Programmbereich Infektionen

Mikrobielle Grenzflächenbiologie

Mission    Projekte    Drittmittel    Methoden    Publikationen    Mitarbeiter/innen



Johannsen, S, Gierse, RM, Olshanova, A, Smerznak, E, Laggner, C, Eschweiler, L, Adeli, Z, Hamid, R, Alhayek, A, Reiling, N, Haupenthal, J & Hirsch, AKH 2023, 'Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign', ChemMedChem, S. e202200590.

Kotimoole, C, Antil, N, Kasaragod, S, Behera, S, Arvind, A, Reiling, N, Flo, T & Prasad, T 2023, 'Development of a spectral library for the discovery of altered genomic events in Mycobacterium avium associated with virulence using mass spectrometry-based proteogenomic analysis', MOLECULAR & CELLULAR PROTEOMICS , S. 100533.



Aryal N, Chen J, Bhattarai K, Hennrich O, Handayani I, Kramer M, Straetener J, Wommer T, Berscheid A, Peter S, Reiling N, Brötz-Oesterhelt H, Geibel C, Lämmerhofer M, Mast Y, Gross H. High Plasticity of the Amicetin Biosynthetic Pathway in Streptomyces sp. SHP 22-7 Led to the Discovery of Streptcytosine P and Cytosaminomycins F and G and Facilitated the Production of 12F-Plicacetin. J NAT PROD. 2022 Mar 25;85(3):530-539. doi: 10.1021/acs.jnatprod.1c01051. Epub 2022 Mar 9.

Brandenburg J, Heyckendorf J, Marwitz F, Zehethofer N, Linnemann L, Gisch N, Karaköse H, Reimann M, Kranzer K, Kalsdorf B, Sanchez-Carballo P, Weinkauf M, Scholz V, Malm S, Homolka S, Gaede KI, Herzmann C, Schaible UE, Hölscher C, Reiling N, Schwudke D. Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis. ACS INFECT DIS. 2022 Jul 8;8(7):1303-1315. doi: 10.1021/acsinfecdis.2c00075.

Gisch N, Utpatel C, Gronbach LM, Kohl TA, Schombel U, Malm S, Dobos KM, Hesser DC, Diel R, Götsch U, Gerdes S, Shuaib YA, Ntinginya NE, Khosa C, Viegas S, Kerubo G, Ali S, Al-Hajoj SA, Ndung'u PW, Rachow A, Hoelscher M, Maurer FP, Schwudke D, Niemann S, Reiling N, Homolka S. Sub-Lineage Specific Phenolic Glycolipid Patterns in the Mycobacterium tuberculosis Complex Lineage 1. FRONT MICROBIOL. 2022 Mar 8;13:832054. doi: 10.3389/fmicb.2022.832054.

Hansen J, Kolbe K, König IR, Scherließ R, Hellfritzsch M, Malm S, Müller-Loennies S, Zallet J, Hillemann D, Wiesmüller KH, Herzmann C, Brandenburg J, Reiling N. Lipobiotin-capture magnetic bead assay for isolation, enrichment and detection of Mycobacterium tuberculosis from saliva. PLOS ONE. 2022 Jul 15;17(7):e0265554. doi: 10.1371/journal.pone.0265554.

Richter A, Seidel RW, Goddard R, Eckhardt T, Lehmann C, Dörner J, Siersleben F, Sondermann T, Mann L, Patzer M, Jäger C, Reiling N, Imming P. BTZ-Derived Benzisothiazolinones with In Vitro Activity against Mycobacterium tuberculosis. ACS MED. CHEM. LETT. 2022, July 25, 2022 epub ahead of print.

Zhu D, Johannsen S, Masini T, Simonin C, Haupenthal J, Illarionov B, Andreas A, Awale M, Gierse RM, van der Laan T, van der Vlag R, Nasti R, Poizat M, Buhler E, Reiling N, Müller R, Fischer M, Reymond JL & Hirsch A. Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening. CHEM SCI. 2022, doi: 10.1039/D2SC02371G Epub 2022 Aug 8.



Brandenburg J, Marwitz S, Tazoll SC, Waldow F, Kalsdorf B, Vierbuchen T, Scholzen T, Gross A, Goldenbaum S, Hölscher A, Hein M, Linnemann L, Reimann M, Kispert A, Leitges M, Rupp J, Lange C, Niemann S, Behrends J, Goldmann T, Heine H, Schaible UE, Hölscher C, Schwudke D, Reiling N. WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis. /J Clin Invest./ 131(16):e141833.

