Priority Research Area Chronic Lung Diseases

Pulmonary Immune Diseases

Mission   Projects  Funding   Techniques   Publications    Staff



Bieber, K, Hundt, JE, Yu, X, Ehlers, M, Petersen, F, Karsten, CM, Köhl, J, Kridin, K, Kalies, K, Kasprick, A, Goletz, S, Humrich, JY, Manz, RA, Künstner, A, Hammers, CM, Akbarzadeh, R, Busch, H, Sadik, CD, Lange, T, Grasshoff, H, Hackel, AM, Erdmann, J, König, I, Raasch, W, Becker, M, Kerstein-Stähle, A, Lamprecht, P, Riemekasten, G, Schmidt, E & Ludwig, RJ 2023, 'Autoimmune pre-disease', AUTOIMMUNITY REVIEWS , Jg. 22, Nr. 2, S. 103236.

Cabral-Marques, O, Moll, G, Catar, R, Preuß, B, Bankamp, L, Pecher, A-C, Henes, J, Klein, R, Kamalanathan, AS, Akbarzadeh, R, van Oostveen, W, Hohberger, B, Endres, M, Koolmoes, B, Levarht, N, Postma, R, van Duinen, V, van Zonneveld, AJ, de Vries-Bouwstra, J, Fehres, C, Tran, F, do Vale, FYN, da Silva Souza, KB, Filgueiras, IS, Schimke, LF, Baiocchi, GC, de Miranda, GC, da Fonseca, DLM, Freire, PP, Hackel, AM, Grasshoff, H, Stähle, A, Müller, A, Dechend, R, Yu, X, Petersen, F, Sotzny, F, Sakmar, TP, Ochs, HD, Schulze-Forster, K, Heidecke, H, Scheibenbogen, C, Shoenfeld, Y & Riemekasten, G 2023, 'Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium', AUTOIMMUNITY REVIEWS , Jg. 22, Nr. 5, S. 103310.

Yu, X, Wax, J, Riemekasten, G & Petersen, F 2023, 'Functional autoantibodies: Definition, mechanisms, origin and contributions to autoimmune and non-autoimmune disorders', AUTOIMMUNITY REVIEWS , Jg. 22, Nr. 9, S. 103386.



Kasper, B, Yue, X, Goldmann, T, Gülsen, A, Kugler, C, Yu, X & Petersen, F 2022, 'Air exposure and cell differentiation are essential for investigation of SARS-CoV-2 entry genes in human primary airway epithelial cells in vitro', Frontiers in Medicine, Jg. 9, S. 897695.

Philippe, A, Kleinau, G, Gruner, JJ, Wu, S, Postpieszala, D, Speck, D, Heidecke, H, Dowell, SJ, Riemekasten, G, Hildebrand, PW, Kamhieh-Milz, J, Catar, R, Szczepek, M, Dragun, D & Scheerer, P 2022, 'Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation', INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , Jg. 23, Nr. 7.

Shan, L, Zhang, L, Zhu, X, Wang, Z, Fang, S, Lin, J, Wang, J, Li, N, Liu, H, Zhang, X, Feng, Y, Liu, J, Pan, J, Ye, G, Yu, X, Tufman, A, Katalinic, A, Goldmann, T, Petersen, F, Jiang, J, Geng, G & Yu, X 2022, 'Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers', RESPIRATORY RESEARCH , Jg. 23, Nr. 1, S. 293.

Shu, Y, Ma, X, Chen, C, Wang, Y, Sun, X, Zhang, L, Lu, Z, Petersen, F, Qiu, W & Yu, X 2022, 'Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms', Journal of neuroimmunology, Jg. 372, S. 577937.

Shu, Y, Yue, X, Wax, J, Kasper, B, Yin, J, Wang, X, Zhang, L, Ahmadi, M, Heidecke, H, Müller, A, Lamprecht, P, Yu, X, Riemekasten, G & Petersen, F 2022, 'Both T and B cells are indispensable for the development of a PBMC transfer-induced humanized mouse model for SSc',  ARTHRITIS RESEARCH & THERAPY , Jg. 24, Nr. 1, S. 209.

