Priority Research Area Asthma and Allergy

Asthma Exacerbation & Regulation

Mission   Projects   Funding   Techniques   Publications    Awards    Staff



Wenzel J, Hansen CE, Bettoni C, Vogt MA, Lembrich B, Natsagdorj R, Huber G, Brands J, Schmidt K, Assmann JC, Stölting I, Saar K, Sedlacik J, Fiehler J, Ludewig P, Wegmann M, Feller N, Richter M, Müller-Fielitz H, Walther T, König GM, Kostenis E, Raasch W, Hübner N, Gass P, Offermanns S, de Wit C, Wagner CA, Schwaninger M. Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice.
Proc Natl Acad Sci U S A. 2020;117:1753-1761.

Žukovskaja O, Ryabchykov O, Straßburger M, Heinekamp T, Brakhage AA, Hennings CJ, Hübner CA, Wegmann M, Cialla-May D, Bocklitz TW, Weber K, Popp J. Towards Raman spectroscopy of urine as screening tool. J Biophotonics. 2020;13:e201900143.



Højen JF, Vindva Kristensen ML, McKee AS, Taylor MK, Azam T, Lunding LP, De Graff DM, Swartzwelter BJ, Wegmann M, Tolstrup M, Beckmann K, Fujita M, Fischer S, Dinarello CA. A Blocking Antibody to IL-1R3 Broadly Attenuates Function of Six Members of the IL-1 Family and Reveals the Inflammatory Contribution of these Cytokines in vitro and in vivo. Nat Immunol. 2019;20:1138-49.

Webering S, Lunding L, Vock C, Schröder A, Gaede KI, Herzmann C, Fehrenbach, Wegmann M. The alpha-melanocyte-stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma. Clin Exp Allergy. 2019;49:1026-1039.



Lindner, K, Webering, S, Stroebele, M, Bockhorn, H, Hansen, T, König, P & Fehrenbach, H 2018, 'Low Dose Carbon Black Nanoparticle Exposure Does Not Aggravate Allergic Airway Inflammation in Mice Irrespective of the Presence of Surface Polycyclic Aromatic Hydrocarbons' Nanomaterials, Bd 8, Nr. 4. DOI: 10.3390/nano8040213

Nissen G, Hollaender H, Tang FSM, Wegmann M, Lunding L, Vock C, Bachmann A, Lemmel S, Bartels R, Oliver BG, Burgess JK, Becker T, Kopp MV, Weckmann M. Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation. Clin Exp Allergy. 2018;48:1483-1493.



Wegmann M. Targeting cytokines in asthma therapy: could IL-37 be a solution? Expert Rev Respir Med. 2017 Sep;11(9):675-677.

George L, Mitra A, Thimraj TA, Irmler M, Vishweswaraiah S, Lunding L, Hühn D, Madurga A, Beckers J, Fehrenbach H, Upadhyay S, Schulz H, Leikauf GD, Ganguly K. Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function. Respir Res. 2017 Aug 9;18(1):152.

Fehrenbach H, Wagner C, Wegmann M. Airway remodeling in asthma: what really matters. Cell Tissue Res. 2017;367:551-569.



Zimmer, J, Weitnauer, M, Boutin, S, Küblbeck, G, Thiele, S, Walker, P, Lasitschka, F, Lunding, L, Orinska, Z, Vock, C, Arnold, B, Wegmann, M & Dalpke, A 2016, 'Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung' Frontiers in Immunology, Bd 7, S. 514. DOI: 10.3389/fimmu.2016.00514

Lunding, L, Webering, S, Vock, C, Schröder, A, Raedler, D, Schaub, B, Fehrenbach, H & Wegmann, M 2016, 'Effect of IL-37 on Allergic Airway Inflammation. Ann Am Thorac Soc 2016;13:S95-6.

Körbelin J, Sieber T, Michelfelder S, Lunding L, Spies E, Hunger A, Alawi M, Rapti K, Indenbirken D, Müller OJ, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M. Pulmonary targeting of adeno-associated viral vectors by next-generation sequencing-guided screening of random capsid displayed peptide libraries.
Molecular therapy. 24, 6, S. 1050-61

Wegmann M, Fehrenbach H, Krauss-Etschmann S. Asthma Update 2015 - What Cell Biology in Basic Pulmonary Research Can Offer to the Pneumologist. Pneumologie. 2016;70:103-9.



Lunding L, Schröder A, Wegmann M. Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR. Expert Rev Respir Med. 2015;11:1-12.

Lunding L, Wegmann M. NK cells in asthma exacerbation. Oncotarget. 2015 Aug 21;6:19932-3.

Voss M, Wolf L, Kamyschnikow A, Honecker A, Herr C, Lepper PM, Wegmann M, Menger MD, Bals R, Beisswenger C. IL-17A contributes to maintenance of pulmonary homeostasis in a murine model of cigarette smoke-induced emphysema. Am J Physiol Lung Cell Mol Physiol. 2015;309:L188-95.

