Priority Research Area Chronic Lung Diseases

Lung Immunology

Mission   Projects   Funding   Techniques   Publications    Awards    Staff



Frey A, Roeckendorf N, Ramaker K, Gaede K, Tapperzhofen C, Lunding L, Wegmann M, Hobert P, Weber K. Parallel detection of multiple biomarkers in a point-of-care-competent device for the prediction of exacerbations in chronic inflammatory lung disease. Sci Rep 2024;14:12830.

Jiang L*, Lunding LP*, Webber W, Beckmann C, Azam T, Højen  JF, Amo-Aparicio J, Dinarello A, Nguyen TT, Pessara U, Parera D, Orlicky D, Fischer S, Wegmann M,* Dinarello DA*, Li S*. Anti-IL-1R7 antibody protects mice from LPS-induced tissue and systemic inflammation. Front Immunol 2024;15:1427100 *equal contribution

Uliczka K, Bossen J, Zissler UM, Fink C, Niu X, Pieper M, Prange RD, Vock C, Wagner C, Knop M, Abdelsadik A, Franzenburg S, Bruchhaus I, Wegmann M, Schmidt-Weber CB, König P, Pfefferle P, Heine H, Roeder T. (2024) FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells eLife 13:RP96385



Frey A, Lunding LP, Wegmann M. The Dual Role of the Airway Epithelium in Asthma: Active Barrier and Regulator of Inflammation. Cells 2023;12(18:2208

Wegmann, M 2023, 'Trained Immunity in Allergic Asthma', The Journal of allergy and clinical immunology.



ALLIANCE Study Group as part of the German Center of Lung Research (DZL) 2022, 'A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype', Asthma research and practice, Jg. 8, Nr. 1, S. 2.

Lunding, LP, Skouras, DB, Vock, C, Dinarello, CA & Wegmann, M 2022, 'The NLRP3 Inflammasome Inhibitor, OLT1177® , Ameliorates Experimental Allergic Asthma in Mice', ALLERGY, Jg. 77, Nr. 3, S. 1035-1038.

Raspe, J & Wegmann, M 2022, 'Neue Therapeutika und Angriffspunkte in der Behandlung von Asthma.', ALLERGOLOGIE, Jg. 45, S. 409-421.

Ritzmann, F, Lunding, LP, Bals, R, Wegmann, M & Beisswenger, C 2022, 'IL-17 Cytokines and Chronic Lung Diseases', Cells, Jg. 11, Nr. 14, S. 2132.

Röckendorf, N, Ramaker, K & Frey, A 2022, Artificial Evolutionary Optimization Process to Improve the Functionality of Cell Penetrating Peptides. in Methods in Molecular Biology . Bd. 2383, Methods in Molecular Biology, S. 45-61.

Schröder, A, Lunding, LP, Zissler, UM, Vock, C, Webering, S, Ehlers, JC, Orinska, Z, Chaker, A, Schmidt-Weber, CB, Lang, NJ, Schiller, HB, Mall, MA, Fehrenbach, H, Dinarello, CA & Wegmann, M 2022, 'IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33', ALLERGY, Jg. 77, Nr. 3, S. 856-869.



Lunding LP, Krause D, Stichtenoth G, Stamme C, Lauterbach N, Hegermann J, Ochs M, Schuster B, Sedlacek R, Saftig P, Schwudke D, Wegmann M*, Damme M*. LAMP3 deficiency affects surfactant homeostasis in mice. PLoS Genet. 2021 Jun 23;17(6):e1009619. *equal contribution

Wagner, C, Uliczka, K, Bossen, J, Niu, X, Fink, C, Thiedmann, M, Knop, M, Vock, C, Abdelsadik, A, Zissler, UM, Isermann, K, Garn, H, Pieper, M, Wegmann, M, Koczulla, AR, Vogelmeier, CF, Schmidt-Weber, CB, Fehrenbach, H, König, P, Silverman, N, Renz, H, Pfefferle, P, Heine, H & Roeder, T 2021, 'Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways', Cell reports, Jg. 35, Nr. 1, S. 108956.

Weckmann M, Bahmer T, Bülow Sand JM, Rank Rønnow S, Pech M, Vermeulen C, Faiz A, Leeming DJ, Karsdal MA, Lunding L, Oliver BGG, Wegmann M, Ulrich-Merzenich G, Juergens UR, Duhn J, Laumonnier Y, Danov O, Sewald K, Zissler U, Jonker M, König I, Hansen G, von Mutius E, Fuchs O, Dittrich AM, Schaub B, Happle C, Rabe KF, van de Berge M, Burgess JK, Kopp MV; ALLIANCE Study Group as part of the German Centre for Lung Research (DZL). COL4A3 is degraded in allergic asthma and degradation predicts response to anti-IgE therapy. <>Eur Respir J. 2021 Jul 29:2003969.


Frey, A, Lunding, L, Ehlers, JC, Weckmann, M, Zissler, UM & Wegmann, M 2020, 'More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis', FRONTIERS IN IMMUNOLOGY, Jg. 11, Nr. 11, 761, S. 761.

Vella, G, Lunding, L, Ritzmann, F, Honecker, A, Herr, C, Wegmann, M, Bals, R & Beisswenger, C 2020, 'The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma', RESPIRATORY RESEARCH , Jg. 21, Nr. 1, S. 176.

Wenzel, J, Hansen, CE, Bettoni, C, Vogt, MA, Lembrich, B, Natsagdorj, R, Huber, G, Brands, J, Schmidt, K, Assmann, JC, Stölting, I, Saar, K, Sedlacik, J, Fiehler, J, Ludewig, P, Wegmann, M, Feller, N, Richter, M, Müller-Fielitz, H, Walther, T, König, GM, Kostenis, E, Raasch, W, Hübner, N, Gass, P, Offermanns, S, de Wit, C, Wagner, CA & Schwaninger, M 2020, 'Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jg. 117, Nr. 3, S. 1753-1761.

