Priority Research Area Infections

2022

Merker M*, Rasigade J-P*, Barbier M*, Cox H, Feuerriegel S, Kohl TA, Shitikov E, Klaos K, Gaudin C, Antoine R, et al. 2022. Nat Commun 13: 5105. 'Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis.'

Finci I*, Albertini A*, Merker M*, Andres S, Bablishvili N, Barilar I, Cáceres T, Crudu V, Gotuzzo E, Hapeela N, et al. 2022. Lancet Microbe 3: e672–e682. 'Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study.'

Diricks M, Merker M, Wetzstein N, Kohl TA, Niemann S, Maurer FP. 2022b. Delineating Nat Commun 13: 4936. 'Mycobacterium abscessus population structure and transmission employing high-resolution core genome multilocus sequence typing.'

Dreyer V, Mandal A, Dev P, Merker M, Barilar I, Utpatel C, Nilgiriwala K, Rodrigues C, Crook DW, CRyPTIC Consortium, et al. 2022. Genome Med 14: 95. 'High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.'

Rachow A, Saathoff E, Mindru R, Popescu O, Lugoji D, Mahler B, Merker M, Niemann S, Olaru ID, Kastner S, et al. 2022. PloS One 17: e0271297. 'Diagnostic performance of the AID line probe assay in the detection of Mycobacterium tuberculosis and drug resistance in Romanian patients with presumed TB.'

The CRyPTIC Consortium. 2022. PLoS Biol 20: e3001755. 'Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms.'

Mesfin EA, Merker M, Beyene D, Tesfaye A, Shuaib YA, Addise D, Tessema B, Niemann S. 2022. PloS One 17: e0271508. 'Prediction of drug resistance by Sanger sequencing of Mycobacterium tuberculosis complex strains isolated from multidrug resistant tuberculosis suspect patients in Ethiopia.'

Fowler PW, Wright C, Spiers H, Zhu T, Baeten EML, Hoosdally SW, Gibertoni Cruz AL, Roohi A, Kouchaki S, Walker TM, The CRyPTIC Consortium et al. 2022. eLife 11: e75046. 'A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates.'

Shuaib YA, Utpatel C, Kohl TA, Barilar I, Diricks M, Ashraf N, Wieler LH, Kerubo G, Mesfin EA, Diallo AB, […], Niemann S*, Merker M*. 2022. Genes 13: 990. 'Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3.'

Walker TM, Miotto P, Köser CU, Fowler PW, Knaggs J, Iqbal Z, Hunt M, Chindelevitch L, Farhat M, Cirillo DM, The CRyPTIC Consortium, et al. 2022. Lancet Microbe 3: e265–e273. 'The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A genotypic analysis.'

Bateson, A, Ortiz Canseco, J, McHugh, TD, Witney, AA, Feuerriegel, S, Merker, M, Kohl, TA, Utpatel, C, Niemann, S, Andres, S, Kranzer, K, Maurer, FP, Ghodousi, A, Borroni, E, Cirillo, DM, Wijkander, M, Toro, JC, Groenheit, R, Werngren, J, Machado, D, Viveiros, M, Warren, RM, Sirgel, F, Dippenaar, A, Köser, CU, Sun, E & Timm, J 2022, 'Ancient and recent differences in the intrinsic susceptibility of Mycobacterium tuberculosis complex to pretomanid', JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Jg. 77, Nr. 6, S. 1685-1693. https://doi.org/10.1093/jac/dkac070

Belheouane, M, Hermes, BM, Van Beek, N, Benoit, S, Bernard, P, Drenovska, K, Gerdes, S, Gläser, R, Goebeler, M, Günther, C, von Georg, A, Hammers, CM, Holtsche, MM, Homey, B, Horváth, ON, Hübner, F, Linnemann, B, Joly, P, Márton, D, Patsatsi, A, Pföhler, C, Sárdy, M, Huilaja, L, Vassileva, S, Zillikens, D, Ibrahim, S, Sadik, CD, Schmidt, E & Baines, JF 2022, 'Characterization of the skin microbiota in bullous pemphigoid patients and controls reveals novel microbial indicators of disease', Journal of advanced research. https://doi.org/10.1016/j.jare.2022.03.019

Chesov, E, Chesov, D, Maurer, FP, Andres, S, Utpatel, C, Barilar, I, Donica, A, Reimann, M, Niemann, S, Lange, C, Crudu, V, Heyckendorf, J & Merker, M 2022, 'Emergence of bedaquiline resistance in a high tuberculosis burden country', The European respiratory journal, Jg. 59, Nr. 3, 2100621. https://doi.org/10.1183/13993003.00621-2021

