Programmbereich Infektionen

Mikrobielle Grenzflächenbiologie

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen



Chang, Y-Y, Stévenin, V, Duchateau, M, Giai Gianetto, Q, Hourdel, V, Rodrigues, CD, Matondo, M, Reiling, N & Enninga, J 2020, 'Shigella hijacks the exocyst to cluster macropinosomes for efficient vacuolar escape', PLOS PATHOGENS, Jg. 16, Nr. 8, S. e1008822.

Mackiewicz, M, Seitzer, U, Ahmed, JS & Reiling, N 2020, 'Theileria annulata surface protein (TaSP) is a target of cyclin‐dependent kinase 1 phosphorylation in Theileria annulata‐infected cells', Transboundary and Emerging Diseases, Jg. 67, Nr. S1, S. 40-55.

Marwitz, S, Turkowski, K, Nitschkowski, D, Weigert, A, Brandenburg, J, Reiling, N, Thomas, M, Reck, M, Drömann, D, Seeger, W, Rabe, KF, Savai, R & Goldmann, T 2020, 'The Multi-Modal Effect of the Anti-fibrotic Drug Pirfenidone on NSCLC', Frontiers in Oncology, Jg. 9, S. 1550.

Naik, SK, Pattanaik, K, Eich, J, Sparr, V, Hauptmann, M, Kalsdorf, B, Reiling, N, Liedtke, W, Kuebler, WM, Schaible, UE & Sonawane, A 2020, 'Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection', iScience, Jg. 23, Nr. 6, S. 101206.

Pinheiro, B, Scheidler, CM, Kielkowski, P, Schmid, M, Forné, I, Ye, S, Reiling, N, Takano, E, Imhof, A, Sieber, SA, Schneider, S & Jung, K 2020, 'Structure and Function of an Elongation Factor P Subfamily in Actinobacteria', Cell reports, Jg. 30, Nr. 13, S. 4332-4342.e5.



Correa, W, Brandenburg, J, Behrends, J, Heinbockel, L, Reiling, N, Paulowski, L, Schwudke, D, Stephan, K, Martinez-de-Tejada, G, Brandenburg, K & Gutsmann, T 2019, 'Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides', Biophysical journal, Jg. 117, Nr. 10, S. 1805-1819.

Crauwels, P, Bank, E, Walber, B, Wenzel, UA, Agerberth, B, Chanyalew, M, Abebe, M, König, R, Ritter, U, Reiling, N & van Zandbergen, G 2019, 'Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages', FRONTIERS IN IMMUNOLOGY, Jg. 10, S. 2697.

Feilcke, R, Arnouk, G, Raphane, B, Richard, K, Tietjen, I, Andrae-Marobela, K, Erdmann, F, Schipper, S, Becker, K, Arnold, N, Frolov, A, Reiling, N, Imming, P & Fobofou, SAT 2019, 'Biological activity and stability analyses of knipholone anthrone, a phenyl anthraquinone derivative isolated from Kniphofia foliosa Hochst', Journal of pharmaceutical and biomedical analysis, Jg. 174, S. 277-285.

Khalil, ZG, Hill, TA, De Leon Rodriguez, LM, Lohman, R-J, Hoang, HN, Reiling, N, Hillemann, D, Brimble, M, Fairlie, D, Blumenthal, A & Capon, RJ 2019, 'Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular Mycobacterium tuberculosis', ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jg. 63, Nr. 3, S. e01773-18.

Khani-Meinagh, H, Mostafavi, H, Reiling, N, Mahdavi, M & Zarrini, G 2019, 'Design, synthesis and evaluation of biological activities of some novel anti-TB agents with bio-reducible functional group', BioImpacts : BI, Jg. 9, Nr. 4, S. 199-209.

Kolbe, K, Veleti, SK, Reiling, N & Lindhorst, TK 2019, 'Lectins of Mycobacterium tuberculosis – rarely studied proteins', Beilstein Journal of Organic Chemistry , Jg. 15, Nr. 15, S. 1-15.

Lentz, F, Reiling, N, Spengler, G, Kincses, A, Csonka, A, Molnár, J & Hilgeroth, A 2019, 'Dually Acting Nonclassical 1,4-Dihydropyridines Promote the Anti-Tuberculosis (Tb) Activities of Clofazimine', Molecules (Basel, Switzerland), Jg. 24, Nr. 16.

Stévenin, V, Chang, Y-Y, Le Toquin, Y, Duchateau, M, Gianetto, QG, Luk, CH, Salles, A, Sohst, V, Matondo, M, Reiling, N & Enninga, J 2019, 'Dynamic Growth and Shrinkage of the Salmonella-Containing Vacuole Determines the Intracellular Pathogen Niche', Cell reports, Jg. 29, Nr. 12, S. 3958-3973.e7.