Zazara, DE, Wegmann, M, Giannou, A, Hierweger, A, Alawi, M, Thiele, K, Huber, S, Pincus, M, Muntau, A, Solano, M-E & Arck, PC 2020, 'A prenatally disrupted airway epithelium orchestrates the fetal origin of asthma in mice.', The Journal of allergy and clinical immunology, Jg. 145, Nr. 6, S. 1641-1654.

Žukovskaja, O, Ryabchykov, O, Straßburger, M, Heinekamp, T, Brakhage, AA, Hennings, JC, Hübner, CA, Wegmann, M, Cialla-May, D, Bocklitz, TW, Weber, K & Popp, J 2020, 'Towards Raman spectroscopy of urine as screening tool', Journal of Biophotonics, Jg. 13, Nr. 1, S. e201900143.



Højen JF, Vindva Kristensen ML, McKee AS, Taylor MK, Azam T, Lunding LP, De Graff DM, Swartzwelter BJ, Wegmann M, Tolstrup M, Beckmann K, Fujita M, Fischer S, Dinarello CA. A Blocking Antibody to IL-1R3 Broadly Attenuates Function of Six Members of the IL-1 Family and Reveals the Inflammatory Contribution of these Cytokines in vitro and in vivo. Nat Immunol. 2019;20:1138-49.

Webering S, Lunding L, Vock C, Schröder A, Gaede KI, Herzmann C, Fehrenbach, Wegmann M. The alpha-melanocyte-stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma. Clin Exp Allergy. 2019;49:1026-1039.



Lindner, K, Webering, S, Stroebele, M, Bockhorn, H, Hansen, T, König, P & Fehrenbach, H 2018, 'Low Dose Carbon Black Nanoparticle Exposure Does Not Aggravate Allergic Airway Inflammation in Mice Irrespective of the Presence of Surface Polycyclic Aromatic Hydrocarbons' Nanomaterials, Bd 8, Nr. 4. DOI: 10.3390/nano8040213

Nissen G, Hollaender H, Tang FSM, Wegmann M, Lunding L, Vock C, Bachmann A, Lemmel S, Bartels R, Oliver BG, Burgess JK, Becker T, Kopp MV, Weckmann M. Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation. Clin Exp Allergy. 2018;48:1483-1493.



Wegmann M. Targeting cytokines in asthma therapy: could IL-37 be a solution? Expert Rev Respir Med. 2017 Sep;11(9):675-677.

George L, Mitra A, Thimraj TA, Irmler M, Vishweswaraiah S, Lunding L, Hühn D, Madurga A, Beckers J, Fehrenbach H, Upadhyay S, Schulz H, Leikauf GD, Ganguly K. Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function. Respir Res. 2017 Aug 9;18(1):152.

Fehrenbach H, Wagner C, Wegmann M. Airway remodeling in asthma: what really matters. Cell Tissue Res. 2017;367:551-569.



Zimmer, J, Weitnauer, M, Boutin, S, Küblbeck, G, Thiele, S, Walker, P, Lasitschka, F, Lunding, L, Orinska, Z, Vock, C, Arnold, B, Wegmann, M & Dalpke, A 2016, 'Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung' Frontiers in Immunology, Bd 7, S. 514. DOI: 10.3389/fimmu.2016.00514

Lunding, L, Webering, S, Vock, C, Schröder, A, Raedler, D, Schaub, B, Fehrenbach, H & Wegmann, M 2016, 'Effect of IL-37 on Allergic Airway Inflammation. Ann Am Thorac Soc 2016;13:S95-6.

Körbelin J, Sieber T, Michelfelder S, Lunding L, Spies E, Hunger A, Alawi M, Rapti K, Indenbirken D, Müller OJ, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M. Pulmonary targeting of adeno-associated viral vectors by next-generation sequencing-guided screening of random capsid displayed peptide libraries.
Molecular therapy. 24, 6, S. 1050-61

Wegmann M, Fehrenbach H, Krauss-Etschmann S. Asthma Update 2015 - What Cell Biology in Basic Pulmonary Research Can Offer to the Pneumologist. Pneumologie. 2016;70:103-9.



Lunding L, Schröder A, Wegmann M. Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR. Expert Rev Respir Med. 2015;11:1-12.

Lunding L, Wegmann M. NK cells in asthma exacerbation. Oncotarget. 2015 Aug 21;6:19932-3.

Voss M, Wolf L, Kamyschnikow A, Honecker A, Herr C, Lepper PM, Wegmann M, Menger MD, Bals R, Beisswenger C. IL-17A contributes to maintenance of pulmonary homeostasis in a murine model of cigarette smoke-induced emphysema. Am J Physiol Lung Cell Mol Physiol. 2015;309:L188-95.

Lunding LP, Webering S, Vock C, Behrends J, Wagner C, Hölscher C, Fehrenbach, Wegmann M. pIC-triggered exacerbation of experimental asthma depends on IL-17A produced by NK cells. J Immunol 2015;194:5615-25.

Vock C, Yildirim AÖ, Wagner C, Schlick S, Lunding LP, Lee CG, Elias JA, Fehrenbach H, Wegmann M. Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signaling components. Clin Exp Allergy. 2015;45:1447-1458.

Lunding L, Webering S, Vock C, Schröder A, Raedler D, Schaub B, Fehrenbach H, Wegmann M. IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice. Allergy. 2015;70:366-73.