Tran, F, Harris, DMM, Scharmacher, A, Graßhoff, H, Sterner, K, Schinke, S, Käding, N, Humrich, JY, Cabral-Marques, O, Bernardes, JP, Mishra, N, Bahmer, T, Franzenburg, J, Hoyer, BF, Glück, A, Guggeis, M, Ossysek, A, Küller, A, Frank, D, Lange, C, Rupp, J, Heyckendorf, J, Gaede, KI, Amital, H, Rosenstiel, P, Shoenfeld, Y, Halpert, G, Rosenberg, AZ, Schulze-Forster, K, Heidecke, H, Riemekasten, G & Schreiber, S 2022, 'Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19', ERJ Open Research, Jg. 8, Nr. 4.

Wang, G, Ma, A, Zhang, L, Guo, J, Liu, Q, Petersen, F, Wang, Z & Yu, X 2022, 'Acute exacerbations of chronic obstructive pulmonary disease in a cohort of Chinese never smokers goes along with decreased risks of recurrent acute exacerbation, emphysema and comorbidity of lung cancer as well as decreased levels of circulating eosinophils and basophils', Frontiers in Medicine, Jg. 9, S. 907893.

Yue, X, Yin, J, Wang, X, Heidecke, H, Hackel, AM, Dong, X, Kasper, B, Wen, L, Zhang, L, Schulze-Forster, K, Junker, J, Grasshoff, H, Müller, A, Wallukat, G, Schimke, I, Zeiner, J, Deckstein, LM, Mertens, N, Kerstein-Staehle, A, Hundt, JE, Kostenis, E, Yu, X, Riemekasten, G & Petersen, F 2022, 'Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarching', ANNALS OF THE RHEUMATIC DISEASES , Jg. 81, Nr. 9, annrheumdis-2021-222088, S. 1281-9.

Zhang, L, Wax, J, Huang, R, Petersen, F & Yu, X 2022, 'Meta-Analysis and Systematic Review of the Association between a Hypoactive NCF1 Variant and Various Autoimmune Diseases', Antioxidants (Basel, Switzerland), Jg. 11, Nr. 8, 1589.



Hiroyasu, S, Zeglinski, MR, Zhao, H, Pawluk, MA, Turner, CT, Kasprick, A, Tateishi, C, Nishie, W, Burleigh, A, Lennox, PA, Van Laeken, N, Carr, NJ, Petersen, F, Crawford, RI, Shimizu, H, Tsuruta, D, Ludwig, RJ & Granville, DJ 2021, 'Granzyme B inhibition reduces disease severity in autoimmune blistering diseases', Nature communications, Jg. 12, Nr. 1, S. 302.

Ma, A, Zhang, L, Ye, X, Chen, J, Yu, J, Zhuang, L, Weng, C, Petersen, F, Wang, Z & Yu, X 2021, 'High Levels of Circulating IL-8 and Soluble IL-2R Are Associated With Prolonged Illness in Patients With Severe COVID-19', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 626235.

Shang, Y, Chen, F, Li, S, Song, L, Gao, Y, Yu, X & Zheng, J 2021, 'Investigation of Interaction between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing System', Biological procedures online, Jg. 23, Nr. 1, S. 16.

Shu, Y, Guo, J, Ma, X, Yan, Y, Wang, Y, Chen, C, Sun, X, Wang, H, Yin, J, Long, Y, Yan, X, Lu, Z, Petersen, F, Yu, X & Qiu, W 2021, 'Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is associated with IRF7, BANK1 and TBX21 polymorphisms in two populations', European journal of neurology, Jg. 28, Nr. 2, S. 595-601.

Shu, Y, He, D, Ma, X, Li, J, Wu, H, Chen, C, Lu, Z, Petersen, F, Qiu, W & Yu, X 2021, 'Infiltration of plasma cells in colorectal adenocarcinoma associated with autoimmune encephalitis', Annals of clinical and translational neurology, Jg. 8, Nr. 2, S. 498-503.