Lentz, F, Reiling, N, Martins, A, Molnár, J & Hilgeroth, A 2018, 'Discovery of Novel Enhancers of Isoniazid Toxicity in' Molecules (Basel, Switzerland), Jg. 23, Nr. 4. DOI: 10.3390/molecules23040825

Reiling, N, Homolka, S, Kohl, TA, Steinhäuser, C, Kolbe, K, Schütze, S & Brandenburg, J 2018, 'Shaping the niche in macrophages: Genetic diversity of the M. tuberculosis complex and its consequences for the infected host' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, Jg. 308, Nr. 1, S. 118-128. DOI: 10.1016/j.ijmm.2017.09.009

Radloff, J, Heyckendorf, J, van der Merwe, L, Sanchez Carballo, P, Reiling, N, Richter, E, Lange, C & Kalsdorf, B 2018, 'Mycobacterium Growth Inhibition Assay of Human Alveolar Macrophages as a Correlate of Immune Protection Following Mycobacterium bovis Bacille Calmette-Guérin Vaccination' FRONTIERS IN IMMUNOLOGY, Jg. 9, Nr. 1708, S. 1708. DOI: 10.3389/fimmu.2018.01708



Kolbe, K, Möckl, L, Sohst, V, Brandenburg, J, Engel, R, Malm, S, Bräuchle, C, Holst, O, Lindhorst, TK & Reiling, N 2017, 'Azido pentoses: A New Tool to Efficiently Label Mycobacterium tuberculosis Clinical Isolates' Chembiochem : a European journal of chemical biology, Bd 18, Nr. 13, S. 1172-1176. DOI: 10.1002/cbic.201600706

Herzmann, C, Ernst, M, Lange, C, Stenger, S, Kaufmann, SHE, Reiling, N, Schaberg, T, van der Merwe, L, Maertzdorf, J & Tb or not Tb consortium 2017, 'Pulmonary immune responses to Mycobacterium tuberculosis in exposed individuals' PLOS ONE, Bd 12, Nr. 11, S. e0187882. DOI: 10.1371/journal.pone.0187882

Prosser, G, Brandenburg, J, Reiling, N, Barry, CE, Wilkinson, RJ & Wilkinson, KA 2017, 'The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition' MICROBES AND INFECTION , Bd 19, Nr. 3, S. 177-192. DOI: 10.1016/j.micinf.2016.10.001

Böscke, R, Vladar, EK, Könnecke, M, Hüsing, B, Linke, R, Pries, R, Reiling, N, Axelrod, JD, Nayak, JV & Wollenberg, B 2017, 'Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps' AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY , Bd 56, Nr. 5, S. 575-584. DOI: 10.1165/rcmb.2016-0024OC

Prosser, G., Brandenburg, J., Reiling, N, Barry, CE, Wilkinson, RJ & Wilkinson, KA 2017, 'The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition' MICROBES AND INFECTION , Bd 19, Nr. 3, S. 177-192. DOI: 10.1016/j.micinf.2016.10.001  (# equal contribution)



Brandenburg, J & Reiling, N 2016, 'The Wnt blows: On the functional role of Wnt signaling in Mycobacterium tuberculosis infection and beyond' Frontiers in Immunology, Bd 7, S. 635. DOI: 10.3389/fimmu.2016.00635

Lentz, F, Hemmer, M, Reiling, N & Hilgeroth, A 2016, 'Discovery of novel N-phenyl 1,4-dihydropyridines with a dual mode of antimycobacterial activity' BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , Bd 26, Nr. 24, S. 5896-5898. DOI: 10.1016/j.bmcl.2016.11.010

Lehmann, J, Vomacka, J, Esser, K, Nodwell, M, Kolbe, K, Rämer, P, Protzer, U, Reiling, N & Sieber, SA 2016, 'Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases' MedChemComm. DOI: 10.1039/C6MD00231E

Moulakakis, C, Steinhäuser, C, Biedziak, D, Freundt, K, Reiling, N & Stamme, C 2016, 'Surfactant Protein A Enhances Constitutive Immune Functions of Clathrin Heavy Chain and Clathrin Adaptor Protein AP2' AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY , Bd 55, Nr. 1, S. 92-104. DOI: 10.1165/rcmb.2015-0219OC

Meyer, CG, Reiling, N, Ehmen, C, Ruge, G, Owusu-Dabo, E, Horstmann, RD & Thye, T 2016, 'TLR1 Variant H305L Associated with Protection from Pulmonary Tuberculosis' PLOS ONE, Bd 11, Nr. 5, S. e0156046. DOI: 10.1371/journal.pone.0156046

Kaufmann, E, Spohr, C, Battenfeld, S, De Paepe, D, Holzhauser, T, Balks, E, Homolka, S, Reiling, N, Gilleron, M & Bastian, M 2016, 'BCG Vaccination Induces Robust CD4+ T Cell Responses to Mycobacterium tuberculosis Complex-Specific Lipopeptides in Guinea Pigs' JOURNAL OF IMMUNOLOGY, Bd 196, Nr. 6, S. 2723-2732. DOI: 10.4049/jimmunol.1502307

