg K. Influence of serum on the immune recognition of a synthetic lipopeptide mimetic of the 19-kDa lipoprotein from Mycobacterium tuberculosis. INNATE IMMUNITY 2010 Aug;16(4):213-25.

Andrä J, Gutsmann T, Müller M, Schromm AB. Interactions between Lipid A and Serum Proteins. ADVANCES IN EXPERIMENTAL MEDICINE 2010 Jul;667:39-51.

Brandenburg K, Schromm AB, Gutsmann T. Endotoxins: relationship between structure, function, and activity. SUBCELLULAR BIOCHEMISTRY 2010 Jun;53:53-67.

Gutsmann T, Howe J, Zahringer U, Garidel P, Schromm AB, Koch MHJ, Fujimoto Y, Fukase K, Moriyon I, Martinez-de-Tejada G, Brandenburg K. Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells. INNATE IMMUNITY 2010 Feb;16(1):39-47.


Moulakakis C, Adam S, Seitzer U, Schromm A, Leitges M, Stamme C. Surfactant protein A activation of atypical protein kinase C zeta in I kappa B-alpha-dependent anti-inflammatory immune regulation. JOURNAL OF IMMUNOLOGY 2007 Oct;179(7):4480-4491.

Gutsmann T, Schromm A, Brandenburg K. The physicochemistry of endotoxins in relation to bioactivity. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY 2007 Sep;297(5):341-352.

2000 – 2006 (Selection)

Mueller M, Stamme C, Draing C, Hartung T, Seydel U, Schromm A. Cell activation of human macrophages by lipoteichoic acid is strongly attenuated by lipopolysaccharide-binding protein. JOURNAL OF BIOLOGICAL CHEMISTRY 2006 Oct;281(42):31448-31456.

Papavlassopoulos M, Stamme C, Thon L, Adam D, Hillemann D, Seydel U, Schromm A. MaxiK blockade selectively inhibits the lipopolysaccharide-induced I kappa B-alpha/NF-kappa B signaling pathway in macrophages. JOURNAL OF IMMUNOLOGY 2006 Sep;177(6):4086-4093.

Scheel O, Papavlassopoulos M, Blunck R, Gebert A, Hartung T, Zahringer U, Seydel U, Schromm A. Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages. INFECTION AND IMMUNITY 2006 Jul;74(7):4354-4356.

Mueller M, Brandenburg K, Dedrick R, Schromm A, Seydel U. Phospholipids inhibit lipopolysaccharide (LPS)-induced cell activation: A role for LPS-binding protein. JOURNAL OF IMMUNOLOGY 2005 Jan;174(2):1091-1096.

Seydel U, Schromm A, Brade L, Gronow S, Andra J, Muller M, Koch M, Fukase K, Kataoka M, Hashimoto M, Kusumoto S, Brandenburg K. Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity. FEBS JOURNAL 2005 Jan;272(2):327-340.

Mueller M, Lindner B, Dedrick R, Schromm A, Seydel U. Endotoxin: physical requirements for cell activation. JOURNAL OF ENDOTOXIN RESEARCH 2005;11(5):299-303.

Mueller M, Lindner B, Kusumoto S, Fukase K, Schromm A, Seydel U. Aggregates are the biologically active units of endotoxin. JOURNAL OF BIOLOGICAL CHEMISTRY 2004 Jun;279(25):26307-26313.

Seydel U, Hawkins L, Schromm A, Heine H, Scheel O, Koch M, Brandenburg K. The generalized endotoxic principle. EUROPEAN JOURNAL OF IMMUNOLOGY 2003 Jun;33(6):1586-1592.

Medvedev A, Henneke P, Schromm A, Lien E, Ingalls R, Fenton M, Golenbock D, Vogel S. Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of toll-like receptors 2 or 4. JOURNAL OF IMMUNOLOGY 2001 Aug;167(4):2257-2267.

Schromm A, Lien E, Henneke P, Chow J, Yoshimura A, Heine H, Latz E, Monks B, Schwartz D, Miyake K, Golenbock D. Molecular genetic analysis of an endotoxin nonresponder mutant cell Line: A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. JOURNAL OF EXPERIMENTAL MEDICINE 2001 Jul;194(1):79-88.

Gutsmann T, Schromm A, Koch M, Kusumoto S, Fukase K, Oikawa M, Seydel U, Brandenburg K. Lipopolysaccharide-binding protein-mediated interaction of lipid A from different origin with phospholipid membranes. PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2000 Sep;2(20):4521-4528.

Schromm A, Brandenburg K, Loppnow H, Moran A, Koch M, Rietschel E, Seydel U. Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion. EUROPEAN JOURNAL OF BIOCHEMISTRY 2000 Apr;267(7):2008-2013.

Book Chapters

Schromm AB, Alexander C, Gutsmann T, Stamme C. Pathogens in Sepsis: Gram-negative Bacterial PAMPs and PRRs.  In: Cavaillon, Jean-Marc (Ed.): Sepsis and non-infectious systemic inflammation : from biology to critical care. Weinheim: Wiley-VCH; 2009 p. 75-104.

Alexander C, Haylett R, Schromm AB, Zähringer U, Rink L. Pathogens in Sepsis: Gram-positive Bacterial PAMPs, PRRs and Superantigens.  In: Cavaillon, Jean-Marc (Ed.): Sepsis and non-infectious systemic inflammation : from biology to critical care. Weinheim: Wiley-VCH; 2009 p. 109-144.