Wen, L, Dong, X, Li, Q, Schramm, G, Zhang, B, Zillikens, D, Ludwig, RJ, Petersen, F & Yu, X 2021, 'Preventive but Not Therapeutic Topical Application of Local Anesthetics Can Inhibit Experimental Epidermolysis Bullosa Acquisita in Mice', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 750160.

Yin, J, Ibrahim, S, Petersen, F & Yu, X 2021, 'Autoimmunomic Signatures of Aging and Age-Related Neurodegenerative Diseases Are Associated With Brain Function and Ribosomal Proteins', Frontiers in Aging Neuroscience, Jg. 13, S. 679688.

Yue, X, Deng, F, Chen, J, Yin, J, Zheng, J, Chen, Y, Huang, Q, Gao, X, Liu, Z, Luo, J, Müller, A, Heidecke, H, Riemekasten, G, Petersen, F & Yu, X 2021, 'Autoantibodies against C5aR1, C3aR1, CXCR3, and CXCR4 are decreased in primary Sjogren's syndrome',  MOLECULAR IMMUNOLOGY, Jg. 131, S. 112-120.

Yue, X, Petersen, F, Shu, Y, Kasper, B, Magatsin, JDT, Ahmadi, M, Yin, J, Wax, J, Wang, X, Heidecke, H, Lamprecht, P, Müller, A, Yu, X & Riemekasten, G 2021, 'Transfer of PBMC From SSc Patients Induces Autoantibodies and Systemic Inflammation in Rag2-/-/IL2rg-/- Mice', FRONTIERS IN IMMUNOLOGY, Jg. 12, S. 677970.

Zillikens, H, Kasprick, A, Osterloh, C, Gross, N, Radziewitz, M, Hass, C, Hartmann, V, Behnen-Härer, M, Ernst, N, Boch, K, Vidarsson, G, Visser, R, Laskay, T, Yu, X, Petersen, F, Ludwig, RJ & Bieber, K 2021, 'Topical Application of the PI3Kβ-Selective Small Molecule Inhibitor TGX-221 Is an Effective Treatment Option for Experimental Epidermolysis Bullosa Acquisita', Frontiers in Medicine, Jg. 8, S. 713312.



Chen, Y, Li, S, Huang, R, Zhang, Z, Petersen, F, Zheng, J & Yu, X 2020, 'Comprehensive meta-analysis reveals an association of the HLA-DRB1*1602 allele with autoimmune diseases mediated predominantly by autoantibodies', AUTOIMMUNITY REVIEWS  Jg. 19, Nr. 6, S. 102532.

Gao, Y, Chen, Y, Zhang, Z, Yu, X & Zheng, J 2020, 'Recent Advances in Mouse Models of Sjögren's Syndrome', FRONTIERS IN IMMUNOLOGY, Jg. 11, S. 1158.

Geng, G, Yu, X, Jiang, J & Yu, X 2020, 'Aetiology and pathogenesis of paraneoplastic autoimmune disorders', AUTOIMMUNITY REVIEWS, Jg. 19, Nr. 1, S. 102422.

Ma, A, Wen, L, Yin, J, Hu, Y, Yue, X, Li, J, Dong, X, Gupta, Y, Ludwig, RJ, Krauss-Etschmann, S, Riemekasten, G, Petersen, F & Yu, X 2020, 'Serum Levels of Autoantibodies Against Extracellular Antigens and Neutrophil Granule Proteins Increase in Patients with COPD Compared to Non-COPD Smokers', International journal of chronic obstructive pulmonary disease, Jg. 15, S. 189-200.

Stüssel, P, Schulze Dieckhoff, K, Künzel, S, Hartmann, V, Gupta, Y, Kaiser, G, Veldkamp, W, Vidarsson, G, Visser, R, Ghorbanalipoor, S, Matsumoto, K, Krause, M, Petersen, F, Kalies, K, Ludwig, RJ & Bieber, K 2020, 'Propranolol Is an Effective Topical and Systemic Treatment Option for Experimental Epidermolysis Bullosa Acquisita', JOURNAL OF INVESTIGATIVE DERMATOLOGY.