Ganbat, D, Seehase, S, Richter, E, Vollmer, E, Reiling, N, Fellenberg, K, Gaede, KI, Kugler, C & Goldmann, T 2016, 'Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells' BMC PULMONARY MEDICINE, Bd 16, Nr. 1, S. 19. DOI: 10.1186/s12890-016-0185-5



Shima K, Klinger M, Schütze S, Kaufhold I, Solbach W, Reiling N et al. The role of ER-related BiP/GRP78 in IFN-γ induced persistent Chlamydia pneumoniae infection. CELLULAR MICROBIOLOGY. 2015 Jan 15;17(7):923-34.

Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T et al. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. PLOS ONE. 2015;10(7):e0133291.



Menck K, Behme D, Pantke M, Reiling N, Binder C, Pukrop T et al. Isolation of human monocytes by double gradient centrifugation and their differentiation to macrophages in teflon-coated cell culture bags. Journal of visualized experiments : JoVE. 2014 Sep 9;(91):e51554. Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T et al. Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLOS ONE. 2014 Mai 1;9(5):e96015.

Steinhäuser, C, Dallenga, T, Tchikov, V, Schaible, UE, Schütze, S & Reiling, N 2014, 'Immuno-magnetic isolation of pathogen-containing phagosomes and apoptotic blebs from primary phagocytes' Current Protocols in Immunology 2014 Apr 2;105:14.36.1-14.36.26.

Helm, O, Held-Feindt, J, Grage-Griebenow, E, Reiling, N, Ungefroren, H, Vogel, I, Krüger, U, Becker, T, Ebsen, M, Röcken, C, Kabelitz, D, Schäfer, H & Sebens, S 2014, 'Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis' International Journal of Cancer 2014;135(4):843-861. doi:10.1002/ijc.28736. [Epub ahead of print]



Schaale K, Brandenburg J, Kispert A, Leitges M, Ehlers S, Reiling N. Wnt6 Is Expressed in Granulomatous Lesions of Mycobacterium tuberculosis-Infected Mice and Is Involved in Macrophage Differentiation and Proliferation. J Immunol. 2013
Nov 15;191(10):5182-95.

Reiling N, Homolka S, Walter K, Brandenburg J, Niwinski L, Ernst M, Herzmann C, Lange C, Diel R, Ehlers S, Niemann, S. Clade-Specific Virulence Patterns of Mycobacterium tuberculosis Complex Strains in Human Primary Macrophages and Aerogenically Infected Mice. MBio. 2013 Jul 30;4(4). pii: e00250-13 Open Access

Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, et al. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7820-5. Open Access

Steinhäuser C, Heigl U, Tchikov V, Schwarz J, Gutsmann T, Seeger K, et al. Lipid-labeling facilitates a novel magnetic isolation procedure to characterize pathogen-containing phagosomes. TRAFFIC. 2013 Mar;(14):321–36.



Steinhäuser C, Heigl U, Tchikov V, Schwarz J, Gutsmann T, Seeger K, Brandenburg J, Fritsch J, Schroeder J, Wiesmüller K-H, Rosenkrands I, Walther P, Pott J, Krause E, Ehlers S, Schneider-Brachert W, Schütze S, Reiling N. Lipid-labeling facilitates a novel magnetic isolation procedure to characterize pathogen-containing phagosomes. TRAFFIC 2012 Dec (in press).

Ungefroren H, Hyder A, Hinz H, Reiling N, Grage-Griebenow E, Schulze M, Ehnert S, Nüssler A, Fändrich F. Peripheral Blood Monocytes Can Be Induced to Acquire Stem Cell-Like Properties. In: Hayat, M.A. (Ed.): Therapeutic Applications in Disease and Injury (Stem Cells and Cancer Stem Cells ; 6). 2012 p. 367–375.

Maertzdorf J, Weiner J 3rd, Mollenkopf H-J, TBornotTB Network, Bauer T, Prasse A, Müller-Quernheim J, Kaufmann SHE. Common patterns and disease-related signatures in tuberculosis and sarcoidosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES 2012 May 15;109(20):7853-8.

Abdullah M, Kähler D, Vock C, Reiling N, Kugler C, Dromann D, Rupp J, Hauber HP, Fehrenbach H, Zabel P, Vollmer E, Dalhoff K, Goldmann T. Pulmonary haptoglobin and CD163 are functional immunoregulatory elements in the human lung. RESPIRATION 2012 Jan;83(1):61-73.

Wenzel UA, Bank E, Florian C, Förster S, Zimara N, Steinacker J, Klinger M, Reiling N, Ritter U, van Zandbergen G. Leishmania major parasite stage-dependent host cell invasion and immune evasion. The FASEB Journal 2012 Jan;26(1):29-39.