Heinbockel, L, Weindl, G, Correa, W, Brandenburg, J, Reiling, N, Wiesmüller, K-H, Schürholz, T, Gutsmann, T, Martinez de Tejada, G, Mauss, K & Brandenburg, K 2021, 'Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 22, Nr. 3.

Jumde, RP, Guardigni, M, Gierse, RM, Alhayek, A, Zhu, D, Hamid, Z, Johannsen, S, Elgaher, WAM, Neusens, PJ, Nehls, C, Haupenthal, J, Reiling, N & Hirsch, AKH 2021, 'Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase', Chemical Science, Jg. 12, Nr. 22, S. 7775-7785.



Brandenburg, J, Marwitz, S, Tazoll, S C, Waldow, F, Kalsdorf, B, Vierbuchen, T, Scholzen, T, Gross, A, Goldenbaum, S, Hölscher, A, Hein, M, Linnemann, L, Reimann, M, Kispert, A, Leitges, M, Rupp, J, Lange, C, Niemann, S, Behrends, J, Goldmann, T, Heine, H, Schaible, UE, Hölscher, C, Schwudke, D, Reiling, N. WNT6-ACC2-induced accumulation of triacylglycerol rich lipid droplets is exploited by M. tuberculosis. BIORXIV (published June 26, 2020)

Chang, Y-Y, Stévenin, V, Duchateau, M, Giai Gianetto, Q, Hourdel, V, Rodrigues, CD, Matondo, M, Reiling, N & Enninga, J 2020, 'Shigella hijacks the exocyst to cluster macropinosomes for efficient vacuolar escape', PLOS PATHOGENS, Jg. 16, Nr. 8, S. e1008822.

Mackiewicz, M, Seitzer, U, Ahmed, JS & Reiling, N 2020, 'Theileria annulata surface protein (TaSP) is a target of cyclin‐dependent kinase 1 phosphorylation in Theileria annulata‐infected cells', Transboundary and Emerging Diseases, Jg. 67, Nr. S1, S. 40-55.

Marwitz, S, Turkowski, K, Nitschkowski, D, Weigert, A, Brandenburg, J, Reiling, N, Thomas, M, Reck, M, Drömann, D, Seeger, W, Rabe, KF, Savai, R & Goldmann, T 2020, 'The Multi-Modal Effect of the Anti-fibrotic Drug Pirfenidone on NSCLC', Frontiers in Oncology, Jg. 9, S. 1550.

Naik, SK, Pattanaik, K, Eich, J, Sparr, V, Hauptmann, M, Kalsdorf, B, Reiling, N, Liedtke, W, Kuebler, WM, Schaible, UE & Sonawane, A 2020, 'Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection', iScience, Jg. 23, Nr. 6, S. 101206.

Pinheiro, B, Scheidler, CM, Kielkowski, P, Schmid, M, Forné, I, Ye, S, Reiling, N, Takano, E, Imhof, A, Sieber, SA, Schneider, S & Jung, K 2020, 'Structure and Function of an Elongation Factor P Subfamily in Actinobacteria', Cell reports, Jg. 30, Nr. 13, S. 4332-4342.e5.



Correa, W, Brandenburg, J, Behrends, J, Heinbockel, L, Reiling, N, Paulowski, L, Schwudke, D, Stephan, K, Martinez-de-Tejada, G, Brandenburg, K & Gutsmann, T 2019, 'Inactivation of Bacteria by γ-Irradiation to Investigate the Interaction with Antimicrobial Peptides', Biophysical journal, Jg. 117, Nr. 10, S. 1805-1819.

Crauwels, P, Bank, E, Walber, B, Wenzel, UA, Agerberth, B, Chanyalew, M, Abebe, M, König, R, Ritter, U, Reiling, N & van Zandbergen, G 2019, 'Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages', FRONTIERS IN IMMUNOLOGY, Jg. 10, S. 2697.

Feilcke, R, Arnouk, G, Raphane, B, Richard, K, Tietjen, I, Andrae-Marobela, K, Erdmann, F, Schipper, S, Becker, K, Arnold, N, Frolov, A, Reiling, N, Imming, P & Fobofou, SAT 2019, 'Biological activity and stability analyses of knipholone anthrone, a phenyl anthraquinone derivative isolated from Kniphofia foliosa Hochst', Journal of pharmaceutical and biomedical analysis, Jg. 174, S. 277-285.

Khalil, ZG, Hill, TA, De Leon Rodriguez, LM, Lohman, R-J, Hoang, HN, Reiling, N, Hillemann, D, Brimble, M, Fairlie, D, Blumenthal, A & Capon, RJ 2019, 'Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular Mycobacterium tuberculosis', ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jg. 63, Nr. 3, S. e01773-18.