Gao, X, Yin, J, Wang, X, Petersen, F & Yu, X 2019, 'A comprehensive comparison of hematological parameters among 39 common diseases', Scandinavian journal of clinical and laboratory investigation, Jg. 79, Nr. 4, S. 251-259.

Shu, Y, Qiu, W, Zheng, J, Sun, X, Yin, J, Yang, X, Yue, X, Chen, C, Deng, Z, Li, S, Yang, Y, Peng, F, Lu, Z, Hu, X, Petersen, F & Yu, X 2019, 'HLA class II allele DRB1*16:02 is associated with anti-NMDAR encephalitis', Journal of neurology neurosurgery and psychiatry, Jg. 90, Nr. 6, S. 652-658.

Shu, Y, Long, Y, Wang, S, Hu, W, Zhou, J, Xu, H, Chen, C, Ou, Y, Lu, Z, Lau, AY, Yu, X, Kermode, AG & Qiu, W 2019, 'Brain histopathological study and prognosis in MOG antibody-associated demyelinating pseudotumor', Annals of clinical and translational neurology, Jg. 6, Nr. 2, S. 392-396.


Epp, A, Hobusch, J, Bartsch, YC, Petry, J, Lilienthal, G-M, Koeleman, CAM, Eschweiler, S, Möbs, C, Hall, A, Morris, SC, Braumann, D, Engellenner, C, Bitterling, J, Rahmöller, J, Leliavski, A, Thurmann, R, Collin, M, Moremen, KW, Strait, RT, Blanchard, V, Petersen, A, Gemoll, T, Habermann, JK, Petersen, F, Nandy, A, Kahlert, H, Hertl, M, Wuhrer, M, Pfützner, W, Jappe, U, Finkelman, FD & Ehlers, M 2018, 'Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions', The Journal of allergy and clinical immunology, Jg. 141, Nr. 1, S. 399-402.e8.

Gao, Y, Li, S, Zhang, Z, Yu, X & Zheng, J 2018, 'The Role of Long Non-coding RNAs in the Pathogenesis of RA, SLE, and SS', Frontiers in Medicine, Jg. 5, S. 193.

Kasprick, A, Holtsche, MM, Rose, EL, Hussain, S, Schmidt, E, Petersen, F, Panicker, S & Ludwig, RJ 2018, 'The anti-C1s antibody TNT003 prevents complement activation in the skin induced by bullous pemphigoid autoantibodies', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Jg. 138, Nr. 2, S. 458-461.

Krauss-Etschmann, S, Yu, X, Petersen, F & Wen, L 2018, 'Autoantibodies in Chronic Obstructive Pulmonary Disease', FRONTIERS IN IMMUNOLOGY, Jg. 9, Nr. 66, S. 66.

Lamprecht, P, Kerstein, A, Klapa, S, Schinke, S, Karsten, CM, Yu, X, Ehlers, M, Epplen, JT, Holl-Ulrich, K, Wiech, T, Kalies, K, Lange, T, Laudien, M, Laskay, T, Gemoll, T, Schumacher, U, Ullrich, S, Busch, H, Ibrahim, S, Fischer, N, Hasselbacher, K, Pries, R, Petersen, F, Weppner, G, Manz, R, Humrich, JY, Nieberding, R, Riemekasten, G & Müller, A 2018, 'Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides', FRONTIERS IN IMMUNOLOGY, Jg. 9, S. 680.

Shu, Y, Chang, Y, Wu, H, Li, J, Cao, B, Sun, X, Wang, J, Peng, L, Hu, X, Yu, X & Qiu, W 2018, 'Serum cystatin C and anti-N-methyl-D-aspartate receptor encephalitis', Acta neurologica Scandinavica, Jg. 137, Nr. 5, S. 515-522.

Shu, Y, Xu, Y, Chen, C, Li, J, Li, R, Wu, H, Hu, X, Lu, Z, Yu, X & Qiu, W 2018, 'Serum Bilirubin and Albumin in Anti-N-Methyl-D-Aspartate Receptor Encephalitis', Neuroimmunomodulation, Jg. 25, Nr. 4, S. 206-214.