Lunding LP, Webering S, Vock C, Behrends J, Wagner C, Hölscher C, Fehrenbach, Wegmann M. pIC-triggered exacerbation of experimental asthma depends on IL-17A produced by NK cells. J Immunol 2015;194:5615-25.

Vock C, Yildirim AÖ, Wagner C, Schlick S, Lunding LP, Lee CG, Elias JA, Fehrenbach H, Wegmann M. Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signaling components. Clin Exp Allergy. 2015;45:1447-1458.

Lunding L, Webering S, Vock C, Schröder A, Raedler D, Schaub B, Fehrenbach H, Wegmann M. IL-37 requires IL-18Rα and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice. Allergy. 2015;70:366-73.



Jordakieva G, Wallmann J, Schmutz R, Lemell P, Wegmann M, Nittke T, Mittlböck M, Fehrenbach H, Godnic-Cvar J, Zieglmayer R, Jensen-Jarolim E. Peripheral Erythrocytes Decrease upon Specific Respiratory Challenge with Grass Pollen Allergen in Sensitized Mice and in Human Subjects. PLoS One. 2014 Jan 22;9(1):e86701. Open Access



Wegmann M, Lunding L, Orinska Z, Wong DM, Manz RA, Fehrenbach H. Long-term Bortezomib treatment reduces allergen-specific IgE but fails to ameliorate chronic asthma in mice. Int Arch Allergy Clin Immunol 2012; 158: 43-53.



Wegmann M. The role of neutrophils and TH17 cells in the immunopathology of severe asthma. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2011; 10(6): 427-41.

Wegmann M. Targeting Eosinophil’s Biology in Asthma Therapy. Am J Respir Cell Mol Biol. 2011;45(4):667-74.
Farwick M, Gauglitz G, Pavicic T, Kohler T, Wegmann M, Schwach-Abdellaoui K, Malle B, Tarabin V, Schmitz G, Korting HC. Low Molecular Weight Hyaluronic Acid: Ist Effects on Inflammation and Epidermal Gene Expression. Skin Pharcol Physiol 2011; 24:210-7.



Vock C, Hauber HP, Wegmann M. The Other T cells in Asthma Pathogenesis.  J Allergy. 2010;:1-14.
Luger EO, Wegmann M, Achatz G, Worm M, Renz H, Radbruch A. Allergy for a Lifetime? Allergol Int. 2010 Mar;59(1):1-8.
Wegmann M, Hauber HP. Experimental Approaches Towards Allergic Asthma Therapy – Murine Asthma Models. Recent Pat Inflam Allergy Drug Disc. 2010 Jan;4(1):37-53.
Luger EO, Fokuhl V, Wegmann M, Abram M, Tillack K, Achatz G, Manz R, Worm M, Radbruch A, Renz H. Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge. J Allergy Clin Immunol. 2009;124(4):819-26. (IF 9.273) (Cit. 8)
Wegmann M. New Aspects in the Immunopathology of Severe Asthma. Immun Endoc Metab Agents Med Chem. 2009 Dec;9(4):234-245.
Hauber HP, Wegmann M. Obesity and Asthma. Recent Pat Endocrine, Metabolic & Immune Drug Discovery. 2009;3(3):162-172.
Abram M, Wegmann M, Fokuhl V, Sonar S, Luger EO, Kerzel S, Radbruch A, Renz H, Zemlin M. Nerve growth factor and neurotrophin-3 mediate survival of pulmonary plasma cells during the allergic airway inflammation. J Immunol. 2009 Apr 15;182(8):4705-12.
Wegmann M. Th2 cells as targets for therapeutic intervention in allergic bronchial asthma. Expert Rev Mol Diagn. 2009 Jan;9(1):85-100.


Schwinge D, Presser K, Wegmann M, Huber S, Schmitt S, Quaas A, Maxeiner JH, Finotto S, Lohse AW, Blessing M, Schramm C. Coexpression of TGF-beta1 and IL-10 enables Treg to completely suppress airway hyperreactivity. J Immunol 2008 Dec 1;181(11):7751-8.
Schiemann Y, Wegmann M, Lersch P, Schmitz G, Heisler E, Farwick M. Polar emollients in cosmetic formulations enhance the anti-aging effects of phytosphingosine. Colloids Surf A 2008 Jul; 331(1-2): 103-7. 
Paragh G,Schling P, Ugocsai P, Kel A, Liebisch G, Heimerl S, Moehle C, Schiemann Y, Wegmann M, Farwick M, Wikonkal N, Mandl J, Langmann T, Schmitz G. Novel sphingolipid derivatives promote keratinocyte differentiation.  Exp Dermatol 2008 Dec;17(12):1004-16.
Wollenweber U, Wegmann M, Farwick M. Cosmetic Ingredients to Strengthen Skin Barrier Function In: Janssen F. Cosmetic Lipids and the Skin Barrier, 2nd Edition. 2008
Wegmann M, Sel S, Sel S, Bauer S, Garn H, Renz H. Immuno-modulatory effects of viral toll-like receptor-ligands – An experimental approach to the hygiene hypothesis. In: Holgate S, Marone G, Ring J (Edts.) Cellular and Molecular Targets in Allergy and Clinical Immunology - Proceedings of the Collegium Internationale Allergicum 2008: 184-6.
Sel S*, Wegmann M*,  Dicke T, Sel S, Henke W, Yildirim AO, Renz H, Garn H. Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme. J Allergy Clin Immunol 2008 Apr;121(4):910-916. *equal contribution
Wegmann M. Animal Models of Chronic Experimental Asthma – Strategies for the Identification of New Therapeutic Targets. J Occup Med 2008; 3(S1):S4
Gabriel G, Garn H, Wegmann M, Renz H, Herwig A, Klenk HD, Stech J. The potential of a protease activation mutant of a highly pathogenic avian influenza virus for a pandemic live vaccine. Vaccine. 2008 Feb 13;26(7):956-965.