Khani-Meinagh, H, Mostafavi, H, Reiling, N, Mahdavi, M & Zarrini, G 2019, 'Design, synthesis and evaluation of biological activities of some novel anti-TB agents with bio-reducible functional group', BioImpacts : BI, Jg. 9, Nr. 4, S. 199-209.

Kolbe, K, Veleti, SK, Reiling, N & Lindhorst, TK 2019, 'Lectins of Mycobacterium tuberculosis – rarely studied proteins', Beilstein Journal of Organic Chemistry , Jg. 15, Nr. 15, S. 1-15.

Lentz, F, Reiling, N, Spengler, G, Kincses, A, Csonka, A, Molnár, J & Hilgeroth, A 2019, 'Dually Acting Nonclassical 1,4-Dihydropyridines Promote the Anti-Tuberculosis (Tb) Activities of Clofazimine', Molecules (Basel, Switzerland), Jg. 24, Nr. 16.

Stévenin, V, Chang, Y-Y, Le Toquin, Y, Duchateau, M, Gianetto, QG, Luk, CH, Salles, A, Sohst, V, Matondo, M, Reiling, N & Enninga, J 2019, 'Dynamic Growth and Shrinkage of the Salmonella-Containing Vacuole Determines the Intracellular Pathogen Niche', Cell reports, Jg. 29, Nr. 12, S. 3958-3973.e7.



Lentz, F, Reiling, N, Martins, A, Molnár, J & Hilgeroth, A 2018, 'Discovery of Novel Enhancers of Isoniazid Toxicity in' Molecules (Basel, Switzerland), Jg. 23, Nr. 4. DOI: 10.3390/molecules23040825

Reiling, N, Homolka, S, Kohl, TA, Steinhäuser, C, Kolbe, K, Schütze, S & Brandenburg, J 2018, 'Shaping the niche in macrophages: Genetic diversity of the M. tuberculosis complex and its consequences for the infected host' INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, Jg. 308, Nr. 1, S. 118-128. DOI: 10.1016/j.ijmm.2017.09.009

Radloff, J, Heyckendorf, J, van der Merwe, L, Sanchez Carballo, P, Reiling, N, Richter, E, Lange, C & Kalsdorf, B 2018, 'Mycobacterium Growth Inhibition Assay of Human Alveolar Macrophages as a Correlate of Immune Protection Following Mycobacterium bovis Bacille Calmette-Guérin Vaccination' FRONTIERS IN IMMUNOLOGY, Jg. 9, Nr. 1708, S. 1708. DOI: 10.3389/fimmu.2018.01708



Kolbe, K, Möckl, L, Sohst, V, Brandenburg, J, Engel, R, Malm, S, Bräuchle, C, Holst, O, Lindhorst, TK & Reiling, N 2017, 'Azido pentoses: A New Tool to Efficiently Label Mycobacterium tuberculosis Clinical Isolates' Chembiochem : a European journal of chemical biology, Bd 18, Nr. 13, S. 1172-1176. DOI: 10.1002/cbic.201600706

Herzmann, C, Ernst, M, Lange, C, Stenger, S, Kaufmann, SHE, Reiling, N, Schaberg, T, van der Merwe, L, Maertzdorf, J & Tb or not Tb consortium 2017, 'Pulmonary immune responses to Mycobacterium tuberculosis in exposed individuals' PLOS ONE, Bd 12, Nr. 11, S. e0187882. DOI: 10.1371/journal.pone.0187882

Prosser, G, Brandenburg, J, Reiling, N, Barry, CE, Wilkinson, RJ & Wilkinson, KA 2017, 'The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition' MICROBES AND INFECTION , Bd 19, Nr. 3, S. 177-192. DOI: 10.1016/j.micinf.2016.10.001

Böscke, R, Vladar, EK, Könnecke, M, Hüsing, B, Linke, R, Pries, R, Reiling, N, Axelrod, JD, Nayak, JV & Wollenberg, B 2017, 'Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps' AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY , Bd 56, Nr. 5, S. 575-584. DOI: 10.1165/rcmb.2016-0024OC

Prosser, G., Brandenburg, J., Reiling, N, Barry, CE, Wilkinson, RJ & Wilkinson, KA 2017, 'The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition' MICROBES AND INFECTION , Bd 19, Nr. 3, S. 177-192. DOI: 10.1016/j.micinf.2016.10.001  (# equal contribution)