Weigold, F, Günther, J, Pfeiffenberger, M, Cabral-Marques, O, Siegert, E, Dragun, D, Philippe, A, Regensburger, A-K, Recke, A, Yu, X, Petersen, F, Catar, R, Biesen, R, Hiepe, F, Burmester, GR, Heidecke, H & Riemekasten, G 2018, 'Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis',  ARTHRITIS RESEARCH & THERAPY , Jg. 20, Nr. 1, S. 52.

Yin, J, Zheng, J, Deng, F, Zhao, W, Chen, Y, Huang, Q, Huang, R, Wen, L, Yue, X, Petersen, F & Yu, X 2018, 'Gene Expression Profiling of Lacrimal Glands Identifies the Ectopic Expression of MHC II on Glandular Cells as a Presymptomatic Feature in a Mouse Model of Primary Sjögren's Syndrome', FRONTIERS IN IMMUNOLOGY, Jg. 9, S. 2362.

Yu, X, Riemekasten, G & Petersen, F 2018, 'Autoantibodies against muscarinic acetylcholine receptor M in Sjogren's syndrome and corresponding mouse models', Frontiers in bioscience (Landmark edition), Jg. 23, S. 2053-2064.

Yu, X & Petersen, F 2018, 'A methodological review of induced animal models of autoimmune diseases', AUTOIMMUNITY REVIEWS , Jg. 17, Nr. 5, S. 473-479.

Yu, X, Kasprick, A, Hartmann, K & Petersen, F 2018, 'The Role of Mast Cells in Autoimmune Bullous Dermatoses', FRONTIERS IN IMMUNOLOGY, Jg. 9, S. 386.

Yu, X, Akbarzadeh, R, Pieper, M, Scholzen, T, Gehrig, S, Schultz, C, Zillikens, D, König, P & Petersen, F 2018, 'Neutrophil Adhesion Is a Prerequisite for Antibody-Mediated Proteolytic Tissue Damage in Experimental Models of Epidermolysis Bullosa Acquisita', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Jg. 138, Nr. 9, S. 1990-1998.

Yue, X, Yu, X, Petersen, F & Riemekasten, G 2018, 'Recent advances in mouse models for systemic sclerosis', AUTOIMMUNITY REVIEWS , Jg. 17, Nr. 12, S. 1225-1234.


Deng, F, Chen, Y, Zheng, J, Huang, Q, Cao, X, Zillikens, D, Petersen, F & Yu, X 2017, 'CD11b-deficient mice exhibit an increased severity in the late phase of antibody transfer-induced experimental epidermolysis bullosa acquisita', EXPERIMENTAL DERMATOLOGY , Jg. 26, Nr. 12, 12, S. 1175-1178.

Michelfelder, M, Becker, W-M, Riedlinger, A, Siegert, E, Drömann, D, Yu, X, Petersen, F & Riemekasten, G 2017, 'Interstitial lung disease increases mortality in systemic sclerosis patients with pulmonary arterial hypertension without affecting hemodynamics and exercise capacity', Clinical Rheumatology, Jg. 36, Nr. 2, S. 381-390.

Petersen, F, Yue, X, Riemekasten, G & Yu, X 2017, 'Dysregulated homeostasis of target tissues or autoantigens - A novel principle in autoimmunity', AUTOIMMUNITY REVIEWS , Jg. 16, Nr. 6, S. 602-611.

Zhao, W, Yue, X, Liu, K, Zheng, J, Huang, R, Zou, J, Riemekasten, G, Petersen, F & Yu, X 2017, 'The status of pulmonary fibrosis in systemic sclerosis is associated with IRF5, STAT4, IRAK1, and CTGF polymorphisms', RHEUMATOLOGY INTERNATIONAL, Jg. 37, Nr. 8, S. 1303-1310.

Zheng, J, Huang, Q, Huang, R, Deng, F, Yue, X, Yin, J, Zhao, W, Chen, Y, Wen, L, Zhou, J, Huang, R, Riemekasten, G, Liu, Z, Petersen, F & Yu, X 2017, 'B Cells Are Indispensable for a Novel Mouse Model of Primary Sjögren's Syndrome', FRONTIERS IN IMMUNOLOGY, Jg. 8, S. 1384.