Diricks, M, Kohl, TA, Käding, N, Leshchinskiy, V, Hauswaldt, S, Vázquez, OJ, Utpatel, C, Niemann, S, Rupp, J & Merker, M 2022, 'Correction to:Whole genome sequencing-based classifcation of human-related Haemophilus species and detection of antimicrobial resistance genes', Genome medicine, Jg. 14, Nr. 1, S. 22. https://doi.org/10.1186/s13073-022-01028-8

Kerubo, G, Ndungu, P, Shuaib, YA, Amukoye, E, Revathi, G, Homolka, S, Kariuki, S, Merker, M & Niemann, S 2022, 'Molecular Epidemiology of Mycobacterium tuberculosis Complex Strains in Urban and Slum Settings of Nairobi, Kenya', Genes, Jg. 13, Nr. 3, 475. https://doi.org/10.3390/genes13030475

Mbelele, PM, Utpatel, C, Sauli, E, Mpolya, EA, Mutayoba, BK, Barilar, I, Dreyer, V, Merker, M, Sariko, ML, Swema, BM, Mmbaga, BT, Gratz, J, Addo, KK, Pletschette, M, Niemann, S, Houpt, ER, Mpagama, SG & Heysell, SK 2022, 'Whole genome sequencing-based drug resistance predictions of multidrug-resistant Mycobacterium tuberculosis isolates from Tanzania', JAC-antimicrobial resistance, Jg. 4, Nr. 2, S. dlac042. https://doi.org/10.1093/jacamr/dlac042

Antimycobacterial Susceptibility Testing Group 2022, 'Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment', The European respiratory journal, Jg. 59, Nr. 4, 2200166. https://doi.org/10.1183/13993003.00166-2022

 

2021

Grobbel, H-P, Merker, M, Köhler, N, Andres, S, Hoffmann, H, Heyckendorf, J, Reimann, M, Barilar, I, Dreyer, V, Hillemann, D, Kalsdorf, B, Kohl, TA, Sanchez-Carballo, P, Schaub, D, Todt, K, Utpatel, C, Maurer, FP, Lange, C & Niemann, S 2021, 'Design of multidrug-resistant tuberculosis treatment regimens based on DNA sequencing', CLINICAL INFECTIOUS DISEASES , Jg. 73, Nr. 7, S. 1194-1202. https://doi.org/10.1093/cid/ciab359

Kontsevaya, I, Lange, C, Comella-Del-Barrio, P, Coarfa, C, DiNardo, AR, Gillespie, SH, Hauptmann, M, Leschczyk, C, Mandalakas, AM, Martinecz, A, Merker, M, Niemann, S, Reimann, M, Rzhepishevska, O, Schaible, UE, Scheu, KM, Schurr, E, Abel Zur Wiesch, P & Heyckendorf, J 2021, 'Perspectives for systems biology in the management of tuberculosis', European Respiratory Review, Jg. 30, Nr. 160. https://doi.org/10.1183/16000617.0377-2020

Merker, M, Egbe, NF, Ngangue, YR, Vuchas, C, Kohl, TA, Dreyer, V, Kuaban, C, Noeske, J, Niemann, S & Sander, MS 2021, 'Transmission patterns of rifampicin resistant Mycobacterium tuberculosis complex strains in Cameroon: a genomic epidemiological study', BMC INFECTIOUS DISEASES , Jg. 21, Nr. 1, S. 891. https://doi.org/10.1186/s12879-021-06593-8

Nadarajan, D, Hillemann, D, Kamara, R, Foray, L, Conteh, OS, Merker, M, Niemann, S, Lau, J, Njoya, M, Kranzer, K, Somoskovi, A & Maurer, FP 2021, 'Evaluation of the Roche cobas MTB and MTB-RIF/INH assays in samples from Germany and Sierra Leone', JOURNAL OF CLINICAL MICROBIOLOGY, Jg. 59, Nr. 5. https://doi.org/10.1128/JCM.02983-20

Peker, N, Schuele, L, Kok, N, Terrazos, M, Neuenschwander, SM, de Beer, J, Akkerman, O, Peter, S, Ramette, A, Merker, M, Niemann, S, Couto, N, Sinha, B & Rossen, JW 2021, 'Evaluation of whole-genome sequence data analysis approaches for short- and long-read sequencing of Mycobacterium tuberculosis', Microbial genomics, Jg. 7, Nr. 11. https://doi.org/10.1099/mgen.0.000695

Sonnenkalb, L, Strohe, G, Dreyer, V, Andres, S, Hillemann, D, Maurer, FP, Niemann, S & Merker, M 2021, 'Microevolution of Mycobacterium tuberculosis Subpopulations and Heteroresistance in a Patient Receiving 27 Years of Tuberculosis Treatment in Germany', ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jg. 65, Nr. 7, S. e0252020. https://doi.org/10.1128/AAC.02520-20