Sel S*, Wegmann M*, Sel S, Bauer S, Garn H, Alber G, Renz H. Immuno-modulatory effects of viral toll-like receptor-ligands on experimental asthma depend on the additive effects of interleukin-12 and interleukin 10. J Immunol. 2007 Jun 15;178(12):7805-13. *equal contribution
Ozdemir C, Sel S, Scholl I, Yildirim A, Bluemer N, Garn H, Ackermann U, Wegmann M, Barlan IB, Renz H, Sel S. CD4+ T-cells from mice with intestinal immediate-type hypersensitivity induce airway hyperreactivity. Clin Exp Allergy. 2007 Oct;37(10):1419-26.
Hausding M, Karwot R, Scholtes P, Lehr HA, Wegmann M, Renz H, Galle PR, Birkenbach M, Neurath MF, Blumberg RS, Finotto S. Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma. Eur J Immunol. 2007 Jun;37(6):1663-77.
Scholl I, Ackermann U, Ozdemir C, Blumer N, Dicke T, Sel S, Sel S, Wegmann M, Szalai K, Knittelfelder R, Untersmayr E, Scheiner O, Garn H, Jensen-Jarolim E, Renz H. Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring. FASEB J. 2007 Apr;21(4):1264-70.
Wegmann M, Goeggel R, Sel S, Kalkbrenner F, Renz H, Garn H. A low molecular weight CCR-3 antagonist prevents from airway remodeling in a mouse model of established experimental asthma. Am J Respir Cell Mol Biol 2007 Jan;36(1):61-7.


2003 – 2006 (selection)

Beisswenger C, Kändler K, Felgentreff K, Garn H, Hess C, Wegmann M, Renz H, Vogelmeier C, Robert B. The allergic airway inflammation inhibits pulmonary antibacterial host defense. J Immunol 2006; 177:1833-7.
Wegmann M, Fehrenbach H, Fehrenbach A, Held T, Schramm C, Garn H, Renz H. Involvement of distal airways in a chronic model of experimental asthma. Clin Exp Allergy. 2005;35:1263-71.
Stech J, Garn H, Wegmann M, Wagner R, Klenk HD. A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin. Nature Med. 2005 Jun;11(6):683-9.
Wegmann M, Fehrenbach A, Heimann S, Fehrenbach H, Renz H, Garn H, Herz U. NO2-induced airway inflammation is associated with progressive airflow limitation and development of emphysema-like lesion in C57BL/6 mice. Exp Tox Pathol 2005; 56(6): 341-350.
Wegmann M, Renz H. Animal Models of Experimental Asthma. In Animal Models of T Cell Mediated Skin Diseases, Ernst Schering Res Found Workshop. Axel Springer Verlag 2005(50):69-87
Wegmann M, Renz H. Tiermodelle für Entzündungsmechanismen der Lunge.
In Aerosole in der Inhalationstherapie VIII. Dustri Verlag 2004:59-78
Blümer N, Herz U, Wegmann M, Renz H. Prenatal lipopolysaccharide-exposure prevents allergic sensitization and airway inflammation, but not airway hyperresponsiveness in a murine model of experimental asthma. Clin Exp Allergy 2005; 35: 397-402.
Heverhagen JT, Hahn HK, Wegmann M, Herz U, Whitaker CD, Matschel V, Alfke H. Volumetric analysis of mice lungs in a clinical magnetic resonance imaging scanner. MAGMA. 2004 Nov;17(2):80-5.
Voswinckel R, Motejl V, Fehrenbach A, Wegmann M, Mehling T, Fehrenbach H, Seeger W. Characterisation of post-pneumonectomy lung growth in adult mice. Eur Respir J. 2004 Oct;24(4):524-32.
Bünder R, Mittermann I, Herz U, Focke M, Wegmann M, Valenta R, Renz H. Induction of autoallergy with an environmental allergen mimicking a self protein in a murine model of experimental allergic asthma. J Allergy Clin Immunol, 2004; 114: 422-28.
Wegmann M, Renz H, Herz U. Long-term NO2 exposure induces pulmonary inflammation and progressive development of airflow obstruction in C57BL/6 mice: a mouse model for chronic obstructive pulmonary disease? Pathobiology. 2002-2003;70(5):284-6.